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24,576 grants matching “microbiome”
Insights into Sickle Cell Trait and Sickle Cell Disease
$628,447Vence L Bonham · National Human Genome Research Institute · ZIA · FY2023 · HG
Mechanisms of fasting-induced radioprotection of small intestinal epithelial cells
$628,444Helen M Piwnica-Worms · University Of Tx Md Anderson Can Ctr · R01 · FY2024 · CA
Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance
$628,341Tracey McLaughlin · Stanford University · R01 · FY2020 · DK
Microbiota-Brain Axis in Alzheimer's Disease: MIND Diet-Induced Effects
$628,309Robin M Voigt · Rush University Medical Center · R01 · FY2021 · AG
Intergrated Biorepository of H3Africa Uganda
$628,248Moses Lutaakome Joloba · Makerere University College Of Health Sciences · U24 · FY2021 · HG
The Oral Microbiome in Type 1 Diabetes and Sub-Clinical Cardiovascular Disease
$628,233Amy Christine Alman · University Of South Florida · R01 · FY2017 · DE
Clostridium difficile Over Testing (C-DOT) Improvement initiative; a Multi-Prevention Epicenter Collaborative Project
$628,149Clare Rock · Johns Hopkins University · U01 · FY2018 · CK
Molecular Mechanisms of Staphylococcus Epidermidis Strain Diversity
$628,111Julia Oh · Jackson Laboratory · R01 · FY2021 · AR
Epidemiologic identification and mechanistic investigation of early life environmental risk factors for eosinophilic esophagitis
$628,011Evan Samuel Dellon · Univ Of North Carolina Chapel Hill · R01 · FY2024 · ES
C3-Dependent Intracellular Killing in Innate Immunity and Bacterial Pathogenesis
$627,952Manuela Raffatellu · University Of California, San Diego · R01 · FY2022 · AI
The Oral Mycobiome and Risk of Pancreatic Cancer
$627,816Jiyoung Ahn · New York University School Of Medicine · U01 · FY2022 · CA
Microbial Interactions between Gardnerella, Prevotella, and Atopobium Prior to Incident Bacterial Vaginosis
$627,727Christina A Muzny · University Of Alabama At Birmingham · R01 · FY2022 · AI
THE VAGINAL MICROBIOME, MATERNAL RESPONSE, AND PRETERM BIRTH
$627,710Kristine M. Wylie · Washington University · R01 · FY2021 · HD
Structural and functional studies of colibactin
$627,662Seth B. Herzon · Yale University · R01 · FY2024 · CA
Ontogenic Programming of Gingival Tissues and Risk of Periodontitis
$627,602Jeffrey L Ebersole · University Of Nevada Las Vegas · R56 · FY2020 · DE
Polymicrobial interactions in Crohn's Disease
$627,568Mahmoud A Ghannoum · Case Western Reserve University · R01 · FY2019 · AI
Quorum sensing, diversity and skin inflammation
$627,561Alexander R Horswill · University Of Colorado Denver · R01 · FY2020 · AI
Blocking CMV transmission through the human milk metabolome and microbiome
$627,556Tatiana T. Marquez-Lago · University Of Alabama At Birmingham · R01 · FY2022 · HD
Identification of Microbiome Based Markers to Improve Colorectal Cancer Detection
$627,529Patrick David Schloss · University Of Michigan At Ann Arbor · R01 · FY2018 · CA
Bacteriophage pathobiology of inflammatory bowel disease
$627,518June Louise Round · University Of Utah · R01 · FY2022 · DK
Metabolomics clocks as a tool to explore mechanisms of aging
$627,466Daniel Edward Lee Promislow · Tufts University Boston · R01 · FY2025 · AG
Prevention Center U01: Early Targets for Antigen-Specific Tolerance Induction in Preclinical Rheumatoid Arthritis
$627,429V Michael Holers · University Of Colorado Denver · U01 · FY2020 · AI
Microbiome Affects Risk of Growth in HIV-exposed but Unifected Infants-Nigeria
$627,361Manhattan E Charurat · University Of Maryland Baltimore · R01 · FY2018 · DE
Insights into a multi-hit process in the development of necrotizing enterocolitis
$627,326Xiao-Di Tan · University Of Illinois At Chicago · R01 · FY2024 · DK
THE OVERALL GOALS OF THIS PROJECT ARE TO INVESTIGATE THE EFFECTS OF BLACKCURRANT (BC) SUPPLEMENTATION ON CHANGES IN GUT MICROBIOTA AND BONE DENSITY IN POSTMENOPAUSAL FEMALES AND TO ELUCIDATE THE INTERRELATIONSHIP OF BC AND GUT MICROBIOTA ON BONE LOSS MITIGATION BY APPLYING A MULTI-OMICS APPROACH. FOR THIS PURPOSE, WE PROPOSE TO CONDUCT A 3-ARM PARALLEL, DOUBLE-BLIND, RANDOMIZED CONTROLLED TRIAL WITH BC SUPPLEMENTATION FOR 12 MONTHS IN POSTMENOPAUSAL FEMALES AGED 45-70 YEARS. THE PRIMARY ENDPOINTS ARE % CHANGES FROM BASELINE IN WHOLE-BODY, LUMBER SPINE, TOTAL HIP, AND FEMORAL NECK BONE MINERAL DENSITY AT MONTHS 6 AND 12; SECONDARY ENDPOINTS INCLUDE P1NP, RANKL, IL-1Β, TREGS, IGF-1, IGFBP4, RUMINOCOCCUS2, SCFA BUTYRATE, GALLIC ACID, AND PROTOCATECHUIC ACID. THE SPECIFIC OBJECTIVES OF THE STUDY ARE TO INVESTIGATE THE EFFECTS OF BC ON: 1) BONE MASS AND BONE REMODELING MARKERS AND 2) CHANGES IN THE GUT MICROBIOME, IMMUNE AND ENDOCRINE RESPONSES AND THEIR INTERRELATIONSHIPS WITH CHANGES IN BONE MASS; 3) DELINEATE THE INTERPLAY OF BC-GUT MICROBIOTA-BONE THROUGH MICROBIOTA-DERIVED METABOLITES; AND 4) DEVELOP AND VALIDATE AN INTERPRETABLE MACHINE LEARNING ALGORITHM THAT INTEGRATES META DATA AND MOLECULAR DATA TO PREDICT EFFECTIVENESS AND PERSONAL VARIABILITY IN RESPONSE TO BC INTERVENTION. THE PROPOSED STUDY WILL PROVIDE NOVEL INSIGHT INTO WHETHER AND HOW BC REDUCES THE RISK OF POSTMENOPAUSAL BONE LOSS VIA THE GUT-BONE AXIS. FURTHERMORE, DEVELOPING AN ALGORITHM FOR EFFECTIVENESS PREDICTION IN A FOOD-BASED CLINICAL TRIAL WILL PROVIDE A SCIENTIFIC BASIS TO ESTABLISH PERSONALIZED NUTRITION RECOMMENDATIONS AND STRATEGIES FOR ADULT FEMALES' HEALTH AND IDENTIFY WHY METABOLIC HETEROGENEITY EXISTS, WHICH IS CRITICAL FOR FUTURE ADVANCES IN PRECISION NUTRITION.
$627,220University Of Connecticut · · FY2025 · National Institute of Food and Agriculture