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15,273 grants matching “antimicrobial resistance”
Antimicrobial dermal matrices to promote infection free wound closure in cutaneous wounds
$1,200,000Manav Mehta · Gel4med, Inc. · SB1 · FY2023 · GM
Modeling of infectious network dynamics for surveillance, control and prevention enhancement (MINDSCAPE)
$1,200,000Travis Christian Porco · University Of California, San Francisco · U01 · FY2021 · CK
Analysis and Simulation of Bacterial Infections and Resource Strain in Hospitals during the COVID-19 Pandemic
$1,200,000Jeffrey L Shaman · Columbia University Health Sciences · U01 · FY2021 · CK
ANTIMICROBIAL RESISTANCE (AMR) RESEARCH, OUTREACH, AND COMMUNICATION INVOLVE MULTIPLE STAKEHOLDERS, YET, TO DATE, THERE HAS NOT BEEN A SYSTEMATIC CHARACTERIZATION OF AMR PERCEPTIONS AND KNOWLEDGE, OR EFFECTIVE DEVELOPMENT OF AMR COMMUNICATION STRATEGIES. IN ADDITION, THERE IS EVIDENCE SUGGESTING THAT THERMAL-BASED PROCESSES ARE MORE EFFECTIVE IN REDUCING AMR, HOWEVER, THE RELATIONSHIP BETWEEN FARM-APPROPRIATE, HIGHER-TEMPERATURE MANURE TREATMENT METHODS AND AMR REDUCTIONS HAVE NOT BEEN SPECIFICALLY QUANTIFIED. THIS RESEARCH WILL ADDRESS THESE NEEDS BY EVALUATING AMR PERCEPTIONS AND CREATING TARGETED OUTREACH CAMPAIGNS FOR FARMERS, POLICYMAKERS AND OTHER KEY STAKEHOLDERS. WE WILL ALSO DETERMINE MANURE MATRIX VARIABILITY AND CREATE A ROBUST. SCIENCE-BASED, MANURE SAMPLING PROTOCOL FOR AMR TO ADDRESS THE INHERENT VARIABILITY OF THE MANURE MATRIXES AND TEST HIGHER-TEMPERATURE MANURE TREATMENT METHODS USING THE PROJECT-DEVELOPED PROTOCOL. THE LONG-TERM GOALS OF THIS PROJECT ARE TO: 1) PROVIDE RESEARCH-BASED KNOWLEDGE OF STAKEHOLDER PERCEPTIONS (AND MISCONCEPTIONS) OF AMR PREVALENCE, CONVEYANCE, AND REDUCTIONS IN THE ENVIRONMENT, 2) CREATE AND IMPLEMENT COMMUNICATION STRATEGIES AND TOOLS THAT BEST CONVEY AMR KNOWLEDGE, AND 3) RESEARCH THE MOST PROMISING THERMAL-BASED AMR MANURE TREATMENT TECHNOLOGIES IN DAIRY OPERATIONS BASED ON OUR CREATED DAIRY MANURE SAMPLING PROTOCOL FOR AMR.THE RESULTS FROM THIS PROJECT CAN BE USED TO INFORM FARMERS ON MANURE MANAGEMENT TECHNOLOGIES AND HOW TO EFFECTIVELY CONVEY AMR KNOWLEDGE. THE TEAM HAS UNIQUE EXPERIENCE WITH MEDIA OUTREACH AND WILL DISSEMINATE SCIENTIFIC RESEARCH EFFECTIVELY THROUGH ITERATIVE DESIGN INVOLVING STAKEHOLDER REVIEW AND FEEDBACK, DISCUSSIONS USING ONLINE SOCIAL MEDIA, REINFORCING MESSAGES WITH IN-DEPTH WEB-BASED INFORMATION, AND IN-PERSON PRESENTATIONS AND DISCUSSIONS WITH KEY STAKEHOLDERS.
