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15,273 grants matching “antimicrobial resistance”
Host Directed Orynotide for MDR Gram Negative Bacterial Infections
$1,005,952Justin Blaine Schaal · University Of Southern California · R01 · FY2023 · AI
Multiplexed, Non-Amplified, Nucleic Acid-Based Identification of Multidrug Resistant Pathogens Using an Integrated Optofluidic Platform
$1,002,828Aaron R. Hawkins · Brigham Young University · R01 · FY2017 · AI
Short and long term outcomes of doxycycline versus TMP-SMX for SSTI treatment
$1,002,378Loren G Miller · Lundquist Institute For Biomedical Innovation At Harbor-Ucla Medical Center · U01 · FY2022 · AI
Resorbable Antimicrobial Envelope to Prevent Infection of Implanted Cardiac Devices
$1,002,182Glenn Brunner · N8 Medical, Inc. · R44 · FY2022 · HL
Development Of New Chemotherapeutics For Tuberculosis
$1,002,104Clifton Barry · National Institute Of Allergy And Infectious Diseases · ZIA · FY2011 · AI
Rapid, Breath Volatile Metabolite-Based Diagnosis, Species Identification, and Antibiotic Resistance Profiling in Bacterial Pneumonia
$1,001,442Sophia Koo · Brigham And Women'S Hospital · R01 · FY2023 · AI
Proof of Principle Evaluation of IV Gallium Nitrate in Patients with CF
$1,001,346Christopher Hooper Goss · University Of Washington · UM1 · FY2013 · HL
Direct-from-specimen identification of pathogens common in endocarditis
$1,001,029Alon Singer · Helixbind, Inc. · R44 · FY2024 · AI
A Rapid, Point-of-Care Diagnostic to Identify Viable Sexually Transmitted Infections, Reduce Overtreatment, and Prevent Emerging Antibiotic Resistance
$1,000,723Rainer Ng · Baebies, Inc. · R44 · FY2025 · AI
Random Shear Shuttle BAC Libraries for Antimicrobial Discovery from Soil Metageno
$1,000,000Chengcang Charles Wu · Lucigen Corporation · R44 · FY2012 · AI
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** OUR PROJECT WILL INFORM THE EFFECTIVENESS OF MITIGATION STRATEGIES IN REDUCING RISK TO HUMAN HEALTH IN AGRO-ECOSYSTEMS BY DEVELOPING AN ADAPTABLE FRAMEWORK, CAMRADES, CONNECTING ANTIMICROBIAL RESISTANCE, AGRICULTURAL DECISIONS, AND ENVIRONMENTAL SYSTEMS. WE WILL INTEGRATE PREDICTIVE MODELS OF AMR TRANSPORT AND ASSOCIATED RISK TO HUMAN HEALTH, AND IMPROVE STAKEHOLDER UNDERSTANDING OF AMR, POTENTIAL RISKS AND MITIGATION STRATEGIES.OBJECTIVE 1. CHARACTERIZE AND PREDICT TRANSPORT OF AMR TARGETS VIA SURFACE AND SUBSURFACE PATHWAYS IN AGRO-ECOSYSTEMS.OBJECTIVE 2. INTEGRATE RESULTS INTO A NOVEL ADAPTABLE FRAMEWORK (CAMRADES) TO ASSESS RISK ASSOCIATED WITH TRANSPORT OF AMR THROUGH AGRICULTURAL ENVIRONMENTS TO HUMANS AS A RESULT OF AGRICULTURAL PRACTICES.OBJECTIVE 3. IMPROVE KNOWLEDGE OF AMR-RELATED RISKS AND INSPIRE ADOPTION OF PRACTICES AMONG FOOD PRODUCERS TO COMBAT AMR-RELATED HEALTH AND FOOD SAFETY RISKS ASSOCIATED WITH AGRO-ECOSYSTEMS.OUR FRAMEWORK INTEGRATES DETECTION OF ANTIBIOTICS, AMR GENES AND INDICATOR ORGANISMS AND EXPOSURE PATHWAYS IN THE ENVIRONMENT WITH HYDROLOGIC AND WATER QUALITY MONITORING. A KEY OUTPUT OF THIS EFFORT WILL BE A PREDICTIVE MODEL OF ANTIBIOTIC AND AMR SOURCES, FATE, AND TRANSPORT, WHICH WILL BE INTEGRATED WITH A NOVEL RISK ASSESSMENT. FINALLY, TO MAXIMIZE REALIZED AMR RISK REDUCTION, COMBINATIONS OF MITIGATION STRATEGIES WILL BE INFORMED BY POTENTIAL EFFICACY SCENARIOS ENCOMPASSING BARN, MANURE, AND LAND MANAGEMENT STRATEGIES AND DISSEMINATED USING THE RECOGNIZED AND TRUSTED IAMRESPONSIBLETM PROJECT PLATFORM AS WELL AS LIVESTOCK EXTENSION PROGRAMS. OUR PROJECT WILL CUMULATE WITH AN AMR SUMMIT AND AMR REDUCTION STRATEGY, A SCIENCE AND TECHNOLOGY-BASED FRAMEWORK TO REDUCE AMR IN SHARED WATER RESOURCES. WE WILL WORK CLOSELY WITH STAKEHOLDERS TO PROVIDE OPTIMAL FLEXIBILITY TO MEET PRODUCER NEEDS.
