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21,281 grants matching “influenza”
Porcine Respiratory Coronavirus as a SARS Model
$472,183Linda J. Saif · Ohio State University · R01 · FY2006 · AI
Randomized Controlled Trial of a Six-Month Mindfulness-Based Intervention for Type 2 Diabetes
$472,098Nazia T. Raja-Khan · Pennsylvania State Univ Hershey Med Ctr · R01 · FY2022 · DK
Plasmablast trafficking and antibody response in influenza vaccination
$472,056Harry Bernard Greenberg · Stanford University · U19 · FY2012 · AI
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV)AND SWINE INFLUENZA A VIRUS (SIAV) INFECTIONS ARE TWO OF THE MOST IMPORTANT VIRAL DISEASES IN PIGS WITH MAJOR ECONOMIC IMPACT ON THE SWINE INDUSTRY AND SUSTAINED FOOD SUPPLY. SIAV CAUSES INFLUENZA OUTBREAKS IN PIGS, LEADING TO MAJOR ECONOMIC LOSSES FOR PIG PRODUCERS. FURTHERMORE, PIGS ARE A POTENTIAL SOURCE FOR EMERGENCE OF PANDEMIC INFLUENZA IN HUMANS FOR THEY CAN BE INFECTED WITH BOTH HUMAN AND PIG INFLUENZA VIRUSES. THEREFORE, CONTROLLING INFLUENZA INFECTION IN PIGS IS HIGHLY IMPORTANT FOR THE SWINE INDUSTRY AND THE PUBLIC HEALTH. PRRSV CAUSES REPRODUCTIVE PROBLEMS AND POST-WEANING MORTALITY IN PIGS, RESULTING IN SIGNIFICANT ECONOMIC LOSSES. SINCE CURRENTLY AVAILABLE VACCINES AND OTHER CONVENTIONAL METHODS ARE NOT EFFECTIVE AT CONTROLLING SIAV AND PRRSV INFECTIONS IN PIGS, DEVELOPMENT OF NOVEL METHODS TO MITIGATE THE BURDEN OF THESE VIRAL DISEASES IS EXPECTED TO GREATLY BENEFIT THE SWINE INDUSTRY AND THE PUBLIC HEALTH. IDENTIFYING HOST FACTORS THAT ARE CRUCIAL FOR BOTH VIRUSES IS AN IMPORTANT STEP TOWARDS THIS GOAL. WE HAVE FOUND THAT PROTEIN DISULFIDE ISOMERASES (PDIS), ESPECIALLY PDIA4, ARE REQUIRED FOR SIAV AND PRRSV IN NON-PORCINE ORIGINATED CELLS. PDIS ARE THE ENZYMES THAT ARE INVOLVED IN PROPER PROTEIN FOLDING IN THE CELLS. IN THIS PROJECT, WE WILL INVESTIGATE WHETHER VARIOUS STRAINS OF HUMAN INFLUENZA VIRUS AND SIAV AND PRRSV ARE DEPENDENT ON THE PDIS FOR THEIR REPLICATION IN THE PORCINE-ORIGINATED CELLS. TO DO THIS, WE WILL GENERATE PDIA4-DELETED (KNOCKOUT) PORCINE CELLS AND GROW HUMAN AND SWINE INFLUENZA VIRUSES AND PRRSV. SIGNIFICANTLY REDUCED VIRAL REPLICATION IN THE PDIA4-KNOCKOUT CELLS INDICATES THAT PDIA4 IS CRITICAL FOR THESE VIRUSES. THE RESULTS WILL BE CONFIRMED BY RESTORING THE EXPRESSION OF PDIA4 IN THE CELLS. THE MECHANISM BY WHICH PDIA4 KNOCKOUT INHIBITS VIRAL REPLICATION WILL BE STUDIED BY CONDUCTING AN ARRAY OF EXPERIMENTS. LASTLY, TRANSGENIC MICE WITH PDIA4 KNOCKOUT WILL BE INFECTED WITH INFLUENZA VIRUS TO STUDY WHETHER PDIA4 KNOCKOUT LEADS TO INCREASED RESISTANCE TO INFLUENZA VIRUS INFECTION. THIS PROOF-OF-CONCEPT STUDY USING A COMMERCIALLY AVAILABLE TRANSGENIC MOUSE MODEL WILL OFFER VALUABLE INSIGHT INTO THE FEASIBILITY OF USING PDIA4 TO PRODUCE TRANSGENIC PIGS WITH INCREASED RESISTANCE TO BOTH VIRAL DISEASES IN FUTURE STUDIES.
