Sort
24,576 grants matching “microbiome”
Prebiotic effect of eicosapentaenoic acid treatment for colorectal cancer
$626,197Andrew T Chan · Massachusetts General Hospital · R01 · FY2021 · CA
Randomized Trial of Diet in GDM: Metabolic Consequences to Mother and Offspring
$626,155Teri L Hernandez · University Of Colorado Denver · R01 · FY2014 · DK
Cutaneous biomarkers of pediatric non-alcoholic fatty liver disease
$626,121Marialena Mouzaki · Cincinnati Childrens Hosp Med Ctr · R01 · FY2024 · DK
Collaborative Research: Direction and Mechanisms of Seasonal Change in Arctic Microbial Communities
$626,054Karen E Nelson · J. Craig Venter Institute, Inc. · · FY2012 · GEO
Microbiome, Environment, and Parkinsons disease (MEP) PESTICIDE EXPOSURES AND THE GUT MICROBIOME IN PARKINSONS DISEASE
$626,033Beate R Ritz · University Of California Los Angeles · R01 · FY2023 · ES
An Integrative Approach to the Etiology of Internalizing Disorders in the Lifelines Cohort
$626,021Kenneth Seedman Kendler · Virginia Commonwealth University · R01 · FY2022 · MH
Developing novel inhibitors of the gut microbiome to modulate drug metabolism
$625,834Bret David Wallace · Symberix, Inc. · R44 · FY2020 · TR
Comprehensive Training Program in Oral Biology
$625,781Jose A Lemos · University Of Florida · T90 · FY2025 · DE
Vitamin D Receptor Regulation of Microbiota in Intestinal Epithelia
$625,763Jun Sun · University Of Illinois At Chicago · R01 · FY2023 · DK
Engineering Native E. coli to Detect, Report, and Treat Colorectal Cancer
$625,751Amir Zarrinpar · University Of California, San Diego · U01 · FY2025 · CA
Dietary and Microbial Reprogramming of Intestinal Microbiota-Produced Metabolites
$625,691Justin Sonnenburg · Stanford University · R01 · FY2023 · DK
Mechanisms of Gastrointestinal COVID-19
$625,575Matthew Aaron Ciorba · Washington University · R01 · FY2024 · AI
The Gut Microbiome, Lifestyle, and Colorectal Neoplasia
$625,531Mingyang Song · Harvard University D/B/A Harvard School Of Public Health · U01 · FY2024 · CA
Epidemiologic identification and mechanistic investigation of early life environmental risk factors for eosinophilic esophagitis
$625,444Evan Samuel Dellon · Univ Of North Carolina Chapel Hill · R01 · FY2025 · ES
Understanding the Association between Sublingual Buprenorphine and Oral Health Outcomes
$625,388Marcia Vanessa Rojas Ramirez · University Of Kentucky · R01 · FY2025 · DE
PHYLOGENOMIC, TRANSCRIPTOMIC, VIROMIC, AND IMMUNOPROTEOMIC DETERMINANTS OF NECROTIZING ENTEROCOLITIS
$625,282Phillip I Tarr · Washington University · R01 · FY2018 · HD
Evaluation of the gut-kidney axis in kidney stone disease
$625,273Gregory Edward Tasian · Children'S Hosp Of Philadelphia · R01 · FY2022 · DK
Collaborative Research: Host ocular microbiome and pathogen dynamics: from individual to population-level effects in a songbird
$625,200Dana M Hawley · Virginia Polytechnic Institute And State University · · FY2018 · BIO
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** OUR GOAL IS TO PREVENT PATHOGENS FROM GETTING INTO THE FOOD SUPPLY. FOOD PRODUCTION IN THE U.S. OFTEN TAKES PLACE IN LARGE, INDUSTRIAL PLANTS WITH COMPLEX NICHES (I.E. PLACES WHERE PATHOGENS CAN HIDE) THAT RESIST SANITATION EFFORTS. HOWEVER, LITTLE ANALYSIS HAS BEEN DONE ON THE MICROBIAL COMMUNITIES LIVING IN THESE NICHES, INCLUDING WHICH ATTRIBUTES OF THE NICHE DRIVE THE SELECTION FOR PARTICULAR MICROBES. MOST ENVIRONMENTAL SANITATION RESEARCH HAS NOT STUDIED THE ROLE OF SANITIZER FLUID FLOW IN AND OUT OF THE NICHE EVEN THOUGH WE KNOW THAT IT GREATLY IMPACTS MICROBIAL REMOVAL. WE AIM TO RESOLVE THESE UNKNOWNS BY IDENTIFYING AND DEFINING SPECIFIC MICROBIAL COMMUNITIES WITHIN DIFFERENT NICHES TO BETTER UNDERSTAND THE SOURCES OF IMPORTANT FOODBORNE PATHOGENS LIKELISTERIA MONOCYTOGENES. WE WILL COLLECT MORE THAN 1,000 ENVIRONMENTAL SAMPLES FROM THREE LARGE DAIRY PLANTS TO DEFINE THE MICROBIOME OF DIFFERENT NICHES. WE WILL THEN APPLY MACHINE LEARNING ALGORITHMS TO IDENTIFY THE FEATURES MOST PREDICTIVE OF SPECIFIC MICROBIAL TAXA, VERIFYING THESE ASSOCIATIONS USING LABORATORY STUDIES. FINALLY, WE WILL EXPLORE HOW COMPLEX FEATURES OF THE NICHE IMPACT ENVIRONMENTAL SANITATION BY RESTRICTING FLUID FLOW, USING SANITATION CHALLENGE STUDIES TO DETERMINE HOW SANITATION IMPACTS DIVERSE MICROBIAL COMMUNITIES. OVERALL, OUR WORK AIMS TO REDUCE OUTBREAKS AND RECALLS; ADVANCE SOURCE TRACKING AND ROOT CAUSE ANALYSIS AFTER CROSS-CONTAMINATION; AND SUPPORT BETTER DESIGN OF FOOD PLANTS TO STRATEGICALLY ELIMINATE MICROBIAL HARBORAGE POINTS.
$625,100Cornell University · · FY2022 · National Institute of Food and Agriculture
The Role in OAT1 in Uremia
$625,043Sanjay K Nigam · University Of California, San Diego · R01 · FY2022 · DK
Gut Microbiota Modulation of Chikungunya Virus Infection and Pathogenesis
$624,846Michael S. Diamond · Washington University · R01 · FY2021 · AI
Identifying critical determinants of vaccine-induced cellular and humoral immunity from birth through childhood in HIV-exposed and unexposed children
$624,693Jennifer Ann Slyker · University Of Washington · R01 · FY2024 · AI
Project 1 - Determining the contributions of the gut microbiota to the physiologi
$624,543Jeffrey Ivan Gordon · Washington University · P01 · FY2017 · DK
Predicting Health Outcomes of Mediterranean Diet via Metabolomics of Foods and Biospecimens
$624,394Nancy F Krebs · University Of Colorado Denver · R01 · FY2022 · DK
Childhood Pulmonary and Related Outcomes after Perinatal Exposure to Adjunctive Azithromycin Prophylaxis for Cesarean Delivery (C/SOAP Follow-Up Study)
$624,240Akila Subramaniam · University Of Alabama At Birmingham · R01 · FY2023 · HD