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15,273 grants matching “antimicrobial resistance”
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** ANTIMICROBIAL RESISTANCE (AMR) IS A SIGNIFICANT PUBLIC HEALTH THREAT, AND THE USE OF ANTIMICROBIALS IN FOOD PRODUCING ANIMALS HAS RECEIVED A GREAT AMOUNT OF SCRUTINY. ADDRESSING AMR IS A HIGH PRIORITY FOR BOTH ANIMAL AGRICULTURE AS WELL AS THE PUBLIC HEALTH SINCE MANY OF THE MEDICALLY IMPORTANT ANTIMICROBIALS ARE USED TO TREAT OR PREVENT INFECTIONS IN ANIMALS. BOVINE RESPIRATORY DISEASE (BRD) IS A MAJOR REASON FOR THE METAPHYLACTIC USE OF ANTIMICROBIALS IN THE BEEF INDUSTRY AND HAS MAJOR ECONOMIC AND ANIMAL HEALTH AND WELFARE IMPLICATIONS. A NUMBER OF MEDICALLY IMPORTANT ANTIBIOTICS ARE WIDELY USED IN THE TREATMENT AND PREVENTION OF BRD IN CATTLE. THEREFORE, BRD TREATMENT AND CONTROL ARE A MAJOR CONCERN FOR EMERGENCE AND DISSEMINATION OF AMR. THE GOAL OF THE PROPOSED PROJECT IS TO GENERATE DATA ON THE IMPACT OF CHLORTETRACYCLINE (CTC) PLUS MACROLIDE ANTIMICROBIAL COMBINATION ON ANIMAL HEALTH AND PERFORMANCE AND TO DEVELOP MITIGATION STRATEGIES WITH THE GOAL TO REDUCE THE USE OF ANTIMICROBIAL METAPHYLAXIS IN BEEF CATTLE. TREATMENT CHOICES CAN DRIVE PATTERNS OF AMR PREVALENCE. METAPHYLACTIC ADMINISTRATION OF IN-FEED CHLORTETRACYCLINE (CTC) AND INJECTABLE MACROLIDE ARE COMMONLY USED IN THE FEEDLOT INDUSTRY TO CONTROL BRD AND OTHER INFECTIONS.WE SEEK TO GUIDE MITIGATION STRATEGIES TOWARD A GOAL OF REDUCING THE USE OF ANTIMICROBIAL METAPHYLAXIS IN FEEDLOT CATTLE. A FIELD STUDY WITH HIGH-RISK CALVES IN A COMMERCIAL FEEDYARD IS PROPOSED FOR EVALUATING IN-FEED CTC (ONE AND TWO PULSES) WITH INJECTABLE TULATHROMYCIN AS METAPHYLAXIS. FECAL, NASAL, FEED, AND WATER SAMPLES WILL BE COLLECTED FROM EACH PEN OF CATTLE ON DAYS 0, 6, 12, 28, AT REIMPLANT, AND PRIOR TO CLOSEOUT FOR ANALYSES TO DETERMINE PREVALENCE, ABUNDANCE OF TETRACYCLINE AND MACROLIDE RESISTANCE GENES, AND ANTIMICROBIAL SUSCEPTIBILITY PATTERNS OF BRD PATHOGENS, GUT COMMENSALS AND FOODBORNE PATHOGENS. A SUBSET OF THE SAMPLES WILL BE SUBJECTED TO SHOTGUN METAGENOMICS ANALYSIS TO IDENTIFY BACTERIAL COMMUNITY COMPOSITION AND AMR GENES (RESISTOME).WE WILL SURVEY FEEDLOT MANAGERS TO IDENTIFY METAPHYLAXIS PRACTICES, ANTIMICROBIAL RESISTANCE PERCEPTIONS, AND POTENTIAL KNOWLEDGE GAPS. RESULTS FROM THE FIELD STUDY WILL BE INCORPORATED INTO TRAINING AND OUTREACH MATERIALS FOR FEEDLOT PRODUCERS, NUTRITIONISTS, VETERINARIANS, STAKEHOLDERS, REGULATORY AGENCIES, AND CONSUMERS TO RECOMMEND ANTIMICROBIAL USE PRACTICES, ANTIMICROBIAL RESISTANCE AND EFFECTIVE MITIGATION STRATEGIES IN FEEDLOT CATTLE. THE PROPOSED STUDY ADDRESSES THE GOALS OF THE PROGRAM PRIORITY AREA TO SPECIFICALLY DESCRIBE AND QUANTIFY THE RISK OF AMR PATHOGENS AND ALSO TO DETERMINE IMPROVED, BEST-MANAGEMENT PRACTICES AND APPROACHES IN ANTIBIOTIC STEWARDSHIP.
