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24,576 grants matching “microbiome”
National Gnotobiotic Rodent Resource Center
$494,397Ryan Balfour Sartor · Univ Of North Carolina Chapel Hill · P40 · FY2023 · OD
Skeletal, Craniofacial and Oral Biology Training Grant
$494,286Mina Mina · University Of Connecticut Sch Of Med/Dnt · T90 · FY2017 · DE
Clinical Resource for Lung and Alcohol Investigations
$494,286Ellen L Burnham · University Of Colorado Denver · R24 · FY2014 · AA
Collaborative Research: A multidimensional approach to understanding microbial carbon cycling beneath the seafloor during cool hydrothermal circulation
$494,256Julie A Huber · Woods Hole Oceanographic Institution · · FY2017 · GEO
Pharmacology & ImmunoPathology (PIP) Core
$494,051Veronique Dartois · Weill Medical Coll Of Cornell Univ · U19 · FY2024 · AI
Targeting bacterial proteases involved in PAR signaling to treat inflammatory bowel diseases
$493,992Matthew S Bogyo · Stanford University · R01 · FY2022 · DK
Project 3: Functional Microbiome and Host Signatures in Transition from Commensal to pathogen
$493,958Tor C. Savidge · University Of Texas Hlth Sci Ctr Houston · P01 · FY2020 · AI
The role of anaerobic microbiota in cystic fibrosis airway disease trajectory
$493,929Ryan Coulson Hunter · State University Of New York At Buffalo · R01 · FY2023 · AI
Molecular and Applied Nutrition Training Program
$493,923Richard S. Eisenstein · University Of Wisconsin-Madison · T32 · FY2020 · DK
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** PLANTING DIVERSE COVER CROP MIXTURES HAS A VARIETY OF AGRICULTURAL AND ECOLOGICAL BENEFITS, BUT IT REMAINS DIFFICULT TO RELIABLY PREDICT WHICH BENEFITS WILL BE REALIZED FROM PARTICULAR COMBINATIONS OF COVER CROP SPECIES. AT THE SAME TIME, THE SOIL MICROBIOME (I.E., THE COMPLETE COMMUNITY OF BACTERIA, FUNGI, AND OTHER MICROORGANISMS LIVING IN SOIL) IS KNOWN TO MEDIATE CROP GROWTH AND ECOLOGICAL BENEFITS, BUT ITS COMPLEXITY MAKES IT DIFFICULT TO MANAGE DIRECTLY. WE HYPOTHESIZE THAT THE SOIL MICROBIOME IS A KEY LINK BETWEEN COVER CROP DIVERSIFICATION AND AGRO-ECOLOGICAL BENEFITS, BUT AN APPLIED UNDERSTANDING OF RELATIONSHIPS BETWEEN PLANT DIVERSITY AND SOIL MICROBIAL DIVERSITY IS STILL LACKING. WE PROPOSE TO DIRECTLY MEASURE THE DIVERSITY OF SOIL MICROBIAL COMMUNITIES SELECTED FOR BY INDIVIDUAL COVER CROP SPECIES. WE WILL THEN DESIGN COVER CROP MIXTURES THAT VARY IN THREE DISTINCT WAYS: THE NUMBER OF CROP SPECIES; THE DIVERSITY OF DIFFERENT ORGANISM TYPES (I.E., PLANT FUNCTIONAL TRAITS VS. SOIL MICROBIOME); AND THE DEGREE OF HOMOGENEITY OR HETEROGENEITY IN THE DIVERSITY. THE AIM IS TO GENERATE NEW KNOWLEDGE ABOUT THE RELATIONSHIPS AMONG COVER CROP DIVERSITY, THE SOIL MICROBIOME, AND ECOSYSTEM FUNCTIONS THAT TRANSLATE TO MORE RELIABLE IMPROVEMENTS IN PLANT PRODUCTION SYSTEMS. THIS WORK IS DIRECTLY RELEVANT TO THE FOUNDATIONAL KNOWLEDGE OF AGRICULTURAL PRODUCTION SYSTEMS PROGRAM AREA PRIORITY BY EXPERIMENTALLY MANIPULATING CROP DIVERSITY IN AN AGRO-ECOLOGICAL CONTEXT TO DETERMINE HOW PRODUCTION SYSTEMS CAN IMPACT SOIL MICROBIAL COMMUNITIES, PRODUCTIVITY, AND NATURAL RESOURCE STEWARDSHIP. THE EXPECTED BENEFITS WILL RESULT IN A SIGNIFICANT STEP TOWARDS USING CROP DIVERSIFICATION MORE PURPOSEFULLY TO MANAGE THE SOIL MICROBIOME, AND BY EXTENSION, IMPROVING YIELD, SOIL HEALTH, AND AGRICULTURAL SUSTAINABILITY.
