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24,576 grants matching “microbiome”
CC*DNI Networking Infrastructure: Enabling Frictionless Scientific Data Transfers in the Texas Medical Center
$499,837Jeffrey Early · Baylor College Of Medicine · · FY2015 · CSE
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** WIDESPREAD DECLINES IN SOIL HEALTH ARE A PERSISTENT PROBLEM FOR AGRICULTURE. SOIL ORGANIC MATTER (SOM) IS THE FOUNDATION OF SOIL HEALTH, ITS EFFECTS ON SOIL MOISTURE, STRUCTURE, FERTILITY, AND SOIL BIOTIA ARE THE BASIS FOR SOIL SUSTAINABILITY. SOM RESTORATION AND MAINTENANCE IS ACHIEVED THROUGH JUDICIOUS USE OF COVER CROPS. HOWEVER, THEIR EFFECTS ON SOM DIFFER BETWEEN SPECIES, SOILS, AND SYSTEMS. THOUGH PLANT-MICROBE-SOIL INTERACTIONS GOVERN SOM DYNAMICS, WE LACK KNOWLEDGE OF THESE BELOWGROUND PROCESSES. CURRENT COVER CROP RECOMMENDATIONS FOR BUILDING SOIL HEALTH LACK A SOLID FOUNDATION OF FUNDAMENTAL KNOWLEDGE. OUR GOAL IS TO DEFINE THE BELOWGROUND MECHANISMS THROUGH WHICH PLANT-MICROBE-SOIL INTERACTIONS GOVERN SOM DYNAMICS. WE FOCUS ON FOUR OBJECTIVES: (I) QUANTIFY COVER CROP EFFECTS ON BELOWGROUND PROCESSES THAT REGULATE SOM POOLS, (II) DEFINE COVER CROP EFFECTS ON BELOWGROUND PROCESSES IN DIFFERENT SOIL HEALTH CONTEXTS (DEGRADED VERSUS HEALTHY SOILS), (III) QUANTIFY CONTRIBUTIONS OF COVER CROP ROOTS AND SHOOTS TO SOM POOLS, AND (IV) DESCRIBE THE MICROBIAL MECHANISMS THAT REGULATE SOM POOLS. THESE OBJECTIVES WILL BE ACHIEVED THROUGH GREENHOUSE EXPERIMENTS THAT MINIMIZE VARIATION AND ISOLATE CRITICAL VARIABLES THAT CONTROL COMPLEX PLANT-MICROBE-SOIL INTERACTIONS DIFFICULT TO DISENTANGLE IN THE FIELD. WE WILL MEASURE THE DYNAMICS OF DISCRETE SOM POOLS WITH RESPECT TO PLANT AND MICROBIAL INPUTS, SOIL PROCESSES, AND RHIZOSPHERE MICROBIOME COMPOSITION. THIS FUNDAMENTAL RESEARCH WILL DEFINE THE MECHANISMS WHEREBY PLANT-MICROBE-SOIL INTERACTIONS REGULATE SOM FORMATION. SUCH KNOWLEDGE IS ESSENTIAL FOR IMPROVING THE PRECISION OF COVER CROP RECOMMENDATIONS DESIGNED FOR ENHANCEMENT AND SUSTAINABILITY OF SOIL HEALTH.
$499,826Cornell University · · FY2021 · National Institute of Food and Agriculture
FET: Small: A Portable and Intelligent Testing System for Power-efficient and Accurate Foodborne Pathogen Detection
$499,808Lei Jiang · Indiana University · · FY2019 · CSE
Continuous glucose monitoring: determinants and prediction of diabetes mellitus development in the Framingham Heart Study
$499,802Nicole L Spartano · Boston University Medical Campus · R01 · FY2022 · DK
THE TRILLIONS OF MICROBES THAT RESIDE WITHIN THE HUMAN GUT ARE KNOWN AS THE MICROBIOME. THESE MICROBES BREAK DOWN NUTRIENTS IN FOODS THAT OUR OWN BODY CANNOT DIGEST. IN TURN, THE MICROBES PRODUCE BY-PRODUCTS THAT CAN IMPACT HEALTH AND WELL-BEING. THE PURPOSE OF THIS STUDY IS TO BETTER UNDERSTAND HOW WALNUT HALVES AND DIFFERENT FATS ARE BROKEN DOWN BY MICROBES AND HOW THIS HELPS REDUCE INFLAMMATION AND IMPROVE HEALTH. ADULTS WITH OBESITY WILL PARTICIPATE IN THIS STUDY. THEY WILL RECEIVE ALL THEIR MEALS FOR A TOTAL OF NINEWEEKS.THEY WILL ALSO BE ASKED TO PROVIDE STOOL, BLOOD, AND URINE SAMPLES DURING THIS STUDY. THE RESULTS WILL HELP US TO BETTER UNDERSTAND OUR FOODS CONTRIBUTE TO IMPROVED HEALTH AND WELL-BEING.
