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89,613 grants matching “depression”
Medical Marijuana, Pain, and Opioid Use in Patients with Chronic Non-cancer Pain
$817,446Jodi Gilman · Massachusetts General Hospital · R01 · FY2022 · DA
Reducing Vulnerability to ICD Shock Treated Ventricular Arrhythmias
$817,416Matthew M. Burg · Yale University · R01 · FY2007 · HL
Genomic Ascertainment - Clinical and Behavioral Aspects
$817,398Leslie Biesecker · National Human Genome Research Institute · ZIA · FY2024 · HG
An Information tecHnology approach to implEmenting depression treAtment in caRdiac patienTs: [iHeart Trial]
$817,337Nathalie Moise · Columbia University Health Sciences · R01 · FY2021 · HL
Neuronal ApoE Drives Selective Neurodegeneration in Alzheimer's Disease
$817,317Yadong Huang · J. David Gladstone Institutes · R01 · FY2023 · AG
Neuronal ApoE Drives Selective Neurodegeneration in Alzheimer's Disease
$817,317Yadong Huang · J. David Gladstone Institutes · R01 · FY2021 · AG
Neuronal ApoE Drives Selective Neurodegeneration in Alzheimer's Disease
$817,317Yadong Huang · J. David Gladstone Institutes · R01 · FY2022 · AG
Neuronal ApoE Drives Selective Neurodegeneration in Alzheimer's Disease
$817,317Yadong Huang · J. David Gladstone Institutes · R01 · FY2024 · AG
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** GROWING EVIDENCE SHOWS THAT THE MICROBIOME OF PLANTS INFLUENCES THEIR PRODUCTIVITY, HEALTH, DROUGHT TOLERANCE, AND REPRODUCTIVE FITNESS. THE PROPOSED RESEARCH WILL USE A FUNCTION FOCUSED APPROACH LEVERAGING NOVEL TECHNIQUES AND FIELD EXPERIMENTS TO UNDERSTAND PLANT-MICROBE INTERACTIONS IN RESPONSE TO FERTILIZATION AND DROUGHT USING MISCANTHUS × GIGANTEUS AS A MODEL BIOENERGY CROP. MISCANTHUS X GIGANTEUS IS A PROMISING FEEDSTOCK FOR SUSTAINABLE BIOENERGY DUE TO ITS HIGH PRODUCTIVITY AND ROBUST GROWTH ON SUB OPTIMAL SOIL. IN COMPARISON TO OTHER CANDIDATE BIOENERGY CROPS SUCH AS CORN AND SWITCHGRASS, MISCANTHUS HAS HIGHER BIOMASS AND ENERGY YIELDS AND LOWER CULTIVATION GREENHOUSE GAS EMISSIONS. INDEED, MISCANTHUS CAN ENHANCE SOIL CARBON (C) STOCKS MAKING THE CROP C-NEGATIVE, THAT IS, A SYSTEM THAT CUMULATIVELY STORES MORE C THAN IT RESPIRES TO THE ATMOSPHERE. APPALACHIA, IS AN IDEAL REGION TO PERFORM RESEARCH ON MICROBIOMES OF BIOENERGY CROPS ON MARGINAL LANDS DUE TO THE REGIONALLEGACY OF COAL ENERGY PRODUCTION. THE ENVIRONMENTALLY DISRUPTIVE NATURE OF COAL MINING HAS RESULTED IN AN ABUNDANCE (~4 MILLION ACRES) OF LAND THAT IS UNSUITABLE FOR THE GROWTH OF MOST ECONOMICALLY VALUABLE CROPS (I.E. MARGINAL LAND). HOWEVER, RECENT EVIDENCE SUGGESTS THAT MARGINAL LAND IS SUITABLE FOR BIOENERGY CROP PRODUCTION, PARTICULARLY CROPS LIKE MISCANTHUS THAT GROW ROBUSTLY EVEN UNDER HARSH CONDITIONS. ESTIMATES SUGGEST THAT ~3.5 MILLION HECTARES OF LAND MARGINALIZED BY SURFACE MINING COULD BE UTILIZED FOR GROWING BIOENERGY CROPS, MOST OF WHICH IS IN APPALACHIA. AS THE ENERGY INDUSTRY SHIFTS AWAY FROM COAL AND TOWARD RENEWABLE SOURCES, APPALACHIA POSSESSES THE UNIQUE OPPORTUNITY TO UTILIZE THE AGRICULTURAL POTENTIAL OF OUR MINED LANDS TO PRODUCE BIOFUEL CROPS LIKE MISCANTHUS. EFFORTS TO UTILIZE MARGINAL LANDS FOR BIOFUEL PRODUCTION WOULD DIVERSIFY THE ECONOMY OF APPALACHIA, A REGION ECONOMICALLY DEPRESSED WITH THE DECLINING AVAILABILITY OF JOBS IN THE FOSSIL FUEL SECTOR. THE FIRST AIM TO IDENTIFY AND CHARACTERIZE THE FUNCTION OF THE MISCANTHUS CORE MICROBIOME (I.E., ORGANISMS THAT RELIABLY ASSOCIATE WITH THE HOST PLANT) ON MARGINAL APPALACHIAN SOILS. THE CORE MICROBIOME OF MISCANTHUS PROVIDES THE PLANT WITH WATER AND NUTRIENTS IN EXCHANGE FOR