$493,836Virginia Polytechnic Institute & State University · · FY2020 · National Institute of Food and Agriculture
Microbial Recognition of Sialic Acid Diversity in the Oral Cavity
$493,806Stefan Hans-Klaus Ruhl · State University Of New York At Buffalo · R01 · FY2022 · DE
THIS STUDY AIMS TO DEFINE THE IMPACT OF DIFFERENT ROUTES OF CEFTIOFUR ADMINISTRATION ON THE INTESTINAL MICROBIOME AND RESISTANCE GENE POOL USING METAGENOMICS IN A POPULATION OF DAIRY CATTLE FOLLOWED LONGITUDINALLY. CEFTIOFUR IS COMMONLY USED IN DAIRY FARMS AND CEFTIOFUR RESIDUES HAVE BEEN FOUND IN THE FECES OF DAIRY COWS TREATED BOTH SUBCUTANEOUSLY AND VIA INTRAMAMMARY INFUSION. ALTHOUGH SEVERAL STUDIES HAVE BEEN CONDUCTED TO EXAMINE THE MILK MICROBIOME USING METAGENOMICS, NO PRIOR STUDIES HAVE EXAMINED INTESTINAL COMMUNITIES. OUR OVERARCHING HYPOTHESIS IS THAT SPECIFIC MICROBIAL COMMUNITIES ARE SELECTED FOR BY CEFTIOFUR, WHICH PROMOTES EXPANSION OF CERTAIN BACTERIAL POPULATIONS THAT MORE READILY HARBOR RESISTANCE GENES. WE AIM TO: 1) DETERMINE HOW SUBCUTANEOUS TREATMENT WITH CEFTIOFUR IMPACTS THE INTESTINAL MICROBIOME IN COWS WITH METRITIS RELATIVE TO HEALTHY, UNTREATED COWS SAMPLED FOR 4-WEEKS; AND 2) DETERMINE HOW DRY COW THERAPY USING INTRAMAMMARY CEFTIOFUR IMPACTS THE INTESTINALMICROBIOME COMPARED TO A NON-ANTIBIOTIC TEAT SEALANT OVER A 12-WEEK PERIOD. WE WILL ALSO DETERMINE HOW FREQUENTLY RESISTANCE DETERMINANTS ARE ACQUIRED BY UNTREATED CATTLE AND ARE SHED IN TO THE ENVIRONMENT AND WILL DETERMINE WHETHER TEAT SEALANT TO PREVENT MASTITIS AT DRY OFF CONTRIBUTES TO FEWER PERTURBATIONS IN THE MICROBIOME COMPARED TO SUBCUTANEOUS OR INTRAMAMMARY TREATMENTS. DATA GENERATED THROUGH THE PROPOSED WORK WILL AID IN THE DEVELOPMENT OF GUIDELINES FOR THE JUDICIOUS USE OF ANTIBIOTICS AS WELL AS NOVEL CONTROL METHODS THAT CAN BE USED TO LIMIT THE FLOW AND POOL OF RESISTANCE GENES AND RESISTANT BACTERIAL HOSTS IN DAIRY CATTLE AND THE FARM ENVIRONMENT.
$493,746Michigan State University · · FY2019 · National Institute of Food and Agriculture
Identify and Evaluate Potential Risk Factors for Amyotrophic Lateral Sclerosis - A Unique Contribution from Sweden
$493,735Fang Fang · Karolinska Institute · R01 · FY2023 · TS
The Antigen Repertoire of CD4 T cells from Pancreatic Islets
$493,725Maki Nakayama · University Of Colorado Denver · R01 · FY2022 · DK
Reducing Use of Antibiotics without a Prescription among Outpatients in a Safety Net Healthcare System
$493,630Barbara Wells Trautner · Baylor College Of Medicine · R01 · FY2020 · HS
Influence of the Enteric Microbiome on the Genesis of Bronchopulmonary Dysplasia
$493,598Thomas W Ferkol · Washington University · U01 · FY2014 · HL
Clinical Resource for Lung and Alcohol Investigations
$493,520Ellen L Burnham · University Of Colorado Denver · R24 · FY2015 · AA
Molecular and Applied Nutrition Training Program
$493,421Richard S. Eisenstein · University Of Wisconsin-Madison · T32 · FY2021 · DK
Biomaterials for modulating the gut microbiome for immune activation
$493,392James J. Moon · University Of Michigan At Ann Arbor · R01 · FY2022 · CA
Microbiome-triggered reprogramming and mutation of colon epithelial cells leading to tumor stem-like cells
$493,126Mark M Huycke · University Of Oklahoma Hlth Sciences Ctr · R01 · FY2020 · CA
Determining the interplay of MAIT cells and the translocated microbiome in HIV-induced neuroinflammation
$492,992Dominic Paquin-Proulx · Henry M. Jackson Fdn For The Adv Mil/Med · R21 · FY2023 · MH
Yale Mouse Metabolic Phenotyping Center
$492,984Gerald I Shulman · Yale University · U2C · FY2016 · DK
Center for the Study of Symptom Science, Metabolomics and Multiple Chronic Conditions
$492,935Linda A McCauley · Emory University · P30 · FY2022 · NR
III: Small: Learning Multi-scale Sequence Features for Predicting Gene to Microbiome Function
$492,871Gail L Rosen · Drexel University · · FY2021 · CSE
Structure-Function Studies of the Proton-Gated Urea Channel from H. Pylori
$492,818Hartmut Luecke · University Of California-Irvine · R01 · FY2016 · AI