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24,576 grants matching “microbiome”
Topical Vancomycin for Craniotomy Wound Prophylaxis
$498,820Edward Sander Connolly · Columbia University Health Sciences · R01 · FY2016 · HS
Topical Vancomycin for Craniotomy Wound Prophylaxis
$498,820Edward Sander Connolly · Columbia University Health Sciences · R01 · FY2015 · HS
The lung microbiota in cystic fibrosis
$498,814John J Lipuma · University Of Michigan At Ann Arbor · RC1 · FY2010 · HL
EXPLORE THE IMPACT OF MICROBIOME IN THE RESPONSE OF THE COMBINATION OF RADIATION WITH IMMUNE CHECKPOINT BLOCKADE IN MUSCLE-INVASIVE BLADDER CANCER
$498,789The Research Institute Of The Mcgill University Health Centre · · FY2020 · Department of the Army
Chicago Prevention and Intervention Epicenter II (CPIE-II)
$498,788Mary Katherine Hayden · Rush University Medical Center · U54 · FY2017 · CK
W-Health: Tungsten is an Essential Metal for a Healthy Gut Microbiome
$498,770Michael W. Adams · University Of Georgia · R01 · FY2020 · GM
Pyruvate oxidase: a molecular determinant of commensalism among the oral microbiome
$498,743Jens Kreth · Oregon Health & Science University · R01 · FY2024 · DE
THE IMPACT OF FESCUE TOXICOSIS (FT), CAUSED BY TOXIC ENDOPHYTE-INFECTED FESCUE GRAZING, ON THE US BEEF INDUSTRY IS ENORMOUS. THE PATHOPHYSIOLOGY OF FT MANIFESTS WITH PHYSIOLOGICAL, ENDOCRINE AND METABOLIC PERTURBATIONS. WE RECENTLY SHOWED THAT THESE PERTURBATIONS ARE ASSOCIATED WITH CHANGES IN THE ANIMAL'S PLASMA AND URINE METABOLOMES, WHICH MIGHT BE REFLECTIVE OF FT-ASSOCIATED ABERRATIONS OF THE ANIMAL'S MICROBIOME AND/OR CHANGES IN THE FESCUE PLANT METABOLOME/MICROBIOME DUE TO THE TOXIC ENDOPHYTE'S PRESENCE. IN THIS PROJECT, WE FOCUS ON THE FESCUE PLANT-GRAZING BEEF MICROBIOME-METABOLOME AXIS WITHIN THE CONTEXT OF FT. OUR OVERALL GOAL IS TO USE THE UNIQUE EXPERTISE OF OUR INTERDISCIPLINARY TEAM TO OBTAIN FUNDAMENTALLY IMPORTANT, TRANSFORMATIVE NEW DATA ON THE EFFECTS OF TOXIC FESCUE GRAZING ON THE MICROBIOMES AND METABOLOMES OF BEEF CATTLE AND CORRELATE THEM WITH KEY SIGNS OF THE DISEASE. SPECIFICALLY, WE WILL FIRST) CHARACTERIZE THE RUMINAL AND FECAL MICROBIOMES (BACTERIAL AND FUNGAL) OF TOXIC AND NON-TOXIC FESCUE-GRAZING BEEF STEERS. THEN, WE WILL CHARACTERIZE THE FESCUE PLANT'S (TOXIC AND NON-TOXIC) MICROBIOMES (BACTERIAL AND FUNGAL) AND METABOLOMES TO DETERMINE THEIR CONTRIBUTION TO THOSE OF THE GRAZING ANIMAL. FINALLY, WE WILL IDENTIFY CRITICAL MICROBIAL ORGANISMS AND/OR MICROBIAL METABOLITES, EITHER ON THE PLANT OR THE ANIMAL SIDE, THAT ARE AFFECTED IN FT OR BY TOXIC ENDOPHYTE'S PRESENCE IN THE PLANT AND ARE AMENABLE TO THERAPEUTIC MANIPULATIONS SO THAT THEY CAN BE EXPLORED IN THE FUTURE. ULTIMATELY, THE DATA WE GENERATE WILL GUIDE THE IMPLEMENTATION OF MICROBIOME/METABOLOME-BASED MANAGEMENT OF FT FROM BOTH ANIMAL AND PLANT PERSPECTIVES.