$499,782University Of Illinois · · FY2020 · National Institute of Food and Agriculture
PLANTS HAVE EVOLVED FOR HUNDREDS OF MILLIONS OF YEARS IN CLOSE ASSOCIATION WITH MICROBIAL PARTNERS. MICROBES COVER EVERY PLANT SURFACE AND IMPACT ALL ASPECTS OF PLANT PHYSIOLOGY AND HEALTH. YET, OUR CURRENT CROP PRODUCTION SYSTEMS TREAT THEM PRIMARILY AS A BLACK BOX. AS NEW TECHNOLOGIES HAVE ENABLED RAPID CHARACTERIZATION OF PLANT MICROBIOMES, WE ARE POISED FOR TRANSFORMATIVE ADVANCES IN AGRICULTURE THAT WILL USE MICROBIOME MANAGEMENT TO INCREASE THE SUSTAINABLE PRODUCTION OF HEALTHY FOOD. TO ACHIEVE THIS VISION, WE FIRST NEED DATA CHARACTERIZING MICROBIOMES ON A VARIETY OF PLANT SPECIES AND ON DIFFERENT PLANT PARTS. IN PARTICULAR, WE KNOW LITTLE ABOUT THE MICROBIOMES ASSOCIATED WITH EDIBLE PLANT PARTS, SUCH AS FRUITS. FRUIT MICROBIOMES ARE LIKELY QUITE DISTINCT FROM THOSE ON LEAVES, AND HAVE THE POTENTIAL TO IMPACT NOT ONLY YIELD, BUT THE QUALITY OF THE FOOD WE ACTUALLY CONSUME. OUR PROJECT WILL PROVIDE THE MOST EXTENSIVE CHARACTERIZATION TO DATE OF THE APPLE FRUIT MICROBIOME, WITH A LONG-TERM GOAL OF ESTABLISHING APPLES AS A MODEL SYSTEM IN CROP MICROBIOME RESEARCH. WE WILL WORK WITH COMMERCIAL GROWERS IN THE EASTERN US AND ESTABLISH AN EXPERIMENTAL ORCHARD IN VIRGINIA TO EXAMINE HOW: 1) ORGANIC AND CONVENTIONAL PEST MANAGEMENT PRACTICES SHAPE MICROBE COMMUNITIES SURROUNDING FRUITS, 2) MICROBE COMMUNITIES, IN TURN, AFFECT FRUIT QUALITY TRAITS THAT DETERMINE MARKET AND NUTRITIONAL VALUE AND, 3) MICROBIAL COMMUNITIES AND FRUIT QUALITY TRAITS AFFECT HARD CIDER PRODUCTION, CURRENTLY THE FASTEST GROWING SEGMENT OF THE AMERICAN BEVERAGE INDUSTRY. OUR MULTI-DISCIPLINARY TEAM WILL BRING TOGETHER EXPERTISE IN PLANT INTERACTIONS AND CHEMICAL ECOLOGY (PD WHITEHEAD), MICROBIAL ECOLOGY AND BIOINFORMATICS (CO-PD KNIGHT), AND FOOD SCIENCE AND CIDER PRODUCTION (CO-PD STEWART). CONSIDERING THE ECONOMIC VALUE OF APPLES AND THEIR ICONIC IMAGE AS BOTH HEALTH-PROMOTING FRUITS AND SYMBOLS OF AMERICAN CULTURE, OUR RESEARCH PROGRAM CAN SIMULTANEOUSLY IMPROVE OUR FUNDAMENTAL UNDERSTANDING OF AGRICULTURAL PRODUCTION SYSTEMS, PROVIDE NEW DIRECTION FOR APPLIED TECHNOLOGY IN MICROBIOME MANAGEMENT, AND ENGAGE STUDENTS AND THE GENERAL PUBLIC IN THE IMPORTANCE OF ECOLOGICAL INTERACTIONS IN SHAPING OUR FOOD SYSTEMS.
