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15,273 grants matching “antimicrobial resistance”
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$1,219,588Bonnie W Ramsey · Seattle Children'S Hospital · U01 · FY2016 · HL
Studies of Receptor Interactions and Effects of Alarmins
$1,219,341Joost J Oppenheim · Division Of Basic Sciences - Nci · ZIA · FY2016 · CA
SCH: INT: Enabling real time surveillance of antimicrobial resistance
$1,219,178Christina Boucher · University Of Florida · · FY2021 · CSE
Innate inflammatory responses during pulmonary infections
$1,218,475Katrin Mayer-Barber · National Institute Of Allergy And Infectious Diseases · ZIA · FY2018 · AI
Bactericidal antibiotic for Vancomycin Resistant Enterococci
$1,218,307Michael Lafleur · Arietis · R44 · FY2016 · AI
Modulation of Biodefense Responses to Bacterial Pathogen
$1,215,884Leo Lefrancois · University Of Connecticut Sch Of Med/Dnt · P01 · FY2007 · AI
Antimicrobial Oligomers for BioDefense and Emerging Food Borne Infectious Disease
$1,215,012Gregory N. Tew · University Of Massachusetts Amherst · U01 · FY2010 · AI
Chemical Inhibitors to Define an Essential M. Tuberculosis Signaling Network
$1,214,907Robert N Husson · Boston Children'S Hospital · R01 · FY2016 · AI
Chemical Inhibitors to Define an Essential M. Tuberculosis Signaling Network
$1,214,907Robert N Husson · Boston Children'S Hospital · R01 · FY2015 · AI
Chemical Inhibitors to Define an Essential M. Tuberculosis Signaling Network
$1,214,907Robert N Husson · Boston Children'S Hospital · R01 · FY2014 · AI
Integrated Data and Simulation Environment in Public Health Informatics
$1,214,479Matthew Samore · University Of Utah · P01 · FY2007 · CD
Colorado Emerging Infections Program
$1,210,463Ken A. Gershman · Colorado State Dept/Pub Hlth & Environmt · U01 · FY2011 · CI
Development of ureadepsipetides for drug-resistant infections
$1,209,617Michael Lafleur · Arietis · R01 · FY2021 · AI
Studies of Receptor Interactions and Effects of Alarmins
$1,207,540Joost J Oppenheim · Division Of Basic Sciences - Nci · ZIA · FY2019 · CA
Mapping the genomic and molecular mechanisms of antifungal resistance in the emerging fungal pathogen Candida auris
$1,206,879P David Rogers · St. Jude Children'S Research Hospital · R01 · FY2025 · AI
Mapping the genomic and molecular mechanisms of antifungal resistance in the emerging fungal pathogen Candida auris
$1,206,879P David Rogers · St. Jude Children'S Research Hospital · R01 · FY2024 · AI
Administration Core
$1,205,763Samuel I. Miller · University Of Washington · U54 · FY2009 · AI
Development of Gene-Silencing Therapeutics for Pseudomonas aeruginosa
$1,204,439David Elihu Greenberg · Ut Southwestern Medical Center · R01 · FY2019 · AI
Rapid multiplex method for direct phenotypic ID/AST of bacterial pathogens
$1,203,777Ian Fleming · Guild Associates, Inc. · R01 · FY2019 · AI
Structural characterization of OM proteins from Gram-negative pathogens
$1,203,447Susan Buchanan · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2019 · DK
FilmArray Direct: Rapid Diagnosis of Antimicrobial-Resistant Pathogens from Blood
$1,203,182Andrew Hemmert · Biofire Diagnostics, Llc · R01 · FY2018 · AI
Mechanisms of Alcoholic Liver Disease
$1,202,007Bin Gao · National Institute On Alcohol Abuse And Alcoholism · ZIA · FY2010 · AA
Development of ureadepsipetides for drug-resistant infections
$1,200,871Michael Lafleur · Arietis · R01 · FY2022 · AI
Modeling of infectious network dynamics for surveillance, control and prevention enhancement (MINDSCAPE)
$1,200,000Travis Christian Porco · University Of California, San Francisco · U01 · FY2021 · CK
TO EFFECTIVELY MITIGATE ANTIMICROBIAL RESISTANCE IN THE AGRICULTURAL ECOSYSTEM, THERE IS AN INCREASING PRESSURE TO REDUCE AND ELIMINATE THE USE OF IN-FEED ANTIBIOTICS FOR GROWTH PROMOTION AND DISEASE CONTROL IN FOOD ANIMALS. HOWEVER, LIMITING ANTIBIOTICS COULD COMPROMISE PRODUCTION EFFICIENCY AND ANIMAL HEALTH. THUS, DEVELOPING EFFECTIVE ALTERNATIVES TO ANTIBIOTICS IS URGENTLY NEEDED. BUILDING UPON OUR ACCUMULATIVE RESEARCH EFFORTS ON FUNCTIONAL MICROBIOME AS WELL AS MODULATION OF HOST INNATE IMMUNITY, WE HAVE DEVELOPED TWO TYPES OF INNOVATIVE SMALL MOLECULES, NAMELY BILE SALT HYDROLASE INHIBITORS AND HOST DEFENSE PEPTIDE-INDUCING COMPOUNDS, AS ALTERNATIVES TO ANTIBIOTICS FOR GROWTH PROMOTION AND DISEASE CONTROL IN POULTRY. IN THIS PROPOSAL, WE PROPOSE TO USE INNOVATIVE AND COST-EFFECTIVE ENCAPSULATION TECHNOLOGIES TO FURTHER IMPROVE THE EFFICACY OF THESE NATURAL COMPOUNDS FOR COMMERCIAL APPLICATIONS. WE ALSO WILL DEVELOP EFFECTIVE EXTENSION AND EDUCATION PROGRAMS WHICH ARE HIGHLY INTEGRATED WITH RESEARCH TO ENCOURAGE ADOPTION OF INNOVATIVE NON-ANTIBIOTIC STRATEGIES. THE PROPOSED WORK WAS DEVELOPED WITH SIGNIFICANT INPUTS FROM STAKEHOLDERS AND RECEIVED ENTHUSIASTIC SUPPORT FROM THE INDUSTRY. THIS MULTI-DISCIPLINARY PROJECT WILL BE CONDUCTED BY A HIGHLY QUALIFIED MULTI-INSTITUTIONAL TEAM WITH MAJOR PARTICIPANTS FROM TWO USDA EPSCOR INSTITUTIONS. THE OUTCOMES OF THE PROJECT WILL LEAD TO THE DEVELOPMENT OF TWO INNOVATIVE NON-ANTIBIOTIC FEEDING TECHNOLOGIES FOR IMMEDIATE ADOPTION AND COMMERCIALIZATION IN POULTRY AND POSSIBLY OTHER LIVESTOCK, THUS MITIGATING ANTIMICROBIAL RESISTANCE ACROSS THE FOOD CHAIN.
$1,200,000University Of Tennessee · · FY2018 · National Institute of Food and Agriculture