$498,708University Of Georgia Research Foundation, Inc. · · FY2020 · National Institute of Food and Agriculture
LONG-TERM VIABILITY OF FRUIT CROP PRODUCTION RELIES ON AVOIDING EARLY CROP DECLINE. IDENTIFYING HOW INCREASED PLANT BIODIVERSITY MAY LEAD TO RESILIENCE OF YOUNG CROPS TO STRESS BY SHIFTING MICROBIAL INTERACTIONS IS OF GROWING INTEREST. HOWEVER, CURRENT EXAMINATIONS OF THE RHIZOSPHERE MICROBIOME NEGLECT THE IMPORTANCE OF KEY ROOT TRAITS IN STRUCTURING MICROBIAL COMMUNITIES. OUR ABILITY TO SHAPE MANAGEMENT PRACTICES THAT HARNESS THE MICROBIOME FOR IMPROVEMENTS IN LONG-TERM PRODUCTIVITY AND SOIL HEALTH IS LIMITED UNTIL WE ADOPT A MORE ROOT-CENTRIC APPROACH.WE WILL INVESTIGATE HOW ROOT TRAITS STRUCTURE THE MICROBIOME IN RESPONSE TO MULTIPLE MANAGEMENT PRACTICES (COVER CROPS, ROOTSTOCK SELECTION) IN GRAPEVINES. THIS WILL PROVIDE NEW INSIGHTS INTO SPECIFIC FACTORS DRIVING ROOT-MICROBE INTERACTIONS, MOVING BEYOND CENSUS-BASED DESCRIPTIVE APPROACHES.OVER MULTIPLE YEARS, WE WILL USE 1-M DEEP ROOT-OBSERVATION BOXES TO MONITOR ROOT TRAITS OF DIFFERENT BRANCHING ORDER, TYPE AND AGE AND COLLECT ROOTS WITH SPECIFIC TRAITS AND ASSOCIATED RHIZOSPHERIC SOIL FOR MICROBIAL COMMUNITY ANALYSIS. THIS WILL ADDRESS OUR OBJECTIVES: 1) DEFINE THE MAJOR ROOT TRAITS (E.G., AGE, BRANCHING ORDER, TYPE) STRUCTURING ROOT AND RHIZOSPHERE MICROBIAL COMPOSITION, 2) EXAMINE HOW PROXIMITY TO GRASS COVER CROP ROOTS SHIFT THE ROOT-ASSOCIATED MICROBIOME OF A WOODY FRUIT CROP SPECIES, AND 3) CHARACTERIZE ROOT DYNAMICS AND RHIZOSPHERIC MICROBIAL COMMUNITY ABUNDANCE AND DIVERSITY BY DEPTH IN A WOODY PERENNIAL SYSTEM IN RESPONSE TO MANAGEMENT PRACTICES. TRAINING OF 2 UNDERGRADUATES PER YEAR AND 1 GRADUATE STUDENT WILL BE SUPPORTED.
$498,572The Pennsylvania State University · · FY2018 · National Institute of Food and Agriculture
Washington National Primate Research Center
$498,548David M Anderson · University Of Washington · P51 · FY2017 · OD
PULSE CONSUMPTION, THE GUT MICROBIOME, AND HUMAN HEALTH: USING PRECLINICAL MODELS TO CONDUCT A PROOF-IN-CONCEPT INVESTIGATIONTHIS PROJECT WILL INVESTIGATE WHETHER PULSE CONSUMPTION INDUCES FUNCTIONAL DIFFERENCES IN GUT MORPHOLOGY, GUT BARRIER INTEGRITY, AND/OR METABOLIC PROCESSES (ENDOTOXEMIA AND INFLAMMATION) THAT IMPACT HEALTH RELATED OUTCOMES, SUCH AS FATTY LIVER DISEASES, OBESITY. TYPE-2 DIABETES, AND CARDIOVASCULAR DISEASE IS THE FOCUS OF THE WORK PROPOSED IN THIS APPLICATION. AIM 1. DETERMINE THE EFFECT OF PULSE CONSUMPTION ON THE DISTRIBUTION OF MICROORGANISMS WITHIN MULTIPLE INTESTINAL COMPARTMENTS, I.E., IN THE LUMEN, BIOFILM ADHERING MUCOUS LAYER, AND ENTEROCYTES, IN ILEUM COLON AND IN STOOL. THERE IS LIMITED UNDERSTANDING OF THE IMPACT OF A SPECIFIC TYPE OF FOOD ON INTERRELATIONSHIPS WITHIN THESE COMPARTMENTS ACROSS INTESTINAL SEGMENTS. AIM 2. EVALUATE THE IMPACT OF PULSE CONSUMPTION ON THE META-METABOLOME (I.E., THE METABOLITES PRODUCED BY THE MICROBIOME) AND THE HOST'S METABOLOME. EMERGING EVIDENCE SHOWS A LARGE LIBRARY OF COMPOUNDS IS PRODUCED BY THE GUT MICROBIOME. IDENTIFICATION OF THE COMPOUNDS PRODUCED BY THE PULSE-ASSOCIATED MICROBIOME AND HOW THAT CORRESPONDS WITH CHANGES IN THE HOST METABOLOME WILL BE UNDERTAKEN. AIM 3. INVESTIGATE WHETHER PULSES ALTER GUT FUNCTIONALITY: BARRIER INTEGRITY AND ENDOTOXEMIA / INFLAMMATION. A THIRD AREA OF THE FOOD-FIBER-GUT HEALTH FIELD THAT HAS RECEIVED LIMITED ATTENTION IS THE IDENTIFICATION OF HOST FUNCTIONS THAT ARE AFFECTED BY THE INTERACTION OF THE HOST WITH THE MICROBIOME AND THE PRODUCTS OF ITS METABOLISM. BARRIER INTEGRITY (TIGHT JUNCTIONS AND FITC-DEXTRAN UPTAKE) AND LOCAL AND SYSTEMIC EVIDENCE OF EFFECTS OF PULSE CONSUMPTION ON ENDOTOXEMIA AND INFLAMMATION WILL BE ASSESSED.
