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34,240 grants matching “atherosclerosis”
Diet-Induced Insulin Resistance and Myocardial Ischemia in Pigs
$472,891Gregory G Schwartz · University Of Colorado Denver · R01 · FY2009 · HL
Inflammation in Vascular Injury and Repair
$472,847Daniel I Simon · Case Western Reserve University · R37 · FY2012 · HL
Beyond the Glomerulus: Novel Clinical Markers of Kidney Health and Prognosis
$472,837Mark J Sarnak · Tufts Medical Center · U01 · FY2020 · DK
DATA MANAGEMENT/ANALYTICAL CORE
$472,818Konstantin G Arbeev · Duke University · P01 · FY2014 · AG
Nlrp3 inflammasome activation in early diabetic retinopathy
$472,784Jayakrishna Ambati · University Of Virginia · R01 · FY2024 · EY
Nlrp3 inflammasome activation in early diabetic retinopathy
$472,784Jayakrishna Ambati · University Of Virginia · R01 · FY2023 · EY
Yeast-based HTS Assay Technologies for Proteases
$472,725John C Reed · Sanford Burnham Prebys Medical Discovery Institute · R01 · FY2010 · AI
RECENT STUDIES INDICATE GUT MICROBIOTA IS INVOLVED IN DEVELOPMENT OF CARDIOVASCULAR DISEASE. GUT MICROBIOTA TRANSFORM CHOLINE AND CARNITINE, COMMONLY FOUND IN MEAT OR EGG YOLK, TO TRIMETHYLAMINE (TMA), WHICH CAN THEN BE CONVERTED INTO TRIMETHYLAMINEN-OXIDE (TMAO) BY HEPATIC ENZYMES. TMAO ACCELERATES ATHEROSCLEROSIS AND IS ASSOCIATED WITH MAJOR ADVERSE CARDIAC EVENTS. THERE IS SOLID REASONING FOR INVESTIGATING ORANGE PEEL TO MODULATE GUT MICROBIOTA SUBSEQUENTLY INHIBITING TMAO FORMATION: 1) OUR PRELIMINARY STUDY SHOWED ORANGE PEEL CAN INHIBIT TMAO FORMATIONIN VIVOVIAALTERATION OF GUT MICROBIOTA AS WELL AS INHIBIT A MICROBIAL CARNITINE-SPECIFIC TMA ENZYME TO PREVENT CARNITINE TRANSFORMING INTO TMAIN VITRO. 2) APPROXIMATELY FIVE MILLION TONS OF ORANGE PEEL ARE GENERATED ANNUALLY IN THE US; 3) NATURAL ORANGE PEEL EXTRACTS ARE CONSIDERED SUBSTANCES GENERALLY RECOGNIZED AS SAFE (GRAS) BY THE FDA; 4) INCREASED USAGE OF ORANGE PEEL DIRECTED AT IMPROVING HEART HEALTH COULD POTENTIALLY PROVIDEADDITIONAL ECONOMIC RETURNS BENEFITING US AGRICULTURE AND FOOD SYSTEMS. THE HYPOTHESES OF THIS PROJECT ARE ORANGE PEEL CAN EFFECTIVELY PREVENT DEVELOPMENT OF ATHEROSCLEROSIS VIA MODIFYING GUT MICROBIOTA, AND ORANGE PEEL CONTAINS BIOACTIVE COMPONENTS THAT INTERFERE WITH ACTIVITY OF CARNITINE-SPECIFIC TMA ENZYMES. TO TEST THESE HYPOTHESES, OUR INTERDISCIPLINARY TEAM WILL COMBINE ANIMAL STUDIES AND NATURAL PRODUCTS CHEMISTRY WITHIN VITROENZYME ASSAYS TO ASSESS PATHWAYS ASSOCIATED WITH ORANGE PEEL CONSUMPTION, TMA/TMAO METABOLISM AND PREVENTION OF ATHEROSCLEROSIS AS WELL AS IDENTIFY TMA INHIBITORS, RESPECTIVELY.
$472,623University Of Florida · · FY2019 · National Institute of Food and Agriculture
Developmental immune programming and postnatal atherosclerosis
$472,614Wulf Palinski · University Of California, San Diego · R01 · FY2011 · HL
Mechanisms controlling skeletal muscle mitochondrial function and metabolic health
$472,546Andrea L Hevener · University Of California Los Angeles · R01 · FY2018 · DK
WASHINGTON UNIVERSITY CLINICAL NUTRITION RESEARCH UNIT
$472,500Washington University · P30 · FY2005 · DK
Shear Stress Activation of Endothelial Membrane Function
$472,500John A Frangos · La Jolla Bioengineering Institute · R37 · FY2010 · HL
Shear Stress Activation of Endothelial Membrane Function
$472,500John A Frangos · La Jolla Bioengineering Institute · R37 · FY2009 · HL
Shear Stress Activation of Endothelial Membrane Function
$472,500John A Frangos · La Jolla Bioengineering Institute · R37 · FY2011 · HL
Advanced Non Invasive Vascular Imaging Methods
$472,436Ahmed Gharib · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2014 · DK
Deriving Bone Density from Thoracic CT Scans, STTR Phase II
$472,431Mike Allen · Bdi, Inc. · R42 · FY2018 · AR
The Lipid Protein Family and Triglyceride Metabolism
$472,413Karen Reue · University Of California Los Angeles · P01 · FY2009 · HL
Novel Pathways for Triglyceride Storage and Adipogenesis
$472,413Peter J Tontonoz · University Of California Los Angeles · P01 · FY2009 · HL
Chlorinated lipids in sepsis
$472,410David A. Ford · Saint Louis University · R01 · FY2015 · GM
Molecular Function of Chemoattractant-Mediated Signaling
$472,398Dianqing Wu · Yale University · R01 · FY2007 · HL
Novel Approaches for Improving Inflammation Resolution Following Chronic Exposure to Air Pollutants
$472,252Srinivasa Reddy · University Of California Los Angeles · R01 · FY2023 · ES
POST-DPP FOLLOW-UP STUDY
$472,238University Of Texas Hlth Sci Ctr San Ant · U01 · FY2004 · DK
Lifecourse determinants and outcomes of epigenetic age acceleration across two generations
$472,163Christopher Kuzawa · Northwestern University · R01 · FY2022 · AG
Neurotoxicity of Airborne Particles: Role of Chronic Cerebral Hypoperfusion
$472,053William J Mack · University Of Southern California · R01 · FY2017 · ES
Endothelial NOS by protein to protein interactions
$471,983William C. Sessa · Yale University · R37 · FY2014 · HL