Sort
40,608 grants matching “prostate cancer”
Hyperpolarized C-13 Diffusion MRI Measures of Cellular Transport and Metabolism
$490,000Peder Eric Zufall Larson · University Of California, San Francisco · R01 · FY2015 · EB
Biomarker Reference Laboratory, EDRN
$489,927University Of Alabama At Birmingham · U24 · FY2005 · CA
Roles of Mouse GLI Genes in Hedgehog Signaling
$489,857Alexandra L. Joyner · Sloan-Kettering Inst Can Research · R01 · FY2011 · CA
Integrated Biochip Sensors for Detection of Cancer
$489,807Rashid Bashir · University Of Illinois At Urbana-Champaign · R01 · FY2011 · CA
System for Automatic Segmentation of Male Pelvis Structures from CT Images
$489,782Edward L. Chaney · Morphormics, Inc. · R44 · FY2008 · CA
EACH YEAR, THE TOMATO PROCESSING INDUSTRY GENERATES LARGE AMOUNTS OF BYPRODUCTS THAT CONTAIN HIGH VALUE BIOACTIVE COMPOUNDS. THESE BYPRODUCTS ARE UNDERUTILIZED AND TREATED AS WASTE, WHICH ULTIMATELY CREATES DISPOSAL PROBLEMS AND NEGATIVELY IMPACTS THE ENVIRONMENT. AMONG THE BIOACTIVE COMPOUNDS IN THE TOMATO WASTES, CAROTENOIDS, PARTICULARLY LYCOPENE, HOLD GREAT POTENTIAL TO COMBAT DISEASES SUCH AS CARDIOVASCULAR DISEASES AND LOWER THE RISK OF PROSTATE, LUNG, AND STOMACH CANCERS. HOWEVER, IN ORDER TO ISOLATE LYCOPENE FROM ITS SOURCE AND CONVERT IT INTO A USEFUL FORM, THREE CHALLENGES MUST FIRST BE ADDRESSED: I) BECAUSE LYCOPENE IS LIPOPHILIC (I.E., WATER-INSOLUBLE), ITS EXTRACTION REQUIRES THE USE OF HAZARDOUS AND TOXIC ORGANIC SOLVENTS, II) LYCOPENE DEGRADES EASILY IN THE PRESENCE OF LIGHT AND OXYGEN, AND III) LYCOPENE HAS LOW BIOAVAILABILITY. NATURAL LYCOPENE IS EXPENSIVE AND CAN BE OBTAINED FROM TOMATOES; THEREFORE, COMMERCIAL LYCOPENE IS MOSTLY OBTAINED FROM CHEMICAL SYNTHESIS. HOWEVER, IN RECENT YEARS, INCREASING DEMAND FOR NATURAL PRODUCTS HAVE NEGATIVELY IMPACTED THE ACCEPTABILITY OF FOOD OR PHARMACEUTICAL PRODUCTS CONTAINING ARTIFICIAL INGREDIENTS, AND IN RESPONSE, INDUSTRY HAS PLACED A HIGH PRIORITY ON THE UTILIZATION OF NATURAL BIOACTIVE COMPOUNDS. THE DEMAND FOR NATURAL LYCOPENE HIGHLIGHTS THAT THE CURRENT PRODUCTION FROM WHOLE TOMATO FRUITS IS SMALL AND NEEDS TO BE INCREASED. THEREFORE, THERE IS A CRITICAL NEED FOR SIMPLE, EFFICIENT, AND CLEAN METHODS TO ISOLATE LYCOPENE FROM ALTERNATIVE NATURAL SOURCES AND THEN CONVERT IT INTO EASY-TO-USE, STABLE AND BIOAVAILABLE FORMS. IN THE ABSENCE OF SUCH METHODS, THE OPPORTUNITY TO ISOLATE LYCOPENE AND TRANSFORM IT INTO USEFUL FORMS FOR EFFICIENTLY IMPROVING HUMAN HEALTH WILL REMAIN