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24,576 grants matching “microbiome”
Treating colon cancer by regulating intestinal immunity through microbial metabolism
$537,163Nicholas Arpaia · Columbia University Health Sciences · R01 · FY2024 · CA
Role of the gut microbiome in the bone loss induced by hyperparathyroidism in mice and humans
$537,126Roberto Pacifici · Emory University · R01 · FY2024 · DK
Precision in Symptom Self-Management (PriSSM) Center
$537,053Suzanne Bakken · Columbia University Health Sciences · P30 · FY2020 · NR
Spatial eco-epidemiology of tick-borne rickettisal pathogens
$537,047Holly Gaff · Old Dominion University · R01 · FY2017 · AI
Genome Evolution During Bacterial Persistence in the Human Airways in COPD
$537,008Timothy F Murphy · State University Of New York At Buffalo · R01 · FY2020 · AI
The Role of Microbiome Composition in Amphetamine Abuse
$536,931Aurelio Antonio Galli · University Of Alabama At Birmingham · R01 · FY2025 · DA
EF: Collaborative Research: MTM 2: Marine Invertebrate Microbiome Assembly, Diversification, and Coevolution
$536,922Purushotham Bangalore · University Of Alabama At Birmingham · · FY2021 · BIO
Impact of periconceptual vaginal microbiota on women's risk of preterm birth
$536,884Raymond Scott McClelland · University Of Washington · R01 · FY2020 · HD
Gut microbiota mediated bile acid alterations in hepatic carcinogenesis
$536,813Wei Jia · University Of Hawaii At Manoa · U01 · FY2015 · CA
A Novel Role for PTPN2 in Intestinal Epithelial Barrier Regulation
$536,713Declan McCole · University Of California Riverside · R01 · FY2024 · DK
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** PLANTS ARE PART OF A COMMUNITY THAT INCLUDES FUNGI, OOMYCETES, BACTERIA, VIRUSES AND OTHER COMPLEX MICROBIOTA. ALTHOUGH THE NUMBER OF MICROBIAL CELLS ON A PLANT OR ANIMAL OFTEN OUTNUMBERS THE HOST'S OWN CELL COUNT BY MANY-FOLD, MICROBES ARE GENERALLY NOT VISIBLE TO THE NAKED EYE. IT HAS BEEN ESTIMATED THAT A SINGLE GRAM OF SOIL MAY CONTAIN 10 BILLION BACTERIAL CELLS AND PLANT ROOTS CAN HARBOR THOUSANDS OF BACTERIAL SPECIES. WHILE SOME MICROBIAL INTERACTIONS ARE DETRIMENTAL TO PLANT HEALTH, SYMBIOTIC RELATIONSHIPS WITH BACTERIA OR FUNGI SUPPLY MINERAL ELEMENTS TO PLANTS AND CAN ALSO PROVIDE TOLERANCE TO VARIOUS ABIOTIC AND BIOTIC STRESSES. CAPITALIZING ON THE BENEFITS OF A HEALTHY MICROBIOME CAN BE TRACED BACK SEVERAL MILLENNIA AND CURRENTLY, HUNDREDS OF AGRICULTURAL PRODUCTS ARE BEING SOLD AS 'BENEFICIALS'. HOWEVER, THESE PRODUCTS SHOW INCONSISTENT PERFORMANCE IN THE FIELD. NONETHELESS, UNEXPLORED MICROBES REPRESENT ONE OF THE GREATEST UNTAPPED OPPORTUNITIES IN PLANT BIOLOGY. PLANT MICROBIOME RESEARCH HAS THE POTENTIAL TO POSITIVELY IMPACT AGRICULTURAL PRODUCTIVITY THAT WILL FEED FUTURE GENERATIONS WHILE MITIGATING GLOBAL CLIMATE CHANGE, RESTORING NATURAL ECOSYSTEMS, AND REDUCING ENERGY INTENSIVE FERTILIZER PRODUCTION. OUR ABILITY TO MANIPULATE THESE COMPLEX ECOSYSTEMS FOR THE BENEFIT OF THE PLANT AND PLANET IS IN ITS INFANCY.AGRICULTURAL PRODUCTIVITY DEPENDS ON INTENSIVE FARMING AND MANAGEMENT PRACTICES INCLUDING FERTILIZERS. U.S. FARMERS RELY ON THIS TECHNOLOGY TO MEET