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24,576 grants matching “microbiome”
Metapangenomics of the Oral Microbiome
$596,768Gary G Borisy · Ada Forsyth Institute, Inc. · R01 · FY2025 · DE
Metapangenomics of the Oral Microbiome
$596,768Gary G Borisy · Ada Forsyth Institute, Inc. · R01 · FY2023 · DE
Microbiome-Targeted Probes to Eliminate Chemotherapy-Induced GI Toxicity
$596,764Matthew Redinbo · Univ Of North Carolina Chapel Hill · R01 · FY2018 · CA
Microbiome-Targeted Probes to Eliminate Chemotherapy-Induced GI Toxicity
$596,764Matthew Redinbo · Univ Of North Carolina Chapel Hill · R01 · FY2017 · CA
Methods to Test the Role of Age-related Lifestyle and Vaginal Microenvironment Changes and the Prevention, Treatment, and Progression of Genitourinary Syndrome of Menopause
$596,717Michelle Denise Shardell · University Of Maryland Baltimore · R01 · FY2025 · AG
Local microbiota signatures of pro-tumor immunity and checkpoint inhibition susceptibility in lung cancer
$596,634Leopoldo Nicolas Segal · New York University School Of Medicine · R37 · FY2024 · CA
Oral microbial signatures in perinatal HIV infection
$596,588Louise Kuhn · Columbia University Health Sciences · R01 · FY2021 · DE
Developmental PBDE exposure, gut microbiome, and diabetes
$596,584Julia Yue Cui · University Of Washington · R01 · FY2023 · ES
Elucidating Gene-Environment-Behavior Interactions to Uncover Causal Mechanisms for Obesity in Early Life
$596,553Sharon Marie Donovan · University Of Illinois At Urbana-Champaign · R01 · FY2025 · DK
A Novel Role for PTPN2 in Intestinal Epithelial Barrier Regulation
$596,461Declan McCole · University Of California Riverside · R01 · FY2023 · DK
How sex, host microenvironment, and immune responses shape acquisition of genital bacteria that increase HIV risk
$596,262Cindy Liu · George Washington University · R01 · FY2024 · DK
Vitamin D Receptor Regulation of Microbiota in Intestinal Epithelia
$596,255Jun Sun · University Of Illinois At Chicago · R01 · FY2025 · DK
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** PLANTS PRODUCE SECONDARY METABOLITES FOR DEFENSE, SIGNALING AND ENVIRONMENTAL INTERACTIONS. SEVERAL OF THESE PHYTOCOMPOUNDS COMPRISE BIOACTIVE PHYTONUTRIENTS WITH ANTIOXIDANT, ANTI-INFLAMMATORY AND IMMUNOSTIMULATORY ACTIVITY. OUR RESEARCH ON FOOD SAFETY IS SHOWING THAT PERSISTENCE OF THE ENTERIC PATHOGEN SALMONELLA ENTERICA ON LEAFY GREENS VARIES WITH PLANT GROWING CONDITIONS AND ABIOTIC STRESS. WE ARE LINKING THIS FOOD SAFETY BENEFIT TO THE PLANT METABOLOME. THE LONG-TERM GOAL OF THIS PROJECT, THEREFORE, IS TO DEVELOP NOVEL, LOW-BUDGET PRACTICES FOR LEAFY GREENS PRODUCTION TO MANIPULATE THE PLANT METABOLOME AND, IN TURN, MODULATE PLANT-ASSOCIATED MICROBIOTA FOR ENHANCED FOOD SAFETY AND EXTENDED SHELF-LIFE. SIMULTANEOUSLY, WE EXPECT TO IMPROVE NUTRITIONAL AND FUNCTIONAL QUALITIES OF SALAD GREENS. THIS PROJECT WILL EVALUATE SUITABLE KALE AND LETTUCE CULTIVARS GROWN UNDER CONDITIONS THAT