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24,576 grants matching “microbiome”
Genomics Core
$498,186Bony De Kumar · University Of North Dakota · P20 · FY2021 · GM
Prebiotic GOS and lactoferrin for beneficial gut microbiota with iron supplements
$498,164Gary M Brittenham · Columbia University Health Sciences · R01 · FY2022 · DK
Collaborative Research: MIM: The impact of the fungal microbiome in metal tolerance and soil biogeochemical transformations
$497,969Jose M Cerrato · University Of New Mexico · · FY2021 · BIO
BRC-BIO: Establishing a new model system to study the relationship between gut microbiome and host niche specialization
$497,916Lily Khadempour · Rutgers University Newark · · FY2023 · BIO
Molecular Profiling and Computational Biology (MPCB)
$497,849King Kennard Holmes · University Of Washington · P30 · FY2015 · AI
Uncovering Microbial Modifiers of Antidepressant Responses during Pregnancy
$497,845Elaine Hsiao · University Of California Los Angeles · R01 · FY2024 · HD
TREAT-VCU
$497,828Arun J Sanyal · Virginia Commonwealth University · U01 · FY2015 · AA
Genetic control over the gut microbiome composition
$497,748Andrew K Benson · University Of Nebraska Lincoln · RC1 · FY2009 · DK
Modification of Gut Microbial Profile in Children with Ulcerative Colitis
$497,721Sonia Michail · Children'S Hospital Of Los Angeles · R01 · FY2019 · HD
Mitigation of GI-ARS by Lactobacillus species
$497,663Radhakrishna Rao · University Of Tennessee Health Sci Ctr · U01 · FY2024 · AI
Role of innate immunity and the microbiome in colitis-associated dysplasia
$497,636Maria Teresa Abreu · University Of Miami School Of Medicine · R01 · FY2024 · DK
Collaborative Research: Prophages and how they manipulate model microbiomes
$497,509Jeffrey A Gralnick · University Of Minnesota-Twin Cities · · FY2023 · BIO
Understanding the Host-Microbiome-Therapeutic Triad: Implications for Designing Alternative Intravaginal Delivery Platforms to Treat Bacterial Vaginosis
$497,404Hermann Frieboes · University Of Louisville · R01 · FY2023 · AI
Antibiotics from nose and throat commensals that impact pathogen colonization
$497,393Katherine Paige Lemon · Baylor College Of Medicine · R01 · FY2020 · AI
Hominid Dental Metagenomes for Pathogen Evolution Research
$497,304Cecil M Lewis · University Of Oklahoma Norman Campus · · FY2021 · SBE
Vibrio Virulence Determinants in a Benign Colonization
$497,118Edward G Ruby · University Of Wisconsin-Madison · R01 · FY2014 · OD
Expanding the utility of transcriptional bacterial computing
$497,049Matthew R. Bennett · Rice University · R01 · FY2016 · GM
Gut Microbiome, Antibiotic Use & Colon Cancer Recurrence
$497,046Veronika Fedirko · Emory University · R01 · FY2019 · CA
Role of type III interferons in Staphylococcus aureus respiratory tract infection
$496,961Dane Parker · Rbhs-New Jersey Medical School · R01 · FY2020 · HL
Role of type III interferons in Staphylococcus aureus respiratory tract infection
$496,961Dane Parker · Rbhs-New Jersey Medical School · R01 · FY2019 · HL
Comprehensive Training Program in Oral Biology
$496,902Jose A Lemos · University Of Florida · T90 · FY2023 · DE
THIS STUDY WILL QUANTIFY DIETARY EXPOSURE OF A NANO- FOOD ADDITIVE IN THE U.S. FOOD SUPPLY, AND DETERMINE ITS IMPACT ON THE HUMAN GUT MICROBIOME (BACTERIAL COMMUNITIES IN THE INTESTINES), GUT INFLAMMATION, AND OTHER MARKERS OF GUT STRESS. TITANIUM DIOXIDE (TIO2, OR E171 FOOD GRADE ADDITIVE) IS USED IN PROCESSED FOODS, WITH THOUSANDS OF TONS PRODUCED ANNUALLY AND AN EXPECTED INCREASE >8.9% FROM 2016 TO 2025. ANIMAL MODELS DEMONSTRATE >99% OF CONSUMED TIO2 IS RETAINED WITHIN THE INTESTINEAND EXCRETED IN THE FECES, SUGGESTING TIO2 COULD GREATLY EFFECT THE GUT. IN ANIMAL MODELS, DIETARY TIO2 CAUSES SHIFTS IN THE GUT MICROBIOME AND OTHER CHANGES IN GUT HEALTH THAT CAUSEPROFOUND DISRUPTION OF GUT HOMEOSTASIS, DUE TOINCREASED INFLAMMATION. HOWEVER, THE RELATION BETWEEN TYPICAL TIO2 INTAKE AND HUMAN GUT HOMEOSTASIS HAS YET TO BE DESCRIBED. FRANCE ISSUED AN EXECUTIVE ORDER TO BAN FOOD GRADE TIO2 USE AFTER JANUARY 1ST 2020, OVER SERIOUS SAFETY CONCERNS. SINCE THEN, MULTIPLE EUROPEAN CIVILSOCIETIES HAVE JOINTLY CALLED FOR AN EXECUTIVE ORDER TO BAN TIO2 ACROSS THE EU. TYPICAL TIO2 INTAKE AMONG U.S. ADULTS REMAINS TO BE DOCUMENTED, AND THERE ARE NO KNOWN STUDIES THAT ESTIMATE DIETARY EXPOSURE OF TIO2 USING A WHOLE FOODS APPROACH. THEREFORE, THE OVERARCHING GOALS OF THIS PROJECT ARE TO: 1) MEASURE DIETARY TIO2 EXPOSURE IN A SAMPLE OF U.S. ADULTS, USING DIETARY RECALLS AND FECAL TIO2 CONTENT; 2) DETERMINE HOW FECAL TIO2 CONTENT IS RELATED TO GUT DYSBIOSIS, METATRANSCRIPTOMICS, INTESTINAL INFLAMMATION, PERMEABILITY AND OXIDATIVE STRESS.
$496,885University Of Massachusetts Lowell · · FY2021 · National Institute of Food and Agriculture
Exploiting the immune response to detect pathogen-induced cancers
$496,815Joshua Labaer · Arizona State University-Tempe Campus · R01 · FY2016 · CA
Identification and single cell analysis of embryonic lymphoid progenitors that generate neonatal innate T cells
$496,750Joonsoo Kang · Univ Of Massachusetts Med Sch Worcester · R01 · FY2021 · AI
NeuroAssessment Core
$496,701Ronald J. Ellis · University Of California, San Diego · P30 · FY2017 · MH