$1,199,999University Of Maryland, College Park · · FY2018 · National Institute of Food and Agriculture
ELEVATED LEVELS OF RESISTANT BACTERIA AND RESISTANCE GENES ARE FINDING THEIR WAY INTO THE ENVIRONMENT THROUGH THE LAND APPLICATION OF MANURE ASSOCIATED WITH ANIMAL PRODUCTION FACILITIES. PRAIRIE STRIPS ARE A NOVEL EDGE-OF-FIELD VEGETATIVE SYSTEM, ALREADY DEMONSTRATED AS A COST-EFFECTIVE STRATEGY FOR SUBSTANTIALLY IMPROVING WATER QUALITY IN RUNOFF FROM ROW-CROPPED AGRICULTURAL WATERSHEDS, WITH MINIMAL IMPACTS ON CROP PRODUCTION. OUR GOAL IS TO DEMONSTRATE THE IMPACT OF PRAIRIE STRIPS ON MITIGATING THE SPREAD OF ANTIMICROBIAL RESISTANCE TO THE ENVIRONMENT.1. DETERMINE THE EFFECTIVENESS OF PRAIRIE STRIPS TO RETAIN AMR FROM MANURE AMENDED CROPLANDS;2. CHARACTERIZE AMR MITIGATION IN AN EXISTING PRAIRIE STRIP;3. CHARACTERIZE AMR FATE AND TRANSPORT IN A MODEL PRAIRIE STRIP SYSTEM TO EVALUATE AND PREDICT PERFORMANCE AND OPTIMIZE DESIGN FOR AMR MITIGATION;4. INTEGRATE EXTENSION AND OUTREACH TOOLS TO ENSURE PRAIRIE STRIPS ARE RECOGNIZED AS A POTENTIAL AMR MITIGATION STRATEGY AND IMPLEMENTED FORTHIS PURPOSE.OUR EXPERIMENTAL DESIGN INCLUDES A SYSTEMATIC EVALUATION OF GENES IN MANURE, SOILS AND WATERS, WITH EMPHASIS ON THE ECOLOGY OF MICROBIAL RESISTANCE GENE RESERVOIRS IN A NOVEL MITIGATION STRATEGY. WE ARE DEVELOPING, EVALUATING AND IMPLEMENTING A NEW PRACTICE TO MITIGATE RESISTANCE AT THE EDGE-OF-THE-FIELD. OUR FINDINGS WILL BE SHARED THROUGH EXTENSION AND OUTREACH EFFORTS AND WILL BENEFIT THE AGRICULTURAL COMMUNITY AND RESEARCHERS.
$1,199,999Iowa State University Of Science And Technology · · FY2018 · National Institute of Food and Agriculture
UNDERSTANDING THE ECOLOGY OF ANTIMICROBIAL RESISTANCE (AMR) AND CONTROL OF HEMOPARASITIC DISEASES ARE NATIONAL PRIORITIES FOR THE UNITED STATES DEPARTMENT OF AGRICULTURE (USDA) AND ARE VITAL TO PROTECTING OUR FOOD SECURITY AND THE CONTINUED SUSTAINABLE DEVELOPMENT OF OUR LIVESTOCK INDUSTRIES. JUDICIOUS USE OF ANTIMICROBIALS ARE ESSENTIAL TO MAINTAIN SUSCEPTIBLE BACTERIAL POPULATIONS AND PROMOTE ANTIMICROBIAL LONGEVITY, WHILE MINIMIZING DEVELOPMENT OF RESISTANT MICROBIAL POPULATIONS. HOWEVER, SEVERAL CURRENTLY FOOD AND DRUG ADMINISTRATION (FDA)-APPROVED MEDICATED LIVESTOCK FEED THERAPIES UTILIZE MEDICALLY