$999,999Kansas State University · · FY2023 · National Institute of Food and Agriculture
A new class of antibiotic to address Antimicrobial Resistance
$999,998Charles Testa · Curza Inc · R44 · FY2024 · AI
Human Monoclonal Antibody To Treat P. aeruginosa Infections in Cystic Fibrosis
$999,998Eric John Patzer · Aridis Pharmaceuticals, Llc · R42 · FY2013 · AI
Human Monoclonal Antibody To Treat P. aeruginosa Infections in Cystic Fibrosis
$999,998Eric John Patzer · Aridis Pharmaceuticals, Llc · R42 · FY2012 · AI
Therapy Against Recalcitrant C. albicans Infection
$999,998Thomas A Dahl · Arietis · R44 · FY2011 · AI
A new class of antibiotic to address Antimicrobial Resistance
$999,997Charles Testa · Curza Inc · R44 · FY2025 · AI
Rapid dissection of the biosynthesis of antiMRSA antibiotics produced in co-culture by extremophilic fungi through the development of Fungal Artificial Chromosomes
$999,997Chengcang Charles Wu · Intact Genomics, Inc. · R44 · FY2022 · AI
Antimicrobial Treatment to Combat Wound Biofilm
$999,993Jennifer Ann Neff · Allvivo Vascular, Inc. · R44 · FY2024 · AI
Preclinical development of Novo29, a new antibiotic
$999,992Losee Lucy Ling · Novobiotic Pharmaceuticals, Llc · R44 · FY2019 · AI
Next-generation phenotypic antimicrobial susceptibility test platform: rapid resultsand comprehensive menus
$999,992Eric Stern · Selux Diagnostics, Inc. · SB1 · FY2021 · AI
Development of a Novel Oral Antibiotic for the Treatment of Drug Resistant Gonorrhea
$999,991Laurene Wang · Aimmax Therapeutics, Inc. · R44 · FY2024 · AI
NSF Engines Development Award: Advancing biosecurity, biodefense, and biomanufacturing technologies (KS, MO)
$999,990Beth A Montelone · Kansas State University · · FY2023 · TIP
Aminoglycosides with reduced ototoxicity
$999,986Dev Priya Arya · Nubad, Llc · R42 · FY2021 · AI
Antimicrobial Treatment to Combat Wound Biofilm
$999,985Jennifer Ann Neff · Allvivo Vascular, Inc. · R44 · FY2025 · AI
Development of peptide nucleic acid antibiotics
$999,985Dev Priya Arya · Nubad, Llc · R42 · FY2021 · AI
AQUAPONIC SYSTEMS ENABLE SIMULTANEOUS CULTURE OF LARGE QUANTITIES OF FISH AND PLANTS WITH LIMITED WATER AND NUTRIENT RESOURCES. THUS, THE AQUAPONIC SYSTEMS HIGHLIGHT THE PROMISE OF SUSTAINABLE AGRICULTURE FOR BOTH PLANT AND SEAFOOD PRODUCTION. HOWEVER, THERE ARE POTENTIAL RISKS. THESE RISKS ARE ASSOCIATED WITH THE TRANSFER OF PATHOGENS FROM THE FISH TO THE PLANT AND THE ANTIMICROBIAL RESIDUES USED TO