UNTAPPED. OUR LONG-TERM GOAL IS TO DEVELOP AN INTEGRATED, GREEN BIOREFINERY APPROACH BASED ON SUPERCRITICAL CARBON DIOXIDE (SC-CO2) TECHNOLOGY TO UTILIZE TOMATO PROCESSING WASTES TO OBTAIN HIGH VALUE FRACTIONS AND PRODUCTS TO BE USED IN THE PHARMACEUTICAL, NUTRACEUTICAL, FOOD, AND COSMETIC INDUSTRIES. THE OBJECTIVE OF THIS PROJECT IS TO DEVELOP AN INTEGRATED EXTRACTION-REACTION-PARTICLE FORMATION PROCESS THAT CAN SEPARATE AND ENRICH LYCOPENE IN A MORE BIOAVAILABLE FORM FROM TOMATO PROCESSING WASTES, NAMELY, TOMATO SEED AND PEEL, AND THEN CONVERT IT TO A HIGH VALUE LYCOPENE FORMULATION, WHILE ELIMINATING THE USE OF TOXIC SOLVENTS AND MINIMIZING WASTE GENERATION. THE SPECIFIC OBJECTIVES OF THE PROJECT ARE: (1) CONVERT TRANS-LYCOPENE TO CIS-LYCOPENE TO OBTAIN A CIS-LYCOPENE-RICH OLEORESIN FROM TOMATO PROCESSING INDUSTRY WASTE USING SC-CO2 AND OPTIMIZE THE SC-CO2 EXTRACTION VIA MATHEMATICALLY MODELING; (2) INTEGRATE SC-CO2 EXTRACTION WITH A CONTINUOUS SC-CO2 ENZYME REACTOR TO ENRICH THE CIS-LYCOPENE IN THE SC-CO2-EXTRACTED OLEORESIN; (3) INTEGRATE THE SC-CO2 EXTRACTION-REACTION PROCESS WITH A SC-CO2-BASED PARTICLE FORMATION PROCESS TO DEVELOP CIS-LYCOPENE-LOADED HOLLOW SOLID LIPID MICROSPHERES, AND PERFORM UP SCALED PROCESS MODELLING, AND COST OPTIMIZATION. THE EXPECTED OUTCOME IS THE DEVELOPMENT OF A NOVEL PROCESS TO FORM A HIGH VALUE PRODUCT FROM TOMATO WASTE. THIS RESEARCH WILL INTRODUCE A NOVEL, ONE-STEP EXTRACTION-REACTION-PARTICLE FORMATION PROCESS THAT CAN SEPARATE A COMPOUND FROM ITS SOURCE, THEN PURIFY AND CONVERT IT INTO A SOLID POWDER FORM FOR VARIOUS APPLICATIONS. THE NOVEL PARTICLE FORMATION METHOD WILL BE AN ALTERNATIVE PROCESS TO FORM LIPID-BASED BIOACTIVE DELIVERY SYSTEMS. IN THE LONG-TERM, THE PROJECT WILL MAXIMIZE THE UTILIZATION OF THE BIOACTIVES DERIVED FROM AGRICULTURAL PRODUCTS AND PROMOTE THE DEVELOPMENT OF INTEGRATED GREEN BIOREFINERIES. WE ANTICIPATE THIS NOVEL APPROACH WILL REDUCE BIOACTIVE WASTE AND WATER AND ENERGY CONSUMPTION USED TO PRODUCE BIOACTIVES. THIS WOULD BE A SIGNIFICANT ADVANCE, PARTICULARLY BECAUSE THE PROPOSED PROCESS IS GREEN - I.E., IT DOES NOT USE TOXIC CHEMICALS AND SOLVENTS AND PRODUCES NO ENVIRONMENTAL POLLUTION. THE HEALTH BENEFITS OF LYCOPENE WILL BE INCREASED DUE TO CONVERSION OF TRANS-LYCOPENE INTO THE CIS FORM DURING PROCESSING, AND IT WILL HAVE AN IMPROVED STORAGE LIFE WITHOUT DEGRADATION. THE POWDER FORM OF OUR LYCOPENE END PRODUCTS WILL ALSO MAKE ITS HANDLING, STORAGE, AND TRANSPORTATION MORE CONVENIENT.
