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24,576 grants matching “microbiome”
Scripps Center for Oceans and Human Health: advancing the science of marine contaminants and seafood security
$607,588Bradley S Moore · University Of California, San Diego · P01 · FY2024 · ES
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** NEUROPATHIC PAIN AFFECTS THE QUALITY OF LIFE OF MANY AMERICANS. NON-PHARMACOLOGICAL STRATEGIES SUCH AS BIOACTIVE COMPOUNDS IN FOODS ARE BEING EXPLORED AS THERAPEUTICS BUT CAN ALSO SERVE AS TOOLS TO BETTER UNDERSTAND PAIN MECHANISMS. WE PREVIOUSLY REPORTED GINGER REDUCED NEUROPATHIC PAIN AND FAVORED GUT MICROBIOME IN ANIMALS. THIS STUDY IS TO TEST HOW 2 MONTHS OF GINGER SUPPLEMENTATION WOULD AFFECT INDIVIDUALS WITH SCIATICA. WE PLAN TO RECRUIT DIRECT PERSON-TO-PERSON SONICATION IN CLINICS, HEALTH FAIRS, COMMUNITY EVENTS, FLYERS, NON-SOLICITED EMAIL SYSTEM, CAMPUS ANNOUNCEMENTS, CLINICAL RESEARCH INSTITUTE WEBSITE, LOCAL RADIO, NEWSPAPERS, SENIOR NEWSLETTERS, AND TV SCRIPTS. WE PLAN TO ENROLL APPROXIMATELY 200-250 PATIENTS TO OBTAIN 80-100 QUALIFIED SUBJECTS AT THE START OF THE STUDY. AFTER SCREENING, QUALIFIED PARTICIPANTS WILL BE RANDOMLY ASSIGNED TO A NO-GINGER GROUP OR GINGER GROUP. THIS STUDY WILL FOCUSE ON GUT FUNCATION (GUT MICROBIOTA COMPOSITION, FECAL METABOLITES, AND PLASMA MARKERS FOR LEAKY GUT) (PRIMAYR OUTCOME), BLOOD METABOLIES, AND BRAIN ACTIVITY (SECONDARY OUTCOME). IN ADDITION, THIS STUDY WILL MONITOR SAFETY AS WELL AS THE CHANGES IN DIETARY INTAKE, PHYSICAL ACTIVITY, AND OTC.ALL OUTCOMES WILL BE ASSESSED AT BASELINE AND AFTER 2 MONTHS OF INTERVENTION. DATA WILL BE ANALYZED STATISTICALLY.
$607,561Texas Tech University Health Sciences Center · · FY2024 · National Institute of Food and Agriculture
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** 1. CURRENT ISSUE OR PROBLEM AND ITS IMPORTANCETHE RESEARCH ADDRESSES THE HEALTH IMPLICATIONS OF CONSUMING FOODS PREPARED IN THERMALLY ABUSED OILS (TAOS), WHICH ARE PREVALENT IN THE FAST-FOOD INDUSTRY. THESE OILS, WHEN REPEATEDLY HEATED, DEGRADE AND GENERATE HARMFUL LIPID OXIDATION PRODUCTS (LOPS). CONSUMING FOODS FRIED IN THESE OILS IS LINKED TO INCREASED RISKS OF CHRONIC DISEASES, INCLUDING GUT HEALTH DISORDERS AND COLORECTAL CANCER. THIS RESEARCH IS ESSENTIAL BECAUSE A SIGNIFICANT PORTION OF THE POPULATION CONSUMES FAST FOOD REGULARLY, AND UNDERSTANDING THE HEALTH IMPACTS OF TAOS CAN LEAD TO IMPROVED DIETARY GUIDELINES AND HEALTHIER COMMERCIAL FOOD PREPARATION METHODS. BEYOND INDIVIDUAL HEALTH, THIS RESEARCH HAS BROADER