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172,184 grants matching “inflammation”
The Development Epithelial Sodium Channel Blockers for Chronic Dry Eye
$1,059,726Karl H Donn · Parion Sciences, Inc. · R44 · FY2011 · EY
A Novel Exosomal Inflammatory Pathway
$1,059,667J. Edwin Blalock · University Of Alabama At Birmingham · R35 · FY2021 · HL
A Novel Exosomal Inflammatory Pathway
$1,059,667J. Edwin Blalock · University Of Alabama At Birmingham · R35 · FY2020 · HL
Epidemiologic Study of Hepatocellular Carcinoma in the US
$1,059,509Herbert Yu · University Of Hawaii At Manoa · R01 · FY2012 · CA
Development of Clinical Prediction Models for Pulmonary Outcomes in Sarcoidosis
$1,059,451Laura L Koth · University Of California, San Francisco · R01 · FY2023 · HL
Inhibition Of Renal Injury
$1,059,411Robert A Star · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2020 · DK
A Laser Microbeam Biotechnology Resource
$1,059,370Bruce J Tromberg · University Of California-Irvine · P41 · FY2015 · EB
Epidemiology of Age-related Hearing Loss
$1,059,323Karen J Cruickshanks · University Of Wisconsin-Madison · R37 · FY2009 · AG
Characterization Of Novel Chemokine Receptors In Lymphocytes
$1,059,248Joshua M Farber · National Institute Of Allergy And Infectious Diseases · Z01 · FY2008 · AI
Exploring roles of protein deamidation in oral inflammation
$1,059,247Pinghui Feng · University Of Southern California · R35 · FY2018 · DE
Brain fluid clearance and misfolded protein dynamics following traumatic brain injury
$1,059,115Tracy A. Butler · Weill Medical Coll Of Cornell Univ · R01 · FY2023 · AG
CHALLENGES TO ASTRONAUT HEALTH CAUSED BY SPACEFLIGHT-RELEVANT STRESSORS WILL IMPACT SIGNALING PATHWAYS BETWEEN SYSTEMS ULTIMATELY LEADING TO DEGENERATIVE CHANGES AS HOMEOSTASIS IS IMPAIRED. FOR EXAMPLE CHANGES IN THE MICROBIAL ENVIRONMENT CAN RESULT IN DRAMATIC CHANGES IN VARIOUS INTERNAL AND EXTERNAL MICROBIOMES. BOTH PSYCHOLOGICAL AND PHYSIOLOGICAL STRESS ACTIVATES THE SYMPATHETIC NERVOUS SYSTEM (SNS) AND INITIATES WIDE-RANGING PHYSIOLOGIC CHANGES. THESE CHANGES HAVE SERIOUS IMPLICATIONS ON IMMUNE FUNCTION AND THE ACTIVATION OF INFLAMMATORY PATHWAYS. WE PROPOSE TO USE CENTRIFUGATION TO CHARACTERIZE THE IMPACT OF CHRONIC CHANGES IN THE GRAVITATIONAL ENVIRONMENT ON CROSS-SYSTEM COMMUNICATION. .WE HYPOTHESIZE THAT HYPER-GRAVITY INDUCED CHANGES IN GUT MICROBIOME SNS FUNCTION AND INFLAMMATORY ACTIVITY LEAD TO A BREAKDOWN IN THE COMMUNICATION BETWEEN DISTINCT PHYSIOLOGICAL SYSTEMS (AS MEASURED BY CHANGES IN CARDIOPULMONARY CONTROL); AND THAT THESE RESPONSES DEPEND ON THE GRAVITATIONAL ENVIRONMENT. FURTHERMORE WE PROPOSE THAT THESE GRAVITY-DEPENDENT DEFICITS CAN BE COUNTERED BY A COMBINATION OF PREBIOTIC NUTRITIONAL SUPPLEMENTS THAT ARE KNOWN TO PREFERENTIALLY EXPAND STRESS PROTECTIVE BACTERIAL SPECIES..SPECIFIC AIMS .SPECIFIC AIM 1. CONFIRM THAT CENTRIFUGATION RESULTS IN DETECTABLE CHANGES IN GUT MICROBIOME AS WELL AS IN SYMPATHETIC AND INFLAMMATORY ACTIVITY INDICATIVE OF INCREASED HEALTH RISK. MICE WILL BE PLACED ON THE 8 FT DIAMETER CENTRIFUGE AT AMES RESEARCH CENTER AND EXPOSED TO 1.5 OR 2 G FOR 4 WEEKS. AFTER CENTRIFUGATION ADRENAL GLANDS BLOOD LIVER SPLEEN AND INTESTINES WILL BE COLLECTED AND ASSESSED FOR CHANGES IN SYMPATHETIC AND INFLAMMATORY ACTIVITY AS WELL AS FOR CHANGES IN MICROBIOME AS COMPARED TO MATCHED 1 G CONTROLS. .SPECIFIC AIM 2. CONFIRM THAT PROLONGED EXPOSURE TO HYPER-GRAVITY LEADS TO A BREAKDOWN IN COMMUNICATION BETWEEN DISTINCT PHYSIOLOGICAL SYSTEMS CAUSING DECREMENTS IN FUNCTION. THE SAME MICE USED IN AIM 1 WILL BE USED HERE. OUR MODEL FOCUSES ON BRAINSTEM CONTROL OF CARDIOPULMONARY FUNCTION DRIVEN