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24,576 grants matching “microbiome”
Reducing Use of Antibiotics without a Prescription among Outpatients in a Safety Net Healthcare System
$491,230Barbara Wells Trautner · Baylor College Of Medicine · R01 · FY2021 · HS
Kidney Stone Disease In ADPKD
$491,228Michel Benjamin Chonchol · University Of Colorado Denver · R01 · FY2024 · DK
Engineering Mucin Analogues to Benefit the Mouth Environment
$491,193Kamil Godula · University Of California, San Diego · R56 · FY2024 · DE
Novel Computational Tools for Studying the Human Microbiome
$491,177David Neal Fredricks · Fred Hutchinson Cancer Research Center · R01 · FY2012 · HG
DIETARY STRATEGIES TO REDUCE COLONIC INFLAMMATION AND PROMOTE GUT HOMEOSTASIS MAY REDUCE RISK OF COLITIS-ASSOCIATED COLORECTAL CANCER (CAC). BIOACTIVES IN BLACK RASPBERRIES HAVE DEMONSTRATED PROTECTIVE EFFECTS AGAINST COLITIS AND/OR COLORECTAL CANCER VIA THEIR ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIONS. HOWEVER, THERE REMAINS A SUBSTANTIAL KNOWLEDGE GAP REGARDING THE ROLE OF THE GUT MICROBIOME IN MEDIATING THE PURPORTED HEALTH BENEFITS OF BLACK RASPBERRIES. THE OVERALL OBJECTIVE OF THIS STUDY IS TO DETERMINE THE DIRECT EFFECTS OF DIETARY SUPPLEMENTATION WITH WHOLE, FREEZE-DRIED BLACK RASPBERRIES ON GUT HEALTH, INCLUDING MEASURES OF COLITIS, PROGRESSION TO COLON TUMORIGENESIS AND COMPOSITION OF THE GUT MICROBIOME. WE PROPOSE AN INTEGRATED, TRANSLATIONAL APPROACH USING A MOUSE MODEL OF CAC THAT INCORPORATES A PRUDENT DIET AND A WESTERN TYPE DIET (WITH RESPECT TO BOTH MACRO- AND MICRONUTRIENT COMPOSITION) AS PART OF THE EXPERIMENT DESIGN AND THAT CONSIDERS THE ROLE OF ROLE OF GUT BACTERIAIN HEALTH MAINTENANCE AND/OR DISEASE DEVELOPMENT. OUR SPECIFIC AIMS ARE: 1) DETERMINE THE IMPACT OF DIETARY SUPPLEMENTATION WITH BLACK RASPBERRIES ON COLITIS, CAC AND COMPOSITION OF THE GUT MICROBIOME IN MICE FED THE TOTAL WESTERN DIET OR AIN93G DIET; AND 2) DETERMINE THE CONTRIBUTION OF THE GUT MICROBIOME TO THE OBSERVED HEALTH BENEFITS OF BRB, AND ASSESS THE CAPACITY FOR BRB-CONDITIONED GUT MICROBIOTA TO PROTECT HOST MICE AGAINST COLITIS AND CAC FOLLOWING MOUSE-TO-MOUSE FECAL TRANSFER.
$491,160Utah State University · · FY2018 · National Institute of Food and Agriculture
PATHWAYS TO NEW BIOMARKERS IN RECURRENT ABDOMINAL PAIN IN CHILDREN
$491,157Robert Shulman · Baylor College Of Medicine · R01 · FY2020 · NR
Training Grant in Circadian and Sleep Research
$490,946Fred W Turek · Northwestern University · T32 · FY2021 · HL
GULF WAR ILLNESS SUSCEPTIBILITY AND GUT MICROBIOME DYSBIOSIS: A SEARCH FOR BIOMARKERS TO BOOST RESILIENCE.
