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24,576 grants matching “microbiome”
TVP23B and Golgi Mediated Control of Intestinal Secretory Cells
$630,696Emre Erol Turer · Ut Southwestern Medical Center · R01 · FY2024 · DK
Multi-Omics Analysis of Pain/Stress Impact on Neurodevelopment in Preterm Infants
$630,638Xiaomei Sophia Cong · University Of Connecticut Storrs · R01 · FY2018 · NR
Diversity and Dynamic Stability of the Ocular Surface Microbiome
$630,621Russell N Van Gelder · University Of Washington · R01 · FY2016 · EY
Genomic Tools For Studying The Ecology Of The Human Vaginal Microflora
$630,605Jacques Ravel · University Of Maryland Baltimore · U01 · FY2010 · AI
Collaborative Research: Understanding spatiotemporal dynamics of plant-soil feedbacks: Consequences for shrub-grass interactions in a dryland ecotone
$630,572Yan Yi Chung · University Of Georgia Research Foundation Inc · · FY2021 · BIO
Oral Microbiome and Lung Cancer Risk
$630,540Qiuyin Cai · Vanderbilt University Medical Center · R01 · FY2019 · CA
Biological Mechanisms through which TMAO Promotes Atherosclerosis
$630,470Hooman Allayee · University Of Southern California · R01 · FY2020 · HL
A Phase II randomized controlled trial to evaluate the role of BB-12 in antibiotic-associated diarrhea and its effects on the gut microbiome
$630,449Daniel J Merenstein · Georgetown University · R01 · FY2018 · HD
STEARIC ACID (18:0) IS A SATURATED FATTY ACID FOUND IN FOODS SUCH AS COCOA BUTTER, MEAT AND DAIRY. UNLIKE OTHERDIETARY SATURATED FATS WHICH ARE CONSIDERED TO BE UNHEALTHY, STEARIC ACID HAS A NEUTRAL EFFECT ON BLOOD LDL CHOLESTEROL LEVELS AND HAS BEEN INVERSELY ASSOCIATED WITH CARDIOVASCULAR DISEASE (CVD) RISK. EXISTING STUDIES HAVE EXPLORED POSSIBLE MECHANISMS SUCH AS REDUCED INTESTINAL ABSORPTION, INCREASED EXCRETION OR OXIDATION, AND CONVERSION TO OLEIC ACID IN THE BODY, BUT THESE DO NOT FULLY ACCOUNT FOR ITS DISTINCT METABOLIC EFFECTS. PRELIMINARY DATA INDICATE THAT STEARIC ACID MAY INFLUENCE THE GUT MICROBIOME, PARTICULARLY MICROBES INVOLVED IN BILE ACID (BA) METABOLISM. CHANGES IN THESE MICROBES CAN ALTER THE PRODUCTION OF SECONDARY BILE ACIDS, WHICH ARE KNOWN TO PLAY ROLES IN LIPID METABOLISM AND INFLAMMATION. MOST PREVIOUS RESEARCH HAS RELIED ON STOOL SAMPLES TO STUDY THE GUT MICROBIOME. HOWEVER, STOOL REFLECTS MICROBIAL ACTIVITY PRIMARILY IN THE LARGE INTESTINE (COLON), NOT THE ENTIRE GASTROINTESTINAL (GI) TRACT. MICROBIAL TRANSFORMATION AND REABSORPTION OF BAS OCCUR MAINLY IN THE ILEUM, A REGION OF THE SMALL INTESTINE, WHICH IS NOT WELL-REPRESENTED IN STOOL-BASED ANALYSES. TO ADDRESS THIS LIMITATION, WE WILL CONDUCT A CLINICAL TRIAL IN OLDER ADULTS USING AN INGESTIBLE SAMPLING DEVICE (MINI-PILL) TO COLLECT REGION-SPECIFIC GASTROINTESTINAL SAMPLES AND EVALUATE THE EFFECTS OF DIETARY STEARIC ACID ON GUT MICROBIAL COMPOSITION, FUNCTION, AND BA METABOLISM. FINDINGS FROM THIS WORK WILL PROVIDE A MORE DETAILED UNDERSTANDING OF THE EFFECTS OF STEARIC ACID WITHIN THE GUT AND ITS RELATIONSHIP TO HOST METABOLIC PROCESSES RELEVANT TO CARDIOVASCULAR HEALTH. THIS WILL CONTRIBUTETO THE EVIDENCE BASE NEEDED TO MODIFY CURRENT DIETARY GUIDANCE/NUTRIENT LABELING RELATED TO SATURATED FAT, AND THE POTENTIAL USE OF STEARIC ACIDAS AN ALTERNATIVE FOR TRANS FATTY ACIDS (TFAS) IN THE FOOD SUPPLY.