IMPORTANT ANTIMICROBIALS WITH NO ON-LABEL DEFINED DURATION OF USE, SUCH AS THE USE OF CHLORTETRACYCLINE (CTC)-MEDICATED FEEDS FOR THE TREATMENT OF BOVINE ANAPLASMOSIS (ANAPLASMOSIS) IN CATTLE. UNINTENDED CONSEQUENCES OF PROLONGED ANTIMICROBIAL EXPOSURE, ESPECIALLY AT SUB-THERAPEUTIC DOSES, INCLUDE SELECTION OF AMR IN BOTH THE TARGET PATHOGEN AND OFF-TARGET ZOONOTIC COMMENSALS. BASED ON THE PREMISE THAT INCREASING EXPOSURE OF BACTERIAL POPULATIONS TO ANTIMICROBIAL DRUGS INCREASES OF THE RISK OF POPULATIONS GENERATING RESISTANCE TO THOSE DRUGS, THE FDA, THROUGH THE FEDERAL REGISTER, HAS SOUGHT INFORMATION TO HELP ESTABLISH APPROPRIATE DOSE AND DURATION OF USE POLICIES WHEREBY CLINICAL THERAPEUTIC EFFECT IS MAXIMIZED AND RISK OF RESISTANCE DEVELOPMENT IS MINIMIZED. THE LONG-TERM GOAL OF THIS PROGRAM OF WORK IS TO PROMOTE SUSTAINABLE LIVESTOCK PRODUCTION BY REDUCING PROTRACTED ANTIMICROBIAL EXPOSURE TO CONTROL INFECTION OF THE HEMOPARASITIC RICKETTSIAL PATHOGEN, ANAPLASMA MARGINALE (AM), THE ETIOLOGIC AGENT OF ANAPLASMOSIS IN CATTLE. THE GUIDING HYPOTHESIS OF THIS PROPOSAL IS THAT TARGETING TREATMENT WITH TETRACYCLINE (TET) ANTIMICROBIALS TO COINCIDE WITH STRATEGIC PERIODS IN THE AM TRANSMISSION CYCLE WILL EFFECTIVELY CONTROL CLINICAL ANAPLASMOSIS IN CATTLE WHILE ALSO MINIMIZING DEVELOPMENT OF AMR IN AM AND OFF-TARGET (BOVINE ZOONOTIC COMMENSALS) BACTERIAL SPECIES. INFORMED BY SCIENTIFIC DATA AND THROUGH ACTIVE, INTEGRATED COOPERATION BETWEEN SCIENTISTS, CLINICIANS, EXTENSION, AND PRODUCERS, THIS PROPOSAL WILL ENABLE LIVESTOCK PRODUCERS TO MAKE MORE EFFICIENT USE OF ANTIMICROBIALS BY ALIGNING ANTIMICROBIAL USAGE WITH THE NATURAL BIOLOGICAL CYCLE OF AM TO OPTIMIZE DISEASE CONTROL. THE PRIMARY OBJECTIVES OF THIS PROPOSAL ARE TO: I) EXAMINE THE IN VIVO EFFICACY OF TET ANTIMICROBIALS TO CONTROL ANAPLASMOSIS IN EXPERIMENTAL AND FIELD CHALLENGES, II) EVALUATE THE ANTIMICROBIAL SUSCEPTIBILITY PROFILE OF TARGET (AM) AND OFF-TARGET (BOVINE ZOONOTIC COMMENSALS) MICROBIAL SPECIES IN TREATED CATTLE; III) DETERMINE THE CONTRIBUTION OF AM TICK VECTOR SPECIES TO THE ECOLOGICAL PERSISTENCE OF AMR IN AM POPULATIONS; AND IV) DEVELOP AN EXTENSION PLATFORM TO PROVIDE RESOURCES TO STAKEHOLDERS TRYING TO MITIGATE ANAPLASMOSIS AND SUPPORT ANTIMICROBIAL STEWARDSHIP.