$499,758Virginia Polytechnic Institute & State University · · FY2019 · National Institute of Food and Agriculture
Microbiome, Environment, and Parkinsons disease (MEP) PESTICIDE EXPOSURES AND THE GUT MICROBIOME IN PARKINSONS DISEASE
$499,701Beate R Ritz · University Of California Los Angeles · R01 · FY2024 · ES
Collaborative Research: A multidimensional approach to understanding microbial carbon cycling beneath the seafloor during cool hydrothermal circulation
$499,679Julie A Huber · Marine Biological Laboratory · · FY2016 · GEO
UNRAVELING THE SOIL MICROBIOME: INTEGRATING CROP PRODUCTION, SOIL MANAGEMENT, AND METAGENOMICS TO BRING SCIENCE TO PRACTICE
$499,671University Of Wisconsin System · · FY2017 · National Institute of Food and Agriculture
A Multi-'omic Analysis of the Vaginal Microbiome during Pregnancy
$499,636Gregory A Buck · Virginia Commonwealth University · U54 · FY2014 · DE
The NICU Antibiotics and Outcomes (NANO) Trial
$499,628Michael Morowitz · University Of Pittsburgh At Pittsburgh · R01 · FY2021 · HD
Define conserved and variable elements of the pan-genomes of members of the adult
$499,611Claire M Fraser-Liggett · Washington University · P01 · FY2007 · DK
Identify and Evaluate Potential Risk Factors for Amyotrophic Lateral Sclerosis - A Unique Contribution from Sweden
$499,560Fang Fang · Karolinska Institute · R01 · FY2021 · TS
Microbial Dysbiosis and TLR2 Activation Contribute to Immune Activation, Inflammation and HIV Persistence in the Context of Opioid Abuse Despite ART Therapy
$499,558Sabita Roy · University Of Miami School Of Medicine · R01 · FY2021 · DA
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE ROOT NODULE MICROBIOME REPRESENTS AN UNTAPPED RESOURCE TO MAXIMIZE SYMBIOTIC NITROGEN FIXATION AND PLANT HEALTH IN SUSTAINABLE AGRICULTURE. WHILE NITROGEN-FIXING RHIZOBIA (THE PRIMARY INHABITANTS OF NODULES) HAVE BEEN STUDIED FOR DECADES, THE REST OF THE ROOT NODULE MICROBIOME REMAINS UNDERSTUDIED. THE PLANT MICROBIOME IS NOW WIDELY RECOGNIZED FOR ITS ROLE IN NUTRIENT ACQUISITION AND RESILIENCE TO BIOTIC AND ABIOTIC STRESSORS.MANIPULATING MICROBIOTA FROM THE ROOT NODULE COULD MAXIMIZE SYMBIOTIC NITROGEN FIXATION IN LEGUME CROPS THROUGH DIRECT INTERACTIONS WITH RHIZOBIA, OR THROUGH INDIRECT INTERACTIONS SUCH AS ENHANCING THE RESILIENCE OF THE NODULE TO STRESS. OUR OVERALL GOAL IS TO UNLOCK THE ROOT NODULE MICROBIOME AS A TOOL FOR SUSTAINABLE AGRICULTURE AND CONTRIBUTE TO THE BROADER UNDERSTANDING OF HOW PLANTS ASSEMBLE THEIR MICROBIAL COMMUNITIES. WE WILL TAKE THE FIRST STEPS TOWARD ACCOMPLISHING THIS BY ELUCIDATING RULES THAT GOVERN THE ASSEMBLY AND COLONIZATION OF THE NODULE MICROBIOME. THIS WILL INVOLVE 1) INVESTIGATING THE RELATIVE STRENGTHS OF HOST, RHIZOBIA, SOIL AND DROUGHT STRESS AS DRIVERS OF NODULE MICROBIOME COMPOSITION, 2) ESTABLISHING A CULTURE COLLECTION OF NODULE MICROBIOTA TO HELP DEVELOP IT AS A SIMPLIFIED MODEL FOR PLANT MICROBIOME ASSEMBLY, AND 3) USING SYNTHETIC COMMUNITIES TO DIRECTLY TEST SEVERAL HYPOTHESES RELATED TO HOW THE NODULE MICROBIAL COMMUNITY IS ESTABLISHED IN THE CONTEXT OF HOST-MICROBIOME INTERACTIONS, MICROBE-MICROBE INTERACTIONS WITH RHIZOBIA, AND DROUGHT STRESS. THIS PROJECT CONTRIBUTES TO UNDERSTANDING MULTIPARTITE PLANT-MICROBE INTERACTIONS, FILLS A KNOWLEDGE GAP REGARDING HOW PLANT MICROBIOMES ARE ASSEMBLED, AND IN THE LONG RUN LEADS TO REDUCED RELIANCE ON CHEMICALS IN AGRICULTURE. ?
