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16,300 grants matching “fatty liver disease”
Growth hormone inhibition in severe insulin resistance
$294,733Rebecca Brown · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2024 · DK
Preclinical Therapeutics
$294,597Frank Patrick McCormick · University Of California, San Francisco · P30 · FY2016 · CA
Molecular Mechanisms of Lipid Droplet Biogenesis
$294,596James A Olzmann · University Of California Berkeley · R01 · FY2016 · GM
Epigenetic and Expression Analysis of PCOS
$294,122Andrea Dunaif · Northwestern University At Chicago · P50 · FY2014 · HD
Pathophysiology and Characterisation of NAFLD
$294,078Michael R Charlton · Mayo Clinic Rochester · R01 · FY2008 · DK
Role of SAMe in Pathogenesis and Treatment of Non-Alcholic Fatty Liver Disease
$294,016Shelly Chi-Loo Lu · Cedars-Sinai Medical Center · R01 · FY2018 · AT
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** DIETARY INCORPORATION OF PULSE CROPS MAY BE AN EFFECTIVE WAY TO LOWER UNHEALTHY ELEVATIONS IN SERUM BILE ACIDS. THESE ELEVATIONS PLAY A DIRECT ROLE IN PROMOTING OBESITY RELATED DISEASES ESTIMATED TO BE PRESENT IN ABOUT 1/3 OF THE US ADULT POPULATION, INCLUDING NON-ALCOHOLIC FATTY LIVER DISEASE AND TYPE 2 DIABETES. OUR OVERARCHING HYPOTHESIS IS THAT PULSE CONSUMPTION INCREASES BILE ACID SECRETION AND EXCRETION, WHICH WILL DECREASE TOXICITY LINKED TO EXCESS ACCUMULATION OF BILE IN THE LIVER, IMPROVE METABOLISM, AND LOWER RESULTING LEVELS OF BILE ACIDS IN THE SERUM. IN DIRECT ALIGNMENT WITH THE USDA-AFRI FOOD, SAFETY, NUTRITION, AND HEALTH PRIORITY TO ADDRESS OBESITY AND RELATED CHRONIC DISEASE WITH INCREASED FRUIT AND VEGETABLE CONSUMPTION AND ALSO WITH THE AMERICAN PULSE ASSOCIATION CALL TO INVESTIGATE THE IMPACT OF REGULAR PULSE CONSUMPTION ON HUMAN PHYSICAL WELL-BEING, OUR LONG-TERM RESEARCH GOAL IS TO ESTABLISH EFFECTIVE AND PRACTICAL THERAPEUTIC STRATEGIES UTILIZING DIETARY INCORPORATION OF PULSE CROPS TO PREVENT OR REVERSE OBESITY DRIVEN DISEASES. OUR SPECIFIC OBJECTIVES IN THIS PROPOSAL ARE TO 1) DETERMINE THE IMPACT OF ACUTE LENTIL INGESTION ON SERUM POSTPRANDIAL BILE ACID RESPONSES AND COMPOSITION IN A HUMAN COHORT WITH OBESITY, AND 2) DETERMINE THE IMPACT OF DAILY LENTIL CONSUMPTION FOR 12 WEEKS ON SERUM FASTING AND POSTPRANDIAL BILE ACID CONCENTRATIONS AND COMPOSITION IN AN OVERWEIGHT OR OBESE COHORT WITH ELEVATED POSTPRANDIAL TRIGLYCERIDES. THIS PROPOSAL IS BEING SUBMITTED IN RESPONSE TO THE AMERICAN PULSE ASSOCIATION COMMODITY BOARD SPONSERED TOPIC OF INVESTIGATING THE IMPACT PULSE CROP CONSUMPTION ON HEALTH.
$294,000Montana State University · · FY2021 · National Institute of Food and Agriculture
Inborn Errors of Long Chain Fat Metabolism
$293,913Gerard Vockley · University Of Pittsburgh At Pittsburgh · R01 · FY2010 · DK
Role of IKK-beta/NF-kappaB in hypothalamic dysregulation of energy balance
$293,896Dongsheng Cai · University Of Wisconsin-Madison · R01 · FY2008 · DK
Novel Adipose Targeted Gene Therapy for Lipodystrophy
$293,842Al Hawkins · Zvelt Therapeutics Inc. · R41 · FY2023 · DK
Molecular Mechanisms of Lipid Droplet Biogenesis
$293,833James A Olzmann · University Of California Berkeley · R01 · FY2017 · GM
TAK1 regulation of metabolism
$293,796Jun Ninomiya-Tsuji · North Carolina State University Raleigh · R01 · FY2015 · GM
Nrf2 as a Master Regulator in Liver Disease Prevention and Therapy
$293,796Curtis Dean Klaassen · University Of Kansas Medical Center · R01 · FY2011 · DK
Pathophysiology and Characterisation of NAFLD
$293,657Michael R Charlton · Mayo Clinic Rochester · R01 · FY2009 · DK
CONTROL OF DRUG AND ETHANOL METABOLISM
$293,622University Of Louisville · R01 · FY2002 · AA
Novel targets that are deregulated by loss of PTEN
$293,578Deborah Johnson · Baylor College Of Medicine · R01 · FY2015 · CA
SUBSTRATE CYCLING IN ENERGY METABOLISM
$293,553University Of Texas Medical Br Galveston · R01 · FY2002 · DK
Structurally engineered N-acyl amino acids for the treatment of NASH
$293,543Francisco Jose Schopfer · Furanica, Inc. · R41 · FY2023 · DK
Regulation of glucose homeostasis by C/EBPB
$293,524Jacob E Friedman · University Of Colorado Denver · R01 · FY2008 · DK
GQ/11-RGS Mediated Signaling
$293,461Thomas M Wilkie · Ut Southwestern Medical Center · R01 · FY2007 · GM
GQ/11-RGS Mediated Signaling
$293,461Thomas M Wilkie · Ut Southwestern Medical Center · R01 · FY2009 · GM
GQ/11-RGS Mediated Signaling
$293,461Thomas M Wilkie · Ut Southwestern Medical Center · R01 · FY2008 · GM
TAK1 regulation of metabolism
$293,394Jun Ninomiya-Tsuji · North Carolina State University Raleigh · R01 · FY2016 · GM
Regulation of glucose homeostasis by C/EBPB
$293,335Jacob E Friedman · University Of Colorado Denver · R01 · FY2009 · DK
Subcutaneous Drug Development for Portal Hypertension Ascites
$293,272Gerardo M. Castillo · Pharmain Corporation · R43 · FY2014 · DK