$1,199,948Kansas State University · · FY2018 · National Institute of Food and Agriculture
Combatting AntiMicrobial Resistance in Africa Using Data Science (CAMRA)
$1,198,845Christian T. Happi · Redeemer'S University · U54 · FY2022 · TW
THERE IS GROWING EVIDENCE THAT AGRICULTURAL PRACTICES INFLUENCE THE SPREAD OF ANTIBIOTIC RESISTANCE TO ANIMALS AND HUMANS. RECENT TECHNOLOGICAL ADVANCES NOW MAKE IT POSSIBLE TO DEEPLY PROBE METAGENOMES AS A MEANS OF TRACKING ANTIBIOTIC RESISTANCE GENES (ARGS) AND MOBILE GENETIC ELEMENTS THAT FACILITATE THEIR PROLIFERATION (I.E., THE "RESISTOME") IN AGRO-ECOSYSTEMS. HOWEVER, THERE IS AN URGENT NEED FOR ACCESSIBLE COMPUTATIONAL TOOLS TO AID IN MEANINGFULLY INTERPRETING SUCH DATA, PARTICULARLY IN THE CONTEXT OF IMPORTANT META-DATA SUCH AS ANTIBIOTIC OCCURRENCE AND PERSISTENCE, PHYSICO-CHEMICAL FACTORS, AND ASSOCIATED MANAGEMENT PRACTICES. SUCH TOOLS ARE NEEDED TO INFORM SCIENCE-BASED REGULATION, POLICY, AND PRACTICE FOR LIMITING THE DISSEMINATION OF RESISTANCE TO THE ENVIRONMENT AND THROUGH THE FOOD CHAIN. THE AIM OF THE PROPOSED PROJECT IS TO DEVELOP WEB-BASED TOOLS INFORMED BY COMPUTATIONAL MODELS APPLIED TO OUR UNIQUE, COMPREHENSIVE ANTIBIOTIC, ARG, AND RESISTANT BACTERIA DATA SETS CORRESPONDING TO VARIOUS MANAGEMENT STRATEGIES (E.G., RESTRICTED ANTIBIOTIC USE, MANURE TREATMENT, LAND MANAGEMENT PRACTICES, AND CROP PRODUCTION). OUR NOVEL SYSTEMS APPROACH WILL INTEGRATE METAGENOMICS, STATE-OF-THE-ART ANTIBIOTIC ANALYSIS, AND POWERFUL COMPUTATIONAL TOOLS, INCLUDING MACHINE LEARNING, TO COLLECTIVELY EVALUATE MULTIPLE CRITICAL CONTROL POINTS FOR MITIGATING ANTIBIOTIC RESISTANCE IN THE FOOD PRODUCTION ECOSYSTEM. EDUCATIONAL AND OUTREACH PROGRAMS WILL DISSEMINATE INFORMATION AND TOOLS TO RELEVANT STAKEHOLDERS, INCLUDING RESEARCHERS, VETERINARIANS, FARMERS, PRACTITIONERS, AND POLICY-MAKERS, THROUGH PUBLICATIONS, WEBINARS, TRAININGS, AND WORKSHOPS. WE WILL EXPAND OUR RECENTLY LAUNCHED AGSOAR TRAINING PROGRAM TO INCLUDE COMPUTATIONAL METHODOLOGIES AND COURSE MODULES FOR UNDERGRADUATE, GRADUATE AND VETERINARY STUDENTS. THE PROPOSAL ADDRESSES PRIORITY CODE A4171, EFFECTIVE MITIGATION STRATEGIES FOR ANTIMICROBIAL RESISTANCE.