CARBON RICH ROOT EXUDATES. IF FERTILIZATION REDUCES ROOT COLONIZATION BY BENEFICIAL MEMBERS OF THE MICROBIOME AND CHANGES MICROBIOME FUNCTION THIS MAY REDUCE THE CROPS ABILITY TO WITHSTAND DROUGHT STRESS. TO TEST THIS HYPOTHESIS, WE WILL USE A FIELD EXPERIMENT AND CUTTING-EDGE MOLECULAR TOOLS TO CHARACTERIZE PLANT MICROBIOME INTERACTIONS. LASTLY, WE WILL ASSESS IF MICROBIOME MANIPULATION, THROUGH THE ADDITION OF BENEFICIAL MICROORGANISMS CAN ENHANCE YIELD AND DROUGHT TOLERANCE IN A FIELD TRIAL. IN SUMMARY, THE PROPOSED WILL ADVANCE OUR THEORETICAL UNDERSTANDING OF PLANT-MICROBIOMES AND PROVIDE PRACTICAL GUIDANCE FOR BIOENERGY CROP PRODUCTION. THE RESULTS OF THIS WORK WILL HELP BUILD A PREDICTIVE UNDERSTANDING OF THE MISCANTHUS MICROBIOME FUNCTION AS WELL AS PLANT-MICROBIOME RESPONSES TO FERTILIZATION AND DROUGHT STRESS.
$817,167West Virginia University Research Corporation · · FY2022 · National Institute of Food and Agriculture
Evaluation of HIV-associated Cardiac Dysfunction in Women
$817,073Jorge R Kizer · Albert Einstein College Of Medicine, Inc · R01 · FY2017 · HL
Exploring the Effects of Corticosteroids on the Human Hippocampus using Neurocognitive Testing and High-Resolution Brain Imaging
$817,036E Sherwood Brown · Ut Southwestern Medical Center · R01 · FY2019 · MH
Lithium's Molecular Mechanism of Action and the Pathology of Bipolar Disorders
$817,018Ramin V Parsey · State University New York Stony Brook · R01 · FY2013 · MH
Look AHEAD: Action for Health in Diabetes Continuation
$816,963James O Hill · University Of Colorado Denver · U01 · FY2013 · DK
Neural circuit mechanisms of affective probabilistic learning
$816,865Peter Rudebeck · Icahn School Of Medicine At Mount Sinai · R01 · FY2024 · MH
Late Pathologies of Exposure to Repetitive Head Impacts from Contact Sports: White Matter and Vascular Contributions to Cognitive Impairment, Dementia, and Neuropsychiatric Symptoms
$816,815Michael Alosco · Boston University Medical Campus · R01 · FY2024 · NS
Synthetic PreImplantation Factor (sPIF) plus hypothermia to treat neonatal brain injury
$816,664Eytan R Barnea · Bioincept, Llc · R44 · FY2025 · HD
Exercise in Smoking Cessation in Postmenopausal Women
$816,655Cheryl Oncken · University Of Connecticut Sch Of Med/Dnt · R01 · FY2012 · DA
Cross-study analysis of coordinated randomized clinical trials for weight managem
$816,583Steven H. Belle · University Of Pittsburgh At Pittsburgh · R01 · FY2015 · HL
Longitudinal Assessment of Manic Symptoms
$816,581Robert L Findling · Case Western Reserve University · R01 · FY2008 · MH
UW Center on Outcomes Research in Rehabilitation(RMI)
$816,393Dagmar Amtmann · University Of Washington · U01 · FY2008 · AR
PRINCIPAL RESEARCH CORE
$816,315Nicholas Ialongo · Johns Hopkins University · P30 · FY2009 · MH
Genetic risk and long-term outcomes associated with Drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in survivors
$816,270Elizabeth Phillips · Vanderbilt University Medical Center · R01 · FY2021 · HG
Enhancing Structural Competency in School-Based Health Centers to Address LGBTQ+ Adolescent Health Equity
$816,186Cathleen E. Willging · Pacific Institute For Res And Evaluation · R01 · FY2025 · NR
Epidemiology of Depression and Heart Failure in Aging
$816,156Northern California Institute Res &Educ · R01 · FY2005 · HL
Understanding Patient, Provider, and Systems Stakeholder Attitudes and Preferences to Optimize Implementation of Long-Acting Injectable Antiretrovirals and Maximize Clinical and Public Health Impact
$816,100Katerina A Christopoulos · University Of California, San Francisco · R01 · FY2021 · MH