TREAT FISH PATHOGENS. THE ANTIMICROBIAL RESIDUES IN AQUAPONIC RECIRCULATING WATER POSE MULTIPLE RISKS AS THESE RESIDUES COULD PROMOTE THE DEVELOPMENT OF ANTIMICROBIAL RESISTANCE (AMR) IN MICROBES ASSOCIATED WITH FISH AND THE ENVIRONMENT IN THE FISH TANK, MICROBES IN THE BIOFILTER USED FOR THE REMOVAL OF AMMONIA AND NITRATE FROM RECIRCULATING WATER, AND THE MICROBES ASSOCIATED WITH THE PLANTS. IN ADDITION, THE ANTIMICROBIAL RESIDUES MAY ACCUMULATE IN THE PLANTS, POSING FURTHER RISKS OF AMR IN THE DOWNSTREAM FOOD SUPPLY CHAIN, INCLUDING RISKS OF EXPOSURE OF THESE CONTAMINANTS TO HUMANS. ANTIBIOTIC RESIDUES IN PLANTS RAISE CONCERNS ABOUT POTENTIAL ADVERSE HEALTH EFFECTS ON HUMANS, SUCH AS FOODBORNE ILLNESSES, ALLERGIC REACTIONS, CHRONIC TOXIC EFFECTS, AND EVEN THE DISRUPTION OF DIGESTIVE SYSTEM FUNCTIONS DUE TO PROLONGED EXPOSURE TO LOW LEVELS OF ANTIBIOTIC RESIDUES. ENVIRONMENTAL MONITORING REPORTS, INCLUDING THE REPORTS FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC), HIGHLIGHT THE PRESENCE OF TRACES OF ANTIBIOTICS, MICROBES, AND GENES THAT CAUSE RESISTANCE TRAITS IN WATERWAYS AND THEIR POTENTIAL RISK OF TRANSFER TO PLANTS. TO ADDRESS THESE CHALLENGES,OUR OVERALL GOAL IS TO DEVELOP INNOVATIVE AND COST-EFFECTIVE RECIRCULATING WATER TREATMENT METHODS TO CAPTURE AND DEGRADE ANTIBIOTIC RESIDUES TO INNOCUOUS COMPOUNDS IN RECIRCULATING AQUAPONIC SYSTEMS AND EVALUATE THEIR IMPACT ON REDUCING THE INCIDENCE OF AMR IN THE AQUAPONIC SYSTEMS.THE SPECIFIC OBJECTIVES ARE TO (A) DEVELOP A NOVEL APPROACH USING A MACROPOROUS FUNCTIONALIZED MATRIX TO CAPTURE OXYTETRACYCLINE RESIDUES FROM RECIRCULATION WATER IN A SETTLING TANK AND EVALUATE THE EFFICIENCY OF THE APPROACH IN A LAB-SCALE SYSTEM; (B) ENGINEER AN E-FENTON APPROACH USING THE FUNCTIONALIZED MATRIX FROM AIM 1 TO DEGRADE THE CAPTURED OXYTETRACYCLINE RESIDUES IN AQUAPONIC SYSTEMS AND VALIDATE THE EFFECTIVENESS IN A PILOT SCALE UNIT; (C) EVALUATE THE REDUCTION IN AMR INCIDENCE USING THE PROPOSED WATER TREATMENT SYSTEMS FOR AQUAPONIC SYSTEMS AND (D) DEVELOP EDUCATIONAL AND OUTREACH PROGRAMS TO ENGAGE STAKEHOLDERS TO ENHANCE THE OVERALL UNDERSTANDING OF AMR RISKS AND ANTIBIOTIC RESIDUES, PROMOTE STEWARDSHIP OF ANTIBIOTIC USE, AND PROVIDE HANDS-ON LEARNING FOR VARIOUS APPROACHES TO REMOVING ANTIBIOTIC RESIDUES.THE SUCCESS OF THIS PROJECT WILL DEVELOP NEW KNOWLEDGE AND SOLUTIONS TO ADDRESS CHALLENGES OF ANTIBIOTIC RESIDUES AND ASSOCIATED RISK OF AMR IN AQUAPONICS.