$490,817Wayne State University · · FY2021 · Department of the Army
Clinical Core
$490,792Daniel W Fitzgerald · Weill Medical Coll Of Cornell Univ · U19 · FY2024 · AI
Microbiota-Immune Interactions in CTLA-4 Antibody Blockade-Induced Colitis
$490,725Gabriel Nunez · University Of Michigan At Ann Arbor · R01 · FY2024 · DK
Spatial Organization of the Oral Microbiome
$490,691Gary G Borisy · Ada Forsyth Institute, Inc. · R01 · FY2017 · DE
ANAPLASMA MARGINALE, THE MOST PREVALENT VECTOR-BORNE PATHOGEN OF CATTLE WORLDWIDE, RESULTS IN >$300 M IN LOSSES EACH YEAR IN THE US. CURRENTLY, THERE ARE NO LICENSED VACCINES FOR ANAPLASMOSIS, AND CONTROL RELIES ON ANTIBIOTIC TREATMENT OF INFECTED ANIMALS. PREVENTION RELIES ON TICK CONTROL, SUCH AS APPLICATION OF CHEMICAL ACARICIDES WHICH RESULTS IN SELECTION OF ACARICIDE-RESISTANT TICK POPULATIONS, CONTAMINATION OF MEAT AND MILK PRODUCTS, AND IS AN IMPORTANT SOURCE OF ENVIRONMENTAL POLLUTION. ADDITIONAL TOOLS TO CONTROL A. MARGINALE WOULD BENEFIT U.S. AGRICULTURE. THE A. MARGINALE BACTERIUM IS TRANSMITTED BY MANY SPECIES OF TICKS INCLUDING THE ROCKY MOUNTAIN WOOD (RMW) TICK (DERMACENTOR ANDERSONI). WE HAVE IDENTIFIED AN ENDOSYMBIONT (NON-DISEASE-CAUSING BACTERIA THAT LIVE WITHIN A HOST) IN THE RMW TICK AND WHEN THIS ENDOSYMBIONT IS PRESENT IN HIGH LEVELS IN THE TICK, THE PATHOGENIC A. MARGINALE BACTERIA CANNOT ESTABLISH HIGH LEVELS OF INFECTION. IN THIS PROJECT WE WILL SHOW THAT OUR PREVIOUS RESULT IS REPRODUCIBLE BY INTRODUCING THE ENDOSYMBIONT INTO A POPULATION OF RMW TICKS THAT DOESN'T ALREADY HAVE IT AND SHOWING THAT IT IS THE ENDOSYMBIONT THAT AFFECTS THE TICKS ABILITY TO ACQUIRE HIGH LEVELS OF A. MARGINALE. THEN WE WILL DETERMINE WHETHER THE ENDOSYMBIONT POSITIVE TICKS HAVE REDUCED THE CARRIAGE OF A. MARGINALE BELOW THE LEVEL FOR EFFICIENT TRANSMISSION. IF THIS IS THE CASE, THEN JUST BY HAVING TICKS THAT CARRY THE ENDOSYMBIONT COULD REDUCE DISEASE TRANSMISSION.WE PROPOSE TO TEST THE HYPOTHESIS THAT THE TICK MICROBIOME IS A DETERMINANT OF THE EFFICIENCY OF A. MARGINALE TRANSMISSION. WE WILL INTRODUCE R. BELLII INTO A D. ANDERSONI POPULATION LACKING THIS ENDOSYMBIONT, AND SHOW THAT A. MARGINALE REPLICATION IS IMPAIRED IN R. BELLII+ TICKS AS COMPARED TO R. BELLII- TICKS. WE WILL EMPLOY AN ARTIFICIAL TICK FEEDING SYSTEM TO IDENTIFY A. MARGINALE INFECTED TICKS AND THEN DO TRANSMISSION EXPERIMENTS USING SINGLE TICK-CALF PAIRINGS. WE EXPECT THAT R. BELLII+ TICKS WILL HAVE LOWER TRANSMISSION EFFICIENCY THAN R. BELLII- TICKS, DEMONSTRATING THAT THE MICROBIOME AFFECTS VECTOR COMPETENCE. THIS WILL LEAD TO THE DEVELOPMENT OF ENVIRONMENTALLY SUSTAINABLE TRANSMISSION BLOCKING STRATEGIES THAT WILL IMPROVE ANIMAL HEALTH. OUR PROPOSAL DIRECTLY ADDRESSES THE PROGRAM AREA PRIORITIES BY TARGETTING THE MICROBIOME TO REDUCE DISEASE TRANSMISSION.