IMPLICATIONS: ECONOMICALLY, BY POTENTIALLY REDUCING HEALTHCARE COSTS AND IMPROVING PRODUCTIVITY; COMMUNITY-WISE, BY ENHANCING PUBLIC HEALTH; ENVIRONMENTALLY, BY PROMOTING MORE SUSTAINABLE COOKING PRACTICES; AND IN AGRICULTURE, BY INFLUENCING THE PRODUCTION OF HEALTHIER COOKING OILS.2. METHODS AND APPROACHESIN OUR STUDY, WE WILL EXPLORE THE EFFECTS OF THERMALLY OXIDIZED OILS (TAOS) ACROSS THREE KEY OBJECTIVES USING C57BL/6J MICE TO MIMIC HUMAN DIETARY PATTERNS. THE FIRST OBJECTIVE INVESTIGATES HOW DIFFERENT DURATIONS OF TAO EXPOSURE--ACUTE, SUBCHRONIC, AND CHRONIC--AFFECT GUT INFLAMMATION, MICROBIOME COMPOSITION, AND IMMUNE RESPONSES. MICE WILL BE FED DIETS WITH VARYING LEVELS OF OXIDIZED OILS AND WILL UNDERGO THOROUGH HEALTH MONITORING, INCLUDING ANALYSIS OF COLON TISSUE AND BLOOD FOR VARIOUS BIOMARKERS, ALONG WITH REGULAR FECAL SAMPLING TO OBSERVE MICROBIOME CHANGES OVER TIME. THE SECOND OBJECTIVE ASSESSES THE IMPACT OF CHRONIC TAO EXPOSURE ON COLITIS AND COLON CANCER DEVELOPMENT USING A MOUSE MODEL OF COLITIS-ASSOCIATED COLORECTAL CANCER TO SIMULATE HUMAN DISEASE PROGRESSION, WITH COMPREHENSIVE EVALUATIONS OF DISEASE MARKERS, GUT MICROBIOME ALTERATIONS, AND IMMUNE RESPONSE. THE THIRD OBJECTIVE INVOLVES LABORATORY STUDIES TO DETERMINE THE DIRECT EFFECTS OF TAOS AND LIPID OXIDATION PRODUCTS ON INTESTINAL EPITHELIAL CELLS AND GUT MICROBIOTA, USING BOTH MOUSE-DERIVED AND HUMAN DONOR SAMPLES IN FERMENTATION SYSTEMS TO STUDY MICROBIOME COMPOSITION AND FUNCTION. THESE INTEGRATED APPROACHES AIM TO ELUCIDATE THE MULTIFACETED IMPACT OF TAOS ON GUT HEALTH AND DISEASE MECHANISMS.3. ULTIMATE GOALS AND EXPECTED IMPACTTHE ULTIMATE GOAL OF THIS PROJECT IS TO DELINEATE THE HEALTH RISKS ASSOCIATED WITH THE CONSUMPTION OF TAOS AND TO USE THIS KNOWLEDGE TO INFORM PUBLIC HEALTH GUIDELINES AND COMMERCIAL FOOD PREPARATION PRACTICES. ACHIEVING THESE GOALS CAN LEAD TO SIGNIFICANT HEALTH IMPROVEMENTS, REDUCING THE INCIDENCE OF DIET-RELATED DISEASES SUCH AS GUT DISORDERS AND COLORECTAL CANCER. THIS WOULD NOT ONLY ENHANCE THE QUALITY OF LIFE FOR INDIVIDUALS BUT ALSO LEAD TO ECONOMIC BENEFITS THROUGH DECREASED HEALTHCARE COSTS AND INCREASED PRODUCTIVITY. SOCIETALLY, THE PROJECT AIMS TO RAISE PUBLIC AWARENESS ABOUT THE RISKS ASSOCIATED WITH FRIED FOODS AND,INFLUENCE POLICY CHANGES THAT PROMOTE HEALTHIER FOOD PREPARATION PRACTICES. THESE EFFORTS ARE EXPECTED TO FOSTER A BROADER UNDERSTANDING OF NUTRITION AND HEALTH, ENCOURAGING MORE INFORMED DIETARY CHOICES AND POTENTIALLY LEADING TO NATIONAL AND GLOBAL CHANGES IN FOOD SAFETY REGULATIONS.
