Sort
24,576 grants matching “microbiome”
Role of Intestinal Microbiota in Dyslipidemia and Atherosclerosis Induced by Ambient Ultrafine Particles
$408,073Jesus Antonio Araujo · University Of California Los Angeles · R01 · FY2018 · ES
Probing nano/bio interactions to understand and overcome biological barriers limiting nanomedicine
$408,005Emily S Day · University Of Delaware · R35 · FY2025 · GM
Probing nano/bio interactions to understand and overcome biological barriers limiting nanomedicine
$408,005Emily S Day · University Of Delaware · R35 · FY2023 · GM
Probing nano/bio interactions to understand and overcome biological barriers limiting nanomedicine
$408,005Emily S Day · University Of Delaware · R35 · FY2024 · GM
An environment-wide association study in autism spectrum disorders using novel bioinformatics methods and metabolomics via mass spectrometry
$407,812Sek Won Kong · Boston Children'S Hospital · R01 · FY2016 · MH
L. reuteri for Pediatric Diarrhea in Peru: Growth, Enteropathy, and Microbiota
$407,796Margaret N Kosek · Johns Hopkins University · U01 · FY2016 · DK
Sample Repository for Human Genetic Research
$407,781Alissa Marie Resch · Coriell Institute For Medical Research · U41 · FY2019 · HG
Functional activity and inter-organismal interactions in the human microbiome
$407,746Curtis Huttenhower · Harvard School Of Public Health · R01 · FY2011 · HG
Improving response to immunotherapy by genistein and antiestrogens
$407,663Leena A Hilakivi-Clarke · University Of Minnesota · R21 · FY2021 · CA
Advancing Clinical Science in Pediatric Gastroparesis
$407,623Robert Shulman · Baylor College Of Medicine · U01 · FY2016 · DK
Protein secretion pathways in the phylum Bacteroidetes
$407,567Harris Bernstein · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2015 · DK
Mechanisms of commensal bacteria induced humoral immunity
$407,500Joel R Wilmore · Upstate Medical University · R35 · FY2025 · GM
Mechanisms of commensal bacteria induced humoral immunity
$407,500Joel R Wilmore · Upstate Medical University · R35 · FY2023 · GM
Mechanisms of commensal bacteria induced humoral immunity
$407,500Joel R Wilmore · Upstate Medical University · R35 · FY2024 · GM
Mechanisms of commensal bacteria induced humoral immunity
$407,500Joel R Wilmore · Upstate Medical University · R35 · FY2022 · GM
Skin Barrier and the Microbiome
$407,421Richard L Gallo · University Of California, San Diego · R01 · FY2018 · AR
Pharmacogenetic Studies
$407,387Neil E. Caporaso · Division Of Cancer Epidemiology And Genetics · ZIA · FY2017 · CA
HONEY BEES ARE THE PRIMARY MANAGED INSECT POLLINATOR IN US AGRICULTURE, YET PROBLEMS PERSIST IN THE MANAGED POPULATION. TWO OF THE PRIMARY PROBLEMS WITH HONEY BEE COLONIES ARE DISEASE AGENTS (PATHOGENS AND PARASITES) AND DIMINISHED REPRODUCTIVE QUALITY OF QUEENS. FOR THE FORMER, BEEKEEPERS REGULARLY APPLY ANTIBIOTICS (TO CONTROL BACTERIAL PATHOGENS) AND ACARICIDES (TO CONTROL VARROA MITES) IN ORDER TO KEEP THEIR COLONIES HEALTHY. FOR THE LATTER, BEEKEEPERS OFTEN REPLACE THEIR QUEENS BECAUSE OF REDUCED LONGEVITY, PREMATURE