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15,273 grants matching “antimicrobial resistance”
Innate Immunity in Otitis Media Pathogenesis
$332,010David J. Lim · House Research Institute · R01 · FY2006 · DC
Bacterial Cell Wall Composition and the Influence of Antibiotics
$331,888Lynette S Cegelski · Stanford University · R01 · FY2022 · GM
Bacterial Cell Wall Composition and the Influence of Antibiotics
$331,888Lynette S Cegelski · Stanford University · R01 · FY2023 · GM
Analyses of sodium bioenergetics in Vibrio cholerae
$331,862Claudia C Hase · Oregon State University · R01 · FY2009 · AI
Understanding in vivo antibiotic resistance in diverse Pseudomonas aeruginosa populations
$331,650Stephen Paul Diggle · Georgia Institute Of Technology · R01 · FY2021 · AI
Discovery and development of drug cocktails evolved by Nature
$331,527Xuejun Zhu · Texas Engineering Experiment Station · R35 · FY2022 · GM
Controlling Catheter-Associated Urinary Tract Infections Using Smart Catheters with Rationally Designed Active Topographies
$331,276Dacheng Ren · Syracuse University · R01 · FY2022 · EB
IN VIVO GENE EXPRESSION IN STAPHYLOCCUS AUREUS
$331,061Dartmouth College · R01 · FY2001 · AI
Structural and functional studies of microbial O-glycosyltransferases that synthesize virulence factors
$331,049Nadine Samara · National Institute Of Dental & Craniofacial Research · ZIA · FY2023 · DE
IN VIVO PATHOGENESIS OF HELICOBACTER PYLORI
$331,000Massachusetts Institute Of Technology · R01 · FY2001 · AI
IN VIVO PATHOGENESIS OF HELICOBACTER PYLORI
$331,000Massachusetts Institute Of Technology · R01 · FY2004 · AI
IN VIVO PATHOGENESIS OF HELICOBACTER PYLORI
$331,000Massachusetts Institute Of Technology · R01 · FY2003 · AI
ELECTRON MICROSCOPY OF MEMBRANE PROTEINS(RMI)
$330,985Scripps Research Institute · R01 · FY2005 · GM
NON-TYPHOIDAL SALMONELLAE ARE THE LEADING CAUSE OF BACTERIAL FOODBORNE GASTROENTERITIS AND BOVINE FOOD PRODUCTS ARE FREQUENTLY IMPLICATED IN DISEASE OUTBREAKS. THE DAUNTING RATE OF SALMONELLA INFECTIONS IN HUMANS COMBINED WITH THE INCREASING NUMBER OF MULTIPLE DRUG RESISTANT (MDR) ISOLATES IS AN ALARMING PUBLIC HEALTH THREAT. MDR SALMONELLA INFECTIONS ARE FREQUENTLY TRACED TO BOVINE SOURCES, MAKING IT IMPERATIVE TO DESIGN NOVEL, NON-ANTIMICROBIAL STRATEGIES TO ELIMINATE MDR SALMONELLA FROM CATTLE. IN THIS BASIC SCIENCE PROPOSAL, WE WILL ESTABLISH THE ROLE OF A HOST-CELL PROTEIN, MARCKS (MYRISTOYLATED ALANINE-RICH C-KINASE SUBSTRATE), IN SALMONELLA INFECTIONS. WE HYPOTHESIZE THAT MARCKS PROTEIN FUNCTION IS ESSENTIAL FOR SALMONELLA-INDUCED NEUTROPHIL RECRUITMENT AND ACTIVATION, EPITHELIAL INVASION, AND THE OVERALL SURVIVAL OF SALMONELLA IN THE HOST INTESTINE. USING A SPECIFIC INHIBITOR OF MARCKS FUNCTION, WE WILL ESTABLISH THE ROLE OF MARCKS IN IMMUNE SIGNALING AND SALMONELLA COLONIZATION OF THE CALF GUT. THESE EXPERIMENTS WILL (1) ESTABLISH THE BASIC BIOLOGY OF MARCKS PROTEIN DURING INFECTION AND (2) ESTABLISH WHETHER A MARCKS PEPTIDE INHIBITOR IS A VIABLE HOST-DIRECTED THERAPEUTIC TO TREAT BOVINE SALMONELLOSIS. SALMONELLA INFECTIONS ARE A THREAT TO BOTH HUMAN AND BOVINE HEALTH SO ALTERNATIVES TO TRADITIONAL ANTIMICROBIALS ARE CRITICALLY NEEDED TO COMBAT THIS IMPORTANT PATHOGEN. THE PROPOSED STUDIES WILL DIRECTLY INFORM DEVELOPMENT OF A NON-ANTIMICROBIAL THERAPEUTIC TO PREVENT AND TREAT SALMONELLA IN CATTLE.
$330,961University Of Wisconsin System · · FY2020 · National Institute of Food and Agriculture
Role of MiT Transcription Factors in Host Defense Against Bacterial Infection
$330,890Javier Elbio Irazoqui · Massachusetts General Hospital · R01 · FY2012 · GM
Biology of Infectious Diseases Training Program
$330,843Matthew G Dorsey · University Of California, San Francisco · T32 · FY2021 · AI
Laboratory Core
$330,824Bernard J. Moncla · Magee-Women'S Res Inst And Foundation · U19 · FY2014 · AI
Salmonella Antimicrobial Peptide Resistance
$330,785John S Gunn · Ohio State University · R01 · FY2012 · AI
Innate immune defense against community associated methicillin-resistant S.aureus
$330,785William Michael Nauseef · University Of Iowa · R01 · FY2011 · AI
Salmonella Antimicrobial Peptide Resistance
$330,785John S Gunn · Ohio State University · R01 · FY2011 · AI
NITRIC OXIDE CYTOTOXICITY IN SALMONELLOSIS
$330,780University Of Washington · R01 · FY2002 · AI
COMBATTING QUINOLONE ANTIMICROBIAL RESISTANCE
$330,668Elizabeth Lynn Zechiedrich · Baylor College Of Medicine · R01 · FY2006 · AI
Airway pH and antimocrobial activity in early cystic fibrosis
$330,630Joseph Zabner · University Of Iowa · P01 · FY2013 · HL
Project 3
$330,620Peter Belenky · Miriam Hospital · P20 · FY2019 · GM
Enzyme therapeutics for biofilm prevention and disruption
$330,616Patricia Lynne Howell · Hospital For Sick Chldrn (Toronto) · R33 · FY2017 · AI