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24,576 grants matching “microbiome”
An integrative and generalizable approach to modulate microbiota small molecules in the host
$2,542,500Chun-Jun Guo · Weill Medical Coll Of Cornell Univ · DP2 · FY2019 · HD
Statistical Methods for Integrative Genomics in Cancer
$2,540,285Duncan C. Thomas · University Of Southern California · P01 · FY2017 · CA
Aging Intervention Studies
$2,539,532Julie Mattison · National Institute On Aging · ZIA · FY2022 · AG
Microbiome Discovery and Mechanisms to Combat Antibiotic Resistance at Mucosal Surfaces
$2,537,842Robert A Britton · Baylor College Of Medicine · U19 · FY2023 · AI
Oxidative Modification Of Proteins
$2,537,006Rodney L. Levine · National Heart, Lung, And Blood Institute · ZIA · FY2024 · HL
Clinical Psychoneuroendocrinology and Neuropsychopharmacology (CPN)
$2,535,440Lorenzo Leggio · National Institute On Drug Abuse · ZIA · FY2022 · DA
MACS/WIHS Combined Cohort Study: Cook County Clinical Research Site (CC_CRS)
$2,535,000Audrey French · Hektoen Institute For Medical Research · U01 · FY2019 · HL
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
$2,532,300Avindra Nath · National Institute Of Neurological Disorders And Stroke · ZIA · FY2021 · NS
Transmission Pathways of Seagrass Wasting Disease in Coastal Meadows
$2,530,899Catherine D Harvell · Cornell University · · FY2021 · GEO
The Genome Analysis Core
$2,530,888Daniel Cesar Douek · National Institute Of Allergy And Infectious Diseases · ZIC · FY2022 · AI
LICI Microbiome and Genetics Core
$2,525,817Colm Ohuigin · Division Of Basic Sciences - Nci · ZIC · FY2024 · CA
Functional Genomics and Bioinformatics Data management Core
$2,523,353Seyed Ali Mortazavi · University Of California-Irvine · U54 · FY2025 · AG
Eukaryotic Transcriptional Regulation
$2,522,520Paul A Wade · National Institute Of Environmental Health Sciences · ZIA · FY2023 · ES
Immunobiology of Allogeneic Hematopoietic Cell Transplantation
$2,522,125Marcel R M Van Den Brink · Sloan-Kettering Inst Can Research · P01 · FY2022 · CA
Mechanisms of Immune Activation and Disease Progression in Animal Models
$2,520,873Jason Brenchley · National Institute Of Allergy And Infectious Diseases · ZIA · FY2023 · AI
HDL Function in Human Disease
$2,512,032Macrae F Linton · Vanderbilt University Medical Center · P01 · FY2024 · HL
Genetic and Biochemical Approaches to Tyrosine Kinase and Lymphocyte Signaling
$2,510,147Pamela Schwartzberg · National Institute Of Allergy And Infectious Diseases · ZIA · FY2025 · AI
Successful Clinical Response In Pneumonia Therapy (SCRIPT) Systems Biology Center
$2,506,053Richard G Wunderink · Northwestern University At Chicago · U19 · FY2023 · AI
MIM: Machine Learning, Systems Modeling, and Experimental Approaches to Understand the Universal Rules of Life of Microbiota Using Marine Time Series Data
$2,500,651Fengzhu Sun · University Of Southern California · · FY2022 · BIO
The Neonatal Microbiome and Necrotizing Enterocolitis
$2,500,000Phillip I Tarr · Washington University · UH3 · FY2010 · AI