YIELD DEMANDS. THIS PROPOSAL WILL PARTIALLY OFFSET FERTILIZER DEMANDS THROUGH PLANT-MICROBE BASED NUTRIENT ACQUISITION. SPECIFICALLY, THIS RESEARCH WILL YIELD NEW STRATEGIES TO DEVELOP MICROBIAL PRODUCTS THAT SHOW ROBUST PERFORMANCE IN THE FIELD. THE KEY TO SUCCESS WILL BE DISCOVERING THE FUNDAMENTAL RULES THAT GOVERN COLONIZATION AND PERSISTENCE (C&P) OF BENEFICIAL MICROBES WITH THEIR PLANT HOSTS. IF WE ARE ABLE TO DEVELOP STRATEGIES TO INCREASE THE C&P OF MICROBIAL BASED PRODUCTS, THIS WILL HELP FARMERS ACHIEVE HIGH YIELDS WITH LESS EXTERNAL INPUTS WHILE ALSO PROTECTING THEIR SOIL HEALTH AND THE ENVIRONMENT. THE LONG-TERM OUTCOME OF THIS RESEARCH WILL BE TO OPTIMALLY REDESIGN PRODUCTION AGRICULTURE THROUGH THE LENS OF THE 'COMMUNITY OF PLAYERS' THAT CAN ENSURE A SUSTAINABLE PLANET.
$536,649Donald Danforth Plant Science Center · · FY2023 · National Institute of Food and Agriculture
Project 2 - Metabolic and controlled diet studies of obesity-discordant and conco
$536,545Andrew C. Heath · Washington University · P01 · FY2015 · DK
Project 2 - Metabolic and controlled diet studies of obesity-discordant and conco
$536,545Andrew C. Heath · Washington University · P01 · FY2014 · DK
Impact of the vaginal microbiome on topical HIV pre-exposure prophylaxis (PrEP)
$536,541Betsy C. Herold · Albert Einstein College Of Medicine · R01 · FY2023 · HD
Role of innate immunity and the microbiome in colitis associated dysplasia
$536,536Maria Teresa Abreu · Cedars-Sinai Medical Center · R01 · FY2025 · DK
Age-related Cognitive Changes: Effects of Combined Flavonoid Intake and Physical Exertion Mediated by the Gut Microbiome
$536,533Mary Ann Ann Lila · North Carolina State University Raleigh · R01 · FY2025 · AG
Mouse Metabolic Phenotyping Center (MMPC) at UC Davis
$536,440Kc Kent Lloyd · University Of California At Davis · U2C · FY2021 · DK
Neuroimaging and gut microbiome markers of development in HIV-exposed uninfected infants
$536,272Andre Jan Willem Van Der Kouwe · Massachusetts General Hospital · R01 · FY2018 · HD
Gut Microbial Enzymes and Human Disease
$536,223Matthew Redinbo · Univ Of North Carolina Chapel Hill · R35 · FY2025 · GM
RSV to Asthma Cooperative Clinical Ascertainment and Biospecimen Research Core
$536,192Tina V Hartert · Vanderbilt University Medical Center · U19 · FY2019 · AI
University of Miami IBD Genetic Research Center: Understanding the Genetic Architecture of IBD in the LatinX Community
$536,020Jacob L McCauley · University Of Miami School Of Medicine · U01 · FY2022 · DK
The Oral Microbiome in Type 1 Diabetes and Sub-Clinical Cardiovascular Disease
$535,972Amy Christine Alman · University Of South Florida · R01 · FY2021 · DE
Microbiome, metabolites, and alcohol in HIV to reduce CVD RCT (META HIV CVD RCT)
$535,916Matthew S Freiberg · Vanderbilt University Medical Center · P01 · FY2024 · AA
Reciprocal Modulation of the Microbiome and Cellular Senescence in Metabolic Dysfunction
$535,801Yanjiao Zhou · University Of Connecticut Sch Of Med/Dnt · R01 · FY2022 · AG
Defined microbial communities to prevent and eradicate infection by AMR pathogens
$535,780Robert A Britton · Baylor College Of Medicine · U19 · FY2024 · AI