$999,984Regents Of The University Of California At Riverside · · FY2025 · National Institute of Food and Agriculture
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE RISE IN ANTIBIOTIC RESISTANCE IS AN EMERGING GLOBAL PROBLEM AFFECTING HUMAN, ANIMAL, AND ENVIRONMENTAL HEALTH. THIS INCREASE MAY BE DUE, IN PART, TO THE INDUSTRIALIZATION OF LIVESTOCK PRODUCTION AND THE WIDESPREAD USE OF NON-THERAPEUTIC ANTIMICROBIAL GROWTH PROMOTANTS LEADING TO DECREASED EFFECTIVENESS OF CURRENT ANTIBIOTICS AGAINST HUMAN AND ANIMAL DISEASES. UNDERSTANDING THE ECOLOGY OF ANTIBIOTIC RESISTANCE GENE POOLS WITHIN LIVESTOCK PRODUCTION SYSTEMS AND ITS EFFECT ON MICROBIAL ECOLOGY WITHIN HOST SPECIES IS CRITICAL TO BETTER UNDERSTAND THE EMERGENCE AND SPREAD OF ANTIBIOTIC RESISTANCE FROM A ONE HEALTH PERSPECTIVE. THEREFORE, A CRITICAL GAP EXISTS IN UNDERSTANDING THE ECOLOGY, EMERGENCE, AND TRANSMISSION OF ANTIBIOTIC RESISTANCE IN THE PORK INDUSTRY, PRIMARILY DUE TO THE LACK OF INVESTIGATIONS FOCUSING ON PLASMIDS OR OTHER INTEGRATIVE AND COGNITIVE ELEMENTS, THE HOTSPOTS FOR ANTIMICROBIAL RESISTANCE (AMR) GENES THAT LEAD TO THE EMERGENCE OF AMR AMONG MICROBIAL POPULATIONS. THIS PROJECT, INVESTIGATES THE EFFECTS OF ANTIBIOTIC USE ON THE ECOLOGY OF THE MICROBIAL COMMUNITY, AMR GENE PREVALENCE, ENRICHMENT, AND TRANSMISSION BY EVALUATING THE MOBILE GENETIC ELEMENTS AND THE MICROBIOME IN THE SWINE PRODUCTION SYSTEM. ADDITIONALLY, THIS STUDY WILL DEVELOP NEW TOOLS TO IDENTIFY HOST-PLASMID ASSOCIATIONS AND HOST RANGE OF PLASMIDS TO PREDICT EMERGING AMR BACTERIA. ADDITIONALLY, THIS STUDY WILL EVALUATE AN ESSENTIAL OIL IDENTIFIED BY THIS TEAM FOR NURSERY PIGS AND DEVELOP SCIENCE-BASED INTERVENTION STRATEGIES TO REDUCE ANTIBIOTIC USE AND MITIGATE EMERGENCE OF AMR AND EFFECT CHANGE IN MANAGEMENT THROUGH OUTREACH. THIS WORK IS EXPECTED TO TRANSLATE TO THE DEVELOPMENT OF MANAGEMENT AND NUTRITIONAL STRATEGIES THAT REDUCE ANTIMICROBIAL USE AND ESTABLISH AN OUTREACH NETWORK THAT WILL IMPROVE THE CAPACITY NATIONWIDE TO ASSESS PRODUCER AND CONSUMER AMR-RELATED FOOD SAFETY NEEDS, AND TO DEVELOP, DELIVER AND EVALUATE OUTREACH PROGRAMS THAT WILL HELP PRODUCERS AND CONSUMERS TO ASSESS AND ADOPT PRACTICES THAT MITIGATE POTENTIAL RISKS FROM FOOD-BORNE AMR.
