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24,576 grants matching “microbiome”
PATHWAYS TO NEW BIOMARKERS IN RECURRENT ABDOMINAL PAIN IN CHILDREN
$466,143Robert Shulman · Baylor College Of Medicine · R01 · FY2021 · NR
Project 3 Identification of Microbial Founder Species and Metabolic Products that Promote Microbiota and Immune Development Resilient to Childhood Allergy and Asthma
$466,041Susan Veronica Lynch · Henry Ford Health System · P01 · FY2019 · AI
STI and Implications for HIV Transmission and Prevention
$466,023Colleen F Kelley · Emory University · R01 · FY2017 · HD
PREBIOTIC FOOD INGREDIENTS CONFER PHYSIOLOGICAL BENEFITS TO HUMANS BY THE MODULATION OF GUT MICROBIOTA, WHICH LEADS TO BENEFITS SUCH AS THE ALLEVIATION OF METABOLIC DERANGEMENTS DUE TO DISEASE STATES SUCH AS OBESITY AND TYPE-2 DIABETES. WE HAVE DEVELOPED A METHOD USING CONTINUOUS EXTRUSION TO PRODUCE NONDIGESTIBLE OLIGOSACCHARIDES FROM SUGARS, SUCH AS LOW-COST LACTOSE, WHICH WE CALL POLYLACTOSE. IN PREVIOUS WORK, WE HAVE DEMONSTRATED THAT POLYLACTOSE INCREASES THE ABUNDANCE OF LACTOBACILLUS AND BIFIDOBACTERIA IN THE LARGE INTESTINE OF RATS, AS WELL AS REDUCES ADIPOSITY AND LIVER LIPIDS. HERE, WE PROPOSE TO REPLICATE AND EXTEND OUR PREVIOUS FINDINGS. FIRST, WE WILL PRODUCE OLIGOSACCHARIDES USING 4 DIFFERENT LACTOSE AND GLUCOSE CONCENTRATIONS RANGING FROM 100% LACTOSE TO 100% GLUCOSE (POLYDEXTROSE). THESE WILL BE CHARACTERIZED FOR THEIR SUGAR COMPOSITION AND DEGREE OF POLYMERIZATION. SECOND, OUR EXTRUDED OLIGOSACCHARIDES, COMMERCIALLY PRODUCED POLYDEXTROSE, ANDGALACTOOLIGOSACCHARIDES WILL BE FED TO DIET-INDUCED OBESE RATS TO EVALUATE THE EFFECT OF THESE OLIGOSACCHARIDES ON GLYCEMIC CONTROL, ADIPOSITY, LIVER LIPIDS, AND METABOLIC CHANGES IN ADIPOSE TISSUE. FINALLY, A MICROBIOME ANALYSIS OF THE LARGE INTESTINAL CONTENTS FROM THE RATS WILL BE CONDUCTED TO ASCERTAIN THE EFFECT OF THE DIFFERENT OLIGOSACCHARIDES ON THE RELATIVE ABUNDANCE OF THE MICROFLORA. THIS STUDY, IF POSITIVE, WILL CONFIRM THAT POLYLACTOSE IS A PREBIOTIC, WILL REVEAL INFORMATION ABOUT ITS MECHANISM OF ACTION FOR REDUCING ADIPOSITY, AND WILL PROVIDE THE JUSTIFICATION FOR A HUMAN TRIAL OF POLYLACTOSE FEEDING. IF POLYLACTOSE IS DEMONSTRATED TO BE A POTENT PREBIOTIC, IT WOULD BE AN ECONOMICAL DIETARY INGREDIENT TO IMPROVE THE DIGESTIVE HEALTH OF AMERICANS.
$465,966Regents Of The University Of Minnesota · · FY2019 · National Institute of Food and Agriculture
Clinical
$465,935James P. Nataro · University Of Maryland Baltimore · U19 · FY2011 · AI
Clinical Trials of Allogeneic Transplantation for Inherited Immune Deficiencies
$465,906Elizabeth Kang · National Institute Of Allergy And Infectious Diseases · ZIA · FY2015 · AI
Fecal Microbiota Transplant and PD-1 blockade in Melanoma
$465,896Hassane M Zarour · University Of Pittsburgh At Pittsburgh · R01 · FY2019 · CA
The Hawaii Advanced Training in Artificial Intelligence for Precision Nutrition Science Research (AIPrN)
$465,779Youping Deng · University Of Hawaii At Manoa · T32 · FY2024 · DK
AS THE LARGEST COMPARTMENT OF THE CATTLE STOMACH, THE RUMEN AND ITS MICROBIOME ARE CRITICAL FOR THE CONVERSION OF LOW-QUALITY FEEDSTUFFS INTO USABLE ENERGY FOR RUMINANTS. THEREFORE, THE RUMINAL MICROBES REPRESENT THE GREATEST OPPORTUNITY TO RAPIDLY IMPROVE BEEF CATTLE NUTRITION AND GROWTH FOR MEETING FUTURE GLOBAL PROTEIN DEMANDS. HOWEVER, IF CERTAIN MICROBES THAT ARE SIGNIFICANT FOR FEED EFFICIENCY, DISEASE RESISTANCE, AND OTHER PRODUCTION TRAITS ARE TO BE MAINTAINED, THERE IS A CRITICAL NEED TO IDENTIFY HOST BEEF CATTLE GENETICS THAT ESTABLISHES AND INFLUENCES THE RUMEN MICROBIOME AND THE POTENTIAL HERITABILITY OF THESE MICROBES. THE OVERARCHING HYPOTHESIS OF THIS PROJECT IS THAT HOST BEEF CATTLE GENETICS ARE ASSOCIATED WITH THE VARIATION OF MICROBES IN THE