PRIMARILY BY SYMPATHETIC/VAGAL INNERVATION. THE BRAINSTEM SPINAL CORD HEART AND LUNGS WILL BE COLLECTED. ANALYSIS WILL FOCUS SPECIFICALLY ON THE NUCLEUS TRACTUS SOLITARII (NTS) THE FIRST-ORDER INTEGRATIVE SITE FOR VAGAL AFFERENTS PROJECTING FROM THE GUT HEART AND LUNGS TO THE CENTRAL NERVOUS SYSTEM. THE NTS COORDINATES EFFERENT OUTPUT TO TARGETS THAT ARE CRITICAL FOR THE CONTROL OF BREATHING HEART/VASCULATURE AND GUT. IN VIVO AND IN VITRO ELECTROPHYSIOLOGY WILL BE USED TO QUANTIFY CHANGES IN SYMPATHETIC TONE AND CONFIRM THAT SYNAPTIC ACTIVITY WITHIN THE NTS IS ALTERED BY CHANGES IN MICROBIOME. IMMUNOHISTOCHEMISTRY AND RNASEQ WILL BE USED TO ASSESS CHANGES IN INFLAMMATION AND STRESS-RELATED MESSAGE ALLOWING US TO DETERMINE THE ROLE CYTOKINES AND DOWNSTREAM EFFECTORS PLAY IN MODULATING NTS NEURONAL ACTIVITY CORRELATED WITH CARDIORESPIRATORY CONTROL. .SPECIFIC AIM 3. DETERMINE THAT CENTRIFUGATION-INDUCED CHANGES IN HEALTH STATUS SIGNALING ARE LINKED TO CHANGES IN MICROBIOME. BASED ON OUR PREVIOUS FINDINGS WE HYPOTHESIZE THAT INGESTION OF A PREBIOTIC SUPPLEMENT BLEND [GALACTOOLIGOSACCHARIDES (GOS) + POLYDEXTROSE (PDX) + LACTOFERRIN + MILK FAT GLOBULE MEMBRANE PROTEIN (MFGMP)] WILL BOTH PREVENT GUT MICROBIAL DYSBIOSIS PRODUCED BY CENTRIFUGATION AND INCREASE SELECTIVE STRESS PROTECTIVE GUT BACTERIA (I.E. LACTOBACILLUS AND BIFIDOBACTERIA). PREBIOTIC-ENRICHED CHOW OR CALORICALLY MATCHED CHOW WILL BE AVAILABLE AD LIBITUM THROUGHOUT THE EXPERIMENT STARTING 1 WEEK PRIOR TO CENTRIFUGATION. MICE WILL BE PLACED ON THE 8 FT DIAMETER CENTRIFUGE AT AMES RESEARCH CENTER AND EXPOSED TO 2 G FOR 4 WEEKS. PARAMETERS DESCRIBED IN AIMS 1&2 WILL BE ASSESSED AS DESCRIBED. .
$1,058,979Loma Linda University · · FY2020 · National Aeronautics and Space Administration
Heart-Lung Micromachine for Safety and Efficacy Testing
$1,058,742Donald E Ingber · Harvard Medical School · U01 · FY2012 · NS
Characterization of Molecular Pathways in Chronic Pain Conditions
$1,058,562Ashok Kulkarni · National Institute Of Dental & Craniofacial Research · ZIA · FY2025 · DE
Evaluation of Exercise Therapy for Small AAA
$1,058,306Ronald L Dalman · Stanford University · P50 · FY2009 · HL
Systemic Inflammation in Microphysiological Models of Muscle and Vascular Disease
$1,058,270George A Truskey · Duke University · UG3 · FY2018 · TR
Critical role for Solute Carrier Proteins (SLCs) for mast cell function
$1,058,168Adrian M Piliponsky · Seattle Children'S Hospital · R01 · FY2025 · AI
Collaborative Protein Technology Resource - Nano-Scale Protein Analysis Section
$1,057,804Jinqiu Chen · Division Of Basic Sciences - Nci · ZIC · FY2020 · CA
Follow-Up Studies of a Genome-Wide Association Analysis in Pima Indians
$1,057,689Leslie J Baier · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2017 · DK
Neurovascular Unit on a Chip: Chemical Communication, Drug and Toxin Responses
$1,057,648John Peter Wikswo · Vanderbilt University · UH2 · FY2012 · TR
Interacting Signaling Pathways that Initiate Squamous Cell Carcinogenesis
$1,057,469Stuart H. Yuspa · Division Of Basic Sciences - Nci · ZIA · FY2018 · CA
Pathways that Suppress or Accelerate Premalignant Progression of Squamous Cancer
$1,057,469Stuart H. Yuspa · Division Of Basic Sciences - Nci · ZIA · FY2018 · CA
LATC Collaborative Projects
$1,057,357Alice F Tarantal · University Of California At Davis · U42 · FY2021 · OD
Physiology, Psychology, and Genetics of Obesity
$1,057,215Jack A. Yanovski · Eunice Kennedy Shriver National Institute Of Child Health & Human Development · ZIA · FY2016 · HD
Venous Window Access Catheter For Hemodialysis
$1,057,200Steven Wayne Johnson · Vital Access, Inc. · R44 · FY2009 · CA