$999,981Board Of Regents Of The University Of Nebraska · · FY2023 · National Institute of Food and Agriculture
Clonotyping Technology for Prediction of Antibiotic Resistance
$999,967Evgeni Veniaminovic Sokurenko · Idgenomics, Inc. · R42 · FY2016 · AI
Development of a Novel Oral Antibiotic for the Treatment of Drug Resistant Gonorrhea
$999,962Laurene Wang · Aimmax Therapeutics, Inc. · R44 · FY2023 · AI
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE USE OF ANTIBIOTICS IN ANIMAL AGRICULTURE IS ONE OF THE DRIVERS OF ANTIMICROBIAL RESISTANCE (AMR). WHILE MAJORITY OF RESEARCH HAS BEEN ON BACTERIA PRESENT IN LAND ANIMALS, VERY LIMITED INFORMATION IS AVAILABLE ABOUT AMR IN AQUACULTURE. THERE ARE THREE ANTIMICROBIALS APPROVED BY THE FDA FOR USE IN AQUACULTURE: OXYTETRACYCLINE HYDROCHLORIDE, SULFADIMETHOXINE AND ORMETOPRIM, AND FLORFENICOL. THESE THREE DRUGS ARE EFFECTIVE FOR TREATING BOTH WARM-WATER FISH DISEASES AND COLD-WATER FISH INFECTIONS. HOWEVER, THERE IS A CRITICAL KNOWLEDGE GAP THAT NEEDS TO BE BRIDGED FOR ENSURE THE SUSTAINABLE USE OF ANTIBIOTICS, THAT IS HOW WATER TEMPERATURES IMPACT THE FORMATION OF AMR IN FISH AND IN AQUACULTURE ENVIRONMENT WHEN THESE ANTIBIOTICS ARE APPLIED AT DIFFERENT DISEASE BREAK-OUT TEMPERATURES. TO ANSWER THIS QUESTION, IN VIVO ANIMAL TREATMENT EXPERIMENT WILL BE CONDUCTED BY UC DAVIS AND AUBURN UNIVERSITY. THE TRIAL AT UCD WILL USE WELL WATER WHILE THE TRIAL AT AUBURN WILL USE SURFACE WATER. THE ABUNDANCE, DIVERSITY, AND CHANGES OF AMR BACTERIA AND ANTIMICROBIAL RESISTANT GENES (ARGS) PRESENT IN FISH AND REARING WATER BEFORE AND AFTER ANTIBIOTIC TREATMENTS WILL BE INVESTIGATED USING CULTURE-BASED AND METAGENOMICS APPROACHES. AN ANTIBIOTIC USAGE GUIDELINE WILL BE DEVELOPED AT THE END OF THE EXPERIMENT AND WILL BE DISSEMINATED TO FARMERS, VETERINARIANS, AND THE GENERAL PUBLIC VIA MULTIPLE EDUCATION AND EXTENSION PLATFORMS.
$999,948University Of California, Davis · · FY2020 · National Institute of Food and Agriculture
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** DAIRY-BEEF AND VEAL CALF PRODUCTION SYSTEMS ARE UNDERRECOGNIZED AND IMPORTANT SOURCES OF ANTIMICROBIAL RESISTANCE (AMR). MALE DAIRY CALVES ARE AN UNWANTED BY-PRODUCT OF THE DAIRY INDUSTRY THAT HAVE LARGELY BEEN IGNORED BY RESEARCHERS. NONETHELESS, HALF THE CALVES BORN ON DAIRY FARMS ARE MALE, AND THE CALVES CONTRIBUTE A SUBSTANTIALLY TO THE FOOD SUPPLY. THEREFORE, OUR GROUP WILL CHARACTERIZE MALE CALF TRANSPORTATION NETWORKS TO IDENTIFY INFLUENTIAL TRANSMISSION POINTS OF ANTIMICROBIAL RESISTANCE, IDENTIFY FACILITY-LEVEL RISK FACTORS FOR S. DUBLIN, A PARTICULARLY IMPORTANT PATHOGEN OF ANIMALS AND PEOPLE. NEXT, WE WILL BUILD SIMULATION MODELS TO INFORM STRATEGIES FOR S. DUBLIN SURVEILLANCE AND CONTROL. THESE DATA ARE NECESSARY TO IDENTIFY COST-EFFECTIVE AND RISK-BASED STRATEGIES THAT EFFECTIVELY LIMIT THE DISSEMINATION OF MDR BACTERIA.FURTHERMORE, OUR GROUP WILL WORK TO REDUCE THE QUANTITY OF ANTIMICROBIALS USED WITHIN THE MALE CALF PRODUCTION SYSTEMS. TO DO THIS, WE WILL TEST THE ABILITY OF BENCHMARKING REPORTS TO MOTIVATE REDUCTIONS CHANGES IN ANTIMICROBIAL USE BEHAVIORS, AND WE'LL IDENTIFY INDIVIDUAL MOTIVATORS AND BARRIERS TO BEHAVIOR CHANGE.LASTLY, WE WILL CREATE CULTURALLY APPROPRIATE MATERIALS FOR THE PREDOMINANTLY AMISH AND MENNONITE COMMUNITY WITHIN THE MALE DAIRY CALF PRODUCTION SYSTEM THAT HAS BEEN MOSTLY NEGLECTED BY THE RESEARCH AND EXTENSION COMMUNITY. THIS MATERIAL WILL SERVE TO IMPROVE BIOSECURITY AND ANTIMICROBIAL STEWARDSHIP PRACTICES THAT WILL BOTH MITIGATE ANTIMICROBIAL RESISTANCE WITHIN THESE PRODUCTION SYSTEMS.