$498,500Colorado State University · · FY2020 · National Institute of Food and Agriculture
Mechanisms of anti-phage defenses and their mobilization in staphylococci
$498,496Asma Hatoum · University Of Illinois At Urbana-Champaign · R01 · FY2023 · AI
Mechanisms of anti-phage defenses and their mobilization in staphylococci
$498,496Asma Hatoum · University Of Illinois At Urbana-Champaign · R01 · FY2024 · AI
Mechanisms of anti-phage defenses and their mobilization in staphylococci
$498,496Asma Hatoum · University Of Illinois At Urbana-Champaign · R01 · FY2025 · AI
Fecal Microbiota Transplant and PD-1 blockade in Melanoma
$498,492Hassane M Zarour · University Of Pittsburgh At Pittsburgh · R01 · FY2020 · CA
Identify and Evaluate Potential Risk Factors for Amyotrophic Lateral Sclerosis - A Unique Contribution from Sweden
$498,395Fang Fang · Karolinska Institute · R01 · FY2022 · TS
A Prospective Investigation of the Oral Microbiome and Pancreatic Cancer
$498,385Julie R Palmer · Boston University Medical Campus · U01 · FY2015 · CA
Prebiotics and Metformin Influences Gut and Hormones in Type 2 Diabetes Youth (MIGHTY-Fiber)
$498,356Stephanie Therese Chung · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2022 · DK
Modulation of Lung Immune Responses to Viral Infection
$498,316Anna Karolina Palucka · Jackson Laboratory · U19 · FY2021 · AI
Modulation of Viral Antigen Presentation in the Lung
$498,316Anna Karolina Palucka · Jackson Laboratory · U19 · FY2021 · AI
Understanding the Host-Microbiome-Therapeutic Triad: Implications for Designing Alternative Intravaginal Delivery Platforms to Treat Bacterial Vaginosis
$498,301Jill Steinbach-Rankins · University Of Louisville · R01 · FY2019 · AI
THE ASSOCIATION BETWEEN GUT MICROBIAL PROGRAMMING AND COGNITIVE DEVELOPMENT DURING THE EARLY STAGE OF LIFE HAS BEEN SUGGESTED AND THE GUT MICROBIOME HAS BECOME A FOCUS OF UNDERSTANDING NEUROCOGNITIVE DEVELOPMENT DURING THE PERINATAL PERIOD. EARLY IN LIFE, THE DEVELOPMENT OF THE GUT MICROBIOME IS MAINLY INFLUENCED BY MATERNAL DIETS. EGGS AND DOCOSAHEXAENOIC ACIDS (DHA) ARE KNOWN TO BENEFIT COGNITIVE DEVELOPMENT IN FETUSES AND INFANTS. THE POTENTIAL SYNERGISM OF EGGS AND DHA ON NEUROFUNCTION HAS BEEN SUGGESTED BY CONTROLLING OXIDATIVE STRESS IN BRAIN. OUR PRELIMINARY STUDY DEMONSTRATED THAT MATERNAL SUPPLEMENTATION OF DHA OF SOWS DURING GESTATION AND LACTATION ENHANCES LEARNING, MEMORY AND EXPLORATORY BEHAVIOR AND INCREASES BRAIN WHITE MATTER MATURATION OF THE OFFSPRING. THESE BENEFICAL EFFECTS OCCUR CONCURRENTLY WITH CHANGES IN GUT MICROBIOTA. IN THIS PROPOSED STUDY, WE WILL INVESTIGATE THE BENEFICIAL EFFECTS OF MATERNAL SUPPLEMENTATION OF EGGS PLUS DHA ON FETAL AND NEONATAL NEUROCOGNITIVE DEVELOPMENT, AND WE WILL FURTHER ELUCIDATE THEIR CONTRIBUTION TO THE EARLY PROGRAMMING OF THE GUT-BRAIN AXIS. WE WILL UTILIZE A PIG MODEL THAT HAS COMPARABLE BRAIN AND GUT ANATOMY AND PHYSIOLOGY TO HUMANS, WHICH WILL LEAD TO RESULTS THAT ARE MORE PREDICTIVE OF HUMAN OUTCOMES.