EVERY INDIVIDUAL HUMAN, ANIMAL AND PLANT SERVES AS HOST FOR A DIVERSITY OF MICROBES THAT TOGETHER COMPRISE ITS MICROBIOME. WHILE THE MICROBIOME IS COMPRISED MOSTLY OF ORGANISMS THAT USUALLY DO NO HARM TO THE HOST, OR EVEN BENEFIT THE HOST, THE MICROBIOME ALSO ALMOST ALWAYS INCLUDES SOME DISEASE-CAUSING ORGANISMS: PATHOGENS AND PARASITES. EACH ORGANISM IN THE MICROBIOME INTERACTS NOT ONLY WITH THE HOST, BUT WITH OTHER ORGANISMS IN THE MICROBIOME. ALSO, EACH HOST'S MICROBIOME IS DIFFERENT. SOME HOSTS MAY HAVE A MICROBIOME THAT PARTIALLY PROTECTS THEM AGAINST INFECTION BY PATHOGENS TRANSMITTED FROM OTHER HOST INDIVIDUALS. A CURRENT SCIENTIFIC ISSUE IS HOW TRANSMISSION OF PATHOGENS ACROSS THE POPULATION OF HOSTS IS INFLUENCED BY THE DIFFERENCES BETWEEN HOSTS IN THEIR MICROBIOMES. THAT IS THE ISSUE THAT WILL BE ADDRESSED BY THIS PROJECT. THIS PROJECT WILL STUDY THE MICROBIOME OF LEAVES OF THE AGRICULTURALLY IMPORTANT GRASS TALL FESCUE. THE MICROBIOME OF LEAVES IS DOMINATED BY FUNGI, AND ACCORDINGLY THE PROJECT WILL STUDY FUNGAL SPECIES THAT RANGE FROM PATHOGENS TO MUTUALISTS OF THE PLANT. THE PROJECT WILL TEST WHETHER KEY MEMBERS OF THE MICROBIOME CAN REDUCE PATHOGEN INFECTION OF HOST INDIVIDUALS, AND UNDER WHAT CONDITIONS THEY CAN ALSO REDUCE PATHOGEN TRANSMISSION ACROSS THE HOST POPULATION. THIS WILL BE DONE BY INTEGRATING A RANGE OF METHODS, INCLUDING HIGH-THROUGHPUT GENOMIC SEQUENCING, FIELD EXPERIMENTS, GREENHOUSE EXPERIMENTS, FIELD SURVEYS, AND MATHEMATICAL MODELS. THE ULTIMATE GOAL OF THE PROJECT IS TO BETTER UNDERSTAND ROLE OF THE MICROBIOME IN PATHOGEN TRANSMISSION. IN THE LONG-TERM, THIS PROJECT MAY PROVIDE INSIGHTS INTO SUSTAINABLE MANAGEMENT OF PESTS. THE FOCAL PATHOGENS ARE SOME OF THE MOST IMPORTANT PESTS OF PASTURES, TURF GRASS, AND SMALL GRAIN CROPS, AND TALL FESCUE IS ONE OF THE MOST IMPORTANT GRASSES FOR BOTH TURF AND FEEDING LIVESTOCK. MOREOVER, THE PROJECT AIMS TO PROVIDE GENERAL UNDERSTANDING THAT WILL APPLY ACROSS SYSTEMS, POTENTIALLY PROVIDING A BASIS FOR IMPROVEMENTS IN PLANT, ANIMAL, AND HUMAN HEALTH.
$2,500,000University Of North Carolina At Chapel Hill · · FY2016 · National Institute of Food and Agriculture
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** MOVEMENT OF PATHOGENS BETWEEN ECOSYSTEMS IS A MAJOR DRIVER OF PATHOGEN EMERGENCE IN HUMANS, ANIMALS, AGRICULTURAL CROPS, AND NATURAL ECOSYSTEMS. INVASIVE PLANTS SPAN NATURAL, DISTURBED, AND AGRICULTURAL SYSTEMS, PROVIDE A NOVEL, ABUNDANT HOSTFOR NOVEL GROUPS OF MICROBES, AND CAN HAVE AN OUTSIZED ROLE IN PATHOGEN TRANSMISSION BECAUSE INVASIVE PLANTS OCCUR IN HIGH DENSITY AND CREATE CONDUCIVE ENVIRONMENTS FOR DISEASE. THIS RESEARCH WILL EXAMINE THE ROLE OF INVASIVE PLANTS IN THE ECO-EVOLUTIONARY DYNAMICS OF TRANSMISSION ACROSS ECOSYSTEMS BOUNDARIES AND CROP DISEASE EMERGENCE, AND CAPTURE INITIAL EPIDEMIC DYNAMICS OF AN EMERGING PATHOGEN ON A NOVEL HOST IN REAL TIME. THE SHARP CONTRASTS BETWEEN AGRICULTURAL AND WILD HOSTS IN SPATIAL AND COMMUNITY STRUCTURE, PHENOLOGY, INDIVIDUAL HETEROGENEITY, AND MICROBIOMES PROVIDE AN IDEAL MODEL SYSTEM FOR EMPIRICAL AND THEORETICAL INVESTIGATION OF THE INTERPLAY OF THESE FACTORS ON ECOLOGICAL AND EVOLUTIONARY DYNAMICS OF INFECTIOUS DISEASES AT AND ACROSS ECOSYSTEM BOUNDARIES. OUR RESULTS WILL ADVANCE UNDERSTANDING OF ECOLOGICAL AND EVOLUTIONARY DRIVERS OF PATHOGEN SPILLOVER AND ADAPTATION TO A NOVEL HOST, INFORM MORE GENERAL THEORY IN INFECTIOUS DISEASE ECOLOGY, AND ULTIMATELY IMPROVE PREDICTION AND MANAGEMENT OF EMERGING DISEASES.
$2,500,000University Of Florida · · FY2023 · National Institute of Food and Agriculture
A Multi-'omic Analysis of the Vaginal Microbiome during Pregnancy
$2,500,000Gregory A Buck · Virginia Commonwealth University · U54 · FY2013 · DE
MTM2: Drivers of functional redundancy across microbiomes
$2,500,000Barbara J Campbell · Clemson University · · FY2020 · BIO
Characterizing the gut microbial ecosystem for diagnosis and therapy in IBD
$2,500,000Ramnik J Xavier · Broad Institute, Inc. · U54 · FY2013 · DE