INCORPORATE REGULATED ABIOTIC STRESSES. WE PLAN TO SUBJECT PLANTS TO DROUGHT STRESS, ALONE, OR IN COMBINATION WITH LIGHT-AND TEMPERATURE RELATED STRESS, TO INDUCE OR ENHANCE THE BIOSYNTHESIS OF SECONDARY METABOLITES. THE OBJECTIVES ARE TO (1) INVESTIGATE FOOD SAFETY OUTCOMES AND SHELF-LIFE (2) IDENTIFY AND QUANTIFY ACTIVE METABOLITES AND (3) ASSESS SENSORY PROPERTIES AND CONSUMER PREFERENCE. TO ACHIEVE THIS, WE WILL ADOPT MICROBIOLOGICAL METHODS, PLANT METABOLOMICS, MICROBIOME ANALYSIS, PLANT PHYSIOLOGICAL MEASUREMENTS, AND FOOD SENSORY AND PHYSICOCHEMICAL EVALUATIONS. THE PROJECT WILL RESULT IN NOVEL KALE AND LETTUCE PRODUCTS WITH ENHANCED FOOD SAFETY POTENTIAL, LONGER SHELF-LIFE AND IMPROVED NUTRITIONAL PROFILES WITHOUT COMPROMISING YIELD OR PREFERRED CONSUMER SENSORIAL TRAITS. TAKING ADVANTAGE OF INHERENT PLANT TRAITS TO ENHANCE FOOD SAFETY AND NUTRITION CONSTITUTES A NOVEL PRODUCTION PROCESS FOR HEALTHIER LEAFY GREENS AND STRONGER INDUSTRY COMPETITIVENESS.
$596,150University Of Maryland, College Park · · FY2022 · National Institute of Food and Agriculture
Toxoplasma Surface Antigens and Immunity
$596,125Michael Grigg · National Institute Of Allergy And Infectious Diseases · ZIA · FY2017 · AI
Povidone Iodine Efficacy Study (PIES)
$596,109Dorota Teresa Kopycka-Kedzierawski · University Of Rochester · UG3 · FY2021 · DE
Role of Gut Microbiota in Modulating Immune Checkpoint Inhibitory Therapy for Cancer
$596,098Andrew Y Koh · Ut Southwestern Medical Center · R01 · FY2020 · CA
Role of Gut Microbiota in Modulating Immune Checkpoint Inhibitory Therapy for Cancer
$596,098Andrew Y Koh · Ut Southwestern Medical Center · R01 · FY2021 · CA
Dietary sulfur, the gut microbiome, and colorectal cancer
$596,028Andrew T Chan · Massachusetts General Hospital · R01 · FY2016 · CA
Features and implications of nitrogen assimilation trait variability in populations of Prochlorococcus
$595,865Paul M Berube · Massachusetts Institute Of Technology · · FY2021 · GEO
Project 1 - Changes in Gut Microbiome and related Metabolome Across Trajectory of Alzheimer's Disease
$595,839Rima F Kaddurah-Daouk · Duke University · U19 · FY2019 · AG
Uncovering pathogenic anti-bacterial defense mechanisms to identify novel targets for prevention of T1D
$595,601Nora E Sarvetnick · University Of Nebraska Medical Center · U01 · FY2018 · AI
Collaborative Research: RUI: Extracellular vesicles as vehicles for microbial interactions in marine Black Queen communities
$595,535Steven J Biller · Wellesley College · · FY2023 · GEO
Oral microbiome and inflammatory status in antimicrobially-treated oral cancer patients
$595,456Yvonne L Kapila · University Of California Los Angeles · R01 · FY2024 · CA
Necrotizing Enterocolitis: Prevention and Prediction
$595,410Mark Alan Underwood · University Of California At Davis · R01 · FY2010 · HD
Quorum sensing, diversity and skin inflammation
$595,187Alexander R Horswill · University Of Colorado Denver · R01 · FY2022 · AI