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21,453 grants matching “tuberculosis”
CD4 T Cells in Tuberculosis
$500,566Joanne L. Flynn · University Of Pittsburgh At Pittsburgh · R01 · FY2009 · AI
A dual-layer flat panel x-ray detector based on an engineered amorphous chalcogenide alloy for quantifying coronary artery calcium
$500,565Shiva Abbaszadeh · University Of California Santa Cruz · R01 · FY2023 · EB
Project 2 - TB Translation as a Target
$500,564James C Sacchettini · Texas A&M Agrilife Research · P01 · FY2022 · AI
Innovative PK/PD Approaches to Optimize TBM Treatment in Children (PATCH Study)
$500,491Kelly E. Dooley · Johns Hopkins University · R01 · FY2017 · HD
Tuberculosis studies in South Africa
$500,474Clifton Barry · National Institute Of Allergy And Infectious Diseases · ZIA · FY2016 · AI
T cell responses to CD1-restricted lipids in tuberculosis
$500,453David Branch Moody · Brigham And Women'S Hospital · R01 · FY2022 · AI
Identification of human Mtb-specific T cell signatures that are associated
$500,373Jyothi Rengarajan · Emory University · U19 · FY2019 · AI
MYCOBACTERIAL RESISTANCE TO REACTIVE NITROGEN/OXYGEN
$500,362Weill Medical College Of Cornell Univ · R01 · FY2003 · HL
Genetic determinants of drug resistance in Mycobacteria tuberculosis
$500,331Megan B Murray · Harvard Medical School · U19 · FY2015 · AI
Role of ribosome modulating proteins in conferring Mycobacterium abscessus antibiotic resistance
$500,324Pallavi Ghosh · Wadsworth Center · R01 · FY2020 · AI
Chemistry and Biology of Bacterial Sulfonucleotide Reductases
$500,021Kate Suzanne Carroll · Scripps Florida · R01 · FY2011 · GM
AFB Smears for Drug Resistance Detection and Surveillance in MTb.
$500,000David Alland · Univ Of Med/Dent Of Nj-Nj Medical School · RC1 · FY2009 · AI
Development of adamantyl ureas against MDR/XDR M.tb
$500,000Mary Jackson · Colorado State University · RC1 · FY2009 · AI
PURCHASE OF 600MHZ NMR SPECTROMETER
$500,000University Of California Los Angeles · S10 · FY2001 · RR
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** 1. PROBLEM TO BE ADDRESSED:HUMAN VIRAL DISEASES SUCH AS HIV, WEST NILE VIRUS, EBOLA, ZIKA VIRUS, SARS COV2 (COVID19); ANTIBIOTIC-RESISTANT BACTERIAL PATHOGENS, E.G., MRSA, TUBERCULOSIS AND GONORRHEA; FUNGAL DEVASTATIONS, E.G., WHITE-NOSE SYNDROME (WNS), AN EMERGENT DISEASE OF HIBERNATING BATS, AND CHYTRIDIOMYCOSIS IN AMPHIBIANS. SUCH ARE BUT A FEW EXAMPLES OF EMERGING INFECTIOUS DISEASES THAT CONJURE UP FRIGHTENING IMAGES AND PROMPT HUMAN CONCERNS ABOUT THE NEXT PANDEMIC. IN THIS REGARD, THE EMERGENCE OF PLANT PATHOGENIC FUNGI IS THE MOST DANGEROUS THREAT TO AGRICULTURE AND FOOD SECURITY. SOME OF THESE PATHOGENS PRESENT HIGH HOST SPECIFICITY BUT THEY CAN RAPIDLY EVOLVE NEW VIRULENCE OR SHIFT TO NOVEL HOSTS, CAUSING DEVASTATION AS EMERGING DISEASES (E.G, NEW RESISTANT WHEAT RUST; FUSARIUM WILT OF BANANA, POPULARLY KNOWN AS PANAMA DISEASE). UNDERSTANDING THE MOLECULAR MECHANISMS OF HOST-PATHOGEN INTERACTIONS AND COEVOLUTION IS OF STRONG FUNDAMENTAL IMPORTANCE BUT ALSO OF IMPORTANCE FOR APPLIED MANAGEMENT, PARTICULARLY IN SUSTAINABLE AGRICULTURE OR FORESTRY. HOWEVER, EVOLUTIONARY TRAJECTORIES CAN BE DIFFICULT TO STUDY IN CROP PATHOGENS, BECAUSE THEY ARE OFTEN CLONAL, INVASIVE AND RESULT FROM RECENT SHIFTS ONTO CROPSTHIS PROJECT ALLOWS THE EXAMINATION OF ORGANISMS THAT CAUSE DISEASE ON HOST PLANT SPECIES OF A WIDE RANGE. UNLIKE THE USUAL MODELS USED IN AGRICULTURE STUDIES, SINCE THE HOSTS ARE WILD PLANT SPECIES, THEY ARE MORE GENETICALLY DIVERSE THAN THOSE VARIETIES MORE OFTEN USED IN AGRICULTURAL STUDIES. THUS, THE STUDIES WILL PROVIDE A BROADER UNDERSTANDING OF HOW PLANTS RESPOND TO INFECTION BY DIFFERENT FUNGAL PARASITE SPECIES. SINCE IT HAS BEEN OBSERVED THAT SOME OF THE