$499,541North Dakota State University · · FY2023 · National Institute of Food and Agriculture
THE DIETARY INTERVENTION OF XANTHOPHYLL-ENRICHED FOODS COULD POTENTIALLY CONTRIBUTE TO MAINTAINING GUT MICROBIOME HOMEOSTASIS AND REDUCTION AND PREVENTION OF CHRONIC INFLAMMATION IN HUMANS, THROUGH UNCLEAR MECHANISMS. SALMON IS A COMMONLY CONSUMED SEAFOOD CONTAINING HIGH XANTHOPHYLLS, PREDOMINANTLY ASTAXANTHIN, A FAT-SOLUBLE CAROTENOID, METABOLIZED BY Β-CAROTENE OXYGENASE 2 (BCO2). THERE REMAINS A SUBSTANTIAL KNOWLEDGE GAP REGARDING THE ROLE OF THE GUT MICROBIOME IN MEDIATING THE PURPORTED HEALTH BENEFITS OF DIETARY XANTHOPHYLLS. THUS, WE PROPOSE AN INTEGRATED, TRANSLATIONAL, AND MECHANISTIC BENCH TO CLINIC RESEARCH APPROACH USING OBESE PREDIABETIC HUMAN SUBJECTS AND MICE AS MODELS TO PURSUE THE FOLLOWING TWO SPECIFIC OBJECTIVES. THE RESULTS FROM THISRESEARCH ARE EXPECTED TO HAVE A SIGNIFICANT IMPACT ON PUBLIC HEALTH BY PROVIDING NEW INSIGHTS IN ASTAXANTHIN-ENRICHED SALMON AS A HEALTHY DIETARY OPTION THAT COULD REDUCE LOCAL AND SYSTEMATIC INFLAMMATION, THROUGH GUT MICROBIOME HOMEOSTASIS. OUR PROPOSAL IS HIGHLY RESPONSIVE TO THEFOOD AND HUMAN HEALTHPRIORITY AREAS, WHICH HAS PLACED A HIGH PRIORITY ON THE PROJECTS THAT USE A WHOLE-FOOD APPROACH TO PROTECT INFLAMMATION, PROMOTE GASTROINTESTINAL HEALTH AND HUMAN MICROBIOME, COVERING PRIORITY AREAS OF THE USDA-NIFA A1343 PROGRAM.
$499,526Oklahoma State University · · FY2020 · National Institute of Food and Agriculture
Molecular Characterization of Breast Duct Epithelium at Risk for Breast Cancer
$499,518David Danforth · Division Of Clinical Sciences - Nci · ZIA · FY2021 · CA
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THIS PROJECT BUILDS ON OUR SUCCESSFUL 8-WEEK SUMMER RESEARCH PROGRAM BUGS IN MY FOOD FUNDED THROUGH THE USDA-REEU SINCE 2017. THE OBJECTIVE OF THE CURRENT REEU IS TO ENGAGE UNDERGRADUATE STUDENTS THROUGH RESEARCH, INFORMATICS, AND EXPERIENTIAL LEARNING IN FOOD MICROBIOLOGY. OUR PREMISE IS THAT STUDENTS FROM UNDERGRADUATE-CENTRIC INSTITUTIONS HAVE FEW CHANCES TO ENGAGE IN HANDS-ON RESEARCH AND ARE OFTEN UNAWARE OF RESEARCH CAREER OPPORTUNITIES IN THE AGRICULTURAL SCIENCES. TO ADDRESS THIS, WE BUILT STRONG RELATIONSHIPS WITH FACULTY AT UNDERGRADUATE-CENTRIC INSTITUTIONS ACROSS PENNSYLVANIA, AND THE UPRAG. THE SUMMER BEGINS WITH A 5-DAY MICROBIOLOGY BOOT CAMP WITH AN OFF-SITE KICK-OFF RETREAT ON DAY 6. DURING THE SUMMER, STUDENTS ARE GUIDED THROUGH INDEPENDENT FOOD MICROBIOLOGY RESEARCH PROJECTS WITH A UNIQUE BIOINFORMATICS COMPONENT IN COLLABORATION WITH ONE OR MORE PDS. WEEKLY SEMINARS RUN BY THE PDS TRAIN STUDENTS IN EXPERIMENTAL DESIGN, CRITICAL READING OF LITERATURE, COMMUNICATION, GRADUATE SCHOOL, AND OTHER CAREER OPPORTUNITIES IN THE AGRICULTURAL SCIENCES. STUDENTS DEVELOP COMPUTATIONAL SKILLS THROUGH WORKING WITH GENOMICS AND MICROBIOME DATA, LEARNING HOW TO DRAW CONCLUSIONS FROM LARGE-SCALE SEQUENCE DATA. VISITS TO GOVERNMENT AGENCIES INCLUDING FDA LABORATORIES INFORM STUDENTS ABOUT SUCH CAREER OPPORTUNITIES. THE SUMMER CULMINATES WITH AN AFTERNOON SYMPOSIUM, PROVIDING STUDENTS THE OPPORTUNITY TO PRESENT THEIR FINDINGS, WHICH THEY ALSO DO AT THE ABASM MEETING HELD EACH FALL. PRE- AND POST-PROGRAM SURVEYS, AND FORMATIVE AND SUMMATIVE ASSESSMENTS MEASURE GAINS IN KNOWLEDGE ABOUT SCIENTIFIC METHOD, AWARENESS OF OPPORTUNITIES IN GRADUATE SCHOOL AND PROFESSIONAL CAREERS, AND PERSONAL GROWTH.