$489,781Board Of Regents Of The University Of Nebraska · · FY2018 · National Institute of Food and Agriculture
Genetic variability in DHFR and folic acid supplementation as novel risk factors for aggressive prostate cancer
$489,650Ping-Ching Hsu · Univ Of Arkansas For Med Scis · R15 · FY2018 · CA
Image-guided radiation-induced permeability (IGRIP) for IGDD
$489,602Stephen J. Kron · University Of Chicago · R01 · FY2018 · CA
Image guided targeted biopsy of clinically significant prostate cancer with acoustic radiation force
$489,592Kathryn R Nightingale · Duke University · R01 · FY2019 · CA
The development of novel radiation-sensitizer based on ultra-small carbon dots
$489,570Zibo Li · Univ Of North Carolina Chapel Hill · R01 · FY2022 · CA
G3BP1 Suppresses SPOP Ubiquitin Ligase to Promote Prostate Tumorigenesis
$489,569Pengbo Zhou · Weill Medical Coll Of Cornell Univ · R01 · FY2018 · CA
Molecular Dissection of Benign Prostatic Hyperplasia
$489,566Brigham And Women'S Hospital · U01 · FY2002 · AG
Vitamin D and Prostate Cancer: Biomarkers and Genetic Variation
$489,539Marian L Neuhouser · Fred Hutchinson Cancer Research Center · R01 · FY2011 · CA
A New Rapid DNA Platform for Neonatal Sepsis Diagnostics
$489,497Dalibor Hodko · Nexogen, Inc. · R44 · FY2019 · HD
TECHNIQUE DEVELOPMENT FOR HYPERPOLARIZED C-13 MR STUDIES
$489,479Daniel B Vigneron · University Of California, San Francisco · R01 · FY2008 · EB
Salicylic acid-based small-molecule Stat3 inhibitors for anticancer therapy
$489,360James K Turkson · University Of Hawaii At Manoa · R01 · FY2012 · CA
The development of novel radiation-sensitizer based on ultra-small carbon dots
$489,318Zibo Li · Univ Of North Carolina Chapel Hill · R01 · FY2023 · CA
Focal HIFU Ablation of Prostate Cancer Using Advanced Ultrasound Guidance
$489,178Ernest Joseph Feleppa · Riverside Research Institute · R01 · FY2012 · CA
Understanding the influence of bone-metastatic prostate cancer and mesenchymal stromal cells on γδ T cells, in the bone microenvironment.
$489,115Daniel Abate-Daga · H. Lee Moffitt Cancer Ctr & Res Inst · R01 · FY2022 · CA
Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study
$489,073Demetrius Albanes · Division Of Cancer Epidemiology And Genetics · ZIA · FY2021 · CA
NYU COOPERATIVE PROSTATE CANCER TISSUE RESOURCE
$489,066New York University School Of Medicine · U01 · FY2003 · CA
Engagement Optimization Unit
$489,066Jennifer W Mack · Broad Institute, Inc. · U2C · FY2024 · CA
The Role of Collagen and its Signaling Mechanisms in Glioma Progression and Invasion.
$489,027Pedro R Lowenstein · University Of Michigan At Ann Arbor · R01 · FY2024 · NS
Cheap and fast ambient air monitoring of pesticides
$489,002Nuria Queralto-Gratacos · Isense, Llc · R44 · FY2015 · ES
QUANTITATIVE DUAL-ENERGY CT IMAGING FOR CANCER IMAGING AND RADIATION THERAPY APPLICATIONS
$488,888Joseph A O'Sullivan · Washington University · R01 · FY2017 · CA