FUNGI WITH WHICH WE WORK ARE ABLE TO JUMP TO CLOSELY-RELATED OR NEW HOSTS, THESE EXPERIMENTS MAY PROVIDE, NOT ONLY A SENSE OF WHAT MAKES A SUSCEPTIBLE VS. RESISTANT HOST, BUT ALSO WILL ALLOW PREDICTION OF EMERGING INFECTIOUS DISEASES THROUGH HOST SHIFTS.2. BASIC METHODS USED.THE METHODS USED IN THESE STUDIES WILL PROVIDE A GLOBAL PICTURE OF BOTH THE FUNGAL PARASITE AND THE RESPONSE OF ITS HOST SPECIES. WE UTILIZE SOPHISTICATED MICROSCOPIC METHODS TO FOLLOW THE INFECTION OF NORMAL HOST PLANTS, COMPARED WITH LESS-SUITABLE OR NON-HOSTS. IN THIS WAY, WE CAN OBSERVE MORPHOLOGICAL DIFFERENCES IN FINE DETAIL. IN ADDITION, WE COMPARE THE OVERALL INTERACTIONS BETWEEN FUNGAL PARASITE PRODUCED PROTEINS AND HOST PLANT TARGET PROTEINS; SUCH ANALYSES WILL PROVIDE AN IN-DEPTH PICTURE OF THESE INTERACTORS AND AID IN OUR UNDERSTANDING OF HOW THE PARASITE MANIPULATES ITS HOST AND FACILITATES THE COMPLETION OF ITS LIFECYCLE. ADDITIONALLY, THE COMPARISONS BETWEEN DIFFERENT PARASITE/HOST SYSTEMS WILL INFORM OUR UNDERSTANDING OF VARIATIONS IN THE PROCESS WHEN INFECTIONS BY THE PARASITE ARE NOT OPTIMAL, LEADING TO HOST RESISTANCE. FINALLY, WE ADD AN EXAMINATION OF THE INVENTORY OF GENE EXPRESSION FOR BOTH FUNGAL PARASITE AND HOST, AGAIN ALLOWING US TO BETTER UNDERSTAND HOW GENE EXPRESSION DIFFERENCES I,N BOTH PARTICIPANTS IN THIS INTERACTION MAY AFFECT THE OUTCOMES, I.E., LEADING TO SUCCESSFUL INFECTION AND REPRODUCTION OF THE FUNGUS, OR ALTERNATIVELY, PREVENTING FURTHER DEVELOPMENT AND DISEASE, BY ALLOWING THE HOST PLANT TO BLOCK THE FUNGUS AS SOME STAGE(S) IN THE NORMAL INFECTION PROCESS.3. ULTIMATE GOALS TO BE ACHIEVED AND POTENTIAL BENEFIT TO SOCIETYOUR OBJECTIVES PROVIDE AN INTEGRATED APPROACH TO ENSURE THAT GROUNDBREAKING DISCOVERIES IN AGRICULTURE-RELATED SCIENCES AND TECHNOLOGIES REACH THE PEOPLE WHO CAN PUT THEM INTO PRACTICE. SO SAYING, WE SEEK INSIGHTS INTO DIFFERENTIAL HOST SUSCEPTIBILITY TO INFECTION BY FUNGAL PATHOGENS, USING WILD HOST MODELS TO PROVIDE GREATER PREDICTIVE POTENTIAL ON EMERGING INFECTIOUS DISEASES OF CROP PLANTS. MOREOVER, WE SEEK TO DISSEMINATE THESE FINDINGS TO BOTH THE SCIENTIFIC COMMUNITY AND THE MORE GENERAL POPULATION THOUGH OUTREACH PROGRAMS IN THE LOCAL COMMUNITIES.
$500,000University Of Louisville · · FY2024 · National Institute of Food and Agriculture
Linked: HIV-Associated Malignancies in Malawi
$500,000Johnstone Jonny Kumwenda · University Of Malawi · R24 · FY2012 · TW
Monochromatic 222 nm UV light: Development of a safe, cost-effective technology for the efficient reduction of bacterial and viral infection and transmission
$500,000Sung-Jin Park · Eden Park Illumination, Inc. · R42 · FY2019 · AI
Non-peptidic HIV vaccine
$500,000Miroslav Malkovsky · University Of Wisconsin-Madison · RC2 · FY2009 · CA
UCB/UCSF AIDS International Training and Research Program (AITRP)
$500,000Arthur L. Reingold · University Of California Berkeley · D43 · FY2011 · TW
Development and Validation of Point-of-Care Tests for Tuberculosis
$500,000Marc D Porter · University Of Utah · U18 · FY2010 · FD
Linked; Building Capacity for Cardiovascular Research and Training in Uganda
$500,000Nelson K Sewankambo · Makerere University College Of Health Sciences · R24 · FY2011 · TW
Acquisition of a 600-MHz Nuclear Magnetic Resonance Spectrometer
$500,000James B Gloer · University Of Iowa · S10 · FY2009 · RR
VACCINE AND EVALUTION TREATMENT UNITS
$500,000Mark Joseph Mulligan · Emory University · N01 · FY2012 · AI
Medical Education Partnership Initiative in Nigeria
$500,000David Olufemi Olaleye · College Of Medicine, University Of Ibadan · R24 · FY2012 · TW
Linked; Building Capacity for Cardiovascular Research and Training in Uganda
$500,000Nelson K Sewankambo · Makerere University College Of Health Sciences · R24 · FY2012 · TW