$630,410Trustees Of Tufts College · · FY2025 · National Institute of Food and Agriculture
THE EARLY YEARS OF LIFE--FROM CHILDHOOD THROUGH ADOLESCENCE--ARE A CRITICAL TIME FOR SETTING THE FOUNDATION FOR LIFELONG HEALTH. WHILE MANY STUDIES HAVE LOOKED AT NUTRITION AFFECTS DURING GESTATION AND LACTATION, THERE'S MUCH LESS RESEARCH ON HOW WHAT CHILDREN AND TEENS EAT IMPACTS THEIR HEALTH AS ADULTS. THIS IS ESPECIALLY CONCERNING, BECAUSE NATIONAL DIETARY DATA SHOWS THAT MOST CHILDREN AND TEENS IN THE U.S. HAVE POOR DIETS--SCORING BELOW 55 OUT OF 100 ON THE HEALTHY EATING INDEX. BREAST CANCER IS THE MOST COMMON CANCER AMONG FEMALES IN THE UNITED STATES, WITH OVER 310,000 NEW CASES EXPECTED IN 2024 ALONE. IT ALSO REMAINS THE SECOND LEADING CAUSE OF CANCER-RELATED DEATHS IN FEMALES. WHILE ADVANCES IN SCREENING AND TREATMENT HAVE HELPED REDUCE DEATH RATES SINCE 1990, THE NUMBER OF NEW BREAST CANCER CASES CONTINUES TO RISE--ESPECIALLY AMONG YOUNGER FEMALES. ALARMINGLY, ABOUT HALF OF FEMALE WHO DIE FROM BREAST CANCER IN THE U.S. TODAY ARE UNDER THE AGE OF 45. ONE KEY GAP IN OUR UNDERSTANDING IS WHY BREAST CANCER IN YOUNGER FEMALE HAS BEEN INCREASING OVER THE PAST 50 YEARS. OUR PROJECT AIMS TO EXPLORE WHETHER POOR WESTERN-STYLE DIET (WSD) DURING CHILDHOOD AND ADOLESCENCE PLAYS A ROLE IN THIS TREND--AND IF IMPROVING EARLY-LIFE NUTRITION COULD HELP PREVENT BREAST CANCER LATER ON. IN OUR EARLY STUDIES USING ANIMAL MODELS, WE FOUND THAT EATING A HIGH-FAT DIET DURING YOUTH LED TO LONG-LASTING CHANGES IN THE GUT MICROBIOME AND IN BREAST TISSUE--CHANGES THAT MAY INCREASE THE RISK OF DEVELOPING BREAST CANCER LATER IN LIFE. THESE FINDINGS SUGGEST THAT THE RISE IN BREAST CANCER AMONG YOUNG FEMALE MAY BE LINKED, AT LEAST IN PART, TO THE INCREASING POPULARITY OF WESTERN-STYLE DIETS, WHICH ARE OFTEN HIGH IN FAT AND LOW IN FIBER AND ESSENTIAL NUTRIENTS. BEANS ARE A POWERFUL, NUTRIENT-RICH FOOD THAT CAN HELP IMPROVE THE QUALITY OF WSD. THEY CONTAIN FIBER, PROTEIN, AND OTHER IMPORTANT NUTRIENTS THAT MANY PEOPLE IN WESTERN COUNTRIES DON'T GET ENOUGH OF. HOWEVER, WE STILL DON'T KNOW ENOUGH HOW EFFECTIVE TO INCORPORATE BEANS INTO WSD FOR CHILDREN AND ADOLESCENTS AND THEREBY TO PROMOTE BREAST HEALTH, REDUCING THE RISK OF EARLY-ONSET BREAST CANCER. THIS PROJECT WILL FOCUS ON THREE MAIN GOALS: 1) TO EXAMINE HOW ADDING BEANS TO A WESTERN-STYLE DIET DURING CHILDHOOD AFFECTS THE GUT AND BREAST HEALTH LATER IN LIFE; 2) TO INVESTIGATE WHETHER THIS DIETARY CHANGE CAN REDUCE THE RISK OF DEVELOPING BREAST CANCER IN ADULTHOOD; AND 3) TO UNDERSTAND THE ROLE OF THE GUT MICROBIOME IN CONNECTING EARLY-LIFE DIET TO BREAST HEALTH OUTCOMES. BY EXPLORING THESE QUESTIONS, WE HOPE TO DEVELOP PRACTICAL, SCIENCE-BASED DIETARY STRATEGIES TO HELP REDUCE THE RISK OF BREAST CANCER--STARTING WITH BETTER NUTRITION IN THE EARLY YEARS OF LIFE.