$1,000,000Iowa State University Of Science And Technology · · FY2022 · National Institute of Food and Agriculture
Direct detection and identification of antimicrobial resistance genes in bloodstream infections
$1,000,000Alon Singer · Helixbind, Inc. · R44 · FY2024 · AI
Commercialization Readiness Pilot (CRP) program support for: An Integrated Device for identification of bloodstream infections directly from blood
$1,000,000Alon Singer · Helixbind, Inc. · SB1 · FY2022 · AI
Narrow-spectrum Agents Acting against Helicobacter pylori
$1,000,000Kenneth Coleman · Arietis · R44 · FY2014 · AI
Development of Small Antimicrobial Peptide Mimics as Drug-Resistant and Susceptib
$1,000,000Richard W Scott · Fox Chase Chemical Diversity Center, Inc · R44 · FY2014 · AI
Next-generation phenotypic antimicrobial susceptibility test platform: rapid results and comprehensive menus
$1,000,000Eric Stern · Selux Diagnostics, Inc. · R44 · FY2020 · AI
A capsule-based bioconjugate vaccine to prevent Klebsiella pneumoniae infections
$1,000,000Christian Harding · Vaxnewmo, Llc · R44 · FY2025 · AI
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** DAIRY IS ONE OF THE MOST SIGNIFICANT ECONOMIC DRIVERS OF PUERTO RICO'S (PR) AGRICULTURE. WHILE DAIRY FARMS ARE DOCUMENTED TO BE RESERVOIRS FOR ANTIMICROBIAL-RESISTANT (AMR) MICROORGANISMS IN OTHER GLOBAL STUDIES, THERE HAS BEEN NO SYSTEMATIC EFFORT TO ANALYZE THE ISSUE ON THE ISLAND. ANECDOTALLY, FARMERS IN PUERTO RICO COMMONLY SELF-ADMINISTER ANTIBIOTICS TO THEIR ANIMALS TO TREAT DISEASES SUCH AS MASTITIS AND OFTEN ARE NOT RECEIVING ADVICE FROM VETERINARIANS OR COUNTY EXTENSION AGENTS CONCERNING BEST PRACTICES. IN THIS PROPOSAL, WE WILL QUANTIFY THE PREVALENCE OF ESCHERICHIA COLI AND STAPHYLOCOCCUS AUREUS, THE BACTERIA MOST COMMONLY CAUSING MASTITIS IN DAIRY COWS, ON 20 FARMS ACROSS PR. WE WILL ALSO COLLECT DATA THAT ARE MARKERS OF MILK QUALITY AND HYGIENE. WE WILL INCORPORATE 16 UNDERGRADUATES FROM THE UNIVERSITY OF PUERTO RICO ARICEBO INTO THIS RESEARCH, AND DELIVER CAREER SEMINARS THAT WE ANTICIPATE WILL LIFT UP FUTURE LEADERS IN THE AMR FIELD. DATA COLLECTED WILL BE USED TO DEVELOP EXTENSION SEMINARS TO COMMUNICATE TO PR DAIRY FARMERS THE RISK OF AMR, AND LOW COST, LOW BARRIER SOLUTIONS THEY CAN IMPLEMENT THAT WILL ADDITIONALLY IMPROVE MILK QUALITY.
$1,000,000The Pennsylvania State University · · FY2023 · National Institute of Food and Agriculture
Commercialization Readiness Pilot (CRP) program support for: An Integrated Device for identification of bloodstream infections directly from blood
$1,000,000Alon Singer · Helixbind, Inc. · SB1 · FY2023 · AI
Antibiotics for Recalcitrant Infection
$1,000,000Kenneth Coleman · Arietis · R44 · FY2017 · AI
Rapid discovery of thousands of intact biosynthetic gene pathways for bioactive natural product compounds from un-sequenced filamentous fungi using a novel FAC-NGS tool
$1,000,000Chengcang Charles Wu · Intact Genomics, Inc. · R44 · FY2020 · AI
Therapy and Prophylaxis for Genital Tract Infection
$1,000,000Dominick Auci · Therapyx, Inc. · SB1 · FY2025 · AI
NSF-RISE: Enhancement of Research and Educational Infrastructure in Nanobiomaterials Science and Engineering at Tuskegee University
$1,000,000Vijaya K Rangari · Tuskegee University · · FY2015 · EDU
HaloFilm: a spray-on, re-chargeable, re-applicable antimicrobial coating
$1,000,000Buket Demir · Halomine, Inc. · R44 · FY2023 · AI
Rapid discovery of thousands of intact biosynthetic gene pathways for bioactive natural product compounds from un-sequenced filamentous fungi using a novel FAC-NGS tool
$1,000,000Chengcang Charles Wu · Intact Genomics, Inc. · R44 · FY2021 · AI