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24,576 grants matching “microbiome”
Diet-derived oxysterols shape intestinal B cell fate by controlling intracellular cholesterol metabolism
$467,227Andrea Reboldi · Univ Of Massachusetts Med Sch Worcester · R01 · FY2023 · AI
Dissecting microbiota-driven lymphangiogenesis in immune health and disease
$467,159Abigail E Overacre-Delgoffe · University Of Pittsburgh At Pittsburgh · DP2 · FY2024 · AI
Dissecting microbiota-driven lymphangiogenesis in immune health and disease
$467,159Abigail E Overacre-Delgoffe · University Of Pittsburgh At Pittsburgh · DP2 · FY2023 · AI
Dissecting microbiota-driven lymphangiogenesis in immune health and disease
$467,159Abigail E Overacre-Delgoffe · University Of Pittsburgh At Pittsburgh · DP2 · FY2025 · AI
Comprehensive atlas of advanced adenomas and their surrounding primed colon: A multi-omics evaluation and clinical impact assessment
$467,151William M Grady · Fred Hutchinson Cancer Center · U54 · FY2024 · CA
HPV and HIV Co-Infection: Clinical, Socio-Behavioral, and Microbiome Implications
$467,098Jennifer L Frustino · Erie County Medical Center Corp. · R21 · FY2023 · DE
Gut pathogen virulence and its therapeutic modulation during surgical injury
$466,862John C. Alverdy · University Of Chicago · R01 · FY2025 · GM
REU Site: Microbiology of Low Oxygen Ecosystems (MLOxE) at Montana State
$466,842Frank J Stewart · Montana State University · · FY2024 · BIO
Translating from Kangaroo Rat Burrows to Geotechnical Engineering by Uncovering Fundamental Processes
$466,838Idil D Akin · University Of California-Los Angeles · · FY2023 · ENG
T Cell Homeostasis and Function in Immune Senescence
$466,791Janko Nikolich-Zugich · University Of Arizona · R37 · FY2024 · AG
T Cell Homeostasis and Function in Immune Senescence
$466,791Janko Nikolich-Zugich · University Of Arizona · R37 · FY2023 · AG
EARTH LIKE NUMEROUS OTHER PLANETS IN OUR SOLAR SYSTEM HAS EXPERIENCED NUMEROUS INTERVALS OF GLACIATION THROUGHOUT ITS HISTORY. ON EARTH ABUNDANT ACTIVE AND DIVERSE MICROBIOMES EXIST BENEATH ICE MASSES WHICH ARE SUPPORTED BY MINERAL BASED ENERGY MADE AVAILABLE THROUGH THE COMMUNITION OF BEDROCK. RECENT RESEARCH CONDUCTED ON ICE MASSES IN SEDIMENTARY AND METASEDIMENTARY CATCHMENTS INDICATE A PRIMARY ROLE FOR FE AND S IN MINERALS SUCH AS PYRITE IN SUSTAINING MICROBES IN A RANGE OF SUBGLACIAL ENVIRONMENTS DESPITE PYRITE ONLY BEING OF LOW ABUNDANCE 1 2 WT IN THE BEDROCK. HOWEVER LITTLE IS KNOWN OF THE ROLE OF MINERALOGYOR OF THE SPECIFIC WATER ROCK INTERACTIONS THAT SUSTAIN MICROBIAL ECOSYSTEMS IN GRANITIC OR BASALTIC SYSTEMS.CRUSHED BASALT WHICH COMPRISES 5 14 WT FEO AND 45 55 WT SIO2 HAS BEEN SHOWN TO GENERATE HYDROGEN H2 WHEN EXPOSED TO WATER AT 30 TO 60OC. THE H2 PRODUCED WAS SUGGESTED TO RESULT FROM THE REDUCTION OF WATER BY REDUCED IRON. HOWEVER RECENT RESEARCH BY THE AUTHORS DEMONSTRATES