$490,500Washington State University · · FY2018 · National Institute of Food and Agriculture
University of Rochester Vaccine and Treatment Evaluation Unit (VTEU)
$490,470Ann R Falsey · University Of Rochester · UM1 · FY2022 · AI
Testing the hypothesis that microbial energetic hijacking of the CF immune response selects for specific pathogens during lung function decline
$490,423Dianne K Newman · California Institute Of Technology · R01 · FY2020 · HL
Host-microbiome interactions shape the metabolic effects of ketogenic diets
$490,405Peter James Turnbaugh · University Of California, San Francisco · R01 · FY2024 · DK
Development of Mucosal and Systemic Immunity and Risk of Food Allergy
$490,338Kirsi Jarvinen-Seppo · University Of Rochester · U01 · FY2017 · AI
The Microbiome as a risk factor for hr-HPV persistence and Cervical Cancer
$490,284Filipa Godoy-Vitorino · University Of Puerto Rico Med Sciences · U54 · FY2025 · MD
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
$490,280Lauren E Fuess · Texas State University - San Marcos · · FY2024 · BIO
Reduction of bloodstream infections from oral organisms in pediatric stem cell transplant: a randomized, multicenter, double-blind, placebo-controlled study evaluating twice daily oral xylitol
$490,242Christopher Eugene Dandoy · Cincinnati Childrens Hosp Med Ctr · UG3 · FY2021 · DE
Genomic Analysis
$490,137Garry Stewart Anthony Myers · University Of Maryland Baltimore · U19 · FY2014 · AI
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** METRITIS IS AN ACUTE INFLAMMATORY DISEASE OF MULTIPLE LAYERS OF THE UTERINE LINING WITH SYSTEMIC IMPLICATIONS THAT AFFECTS ~ 20% OF POSTPARTUM DAIRY COWS AND HAS MARKED WELFARE, HEALTH, PRODUCTION, REPRODUCTION, AND ECONOMIC CONSEQUENCES TO THE INDIVIDUAL ANIMAL AND THE HERD. THE DAIRY COW IS UNIQUE IN THE SENSE THAT VIRTUALLY ALL COWS ARE COLONIZED BY BACTERIA IN THE FIRST DAYS AFTER CALVING, AND FAILURE TO ELIMINATE PATHOGENIC BACTERIA LEADS TO THE ESTABLISHMENT OF DISEASE. OUR PREVIOUS WORK SHOWED THAT THE MICROBIOTA IS IDENTICAL BETWEEN COWS THAT DEVELOP METRITIS AND HEALTHY COWS UP UNTIL 2 DAYS POSTPARTUM, AFTER WHICH THE BACTERIAL NUMBER AND STRUCTURE DEVIATE IN FAVOR OF GREATER ABUNDANCE OF PATHOGENIC GRAM-NEGATIVE ANAEROBIC BACTERIA IN METRITIC COWS, PARTICULARLY FUSOBACTERIUM, BACTEROIDES AND PORPHYROMONAS. INTERESTINGLY, WE SAW THAT A SUB-COMMUNITY OF UTERINE PATHOGENS THAT INCLUDED FUSOBACTERIUM, BACTEROIDES AND PORPHYROMONAS WAS PRESENT IN BLOOD SHORTLY AFTER CALVING, WHICH INDICATE THAT A HEMATOGENOUS ROUTE OF UTERINE INFECTION WAS POSSIBLE IN COWS. THEREFORE, UTERINE PATHOGENS COULD BE TRANSFERRED TO THE UTERUS SHORTLY AFTER CALVING OR EVEN BEFORE CALVING. INDEED, A RECENT STUDY HAS IDENTIFIED A UTERINE MICROBIOME IN THE PLACENTA AND AMNIOTIC FLUID OF PREGNANT COWS, AND ANOTHER GROUP OF RESEARCHER WERE ABLE TO VISUALIZE IMPORTANT BACTERIA SUCH AS FUSOBACTERIUM NECROPHORUM AND PORPHYROMONAS LEVII WITHIN THE ENDOMETRIUM OF PREGNANT COWS USING FLUORESCENCE IN SITU HYBRIDIZATION (FISH). MEANWHILE, OUR GROUP