$1,198,685Virginia Polytechnic Institute & State University · · FY2017 · National Institute of Food and Agriculture
ANTIMICROBIAL USE IS IMPORTANT FOR THE PREVENTION, CONTROL, AND TREATMENT OF INFECTIOUS DISEASES IN FOOD ANIMALS, BUT POTENTIALLY CONTRIBUTES TO ANTIMICROBIAL RESISTANCE (AMR) DETERMINANTS ESCAPING FROM FEEDYARDS. FUGITIVE DUST FROM CATTLE FEEDYARDS HAVE BEEN RECOGNIZED AS AN ENVIRONMENTAL CONCERN; HOWEVER LITTLE IS KNOWN ABOUT VIABLE BACTERIA AND AMR DETERMINANTS IN THE DUST DOWNWIND FROM CATTLE FEEDYARDS. OUR IMMEDIATE GOALS ARE TO DETERMINE THE CONTRIBUTION OF DUST FROM CATTLE FEEDYARDS TO THE DISSEMINATION OF AMR BACTERIA IN THE DOWNWIND ENVIRONMENT; FURTHER, TO ASSIST FEEDYARD MANAGERS WITH IDENTIFYING CRITICAL CONTROL POINTS THAT ALLOW THEM TO MAKE INFORMED DECISIONS ABOUT EFFECTIVE MITIGATION STRATEGIES TO REDUCE THE RISK OF AMR BACTERIA IN FUGITIVE DUST. OUR HIGHLY INTEGRATED RESEARCH TEAM PROPOSES TO ACCOMPLISH THIS THROUGH:1) LONGITUDINAL SAMPLING CAMPAIGNS TO ESTIMATE THE BASELINE DISTRIBUTION AND DETERMINANTS OF VIABLE BACTERIA AND RESISTANCE DETERMINANTS IN FEEDYARD DUST.2) INTENSIVE SAMPLING TO CHARACTERIZE AND QUANTIFY CHANGES IN THE DISTRIBUTION ASSOCIATED WITH PARTICLE SIZES AND DOWNWIND DISTANCES.3) IDENTIFYING EFFECTIVE MITIGATION STRATEGIES TO REDUCE AMR BACTERIA IN DUST.4) DEVELOPING A DECISION TOOL REGARDING THE RISKS AND MITIGATION STRATEGIES TO REDUCE AMR BACTERIA IN DUST FROM CATTLE FEEDYARDS.THE PROPOSED STUDY CONTRIBUTES TO THE LONG-RANGE IMPROVEMENT IN AND SUSTAINABILITY OF U.S. AGRICULTURE AND FOOD SYSTEMS BY DETERMINING EFFECTIVE MITIGATION STRATEGIES FOR THE CONTROL OF FUGITIVE BIOAEROSOLS CONTAINING ANTIMICROBIAL RESISTANCE DETERMINANTS ARISING FROM CATTLE FEEDYARDS. THESE MITIGATION STRATEGIES WILL BE USED TO DEVELOP A TOOL FOR USE BY THE CATTLE INDUSTRY TO IDENTIFY RISKS AND DEPLOY MITIGATION STRATEGIES FOR REDUCING BIOAEROSOLS AND ANTIMICROBIAL RESISTANCE DETERMINANTS ON INDIVIDUAL FEEDYARDS.
$1,197,255Texas A&M Agrilife Research · · FY2018 · National Institute of Food and Agriculture
Development of Gene-Silencing Therapeutics for Pseudomonas aeruginosa
$1,195,983David Elihu Greenberg · Ut Southwestern Medical Center · R01 · FY2024 · AI
Structural characterization of OM proteins from Gram-negative pathogens
$1,194,758Susan Buchanan · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2025 · DK
Innovative technologies to transform antibiotic discovery. Project 4 Infection site-specific amplification of antimicrobial conjugates
$1,193,998Deborah T Hung · Broad Institute, Inc. · U19 · FY2022 · AI
Ultra-low Fouling and Anti-infective and Anti-thrombotic Nitric Oxide Releasing Intravascular Catheters
$1,193,055Ronald J. Shebuski · Nytricx Inc. · R42 · FY2023 · HL
TARGETED CLINICAL TRIALS TO REDUCE THE RISK OF ANTIMICROBIAL RESISTANCE
$1,188,983Keith Kaye · University Of Michigan At Ann Arbor · N01 · FY2018 · AI
Innate inflammatory responses during pulmonary infections