SIGNIFICANT H2 PRODUCTION FOLLOWING ABIOTIC CRUSHING OF A VARIETY OF SILICATE MINERALS AT 0OC AND SUBSEQUENT WETTING IN A PROCESS THAT SIMULATES GLACIAL COMMUNITION OF SILICATE BEDROCK. DESPITE ITS HIGH SI CONTENT BASALT WAS NOT ANALYZED IN OUR RECENT STUDY AND SO RATES OF ABIOTIC H2 RELEASE FROM CRUSHED WETTED BASALT VIA A SI MINERAL SHEARING MECHANISM AT TEMPERATURES RELEVANT TO SUBGLACIAL ECOSYSTEMS 0 1OC ARE UNKNOWN. MOREOVER IT IS UNCLEAR IF SI MINERAL SHEARING OR FE BASED MECHANISMS ARE MOST LIKELY TO CONTRIBUTE H2 IN BASALTIC SUBGLACIAL SYSTEMS AND WHETHER MICROBIAL COMMUNITIES PRESENT IN THESE SYSTEMS ARE FOUNDED ON H2 BASED CHEMOLITHOAUTOTROPHY. THIS LEADS TO OUR OVERARCHING HYPOTHESIS BASALT IN SUBGLACIAL SYSTEMS COMMINUTED BY GLACIAL GRINDING AND ABRASION LIBERATES H2 ABIOTICALLY WHICH SUSTAINS A DIVERSE AND ACTIVE H2 BASED CHEMOLITHOAUTOTROPHIC MICROBIAL COMMUNITY AT 0 1OC. OUR OVERARCHING OBJECTIVE IS TO INVESTIGATE THE PRODUCTION OF H2 IN SUBGLACIAL BASALTIC SYSTEMS AND ITS ROLE IN SUSTAINING CHEMOLITHOTROPHIC COMMUNITIES. SPECIFIC OBJECTIVES ARE TO 1. CHARACTERIZE THE CHEMISTRY OF MELTWATERS IN A RANGE GLACIAL CATCHMENTS IN ICELAND AND DETERMINE THE CAPACITY FOR SILICATE MINERAL SHEARING AND BASALT IRON TO GENERATE H2 2. DETERMINE RATES OF BIOLOGICALH2 TRANSFORMATION AND CO2 FIXATION IN SUBGLACIAL SEDIMENT COMMUNITIES 3. QUANTIFY ENRICHMENT IN H2 BASED METABOLISM ALONG GEOCHEMICAL GRADIENTS USING METAGENOMICS AND TARGETED TRANSCRIPTOMICS AND 4. MODEL THE RELATIONSHIPS BETWEEN ABIOTIC MECHANISMS OF H2 PRODUCTION PROCESS RATES AND GENETIC TRANSCRIPTIONAL DATA. THE INTEGRATION OF THE PROPOSED DATA WILL PROVIDE KEY NEW INSIGHTS INTO THE POTENTIAL FOR WATER ROCK INTERACTIONS IN SUPPORTING MICROBIAL LIFE IN COLD DARK SUBGLACIAL ENVIRONMENTS.THE PROPOSED RESEARCH IS RELEVANT TO SEVERAL ASPECTS OF NASAS EXOBIOLOGY PROGRAM INCLUDING EARLY EVOLUTION OF LIFE AND THE BIOSPHERE LARGE SCALE ENVIRONMENTAL CHANGE AND MACRO EVOLUTION AND BIOSIGNATURES AND LIFE ELSEWHERE. THE ADVANCE AND RETREAT OF ICE DURING GLACIAL INTERGLACIAL CYCLES THROUGHOUT EARTHS HISTORY IS THOUGHT TO HAVE DRIVEN LARGE SCALE SHIFTS IN THE DISTRIBUTION OF TAXA TO HABITATS WITH MORE STABLE CLIMATIC CONDITIONS REFUGIA ENABLING DIVERSE MICROBIAL ASSEMBLAGES TO PERSIST IN SUBGLACIALSEDIMENTS. AS EARTH HAS EXPERIENCED A NUMBER OF SNOWBALL EARTH EVENTS FINDINGS FROM THIS RESEARCH WILL PROVIDE KEY INSIGHTS INTO THE PREDOMINANT METABOLIC PROCESSES CAPABLE OF SUSTAINING EARTHS BIOSPHERE DURING WIDESPREAD GLACIATION AND ITS POTENTIAL IN DRIVING CHANGES IN MAJOR GEOCHEMICAL CYCLES. FINALLY MICROBIALLY DRIVEN SUBGLACIAL WEATHERING OF BASALTS IN TERRESTRIAL SYSTEMS MAY PRODUCE BIOSIGNATURES FE OXIDES THAT COULD BE RELEVANT FOR THE FORMATION AND RETENTION OF BIOSIGNATURES UNDER NON EARTH CONDITIONS GIVENTHE PRESENCE OF BASALT IN FORMERLY GLACIATED REGIONS ON MARS AND OTHER PLANETARY BODIES.