HAS SHOWN THAT THETHE FIRST STOOL OF CALVES HAD A MICROBIOME, AND THAT THE ABUNDANCE OF BACTEROIDACEAE AND PREVOTELLACEAE, TWO KNOWN FAMILIES OF UTERINE PATHOGENS, IN CALVES' BLOOD WAS POSITIVELY CORRELATED WITH ABUNDANCE OF THESE BACTERIA IN COWS' BLOOD. THESE FINDINGS BEG THE QUESTION: IF BACTERIA CAN COLONIZE THE AMNIOTIC FLUID OF THE DAM AND THE GASTROINTESTINAL (GI) TRACT OF THE FETUS, AND CAN BE FOUND IN THE FETAL CIRCULATION, COULD IT ALSO COLONIZE THE UTERUS OF THE FETUS? IF THE ANSWER IS YES, WE WOULD LIKE TO STUDY POSSIBLE ROUTES OF BACTERIAL TRANSLOCATION FROM THE DAM TO THE FETAL UTERUS. IF THE ANSWER IS NO, THEN WE WOULD LIKE TO KNOW WHEN IN THE LIFE OF A CALF/HEIFER DOES THE UTERUS BECOME COLONIZED WITH BACTERIA. WE WOULD ALSO LIKE TO DETERMINE THE PROGRESSION OF THE UTERINE MICROBIOME FROM FETAL LIFE TO THE PREGNANT STATE. THIS KNOWLEDGE WOULD GIVE US A BETTER UNDERSTANDING OF THE UTERINE MICROBIOTA AND UTERINE DISEASE ETIOLOGY AND COULD COMPLETELY CHANGE THE WAY WE APPROACH UTERINE INFECTION IN COWS, FROM PREVENTION OF UTERINE INFECTION TO PREVENTION OF UTERINE MICROBIOME DYSBIOSIS. OUR LONG-TERM GOAL IS TO DEVELOP SOLUTIONS FOR IMPROVING ANIMAL HEALTH AND WELFARE. HEREIN, WE WILL INVESTIGATE THE UTERINE MICROBIOME FROM FETAL LIFE UNTIL PREGNANCY ESTABLISHMENT WITH THE OVERALL GOAL OF DETERMINING WHEN AND HOW A UTERINE MICROBIOME IS ESTABLISHED AND DETERMINING THE PROGRESSION OF THE UTERINE MICROBIOME UNTIL THE FIRST PREGNANCY. ADDITIONALLY, WE WILL INVESTIGATE THE ESTABLISHMENT AND PROGRESSION OF A MICROBIOME IN OTHER MAJOR ORGANS SUCH AS THE GI TRACT, LUNGS AND THE MAMMARY GLAND. OUR CENTRAL HYPOTHESIS IS THAT BACTERIA FROM THE DAM COLONIZE THE GI TRACT OF THE FETUS AND THEN TRANSLOCATE TO THE UTERUS OF THE FETUS OR THAT BACTERIA FROM THE DAM TRANSLOCATE TO THE BLOOD CIRCULATION OF THE CALF AND THEN COLONIZE THE UTERUS OF THE FETUS. ALTERNATIVELY, A CALF WOULD BE BORN WITHOUT A UTERINE MICROBIOME BUT WOULD ACQUIRE A MICROBIOME BEFORE THE ESTABLISHMENT OF ITS FIRST PREGNANCY. OUR RATIONALE FOR THIS PROPOSAL IS THAT DEVELOPING AN UNDERSTANDING OF THE ORIGIN AND PROGRESSION OF THE UTERINE MICROBIOME WILL PROVIDE INSIGHT ON UTERINE DISEASE ETIOLOGY AND ALLOW FOR THE DEVELOPMENT UTERINE MICROBIOME MODULATION STRATEGIES. ALTHOUGH OUR PROJECT IS FOCUSED ON THE UTERINE MICROBIOME, WE WILL ALSO DEVELOP AN UNDERSTANDING OF THE MICROBIOME OF MAJOR ORGANS SUCH AS THE GI TRACT, LUNGS AND THE MAMMARY GLAND FROM FETAL LIFE UNTIL ADULTHOOD, WHICH WILL PROVIDE INSIGHT INTO THE ETIOLOGY OF GI DISEASE, PNEUMONIA AND MASTITIS, THE MAJOR DISEASES OF DAIRY CALVES AND COWS. THIS IS EXPECTED TO IMPROVE ANIMAL HEALTH, WELFARE, AND FERTILITY WHICH IS EXPECTED TO ENHANCE FARM PROFITABILITY AND SUSTAINABILITY. FURTHERMORE, REDUCING DISEASE BURDEN WILL DECREASE ANTIBIOTIC USE, WHICH IS EXPECTED TO DELAY THE DEVELOPMENT OF BACTERIAL RESISTANCE TO ANTIBIOTICS USED IN HUMAN MEDICINE, WHICH WILL IMPROVE PUBLIC SENTIMENT TOWARDS ANIMAL AGRICULTURE WHICH WILL ULTIMATELY IMPROVE THE SUSTAINABILITY OF THE DAIRY INDUSTRY.