FAILURE, OR EARLY REJECTION, BUT THE CAUSE(S) OF DIMINISHED REPRODUCTIVE QUALITY ARE STILL UNCLEAR. WE PROPOSE TO TEST A POTENTIAL LINK BETWEEN BEEKEEPER-APPLIED COMPOUNDS AND REDUCED QUALITY OF QUEENS (AND THE DRONES WITH WHICH THEY MATE). OUR OBJECTIVES ARE TO DETERMINE IF IN-HIVE TREATMENTS, I.E., ANTIBIOTICS AND ACARICIDES, (1) IMPACT THE REPRODUCTIVE HEALTH AND PHYSIOLOGY, (2) ACCUMULATE IN THE REPRODUCTIVE ORGANS, AND (3) ALTER THE GUT AND REPRODUCTIVE MICROBIOMES OF QUEENS AND DRONES. LASTLY, (4) WE WILL PROMOTE CLINICAL SERVICES FOR MEASURING QUEENS AND DRONES FOR BEEKEEPERS IN REAL TIME SO THAT THEY CAN MEASURE THESE EFFECTS IN THEIR OWN OPERATIONS. PRELIMINARY AND PUBLISHED WORK HAS DEMONSTRATED THAT BEEKEEPER-APPLIED MEDICATIONS MAY HAVE INDIRECT EFFECTS ON HONEY BEE FECUNDITY, THUS FINDING A BALANCE BETWEEN MAINTAINING COLONY HEALTH AND PRODUCTIVITY IS PARAMOUNT TO MAINTAIN A SUSTAINABLE MANAGED POLLINATOR POPULATION.WE PREDICT THAT THIS RESEARCH WILL LEAD TO IMPORTANT INFORMATION ABOUT THE IMPACTS OF IN-HIVE TREATMENTS ON THE REPRODUCTIVE FITNESS OF BOTH QUEENS AND DRONES. THIS INFORMATION WILL BE PARTICULARLY RELEVANT FOR BEEKEEPERS, BREEDERS, AND BEE VETERINARIANS. THROUGH THE NORTH CAROLINA STATE HONEY BEE QUEEN & DISEASE CLINIC AND THE UNIVERSITY OF NORTH CAROLINA AT GREENSBORO PLANT AND POLLINATOR CENTER, WE WILL PROMOTE CLINICAL SERVICES FOR MEASURING REPRODUCTIVE FITNESS OF QUEENS AND DRONES AS WELL AS HOST PUBLIC OUTREACH EVENTS TO COMMUNICATE OUR RESEARCH AND ADVISE BEST TREATMENTS PRACTICES TO BEEKEEPERS AND BEE VETERINARIANS BASED ON OUR FINDINGS. OVERALL, THIS WORK WILL IMPROVE THE QUALITY OF BEEKEEPER DECISION-MAKING AND CRITICAL ANALYSES, THROUGH PROMOTING DATA-DRIVEN MANAGEMENT PRACTICES. THE PROPOSED RESEARCH WILL ADDRESS THE AFRI PROGRAM AREA PRIORITY POLLINATOR HEALTH: RESEARCH AND APPLICATION BY INVESTIGATING THE IMPACT OF BEEKEEPER APPLIED ACARICIDES AND ANTIBIOTICS ON HONEY BEE REPRODUCTIVE HEALTH.
$407,093North Carolina State University · · FY2024 · National Institute of Food and Agriculture
Alterations and Renovations for Microbiome Facility
$407,076Maria A Sosa · University Of Puerto Rico Med Sciences · P20 · FY2025 · GM
SCODA DNA extraction to normalize species representation
$406,968Andre Marziali · Boreal Genomics Inc. · R01 · FY2008 · HG
Dietary fat effects on gut microbes, host immune state and experimental colitis
$406,961Eugene B Chang · University Of Chicago · R01 · FY2013 · DK
Innate immune defense against clostridium Difficile Infection
$406,869Eric G Pamer · Sloan-Kettering Inst Can Research · R01 · FY2017 · AI
Innate immune defense against clostridium Difficile Infection
$406,869Eric G Pamer · Sloan-Kettering Inst Can Research · R01 · FY2016 · AI
PROSPECT: Pathways, Risk factors, and mOleculeS to Prevent Early-onset Colorectal Tumors
$406,707Emily Patricia Balskus · Harvard University · OT2 · FY2024 · CA
Innate and Adaptive Immune Markers in Farming Lifestyle and Early Atopic Diseases
$406,683Kirsi Jarvinen-Seppo · University Of Rochester · U19 · FY2025 · AI