Sort
21,281 grants matching “influenza”
Role of FABP5 in COPD Exacerbations
$495,444Fabienne Gally · National Jewish Health · R01 · FY2022 · HL
Project 4: Translational Studies to Identify Epithelial Biomarkers of
$495,429Ilona Jaspers · Univ Of North Carolina Chapel Hill · P50 · FY2017 · HL
Sphingolipid signaling in age-associated vascular pathology
$495,416Timothy Tun Hla · Boston Children'S Hospital · R01 · FY2025 · AG
A Simulator for Sound Production in Airways
$495,365Ingo R Titze · University Of Utah · R01 · FY2009 · DC
Novel immunotherapeutics for the management of otitis media due to H. influenzae
$495,349Lauren O Bakaletz · Research Inst Nationwide Children'S Hosp · R01 · FY2011 · DC
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** PRESENT KNOWLEDGE ABOUT THE IMMUNE RESPONSES THAT PROTECT PIGS FROM INFLUENZA VIRUS INFECTIONS IS LARGELY BASED ON OUR UNDERSTANDING OF A GROUP OF IMMUNE CELLS CALLED CONVENTIONAL T CELLS WHICH HAVE BEEN WELL DESCRIBED FOR DECADES. HOWEVER, MUCH LESS IS KNOWN ABOUT THE ROLE OF MORE RECENTLY DISCOVERED POPULATIONS OF UNCONVENTIONAL T CELLS CALLED INNATE-LIKE T CELLS (ITC). THESE ITCS SPECIALIZE IN PRODUCING LARGE QUANTITIES OF IMMUNE SIGNALING MOLECULES IN BARRIER ORGANS LIKE THE LUNG, AND PROBABLY MAKE PIVOTAL CONTRIBUTIONS TO INFLUENZA IMMUNITY. ALTHOUGH ITCS PROBABLY MAKE UP A SUBSTANTIAL PORTION OF THE SWINE INFLUENZA RESPONSE, MOST OF HOW THEY CONTRIBUTE TO PIG IMMUNITY CAN ONLY BE SPECULATED ABOUT FROM MOUSE MODELS WHICH HAVE SIGNIFICANT DRAWBACKS, INCLUDING THAT MICE COMPLETELY LACK AN ENTIRE CATEGORY OF ITCS CALLED GROUP I CD1-RESTRICTED T-CELLS. WE HYPOTHESIZE THAT ITCS PLAY IMPORTANT ROLES IN EARLY IMMUNE RESPONSES DURING INFLUENZA INFECTIONS AS WELL AS IN SHAPING IMMUNE MEMORY AGAINST SUBSEQUENT INFECTIONS. WE WILL TEST THIS THEORY USING GENETICALLY MODIFIED SWINE INDIVIDUALLY LACKING THREE DIFFERENT TYPES OF ITCS. FIRSTLY, ITC-DEFICIENT AND -INTACT PIGS WILL BE COMPARED FOR THEIR SUSCEPTIBILITY TO DIFFERENT INFLUENZA A VIRUS STRAINS USING A RANGE OF INNOVATIVE TOOLS. SECONDLY, WE WILL DETERMINE THE RESISTANCE OF ITC-DEFICIENT AND INTACT PIGS TO SUBSEQUENT CHALLENGE WITH DISTANT AND CLOSELY RELATED INFLUENZA VIRUS STRAINS. THESE EXPERIMENTS WILL PROVIDE THE FIRST COMPREHENSIVE EXAMINATION OF ITCS TO THE HEALTH OF PIGS, WHICH HAS THE POTENTIAL TO TRANSFORM CURRENT UNDERSTANDING OF HOW SWINE PROTECT THEMSELVES AGAINST RESPIRATORY VIRUSES.
$495,297University Of Missouri System · · FY2022 · National Institute of Food and Agriculture
HUMAN ANTIBODY REPERTOIRE TO H INFLUENZAE B
$495,151Children'S Hospital &Res Ctr At Oakland · R37 · FY2001 · AI
Development of broadly-protective vaccines for influenza B viruses
$495,150Yoshihiro Kawaoka · University Of Wisconsin-Madison · R33 · FY2025 · AI
Metabolic alterations in age-associated dendritic cell dysfunction
$494,954Claire A Chougnet · Cincinnati Childrens Hosp Med Ctr · R01 · FY2021 · AG
Metabolic alterations in age-associated dendritic cell dysfunction
$494,954Claire A Chougnet · Cincinnati Childrens Hosp Med Ctr · R01 · FY2020 · AG
Metabolic alterations in age-associated dendritic cell dysfunction
$494,937Claire A Chougnet · Cincinnati Childrens Hosp Med Ctr · R01 · FY2019 · AG
Therapeutically harnessing anti-viral resident memory T cells in solid tumors
$494,877Pamela Rosato · Dartmouth College · R01 · FY2025 · CA
Caveolae structure and function
$494,751Peter A Michaely · Ut Southwestern Medical Center · R01 · FY2010 · GM
Effectiveness of Selected NPIs in Reducing ILI among University Students
$494,583Tomas Javier Aragon · University Of California Berkeley · U01 · FY2006 · CI
Role of FABP5 in COPD Exacerbations
$494,460Fabienne Gally · National Jewish Health · R01 · FY2021 · HL
Single cell molecular analysis of influenza vaccine responses in elderly individuals
$494,406Spyros A Kalams · Vanderbilt University Medical Center · R01 · FY2021 · AI
Clinical Resource for Lung and Alcohol Investigations
$494,286Ellen L Burnham · University Of Colorado Denver · R24 · FY2014 · AA
Electron Spin Relaxation in Model Membranes
$494,276Jack H Freed · Cornell University · R01 · FY2018 · GM
Inflammatory dysregulation of vaccine responses in sickle cell disease
$494,275Ruth R Montgomery · Yale University · U19 · FY2025 · AI
Medicare Annual Wellness Visit Practice Redesign Toolkit: A Tailored Intervention to Improve Preventive Health Service Use
$494,272Derjung M Tarn · University Of California Los Angeles · R33 · FY2023 · AG
Electron Spin Relaxation in Model Membranes
$494,236Jack H Freed · Cornell University · R01 · FY2019 · GM
Supplemental Citicoline Administration for Reduction of Lung Injury Efficacy Trial (SCARLET)
$494,210Elliott D Crouser · Ohio State University · U01 · FY2024 · AI
Spatial Regulation of Developmental Gene Expression
$494,199Ronald M. Evans · Salk Institute For Biological Studies · R01 · FY2012 · HL
Electron Spin Relaxation in Model Membranes
$494,198Jack H Freed · Cornell University · R01 · FY2020 · GM
Polysaccharide Antibody Repertoires
$494,138Alexander H. Lucas · Children'S Hospital & Res Ctr At Oakland · R01 · FY2007 · AI