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15,273 grants matching “antimicrobial resistance”
Multivalent Adjuvant Immunization to Prevent Hospital Acquired Infections
$995,098Brad J Spellberg · Exbaq Llc · R42 · FY2022 · AI
AGRICULTURAL OPERATIONS REPRESENT SIGNIFICANT SOURCES OF ANTIMICROBIAL RESISTANCE (AMR) TO FLOWING WATERS, FOR EXAMPLE VIA STORAGE AND LAND APPLICATION OF ANIMAL MANURES. UNDERSTANDING THE FATE AND TRANSPORT OF AMR IN FLOWING WATERS IS CRITICAL TO INFORM MANURE MANAGEMENT, LAND CONSERVATION, AND MONITORING PRACTICES. WE PROPOSE A MULTISCALE EXPERIMENTAL APPROACH TO QUANTIFY DEGRADATION, TRANSPORT, AND SORPTION OF AMR IN CONTROLLED FLOWING WATER SYSTEMS USING RECIRCULATING MESOCOSMS AND EXPERIMENTAL STREAMS. THIS WORK USES THE UNIQUE ND-LEEF FACILITY WITH INTERMEDIATE SIZED STREAMS AND WATERSHEDS TO PERFORM CONTROLLED FATE EXPERIMENTS. FATE AND TRANSPORT EXPERIMENTS WILL BE PERFORMED UNDER VARYING WATER QUALITY CONDITIONS, SEASONS, AND STREAM SUBSTRATES; THE RESULTING DATA WILL BE USED TO DEVELOP A STATE OF THE ART STOCHASTIC TRANSPORT MODEL. WE WILL MEASURE BOTH CULTURE-BASED AND MOLECULAR MARKERS (I.E., ANTIBIOTIC RESISTANCE GENES) OF AMR TO OBSERVE DIFFERENTIAL FATE OF AMR MARKERS. IN ADDITION, WE WILL PERFORM SAMPLING AND AMR QUANTIFICATION IN NATURAL FLOWING WATERS IN PINE CREEK WATERSHED, MICHIGAN TO BOTH INFORM AND FIELD VALIDATE AMR FATE AND TRANSPORT PREDICTIONS. FINALLY, WE WILL INTEGRATE FATE AND TRANSPORT MODELS ACROSS A GRADIENT OF ENVIRONMENTAL COMPLEXITY TO ALLOW FOR AMR FATE AND TRANSPORT PREDICTIONS ACROSS VARYING CONDITIONS. WE WILL USE RESEARCH ACTIVITIES AND FINDINGS TO DEVELOP EDUCATION AND EXTENSION MODULES ABOUT AMR, WATER QUALITY, AND CONSERVATION PRACTICES. DIGITAL EDUCATION MODULES WILL BE DEVELOPED WITH ND-LEARNING AND IMPLEMENTED THROUGH EXISTING ND-LEEF EDUCATIONAL ACTIVITIES. EXTENSION MODULES WILL BE DEVELOPED AND IMPLEMENTED IN PARTNERSHIP WITH THE VAN BUREN CONSERVATION DISTRICT, THE SITE OF PINE CREEK WATERSHED SAMPLING.?
$995,051University Of Notre Dame Du Lac · · FY2021 · National Institute of Food and Agriculture
Heterocyclic Inhibitors of QcrB as Novel Drugs for Tuberculosis
$994,977Thomas Joseph Hannan · Fimbrion Therapeutics, Inc. · R44 · FY2024 · AI
Integrated Comprehensive Droplet Digital Detection (IC 3D) system for rapid detection of bacteria andantimicrobial resistance
$994,881Weian Zhao · University Of California-Irvine · R01 · FY2016 · AI
Boosting Innate Immunity Through HIF to Treat Antibiotic-Resistant Infections
$994,866Victor Nizet · University Of California, San Diego · R01 · FY2012 · AI
Direct from blood identification of bloodstream infections in newborns
$994,610Alon Singer · Helixbind, Inc. · R44 · FY2022 · AI
Rapid Immunodiagnosis of Drug-Resistant Bacterial Pathogens
$994,558Mark Geisberg · Silver Lake Research Corporation · R42 · FY2016 · AI
Task B05: Refinement of a Pig-Tail Macaque model of Gonococcal Infection
$994,264Hanne Andersen · Bioqual, Inc. · N01 · FY2020 · AI
Resorbable Antimicrobial Envelope to Prevent Infection of Implanted Cardiac Devices
$993,460Glenn Brunner · N8 Medical, Inc. · R44 · FY2023 · HL
Antimicrobial and Regenerative Treatment for Oral Mucositis
$992,846Shenda Baker · Synedgen, Inc. · R44 · FY2011 · DE
Nitric Oxide-Releasing Wound Dressing for Preventing Chronic Wound Infections
$991,948Nathan Allan Stasko · Novan, Inc. · R44 · FY2011 · AI
SBIR Phase II: Automated One-Hour Testing for Bacterial Detection and Antibiotic Sensitivity in Clinical Samples
$991,832Christopher G Skipwith · Astek Diagnostics Llc · · FY2024 · TIP
Novel, low corrosion, bio-compatible disinfectant with biofilm and residual efficacy
$991,808Carine Nkemngong · Halomine, Inc. · R44 · FY2025 · AI
Studies of Receptor Interactions and Effects of Alarmins
$991,767Joost J Oppenheim · Division Of Basic Sciences - Nci · ZIA · FY2014 · CA
Rapid antimicrobial susceptibility testing directly from urine specimens
$991,573Don Straus · First Light Diagnostics , Inc. · R44 · FY2021 · AI
Rapid antimicrobial susceptibility testing directly from urine specimens
$991,573Lawrence Burg · First Light Diagnostics , Inc. · R44 · FY2022 · AI
Rapid antimicrobial susceptibility testing directly from urine specimens
$991,573Lawrence Burg · First Light Diagnostics , Inc. · R44 · FY2023 · AI
Point-of-care antimicrobial susceptibility testing based on simultaneous tracking of multi-phenotypic features of single bacterial cells
$991,540Shaopeng Wang · Arizona State University-Tempe Campus · R01 · FY2019 · AI
Point-of-care antimicrobial susceptibility testing based on simultaneous tracking of multi-phenotypic features of single bacterial cells
$991,540Shaopeng Wang · Arizona State University-Tempe Campus · R01 · FY2020 · AI
Preventing outbreaks of foodborne pathogenic bacteria in edible sprouts via novel resistance-conferring seed treatments
$991,328Murli Manohar · Ascribe Bioscience Inc. · R44 · FY2023 · AI
Direct from blood identification of bloodstream infections in newborns
$991,282Alon Singer · Helixbind, Inc. · R44 · FY2023 · AI
Biomimetic Macrophage Membrane-Coated Nanosponges: A Novel Therapeutic for Multidrug-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii Hospital-Associated Pneumonia
$991,226Victor Nizet · University Of California, San Diego · R01 · FY2025 · AI
Discovery and Preclinical Development of Drugs for Anthrax, Plague and Tularemia
$990,493Christie G. Brouillette · University Of Alabama At Birmingham · U01 · FY2008 · AI
Establishing the Genetic Basis of Altered Drug Responses in Mycobacterium tuberculosis
$990,348Sarah M Fortune · Harvard Medical School · U19 · FY2022 · AI
Broad-Spectrum Antimicrobials Targeting the D-Alanine Pathway
$989,745Karen G. Anthony · L2 Diagnostics, Llc · U01 · FY2010 · AI