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17,054 grants matching “genome editing”
Diabetes Research Center (DRC)
$1,488,858Alan R. Saltiel · University Of California, San Diego · P30 · FY2023 · DK
Investigations of Methylmalonic Acidemia and Related Disorders
$1,488,296Charles P Venditti · National Human Genome Research Institute · ZIA · FY2018 · HG
Comprehensive NeuroHIV Center
$1,487,917Kamel Khalili · Temple Univ Of The Commonwealth · P30 · FY2023 · MH
Collaborative Research: Formation of a High Flux Student Research Network (HF-SRN) as a Laboratory for Enhancing Interaction in the PoLS SRN
$1,485,949Aravinthan D T Samuel · Harvard University · · FY2018 · MPS
Discovery and characterization of programmable biological systems
$1,485,000Jonathan Strecker · Massachusetts General Hospital · DP2 · FY2025 · HL
Differentiation of human induced pluripotent stem cells as a tool to study the effects of type 2 diabetes loci.
$1,482,602Leslie J Baier · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2022 · DK
Optimization of genetic modification of HSCs in the NHP model and creation of relevant preclinical models of human disease and therapies
$1,481,031Cynthia E Dunbar · National Heart, Lung, And Blood Institute · ZIA · FY2021 · HL
Behavioral Genomics of Alcohol Neuroadaptation
$1,480,936Tamara J. Phillips · Oregon Health & Science University · P60 · FY2025 · AA
Base-Editing the Cancer Kinome to Enable Drug Discovery
$1,480,500Neil Vasan · Columbia University Health Sciences · DP2 · FY2023 · CA
Investigations of Methylmalonic Acidemia and Related Disorders
$1,480,072Charles P Venditti · National Human Genome Research Institute · ZIA · FY2012 · HG
Clinical Analysis of Disorders of Hearing and Balance
$1,477,827Carmen Crowell Brewer · National Institute On Deafness And Other Communication Disorders · ZIA · FY2019 · DC
Gene Transfer Core, NIDCR-DIR
$1,476,850Ashok Kulkarni · National Institute Of Dental & Craniofacial Research · ZIC · FY2019 · DE
Genetic models of sporadic Alzheimers Disease in the marmoset
$1,476,351Kuo-Fen Lee · Salk Institute For Biological Studies · R24 · FY2023 · AG
Engineering enhanced erythropoiesis for red blood cell disorders
$1,476,000Michael Kyle Cromer · University Of California, San Francisco · DP2 · FY2025 · HL
Genotype-Tissue-Protein: proteomic variation and quantitative trait loci (pQTL)
$1,475,551Michael P Snyder · Stanford University · U01 · FY2014 · HG
Discovery of genes required for expression or activity of fusion oncogenes
$1,475,356Natasha Caplen · Division Of Basic Sciences - Nci · ZIA · FY2019 · CA
Genetic Risk Variants in Atopic Dermatitis Associated with Eczema Herpeticum
$1,473,611Donald Ym Leung · National Jewish Health · U19 · FY2017 · AI
UNIVERSITY OF WISCONSIN SYSTEM - NEW AWARD CONTROL# 2784-1833 EXPLORATORY TOPICS DE-FOA-0002784, TOPIC L (PHYTOMINES) PROJECT TITLE: ''DESIGN AND APPLICATION OF A GENETIC TOOLBOX TO DOMESTICATE ODONTARRHENA CORSICA AND ODONTARRHENA CHALCIDICA FOR NICKEL PHYTOMINING IN THE UNITED STATES.'' THERE IS INCREASING DEMAND FOR NICKEL (NI) FOR THE EMERGING CLEAN ENERGY ECONOMY, PARTICULARLY FOR BATTERY PRODUCTION FOR ELECTRICAL VEHICLES AND POWER STORAGE. HOWEVER, DECLINING ORE GRADES ARE MAKING EFFICIENT EXTRACTION OF CRITICAL METALS INCREASINGLY DIFFICULT, ADDING URGENCY TO DEVELOPING NEW SOURCES. PHYTOMINING PRESENTS AN OPPORTUNITY TO DEVELOP ECONOMICAL, LOW CARBON INTENSITY OPERATIONS USING NI-HYPERACCUMULATING PLANTS AS CROPS TO MINE NI-ABUNDANT ULTRAMAFIC SOILS. INDEED, THE MATERIAL REMAINING AFTER COMBUSTION OF NI-HYPERACCUMULATING PLANTS (BIO-ORE) CAN CONTAIN GREATER THAN 25% NI BY WEIGHT AND THUS BIO-ORE IS THE RICHEST AND PUREST NI ORE KNOWN. THIS PROJECT IS TO DEVELOP THE MOLECULAR AND GENETIC TOOLS TO DOMESTICATE WILD ODONTARRHENA CORSICA AND ODONTARRHENA CHALCIDICA FOR USE IN AN EFFICIENT PHYTOMINING SYSTEM ADAPTED TO THE UNITED STATES’ CLIMATIC CONDITIONS AND REQUIREMENTS FOR BIOSAFETY, WITH GREATLY ENHANCED NI HARVESTING PROPERTIES COMPARED TO THEIR WILD PROGENITORS. THE OVERALL DOMESTICATION GOALS ARE TO INCREASE THE HARVESTED NI YIELD PER HECTARE COMPARED TO CURRENT WILD PROGENITOR MATERIAL BY 200% WITH AN ULTIMATELY GOAL OF >250 KG PER HECTARE, AND TO MITIGATE THE RISK ASSOCIATED WITH WEEDINESS OF WILD-TYPE ODONTARRHENA SPECIES. A KEY COMPONENT OF DOMESTICATION OF THESE PLANT SPECIES IS THE DEVELOPMENT OF A BIOMOLECULAR TOOLKIT INCLUDING AN ANNOTATED GENOME SEQUENCE, AN ATLAS OF EXPRESSED GENES, AND DEVELOPMENT OF PLANT TRANSFORMATION AND GENE EDITING SYSTEMS. OTHER GOALS ARE THE DEVELOPMENT OF GENETICALLY SEGREGATING POPULATIONS TO SELECT FOR ENHANCED NI ACCUMULATION AND DEVELOPMENT OF SPEED BREEDING PROTOCOLS TO ACCELERATE BREEDING. THIS PROJECT WILL ENHANCE THE ECONOMIC VIABILITY OF US PHYTOMINING.
$1,471,655University Of Wisconsin System · · FY2025 · Department of Energy
WormBase: a core data resource for C. elegans and other nematodes
$1,469,582Paul Warren Sternberg · California Institute Of Technology · U24 · FY2023 · HG
TRANSFORM-PGR: Manipulating Agrobacterium-mediated transformation and T-DNA integration for plant synthetic biology and genome engineering
$1,467,146Stanton B Gelvin · Purdue University · · FY2017 · BIO
Comprehensive NeuroHIV Center
$1,464,828Kamel Khalili · Temple Univ Of The Commonwealth · P30 · FY2025 · MH
NEI Genetic Engineering Core
$1,461,046Lijin Dong · National Eye Institute · ZIC · FY2019 · EY
Restoring Vision with High-Fidelity Nonsense Codon Correction
$1,460,184Bikash Ranjan Pattnaik · University Of Wisconsin-Madison · R24 · FY2023 · EY
Synthetic organogenesis: new paradigms in reconstituting human organ development in vitro
$1,458,000Mijo Simunovic · Columbia Univ New York Morningside · DP2 · FY2021 · HD
Isolation, characterization, and transplantation of candidate stem cells
$1,457,612John Tisdale · National Heart, Lung, And Blood Institute · ZIA · FY2025 · HL