$999,938Ohio State University, The · · FY2022 · National Institute of Food and Agriculture
SBIR Phase II: Permanent Attachment of Antimicrobial Peptides to Central Venous Catheters.
$999,923Christopher R Loose · Semprus Bioscience Corporation · · FY2008 · TIP
EVALUATING DIFFERENT MANURE MANAGEMENT PRACTICES IN CONTROLLING SPREAD OF ANTIMICROBIAL RESISTANCE FROM DAIRY FARMS
$999,921The Research Foundation For The State University Of New York · · FY2016 · National Institute of Food and Agriculture
Novel Strategies to Clear Bacteria from the CF Lung
$999,919Saira Ahmad · Eldec Pharmaceuticals, Inc. · R44 · FY2022 · HL
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** CARBAPENEMS ARE AMONG OUR MOST VALUABLE ANTIBIOTICS, AND CARBAPENEM-RESISTANT ENTEROBACTERIACEAE (CRE) REPRESENT AN URGENT PUBLIC HEALTH THREAT. WE HAVE FOUND THAT CRE IN HEALTHCARE ARE TRANSPORTED IN HOSPITAL WASTE TO TREATMENT PLANTS WHERE THEY SURVIVE AND ARE DISCHARGED INTO SURFACE WATERS AND ACCUMULATE IN FISH AND WILDLIFE. THUS, CRE CAN BE DISSEMINATED FROM SURFACE WATERS INTO LIVESTOCK POPULATIONS IN THE BROADER WATERSHED. THERE IS EVIDENCE THAT FREQUENT CEPHALOSPORIN USE IN LIVESTOCK CAN AMPLIFY CRE. THUS, IF CRE WERE INTRODUCED INTO FOOD ANIMALS, THEY WOULD THREATEN ANIMAL HEALTH AND PRODUCTION, AND COULD ENTER THE FOOD SUPPLY IN FRESH MEAT. THEREFORE, PREVENTING THE DISSEMINATION OF CRE INTO THE ENVIRONMENT AND LIVESTOCK IS A CRITICALLY IMPORTANT FOOD-SAFETY INTERVENTION. WE PROPOSE TO ASSESS AND IDENTIFY MEANS TO MITIGATE THE RISK TO THE FOOD CHAIN THAT IS POSED BY THE DISSEMINATION OF CRE INTO AGRICULTURAL WATERSHEDS. OUR GOAL IS TO UNDERSTAND THE RISK THAT CRE ENVIRONMENTAL DISSEMINATION POSES TO US ANIMAL AGRICULTURE AND INLAND FISHERIES. TO ACCOMPLISH THIS, WE PROPOSE TO: 1. QUANTIFY CRE AND CARBAPENEMASE GENES IN WASTEWATER FLOWS, FISH POPULATIONS, AND SURFACE WATERS OF AGRICULTURAL WATERSHEDS; 2. IDENTIFY TRANSPORT VECTORS CAPABLE OF INTRODUCING CRE INTO AGRICULTURAL ANIMAL POPULATIONS IN THE WATERSHED; 3. MONITOR FOR THE INTRODUCTION OF CRE INTO AGRICULTURAL ANIMAL POPULATIONS; AND 4) CREATE A TRANSDISCIPLINARY ONE HEALTH STUDENT TRAINING PROGRAM ADDRESSING ISSUES OF ANTIMICROBIAL USE, RESISTANCE, AND STEWARDSHIP FROM THE HUMAN, ANIMAL, AND ENVIRONMENTAL HEALTH PERSPECTIVES. THIS DIRECTLY ADDRESSES TWO PROGRAM PRIORITIES: (1) THE ROLE OF COMMENSAL ORGANISMS IN THE EMERGENCE, SPREAD AND SELECTION OF AMR IN AGRO-ECOSYSTEMS; AND (2) IDENTIFY AND ESTABLISH RESOURCES FOR COMMUNICATING AND DISPENSING AMR-RELATED CURRICULA, BEST MANAGEMENT PRACTICES, AND OTHERS TO COMBAT AMR.
$999,844Ohio State University, The · · FY2020 · National Institute of Food and Agriculture