$490,113University Of Florida · · FY2021 · National Institute of Food and Agriculture
Divergent Functional and Metabolic Development of the Infant Microbiome
$490,093Susan Veronica Lynch · University Of Arizona · P01 · FY2022 · AI
BOVINE RESPIRATORY DISEASE (BRD) COMPLEX IS AN ECONOMICALLY IMPORTANT AND SOMETIMES FATAL DISEASE OF CATTLE, PARTICULARLY IN YOUNG CALVES AND RECENTLY WEANED CATTLE WORLDWIDE. IN BOTH THE US AND IRELAND, RESPIRATORY DISEASE IS THE MOST COMMONCAUSE OF MORTALITY IN CATTLE. IN THE US, OVER 50% OF FEEDLOT DEATHS ARE ATTRIBUTABLE TO BRD AND APPROXIMATELY 45% AND 32% OF DEATHSARE ATTRIBUTABLE TO BRD IN CALVES AGED 1 TO 5 MONTHS OLD INNORTHERN IRELAND AND REPUBLIC OF IRELAND, RESPECTIVELY. BRD CAN RESULT BY BOTH BACTERIAL AND VIRAL AGENTS, AS DISEASE INCIDENCE IS INTIMATELY ASSOCIATED WITH AN ANIMAL'S BACTERIAL (MICROBIOME) AND VIRAL (VIROME) POPULATIONS. THEREFORE, EVALUATION OF THE ANIMAL'S RESIDENT RESPIRATORY PATHOGENS INCLUDING BACTERIAL AND VIRAL PATHOGENS IN THE UPPER NASAL CAVITY MAY HELP US TO UNDERSTAND THE IMPACT OF THESE PATHOGENS ON INCIDENCE OF BRD IN CATTLE. THIS PROJECT PROPOSAL IS COMPRISED OF THREE INTER-RELATED PROJECTS, WHICH WILL EACH INVESTIGATE SPECIFIC RESEARCH OBJECTIVES AND WILL BENEFIT FROM CATTLE POPULATION RESOURCES AND THE COMPLEMENTARY EXPERTISE OF PRINCIPAL RESEARCHERS THAT ARE INTEGRAL TO THE ENTIRE PROJECT.FOR THIS PROPOSAL, WE WILL INCORPORATE MULTIPLE CATTLE POPULATIONS, CUTTING EDGE SEQUENCING TECHNOLOGY, AND SCIENTIFIC EXPERTISE. INITIALLY, PREVELENCE OF BRD WILL BE DETERMINE IN POPULATIONS OF CALVES IN THE US AND IRELAND BY EVALUATING HEALTH RECORDS OF CALVES AT BOTH LOCATIONS. BACTERIAL AND VIRAL PATHOGENS WILL THEN BE IDENTIFIED IN THE UPPER NASAL CAVITY OF THESE CALVES TO DETERMINE THE PATHOGENS ASSOCIATED WITH BRD. TO ACCOMPLISH THIS, NASAL SAMPLES WILL BE COLLECTED FROM THESE CALVES AT TIME POINTS PRIOR TO BRD DIAGNOSIS AND AT THE TIME OF BRD DIAGNOSIS. THE DNA AND RNA FROM THESE NASAL SWABS WILL BE EVALUATED THROUGH SEQUENCING TO IDENTIFY THE BACTERIAL AND VIRAL PATHOGENS THAT ARE PRESENT IN THE NASAL SWABS COLLECTED FROM CALVES. THROUGH THIS, WE WILL BE ABLE TO IDENTIFY PATHOGENS THAT ARE PRESENT IN HEALTHY CALVES ANDCALVES DIAGNOSED WITH BRD. WE WILL THEN DETERMINE HOW BACTERIAL AND VIRAL PATHOGENS CHANGE AFTER EXPERIMENTALLY INFECTING CALVES WITH KNOWN VIRUSES THAT ARE ASSOCIATED WITH BRD. NASAL SWABS WILL BE COLLECTED FROM CALVES INFECTED WITH KNOWN VIRUSES AND CONTROL CALVES THAT WILL NOT BE INFECTED. CHANGES IN BACTERIAL AND VIRAL PATHOGENS DUE TO EXPERIMENTAL INFECTION WILL BE DETERMINED BY SEQUENCING THE DNA AND RNA FROM THE NASAL SWABS.OVERALL, THE NOVEL METHODS AND APPROACHES EMPLOYED IN THE PROJECT WILL BE OF VALUE TO NATIONAL AND INTERNATIONAL RESEARCHERS STUDYING A WIDE RANGE OF RESPIRATORY PATHOGENS INFECTING CATTLE. OUTCOMES OF THE PROJECT WILL INCLUDE: 1) A DECREASE IN ANIMAL AND PRODUCTION LOSSES DUE TO BRD, 2) IMPROVED DIAGNOSTICS FOR THE MANAGEMENT OF BRD, 3) A REDUCTION IN DRUG USE FOR BRD, 4) IMPROVED ANIMAL WELFARE, AND 5) ENHANCED AGRICULTURE COMPETITIVENESS. THUS, THE RESEARCH PROGRAM OUTLINED IN THIS PROPOSAL WILL OPTIMIZE OUR RESEARCH CAPACITY AND CAPABILITIES IN THE AREASOF ANIMAL HEALTH.
