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24,576 grants matching “microbiome”
Uncovering pathogenic anti-bacterial defense mechanisms to identify novel targets for prevention of T1D
$595,157Nora E Sarvetnick · University Of Nebraska Medical Center · U01 · FY2019 · AI
Project 3: Exploring Tobacco Microbial Constituents and the Oral Microb p215-251
$595,056Pamela I Clark · Univ Of Maryland, College Park · P50 · FY2016 · CA
Quorum sensing, diversity and skin inflammation
$594,998Alexander R Horswill · University Of Colorado Denver · R01 · FY2023 · AI
Viral MEM: Viral Enrichment and Precise Stochastic Quantification with Microbial Context Preservation for Rigorous Virome Analysis of Challenging Human Samples
$594,934Rustem F Ismagilov · California Institute Of Technology · U01 · FY2024 · DE
Viral MEM: Viral Enrichment and Precise Stochastic Quantification with Microbial Context Preservation for Rigorous Virome Analysis of Challenging Human Samples
$594,934Rustem F Ismagilov · California Institute Of Technology · U01 · FY2025 · DE
Characterizing and predicting colitis in immune checkpoint blockade-treated cancer patients
$594,873Sacha Gnjatic · Icahn School Of Medicine At Mount Sinai · U01 · FY2020 · DK
Mediterranean Diet and Weight Loss: Targeting the Bile Acid/Gut Microbiome Axis to Reduce Colorectal Cancer Risk
$594,865Marian L Fitzgibbon · University Of Illinois At Chicago · R01 · FY2024 · CA
Engineering Native E. coli to Detect, Report, and Treat Colorectal Cancer
$594,784Amir Zarrinpar · University Of California, San Diego · U01 · FY2024 · CA
Mucosal Immune Defense Mechanisms of the Urinary Bladder
$594,739Marco Colonna · Washington University · R01 · FY2024 · DK
Circulating microbiome and premature mortality in hemodialysis patients
$594,716Keiichi Sumida · University Of Tennessee Health Sci Ctr · R01 · FY2022 · DK
Antimicrobial Resistant Bacteria: Exposures and Health of Cattle Workers
$594,607Joshua William Schaeffer · Colorado State University · R01 · FY2021 · OH
CK20-004, J. Craig Venter Insitute and Cleveland VA Prevention and Intervention Epicenter
$594,596Derrick E Fouts · J. Craig Venter Institute, Inc. · U54 · FY2024 · CK
Mapping Protein Interaction Networks Essential for Gonococcal Pathogenesis
$594,564Andrew Emili · Oregon Health & Science University · R01 · FY2023 · AI
Development and clinical evaluation of the CapScan gastrointestinal sampling device for metabolomics monitoring
$594,530Tidhar Dari Shalon · Envivo Bio Inc · R33 · FY2025 · CA
CONCERNS REGARDING THE HEALTH AND WELFARE OF FARM ANIMALS HAVE GROWN SIGNIFICANTLY OVER THE LAST FEW DECADES. ANIMAL HEALTH AND WELFARE ARE TYPICALLY EVALUATED THROUGH VARIOUS INDICATORS SUCH AS PHYSICAL HEALTH, IMMUNE RESPONSE, BEHAVIOR, AND OTHER PHYSIOLOGICAL MARKERS, INCLUDING THOSE RELATED TO STRESS. THE STRESS EXPERIENCED BY SOWS DURING PREGNANCY CAN HAVE A LASTING IMPACT ON THE PHYSIOLOGY AND BEHAVIOR OF THEIR OFFSPRING, BOTH BEFORE AND AFTER BIRTH, POTENTIALLY LEADING TO LONG-TERM HEALTH AND WELFARE ISSUES LATER IN LIFE. THE GUTMICROBIAL ENVIRONMENT, OR MICROBIOTA, HAS BEEN