$498,282University Of Georgia Research Foundation, Inc. · · FY2020 · National Institute of Food and Agriculture
Pyruvate oxidase: a molecular determinant of commensalism among the oral microbiome
$498,250Jens Kreth · Oregon Health & Science University · R01 · FY2022 · DE
Pathogen and Microbiome Temporal Changes During Resolution of HAP
$498,240Alan R Hauser · Northwestern University At Chicago · U19 · FY2021 · AI
RNA INTERFERENCE (RNAI) DIRECTED AGAINST PESTS AND PATHOGENS, OFTEN CALLED HOST INDUCED GENE SILENCING (HIGS), IS A NEW APPROACH FOR ENGINEERING RESISTANT PLANT VARIETIES. HIGS IS EXPECTED TO PRODUCE HIGHLY SPECIFIC FORMS OF RESISTANCE COMPARED TO PESTICIDES AND MOST OTHER RESISTANT VARIETIES; HOWEVER, THIS PREDICTION HAS NOT BEEN RIGOROUSLY TESTED. A BETTER UNDERSTANDING OF THE SPECIFICITY OF HIGS WILL INFORM THE DEVELOPMENT OF REGULATORY STANDARDS FOR NON-TARGET ORGANISM STUDIES. WE PROPOSE TO USE THE POPULUS TRICHOCARPA MODEL SYSTEM TO STUDY HIGS. POPULUS IS GENETICALLY TRANSFORMABLE, HAS A WELL CHARACTERIZED MICROBIOME, AND HAS EXCELLENT GENOMIC RESOURCES. WE WILL FOCUS ON THE SPHAERULINA CANKER AND LEAF SPOT, THE MOST ECONOMICALLY IMPORTANT DISEASE OF POPLAR TREES. OUR PROPOSED STUDY WILL USE A COMBINATION OF FIELD AND GREENHOUSE EXPERIMENTS TO EVALUATE THE ECOLOGICAL IMPACT OF HIGS BASED DISEASE RESISTANCE ON THE POPULUS MICROBIOME. WE HAVE ALREADY CREATED HIGS CONSTRUCTS THAT ARE EFFECTIVE AGAINST THE SPHAERULINA PATHOGENS. THESE CONSTRUCTS ARE CURRENTLY BEINGTRANSFORMED INTO POPULUS. WE WILL TEST THESE TRANSGENIC LINES IN RANDOMIZED GREENHOUSE AND FIELD TRIALS TO ASSESS DISEASE RESISTANCE AND NON-TARGET EFFECTS OF HIGS ON THE POPULUS MICROBIOME.THIS PROJECT WILL PROVIDE GUIDANCE TO REGULATORY AGENCIES, INFORM THE DESIGN OF HIGS APPROACHES, AND ESTABLISH WHETHER HIGS IS EFFECTIVE FOR PRODUCING RESISTANCE AGAINST A MAJOR PATHOGEN OF POPLARS. OUR OVERARCHING OBJECTIVE WAS TO EVALUATE THE EFFECTIVENESS OF HIGS FOR DISEASE CONTROL WHILE CONFIRMING WITH SMALL TO NEGLIGIBLE IMPACTS TO THE HEALTH OF THE GE ORGANISM(OFF-TARGET) AND ITS ASSOCIATED MICROBIOME (NON-TAGET). SPECIFICALLY WE WILL: 1) SCREEN TRANSGENIC LINES FOR RESISTANCE TO SPHAERULINA IN VITRO AND BY ANALYSIS OF SIRNA PRODUCTION; 2) EVALUATE SPHAERULINA CANKER AND LEAF SPOT RESISTANCE OF TRANSGENIC LINES AND CONTROLS IN THE GREENHOUSE; 3) TEST THE IMPACT OF RNAI TRANSGENIC LINES ON: A) THE COMPOSITION OF A SYNTHETIC, INOCULATED FUNGAL LEAF ENDOPHYTE COMMUNITY; AND B) THE ABUNDANCE OF PATHOGEN ANTAGONISTS WITHIN THE COMMUNITY; AND 4) EVALUATE MICROBIOME DEVELOPMENT AND DISEASE RESISTANCE OF RNAI TRANSGENIC LINES AT FIELD SITES NEAR CORVALLIS, OR AND IN AN AREA OF HIGH NATURAL INOCULUM LOAD IN MORGANTOWN, WV.
$498,211Oregon State University · · FY2019 · National Institute of Food and Agriculture