$490,000Agricultural Research Service · · FY2019 · National Institute of Food and Agriculture
NATURALLY-SUPPRESSIVE SOILS PROVIDE STRONG EVIDENCE OF THE POTENTIAL FOR INDIGENOUS SOIL MICROBES TO DELIVER SIGNIFICANT, STABLE, AND LONG-LASTING DISEASE CONTROL IN AGRICULTURAL PRODUCTION SYSTEMS. HOWEVER, PRACTICAL MANAGEMENT TO ACHIEVE CONSISTENT DISEASE SUPPRESSION HAS BEEN ELUSIVE IN AGRICULTURAL SYSTEMS. HERE WE PROPOSE TO UTILIZE A NOVEL COEVOLUTIONARY FRAMEWORK FOR STUDYING THE GENERALIZABILITY OF ECOLOGICAL AND EVOLUTIONARY MECHANISMS FOR GENERATING PATHOGEN-SUPPRESSIVE MICROBIOMES AMONG DISTINCT CROP MANAGEMENT SYSTEMS. IN ADDITION, WE WILL EXPLORE THE SPECIFIC ROLES THAT ANTIBIOTICS PLAY IN MEDIATING PATHOGEN-ANTAGONIST INTERACTIONS AND DISEASE SUPPRESSION, AND CHARACTERIZE THE NETWORKS OF ANTIBIOTIC-MEDIATED SPECIES INTERACTIONS ACROSS SUPPRESSIVE SOIL MICROBIOMES. FINALLY, WE WILL CHARACTERIZE CO-ASSOCIATION AND INTERACTION NETWORKS FOR BACTERIAL AND FUNGAL MICROBIOMES FROM SUPPRESSIVE SOILS INDUCED BY DISTINCT CROP MANAGEMENT SYSTEMS TO IDENTIFY CONSISTENT FINGERPRINTS' OF SUPPRESSIVE SOIL MICROBIOMES. THIS PROJECT WILL ADDRESS KEY PROGRAM AREA PRIORITIES OF PROMOTING HEALTHY POPULATIONS OF BENEFICIAL ORGANISMS, AND INCREASING OUR UNDERSTANDING OF INTERACTIONS BETWEEN PESTS AND BENEFICIAL MICRO-ORGANISMS. IN ADDITION, THIS FUNDAMENTAL RESEARCH WILL CONTRIBUTE TO THE DEVELOPMENT OF BIOLOGICALLY-BASED PEST MANAGEMENT APPROACHES TO SUSTAIN BENEFICIAL SPECIES AND MANAGE PESTS, AND PROVIDE NOVEL INSIGHTS INTO THE BASES FOR PATHOGEN SUPPRESSION BY INDIGENOUS SOIL MICROBES. IN TOTAL, THE PROPOSED WORK WILL CONTRIBUTE SIGNIFICANTLY TO ADVANCES IN OUR POTENTIAL TO MANAGE SOIL MICROBIOMES TO ACHIEVE DISEASE SUPPRESSION, CONTRIBUTING TO INCREASES IN PLANT PRODUCTIVITY, REDUCTIONS IN RELIANCE ON PESTICIDES, AND MORE SUSTAINABLE FOOD PRODUCTION.
$489,949Regents Of The University Of Minnesota · · FY2018 · National Institute of Food and Agriculture
Human microbiome and cancer
$489,922Emily Vogtmann · Division Of Cancer Epidemiology And Genetics · ZIA · FY2023 · CA