$466,728Montana State University · · FY2016 · National Aeronautics and Space Administration
Genomics Core
$466,679Donald Anthony Primerano · Marshall University · P20 · FY2014 · GM
Mechanisms sustaining lytic herpesviral infection in the oral cavity
$466,640Bernadett Papp · University Of Florida · R01 · FY2025 · DE
Immunoengineering Postdoctoral Training Program - Resubmission - 1
$466,604Melody A Swartz · University Of Chicago · T32 · FY2022 · AI
THE ROLE OF THE TUMOR MICROBIOME IN MUCOSAL MELANOMA DEVELOPMENT AND ANTITUMOR IMMUNITY
$466,491The Regents Of The University Of Colorado · · FY2021 · Defense Health Agency
Training in Pediatric Gastroenterology and Nutrition
$466,473Wayne Lencer · Boston Children'S Hospital · T32 · FY2016 · DK
Research Training in Digestive Health, Diseases, and Nutrition
$466,431Eugene B Chang · University Of Chicago · T32 · FY2019 · DK
Facilitation of Post-Acute Sequela to COVID Studies in Mouse Models
$466,389Craig L Franklin · University Of Missouri-Columbia · U42 · FY2021 · OD
Lifestyle Interventions, metabolites, microbiome, and diabetes risk
$466,382Frank B Hu · Harvard School Of Public Health · R01 · FY2023 · DK
THE PHASEOUT OF METHYL-BROMIDE LEFT MANY AGRICULTURAL SYSTEMS VULNERABLE TO SOILBORNE PESTS. REGIONAL PEST MANAGEMENT STRATEGIC PLANS, GROWER ASSOCIATION PRIORITIES, AND EXTENSION/RESEARCH-BASED INTERACTIONS WITH GROWERS AND INDUSTRY PARTNERS IDENTIFY MAJOR GAPS IN EFFICACIOUS MANAGEMENT OF TOMATO DISEASES (VERTICILLIUM WILT AND BACTERIAL WILT), CAUSED BY SOILBORNE PATHOGENS, AND SECURING OPTIMUM YIELDS. ADDRESSING THESE THREATS REQUIRES INTEGRATED MULTIFACETED AND SYSTEMS-BASED APPROACHES, AS ARTICULATED IN THE MBT RFA. THIS PROPOSAL PARTNERS WITH GROWERS AND OTHER PROFESSIONALS TO DEVISE INTEGRATED AND BIOLOGICALLY-BASED SYSTEMS COMPARED TO STANDARD OR OPTIMIZED FUMIGATION SYSTEMS; SEEKS TO RESTORE TIRED SOILS, AND REDUCE HIGH PATHOGEN INOCULUM PRESSURE BY RESEARCHING HOW GROWER INPUTS, PLANT GENETICS, AND MICROBIOMES ARE INTERCONNECTED. WE SEEK TO INTEGRATE ANAEROBIC SOIL DISINFESTATION (ASD) INTO CURRENT PRODUCTION SYSTEMS TO SUPPRESS SOILBORNE PATHOGENS (AND WEEDS) AND ENHANCE CARBON INPUTS IN SOILS, AND YIELDS. THE PROPOSAL ALSO HYPOTHESIZES THAT AFTER ASD, RESTORING/MAINTAINING BENEFICIAL MICROORGANISMS AND REDUCING PATHOGEN INOCULUM CAN BE ACHIEVED BY PLANTING TOMATO HYBRIDS, OR CAPTURING THIS BENEFICIAL FUNCTION, USING NOVEL NCSU/COMMERCIAL GENETICS SECURED IN ROOTSTOCKS VIA GRAFTED PLANTS. SOIL HEALTH WILL BE ASSESSED BY MEASURING CHEMICAL, PHYSICAL AND BIOLOGICAL SOIL PARAMETERS, MICROBIOME DIVERSITY, DISEASE SEVERITY, AND YIELD IMPACTS. THE PROJECT WILL SECURE COMPREHENSIVE DATA SETS ON THE INFLUENCE OF TOMATO ROOTSTOCKS PLANTED IN ASD TREATED SOILS TO BETTER UNDERSTAND AND MANAGE RHIZOSPHERE MICROBIOMES TOWARD CONCEIVABLE FUTURE PRODUCTION SYSTEMS. INTEGRATED OBJECTIVES WILL ALSO PURSUE ECONOMIC ANALYSIS AND EXTENSION PROGRAMMING TO ENGAGE WITH GROWERS AND OTHER PARTNERS TO ADVANCE ECONOMICALLY AND TECHNICALLY FEASIBLE ALTERNATIVES THAT COMPLIMENTS SOLE RELIANCE ON FUMIGANTS.
$466,340North Carolina State University · · FY2021 · National Institute of Food and Agriculture
Continuous glucose monitoring: determinants and prediction of diabetes mellitus development in the Framingham Heart Study
$466,336Nicole L Spartano · Boston University Medical Campus · R01 · FY2023 · DK
Equipment: MRI Track 1 Acquisition of a Spinning-Disk Confocal Microscope for Cell and Molecular Biology Research and Undergraduate Teaching and Training
$466,187David Wynne · University Of Portland · · FY2024 · BIO
The Role of the Microbiome and Notch Signaling in Esophageal Adenocarcinoma
$466,166Julian Abrams · Columbia University Health Sciences · R01 · FY2025 · CA
Precision coordination of therapeutic and prophylactic antibiotics to reduce infection, toxicity, and emergence of resistance following acute abdominal surgery
$466,165Stewart C Wang · University Of Michigan At Ann Arbor · R01 · FY2022 · HS