$472,017Kansas State University · · FY2019 · National Institute of Food and Agriculture
Systems Approach to Immunity and Inflammation
$471,985Richard J Ulevitch · Scripps Research Institute, The · U19 · FY2021 · AI
Tyrosine Kinase inhibition: The New Front in HIV Cure Efforts
$471,902Vicente Planelles · University Of Utah · R01 · FY2020 · AI
Center for Computational Mass-Spectrometry
$471,897Pavel A Pevzner · University Of California, San Diego · P41 · FY2012 · GM
Immunogenetic Mechanisms of Vaccine Response
$471,883Gregory A. Poland · Mayo Clinic Rochester · R37 · FY2014 · AI
Genetics of Coxiella burnetii
$471,874Robert A Heinzen · National Institute Of Allergy And Infectious Diseases · ZIA · FY2012 · AI
Modeling Core
$471,664Sourav Bandyopadhyay · Icahn School Of Medicine At Mount Sinai · U19 · FY2013 · AI
Molecular basis of glycan recognition by T and B cells
$471,585Luc Teyton · Scripps Research Institute, The · P01 · FY2025 · AI
Integrative analysis and modeling of human immune responses and pathologies
$471,538John Tsang · National Institute Of Allergy And Infectious Diseases · ZIA · FY2013 · AI
Development of lung T cell responses in infant respiratory immunity
$471,432Donna L Farber · Columbia University Health Sciences · R01 · FY2012 · AI
Development of lung T cell responses in infant respiratory immunity
$471,432Donna L Farber · Columbia University Health Sciences · R01 · FY2016 · AI
Development of lung T cell responses in infant respiratory immunity
$471,432Donna L Farber · Columbia University Health Sciences · R01 · FY2014 · AI
DETERMINANTS OF H. INFLUENZAE VIRULENCE IN OTITIS MEDIA
$471,312Research Inst Nationwide Children'S Hosp · R01 · FY2001 · DC
Administrative Core
$471,303Mark M Davis · Stanford University · U19 · FY2015 · AI
Development of an Automated Diagnostic Platform for SARS-CoV-2 Monitoring in Vulnerable Areas
$471,237Diana Carolina Vanegas-Gamboa · Clemson University · U01 · FY2021 · AA
Mechanisms of innate resistance to virus infections
$471,166Jacob Yount · Ohio State University · R01 · FY2022 · AI
Caveolae structure and function
$471,059Richard G. Anderson · Ut Southwestern Medical Center · R01 · FY2008 · GM
Anti-inflammatory functions for non-transcriptional IRF3
$471,039Saurabh Chattopadhyay · University Of Toledo Health Sci Campus · R01 · FY2021 · AI
Motor abnormalities and functional brain mechanisms in autism spectrum disorder
$470,911Matthew W Mosconi · University Of Kansas Lawrence · R01 · FY2020 · MH
Context dependent amino acid availability and sensing determines humoral immunity
$470,828Hu Zeng · Mayo Clinic Rochester · R01 · FY2024 · AI
Context dependent amino acid availability and sensing determines humoral immunity
$470,828Hu Zeng · Mayo Clinic Rochester · R01 · FY2023 · AI
Context dependent amino acid availability and sensing determines humoral immunity
$470,828Hu Zeng · Mayo Clinic Rochester · R01 · FY2022 · AI