$499,499The Pennsylvania State University · · FY2021 · National Institute of Food and Agriculture
The Surface of Hospitals Intensive Environmental Load Disinfection (SHIELD) Study
$499,472Brad J Spellberg · University Of Southern California · R01 · FY2019 · HS
Mechanisms underlying the variation in rate and levels of gingival inflammatory responses among the human population
$499,446Jeffrey Scott McLean · University Of Washington · R01 · FY2025 · DE
CONSUMPTION OF PLANT FOODS THAT CONTAIN FLAVONOIDS REDUCES THE RISK OF IBD. GUT BACTERIA CONTRIBUTE TO THE ANTI-INFLAMMATORY PROPERTIES OF FLAVONOIDS BY CONVERTING THEM INTO ACTIVE METABOLITES, AND FLAVONOID GUT BACTERIAL-METABOLISM DEPENDS ON THE GUT BACTERIAL COMPOSITION, FLAVONOID TYPE, AND ASSOCIATED FOOD MATRIX. HOWEVER, FOOD MATRIX/DIET CONSISTS OF A WIDE VARIETY OF FLAVONOIDS, AND THERE IS CONSIDERABLE VARIATION IN THE GUT BACTERIAL PROFILES BETWEEN IBD PATIENTS AND HEALTHY SUBJECTS. THUS, IT IS DIFFICULT TO IDENTIFY WITH CERTAINTY THE SPECIFIC CLASS OF COMPOUNDS IN THE FOOD MATRIX THAT IS ANTI-INFLAMMATORY AND THE EXTENT TO WHICH INFLAMMATION-INDUCED CHANGES IN MICROBIOME ALTER THEIR HEALTH BENEFITS. WE PROPOSE TO DETERMINE THE ANTI-COLITIS ACTIVITY OF 3-DEOXYFLAVONOIDS (3-DF - PHLOBAPHENES) AND/OR 3-HYDROXYFLAVONOIDS (3-HF - ANTHOCYANINS) USING MAIZE, A STAPLE CROP, NEAR ISOGENIC LINES (NILS) THAT DIFFER IN A SINGLE CLASS OF FLAVONOIDS AS WELL AS GERM-FREE MICE COLONIZED WITH HEALTHY VS. COLITIS-ASSOCIATED MICROBIOTA.THE PROPOSED PROJECT WILL DOCUMENT THE BENEFICIAL EFFECTS OF 3-DF AND/OR 3-HF IN MAIZE ON THE GUT INFLAMMATION AND WILL POTENTIALLY PROVIDE INFORMATION THAT WILL IMPROVE THE CONSUMERS' HEALTH THROUGH FLAVONOID RICH CROPS.
$499,423Purdue University · · FY2019 · National Institute of Food and Agriculture
Center for Cancer Immunology and Immunotherapy (CCII) - Functional Immunomics Core (FIC)
$499,422Haribabu Bodduluri · University Of Louisville · P20 · FY2025 · GM
Pathogenesis of Early Onset Colorectal Cancer: Microbiome Contributions and Mechanisms
$499,385Cynthia L Sears · Johns Hopkins University · R01 · FY2022 · CA
Dysbiosis Impact on Lung Disease in HIV (DImpL) Study
$499,382Alison Morris · University Of Pittsburgh At Pittsburgh · R01 · FY2017 · HL
Microbiome in TB treatment response and disease resolution
$499,379Sabine Ehrt · Weill Medical Coll Of Cornell Univ · U19 · FY2022 · AI