$1,188,232Katrin Mayer-Barber · National Institute Of Allergy And Infectious Diseases · ZIA · FY2017 · AI
Therapeutic Inhibitors of Bacterial Quorum Sensing from Filamentous fungi
$1,188,187William Charles Nierman · J. Craig Venter Institute, Inc. · R56 · FY2010 · AI
Development of ureadepsipetides for drug-resistant infections
$1,186,918Michael Lafleur · Arietis · R01 · FY2023 · AI
Consortium for drug-resistant Gram-negative pathogen detection
$1,185,876Lee W Riley · University Of California Berkeley · R01 · FY2017 · AI
Sexually Transmitted Infections Clinical Trials Group: Whole Genomic Sequencing to Detect Reduced Antibiotic Susceptibility in Neisseria gonorrhoeae
$1,184,422Sheldon Morris · Social And Scientific Systems, Inc. · N01 · FY2018 · AI
THE REDUCTION OF ANTIBIOTIC USE IN ANIMAL AGRICULTURE IN THE UNITED STATES IS A NECESSARY STEP TOWARDS REDUCING THE EMERGENCE AND PERSISTENCE OF ANTIMICROBIAL RESISTANCE IN BACTERIAL PATHOGENS OF HUMANS AND ANIMALS. HOWEVER, REDUCTION OF USE DOES NOT PROMISE REDUCTION OF RESISTANCE, AND THIS APPROACH MAY CREATE ANCILLARY PROBLEMS RELATED TO INCREASED DISEASE-ASSOCIATED MORTALITY. THIS WORK WILL ATTACK THESE PROBLEMS IN A MULTI-PRONGED EFFORT. FIRST, GENETIC TECHNOLOGY WILL BE USED DEVELOP A SYSTEM THAT TARGETS ANTIMICROBIAL RESISTANCE. SECOND, WEB-BASED OPEN ACCESS TOOLS WILL BE DEVELOPED TO EDUCATE POULTRY PRODUCERS ABOUT VACCINATION STRATEGIES AND PROVIDE A SIMPLE WAY TO CHOOSE VACCINE STRAINS. THIRD,PROBIOTICS WILL BE CHARACTERIZED AND EXAMINED IN COMMERCIAL TURKEYS TO DEVELOP BETTER PROBIOTICS. FINALLY, SYMPOSIA AND ONLINE EDUCATIONAL MATERIALS RELATED TO PREBIOTICS AND PROBIOTICS WILL BE DELIVERED TO APPROPRIATE AUDIENCES TO PROVIDE CLARITY TO THE CONFUSING REALM OF ALTERNATIVE FEED ADDITIVE SELECTION AND USE. OVERALL, THIS PROJECT WILL BUILD ON THE FUTURE OF MITIGATION STRATEGIES AGAINST ANTIMICROBIAL RESISTANCE AND WILL PROVIDE EDUCATIONAL AND HANDS-ON TOOLS TO ENABLE SCIENCE-BASED DECISION-MAKING BY THE POULTRY PRODUCER.
$1,183,783Regents Of The University Of Minnesota · · FY2018 · National Institute of Food and Agriculture
Cross-Kingdom Vaccine Targeting Healthcare-Associated Priority Pathogens
$1,181,298Ashraf S. Ibrahim · Lundquist Institute For Biomedical Innovation At Harbor-Ucla Medical Center · R01 · FY2019 · AI
Task A29: Evaluation of Candidate Medical Countermeasures for Inhalational Anthrax in the NZW Rabbit Model
$1,179,674David Beasely · University Of Texas Med Br Galveston · N01 · FY2019 · AI
Molecular Genetic Basis of the Infectious Cycle of Borrelia burgdorferi
$1,178,296Patricia A Rosa · National Institute Of Allergy And Infectious Diseases · ZIA · FY2009 · AI
Bacterial Functions Involved in Cell Growth Control
$1,176,355Susan Gottesman · Division Of Basic Sciences - Nci · ZIA · FY2014 · CA
Microbial exploration for new antimicrobial discovery
$1,172,547Akintunde Emiola · National Institute Of Dental & Craniofacial Research · ZIA · FY2022 · DE