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15,273 grants matching “antimicrobial resistance”
PGA exopolysaccharide in biofilm formation and pathogenicity of Aggregatibacter a
$238,120Narayanan Ramasubbu · Rbhs-School Of Dental Medicine · R01 · FY2013 · DE
Insights from Comparative Genomics for the Treatment of Pneumococcal Infections
$238,055Natalia Luisa Hiller · Carnegie-Mellon University · R00 · FY2014 · DC
Identifying polyamine dependent mechanisms in pneumococcal pneumonia
$238,007Bindu Nanduri · Mississippi State University · P20 · FY2014 · GM
Ampetoids as Biostable Functional Mimics of Antimicrobial Peptides
$237,938Annelise Emily Barron · Northwestern University · R01 · FY2007 · AI
Mechanisms of Haemophilus influenzae pathogenesis in the lung
$237,927Brian J. Akerley · Univ Of Massachusetts Med Sch Worcester · R01 · FY2012 · AI
Antimicrobial activity of pH-activated polypeptides toward H. pylori
$237,900Lin-Feng Chen · University Of Illinois At Urbana-Champaign · R21 · FY2016 · AI
Harnessing the acid-base cellular machinery of intercalated cells in the bacterial defense of the kidney
$237,750Andrew Lawrence Schwaderer · Indiana University Indianapolis · R01 · FY2022 · DK
Analysis of Novel Acinetobacter baumannii Adhesins
$237,750Anthony A Campagnari · State University Of New York At Buffalo · R21 · FY2012 · AI
IFNGR Down Regulation as a Host Target for Therapy of Infectious Diseases
$237,750Laurel L Lenz · National Jewish Health · R21 · FY2012 · AI
Type III Secretion Translocon Structure and Function
$237,750Arne Rietsch · Case Western Reserve University · R21 · FY2014 · AI
Harnessing the acid-base cellular machinery of intercalated cells in the bacterial defense of the kidney
$237,750Andrew Lawrence Schwaderer · Indiana University Indianapolis · R01 · FY2023 · DK
Health and Environmental Impacts of a Citywide Sanitation Intervention in Indiana
$237,750Drew Capone · Trustees Of Indiana University · R21 · FY2025 · AI
Glutamine metabolism in tuberculosis
$237,704Lanbo Shi · Rbhs-New Jersey Medical School · R21 · FY2022 · AI
Complement-independent role of C4 binding protein in gonococcal survival from human neutrophils
$237,521Alison K Criss · University Of Virginia · R21 · FY2022 · AI
Characterization of an infant rabbit model of bacillary dysentery
$237,521Herve F Agaisse · University Of Virginia · R21 · FY2020 · AI
Defining the bacterial factors that modulate sensitivity to B-lactam in CA-MRSA
$237,452Ambrose L. Cheung · Dartmouth College · R21 · FY2010 · AI
Bacterial acyl homoserine lactones as immune modulators and drug targets
$237,375Gunnar Joerg Floris Kaufmann · Scripps Research Institute, The · R21 · FY2010 · AI
Asymptomatic Bacteriuria & Risk of Urinary Tract Infection in Renal Transplants
$237,375James Carter Rice · Scripps Research Institute, The · R21 · FY2010 · DK
Mycoplasma genitalium Susceptibility and Treatment
$237,326Lisa E Manhart · University Of Washington · U19 · FY2008 · AI
Optimization of novel inhibitors of mycolic acid synthesis as TB drug candidates.
$237,288Kyle H Rohde · University Of Central Florida · R21 · FY2024 · AI
Project 3: Immunoassays for Human and Environmental Monitoring
$237,257Bruce D Hammock · University Of California At Davis · P42 · FY2011 · ES
Predictions of Response to Treatment in Fungal Keratitis
$237,249Jennifer Rose-Nussbaumer · University Of California, San Francisco · K23 · FY2017 · EY
PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV) CAUSES THE MOST COSTLY DISEASE TO SWINE PRODUCTION IN THE UNITEDSTATES. DISEASE CAUSED BY THIS VIRUS OFTEN INVOLVES SECONDARY BACTERIAL PATHOGENS, WHICH EXACERBATES RESPIRATORY DISEASE ANDINCREASES ANTIMICROBIAL ADMINISTRATION IN YOUNG GROWING PIGS. ALTHOUGH COMMERCIAL VACCINES ARE USED TO REDUCE THE EFFECTS OFPRRSV ON SWINE HEALTH, THE CURRENTLY AVAILABLE VACCINES ARE CONSIDERED INADEQUATE FOR DISEASE CONTROL. ALTERNATIVE STRATEGIESFOR CONTROL OF PRRSV IS NEEDED TO MAINTAIN SWINE HEALTH AND WELFARE WHILE LESSENING THE ECONOMIC EFFECTS OF THIS DISEASE ONPORK PRODUCERS. THE GOAL OF THIS WORK IS TO INVESTIGATE THE GUT MICROBIOME AS AN ALTERNATIVE TOOL FOR PRRSV CONTROL DUE TO ITSIMPACT ON THE IMMUNE SYSTEM AND OUTCOME AFTER INFECTION. OBJECTIVES OF THE WORK INCLUDE INVESTIGATING THE EFFECTS OFMICROBIOME MODULATION ON OUTCOME OF SWINE WITH RESPIRATORY DISEASE AND IDENTIFYING WHAT BENEFICIAL MICROBES ARE ASSOCIATEDWITH IMPROVED HEALTH. WE ANTICIPATE THE DATA GENERATED IN THIS PROJECT WILL ALLOW US TO CHARACTERIZE AND DETERMINE THE GUTMICROBES WHICH IMPROVE PIG HEALTH IN THE PRESENCE OF PRRSV. OUR GOAL IS TO DETERMINE HOW BENEFICIAL GUT MICROBES MAY BEUSED AS A PREVENTATIVE MEDICINE TOOL TO REDUCE THE EFFECTS OF RESPIRATORY DISEASE AND DECREASE THE NEED FOR ANTIMICROBIALS INSWINE. THE IMPACTS OF THIS WORK WILL IMPROVE ANIMAL WELFARE AND ANIMAL HEALTH, LESSEN THE ECONOMIC LOSSES TO PRODUCERSASSOCIATED WITH PRRSV, AND REDUCE THE RISK OF ANTIMICROBIAL RESISTANCE IN SWINE.
$237,204Regents Of The University Of Minnesota · · FY2024 · National Institute of Food and Agriculture
The molecular basis of the epidemic blaKPC gene Klebsiella
$237,188Barry Neal Kreiswirth · Univ Of Med/Dent Of Nj-Nj Medical School · R01 · FY2011 · AI
In Vitro Glycorandomization of Natural Products
$237,082Jon Scott Thorson · University Of Wisconsin-Madison · R01 · FY2010 · AI