SHOWN TO HAVE A SIGNIFICANT IMPACT ON HOST PHENOTYPES. NEVERTHELESS, THE GUT MICROBIOTA, WHICH PLAYS A CRUCIAL ROLE IN INFLUENCING THE BRAIN AND IMMUNE SYSTEM AND ULTIMATELY AFFECTS BEHAVIOR AND OVERALL WELL-BEING, IS FREQUENTLY OVERLOOKED IN WELFARE EVALUATIONS. IT HAS BEEN PROPOSED THAT THE MATERNAL MICROBIOME AND THE METABOLITES IT TRANSFERS ARE ESSENTIAL IN PREPARING THE NEONATE FOR OPTIMAL INTERACTIONS BETWEEN HOST AND MICROBES, WHICH IN TURN INFLUENCE IMMUNE FUNCTION AND BEHAVIOR LATER IN LIFE. HOWEVER, DATA ARE SCARCE REGARDING THE IMPACT OF PRENATAL STRESS ON THE MATERNAL MICROBIOME-IMMUNE AXIS, WHICH IS CRITICAL FOR DETERMINING THE HEALTH AND WELFARE OUTCOMES OF THE OFFSPRING. EXPLORING THE EFFECTS OF MATERNAL STRESS ON THE GUT-BRAIN-IMMUNE AXIS PRESENTS A NOVEL METHOD FOR ASSESSING ANIMAL WELFARE; THEREFORE, THE DATA GATHERED FROM THESE PROPOSED STUDIES CAN BE UTILIZED TO EVALUATE AND IMPROVE POOR WELFARE CONDITIONS SYSTEMATICALLY. WE WILL FOCUS ON THE FOLLOWING SPECIFIC OBJECTIVES: (A) TO IDENTIFY THE ROLE OF THE GUT MICROBES-IMMUNE AXIS IN STRESSED SOWS ON THE COLONIZATION OF THEIR PROGENY, (B) TO CHARACTERIZE THE EFFECTS OF VARIOUS STRESSORS ON THE MICROBIOTA-BRAIN-IMMUNE AXIS IN OFFSPRING BORN TO STRESSED SOWS, AND (C) TO DECIPHER THE MOLECULAR MICROBIOTA SIGNATURES ALONG WITH GUT-IMMUNE AND BEHAVIORAL PHENOTYPES THAT ARE IMPRINTED ON THE PROGENY IN SUBSEQUENT GENERATIONS. THIS DATA WILL CONTRIBUTE TO ENHANCING OUR UNDERSTANDING OF THE MATERNAL MICROBIOME AND THE EFFECTS OF STRESS RESPONSIVENESS ON MICROBIAL-BRAIN-IMMUNE SIGNATURES IN THE OFFSPRING, WHICH MAY INDICATE IMPROVED HEALTH AND WELL-BEING.
$594,520Michigan State University · · FY2025 · National Institute of Food and Agriculture
ZEISS LSM 980 plus AIRYSCAN 2 for NYMC Imaging Core
$594,269Dana G Mordue · New York Medical College · S10 · FY2020 · OD
Fiber-rich Foods to Treat Obesity and Prevent Colon Cancer
$594,260Terryl Johnson Hartman · Emory University · R01 · FY2024 · CA
Antimicrobial Resistant Bacteria: Exposures and Health of Cattle Workers
$594,220Joshua William Schaeffer · Colorado State University · R01 · FY2022 · OH
Metapangenomics of the Oral Microbiome
$594,141Gary G Borisy · Ada Forsyth Institute, Inc. · R01 · FY2022 · DE
Developmental Funds
$594,000Barry P Sleckman · University Of Alabama At Birmingham · P30 · FY2021 · CA
Detrimental Effects of Age Related Dysbiosis
$593,950Louise Deborah McCullough · University Of Texas Hlth Sci Ctr Houston · R01 · FY2022 · NS
Role of the Macrophage in Developmentally Programmed NAFLD
$593,946Jacob E Friedman · University Of Oklahoma Hlth Sciences Ctr · R01 · FY2022 · DK
Epigenetic mechanisms of carcinogenesis by Parvimonas micra, an oral cavity commensal turned colon cancer pathogen
$593,887Khashayarsha Khazaie · Mayo Clinic Arizona · R01 · FY2023 · CA
Microbiome-mediated weight, anxiety, and stress dysregulation in anorexia nervosa
$593,882Ian Michael Carroll · Univ Of North Carolina Chapel Hill · R01 · FY2015 · MH
Illumina NovaSeq 6000 DNA Sequencing System
$593,853Yehia Mechref · Texas Tech University · S10 · FY2018 · OD