$630,393University Of Massachusetts · · FY2025 · National Institute of Food and Agriculture
Diversity and Dynamic Stability of the Ocular Surface Microbiome
$630,276Russell N Van Gelder · University Of Washington · R01 · FY2013 · EY
Core A: Biospecimen and Pathology
$630,250Deborah Dillon · Dana-Farber Cancer Inst · P50 · FY2025 · CA
Childhood Pulmonary and Related Outcomes after Perinatal Exposure to Adjunctive Azithromycin Prophylaxis for Cesarean Delivery (C/SOAP Follow-Up Study)
$630,181Akila Subramaniam · University Of Alabama At Birmingham · R01 · FY2021 · HD
Developing an Oncology Workforce for the 21st Century
$630,175Olufunmilayo I Olopade · University Of Chicago · K12 · FY2021 · CA
Administrative Core: Coordinating and collaborating to facilitate VCC work
$630,173Pardis Christine Sabeti · Broad Institute, Inc. · U54 · FY2025 · AG
Microbiomes in Human Pancreatic Cancer
$630,157Dominique S Michaud · Tufts University Boston · R01 · FY2015 · CA
Determinants of H. influenzae Virulence in Otitis Media
$630,017Lauren O Bakaletz · Research Inst Nationwide Children'S Hosp · R01 · FY2024 · DC
Determinants of follicular helper T cell expansion in lupus
$629,963Laurence Morel · University Of Texas Hlth Science Center · R01 · FY2022 · AI
Molecular characterization of the ocular microbiome in healthy adults
$629,951Seesandra Venkatappa Rajagopala · Vanderbilt University Medical Center · U24 · FY2023 · EY
Investigating neutrophilic inflammation as an APOE genotype-specific mediator of neuroinflammation and cognitive decline in aging
$629,748Tiffany Hensley-McBain · Mc Laughlin Research Institute · R01 · FY2024 · AG
Prenatal maternal obesity and neurodevelopment: The mediating role of the microbiome and metabolome
$629,722Jonathan E Posner · Duke University · R01 · FY2025 · MH
Vaginal Microbiome, Inflammatory Mediators, Metabolome, and Dysmenorrhea Symptom-based Phenotypes
$629,557Chen Xiao Chen · University Of Arizona · R01 · FY2025 · HD
The Female Urinary Microbiome and Urinary Incontinence
$629,504Alan J Wolfe · Loyola University Chicago · R01 · FY2018 · DK
Toxoplasma Surface Antigens and Immunity
$629,438Michael Grigg · National Institute Of Allergy And Infectious Diseases · ZIA · FY2021 · AI
Delivery mode, environment and the gut microbiome: influence on childhood body size
$629,428Andrea E Cassidy-Bushrow · Henry Ford Health System · R01 · FY2016 · HD