RUMEN, PRODUCING AN INDIVIDUALIZED RUMEN MICROBIOTA AMONG ANIMALS. TO TEST THE OVERARCHING HYPOTHESIS OF THIS PROJECT AND DETERMINE ITS IMPACT ON FEED EFFICIENCY, THE SPECIFIC OBJECTIVES INCLUDE, 1) DETERMINE THE MICROBES AND MICROBIAL INTERACTIONS IN THE RUMEN OF ANGUS CATTLE AND THEIR RELATION TO FEED EFFICIENCY,2) ESTIMATE THE HERITABILITY OF THE RUMEN MICROBES AND MICROBIAL FEATURES,AND 3) IDENTIFY HOST GENOMIC MARKERS FOR RUMEN MICROBES AND MICROBIAL FEATURES. AT THE COMPLETION OF THIS PROJECT, WE EXPECT TO HAVE IDENTIFIED HERITABLE RUMEN MICROBES AND MICROBIAL FEATURES THAT ARE IMPORTANT FOR FEED EFFICIENT BEEF CATTLE. ALTHOUGH THE STUDY WILL FOUNDATIONALLY DEFINE A HOST GENOMIC LINK TO HERITABLE RUMEN MICROBES, THIS PROJECT WILL ULTIMATELY, A) PROVIDE A STEPPINGSTONE TOWARD MICROBIOME MANIPULATION AND A MEANS TO INCREASE FOOD AVAILABILITY WHILE LOWERING ENVIRONMENTAL IMPACTS,B) DEVELOP MORE SUSTAINABLE COW-CALF PRODUCTION SYSTEMS,AND C) ENHANCE ANGUS BREEDING PROGRAMS,GENOMIC PREDICTIONS, AND US AGRICULTURE. THE PROJECT WILL DRAMATICALLY ADVANCE THE FIELD OF BEEF PRODUCTION AGRICULTURE TO SUSTAINABLY MEET THE PROTEIN REQUIREMENTS OF AN EVER-INCREASING GLOBAL POPULATION
$465,716University Of Tennessee · · FY2020 · National Institute of Food and Agriculture
Role of altered gut immune response in Lewy Body Disease
$465,704Kathleen Lombard Poston · Stanford University · U01 · FY2024 · DK
Dimensions: Collaborative Research: Community genomic drivers of moss microbiome assembly and function in rapidly changing Alaskan ecosystems
$465,675Michelle C Mack · Northern Arizona University · · FY2015 · BIO
Characterization of the role of neuropeptide VIP-mediated fucosylation in alcohol associated liver disease
$465,588Zhong-Bin Deng · University Of Louisville · R01 · FY2023 · AA
High Fat Feeding Reduces Energy Expenditure in Brown Adipose Tissue
$465,464John W Wiley · University Of Michigan At Ann Arbor · R01 · FY2024 · DK
Do Rhizosolenia mats obtain N from cryptic nitrogen-fixing microbes?
$465,365Kevin R Arrigo · Stanford University · · FY2025 · GEO
Inhibition of Candida virulence and biofilm formation by a bacterial peptide
$465,335Michael C Lorenz · University Of Texas Hlth Sci Ctr Houston · R01 · FY2022 · DE
Determinants of colonization for commensal skin bacteria
$465,291Tami D Lieberman · Massachusetts Institute Of Technology · R01 · FY2025 · AR
Improving growth and neurodevelopment of very low birth weight infants through precision nutrition: The Optimizing Nutrition and Milk (Opti-NuM) Project.
$465,256Deborah O'Connor · Hospital For Sick Chldrn (Toronto) · R01 · FY2022 · HD
ROS responses during Vibrio cholerae infection
$465,215Jun Zhu · University Of Pennsylvania · R01 · FY2019 · AI
Core C: Phenotyping Core
$465,183Nathan R. Qi · University Of Michigan At Ann Arbor · U2C · FY2023 · DK
Microbiome-triggered reprogramming and mutation of colon epithelial cells leading to tumor stem-like cells
$465,052Mark M Huycke · University Of Oklahoma Hlth Sciences Ctr · R01 · FY2019 · CA
Microbiome, metabolites, and alcohol in HIV to reduce CVD RCT (META HIV CVD RCT)
$464,976Matthew S Freiberg · Vanderbilt University Medical Center · P01 · FY2022 · AA
Dysbiosis Impact on Lung Disease in HIV (DImpL) Study
$464,950Alison Morris · University Of Pittsburgh At Pittsburgh · R01 · FY2019 · HL
Heterogeneous synthetic microbiome constructed with biopolymer fluitrodes
$464,934Xiaolong Luo · Catholic University Of America · R15 · FY2018 · GM
Gut Microbiome Contributions to Human Episodic Memory and the Role of Early Life Stress
$464,750Elizabeth A. Phelps · Harvard University · R21 · FY2023 · MH
Mathematical modeling from metagenomics - minimizing risk of enteric infections
$464,739Vanni Bucci · University Of Massachusetts Dartmouth · R15 · FY2015 · AI