$607,561Utah State University · · FY2024 · National Institute of Food and Agriculture
Randomized Trial of Diet in GDM: Metabolic Consequences to Mother and Offspring
$607,560Teri L Hernandez · University Of Colorado Denver · R01 · FY2016 · DK
Administrative Core
$607,534Craig J McClain · University Of Louisville · P20 · FY2021 · GM
Microbiome origins and insulin regulatory responses of the short chain fatty acid acetate
$607,517Gary W Cline · Yale University · R01 · FY2019 · DK
Microbiome origins and insulin regulatory responses of the short chain fatty acid acetate
$607,517Andrew L Goodman · Yale University · R01 · FY2021 · DK
Microbiome origins and insulin regulatory responses of the short chain fatty acid acetate
$607,517Gary W Cline · Yale University · R01 · FY2020 · DK
Metabolic deficits and immune dysfunction in aging people living with HIV
$607,120Daniela Frasca · University Of Miami School Of Medicine · R01 · FY2025 · AG
Role of inflammation, innate resistance, and immunity in carcinogenesis
$607,045Giorgio Trinchieri · Division Of Basic Sciences - Nci · ZIA · FY2024 · CA
Molecular basis of heme scavenging by Gram-positive bacteria
$606,938Robert Thompson Clubb · University Of California Los Angeles · R01 · FY2024 · AI
Molecular basis of heme scavenging by Gram-positive bacteria
$606,938Robert Thompson Clubb · University Of California Los Angeles · R01 · FY2023 · AI
Molecular basis of heme scavenging by Gram-positive bacteria
$606,938Robert Thompson Clubb · University Of California Los Angeles · R01 · FY2021 · AI
Effects of systemic and topical perturbations on human microbes
$606,844Heidi Kong · Division Of Basic Sciences - Nci · ZIA · FY2015 · CA
The role of microbiota amino acid metabolism in cancer
$606,839Chun-Jun Guo · Weill Medical Coll Of Cornell Univ · R01 · FY2025 · CA
Toward field-ready paratransgenesis for malaria: bacterial strain optimization and microbiota interactions
$606,815David J Lampe · Duquesne University · U01 · FY2025 · AI
Program for Training in Cancer Epidemiology
$606,731Meir J Stampfer · Harvard School Of Public Health · T32 · FY2019 · CA
Longitudinal investigations of the infant virome and its associations with obesity
$606,708Julie Parsonnet · Stanford University · R01 · FY2017 · HD
Annotating carbohydrate structures to develop markers for consumption of food
$606,677Carlito B Lebrilla · University Of California At Davis · R01 · FY2022 · DK
Physiological Responses to Activation of Human Brown Adipose Tissue
$606,674Aaron Cypess · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2020 · DK
Study interactions between lung microbiota and immune cells in NSCLC
$606,600Chen Zhao · Division Of Basic Sciences - Nci · ZIA · FY2025 · CA
Establishment of the New York University Vaccine and Treatment Evaluation Unit (NYU VTEU)
$606,446Angelica Cifuentes Kottkamp · New York University School Of Medicine · UM1 · FY2025 · AI
Impact of microbiota-derived metabolites on traumatic brain injury-related neurodegeneration
$606,431Dennis William Simon · University Of Pittsburgh At Pittsburgh · R01 · FY2023 · NS
Novel genetic and salivary glycan biomarkers for risk of NEC in ELBW infants.
$606,407Ardythe L. Morrow · Cincinnati Childrens Hosp Med Ctr · R01 · FY2010 · HD
Boston University/Lata Medical Research Foundation Global Network for Women's Children's Health Research Unit
$606,400Patricia L Hibberd · Boston University Medical Campus · UG1 · FY2024 · HD