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51,570 grants matching “autoimmune disease”
Intravital Multiphoton Microscope
$500,000Florea Lupu · Oklahoma Medical Research Foundation · S10 · FY2010 · RR
Multiphoton Facility for Intravital Imaging
$500,000Jonathan James Art · University Of Illinois At Chicago · S10 · FY2010 · RR
Immune Activation and Myocardial Recovery in Peripartum Cardiomyopathy
$500,000Dennis M. McNamara · University Of Pittsburgh At Pittsburgh · RC1 · FY2009 · HL
Phase 2/3 Study of Toca 511-Toca FC vs SOC in Recurrent GBM-AA IND 14173 9Jul2015
$500,000Asha Das · Tocagen, Inc. · R01 · FY2017 · FD
Hormones & Genes in Women's Health: Bench to Bedside
$500,000Jill M Goldstein · Brigham And Women'S Hospital · K12 · FY2011 · HD
Hormones & Genes in Women's Health: Bench to Bedside
$500,000Jill M Goldstein · Brigham And Women'S Hospital · K12 · FY2010 · HD
Phase 2/3 Study of Toca 511-Toca FC vs SOC in Recurrent GBM-AA IND 14173 9Jul2015
$500,000Sophie Visonneau · Tocagen, Inc. · R01 · FY2019 · FD
Identification of Susceptibility Genes for SLE of Amerindian Origin in Hispanics
$500,000Marta E Alarcon-Riquelme · Oklahoma Medical Research Foundation · RC1 · FY2009 · AR
Hormones & Genes in Women's Health: Bench to Bedside
$500,000Jill M Goldstein · Brigham And Women'S Hospital · K12 · FY2012 · HD
Building a next-generation AMP-AIM Data Management Core to maximize FAIR-ness of autoimmune and immune-mediated disease research resources
$500,000Anna K Greenwood · Sage Bionetworks · U24 · FY2023 · AG
Career Development in Women's Health (CDWH)
$500,000Andrea Dunaif · Northwestern University At Chicago · K12 · FY2012 · HD
Modulating T Cell Activation to Combat HIV Persistence
$500,000David Randolph Collins · Massachusetts General Hospital · DP2 · FY2025 · AI
Inositol-Trisphosphate Kinase B (ItpkB) in T Cell Development and Function
$500,000Karsten Sauer · Scripps Research Institute, The · R01 · FY2009 · AI
Measuring toxicant effects on cellular function in a microarray format
$500,000Ernest Fitch Guignon · Ciencia, Inc. · R42 · FY2019 · ES
Defining the complex genetics of JIA
$500,000Susan D Thompson · Cincinnati Childrens Hosp Med Ctr · RC1 · FY2009 · AR
Comparative Effectiveness of Biologics for Psoriasis
$500,000Joel M Gelfand · University Of Pennsylvania · RC1 · FY2009 · AR
Predicting Systemic Autoimmunity through Follow-up of Blood Relatives
$500,000Judith A James · Oklahoma Medical Research Foundation · RC1 · FY2009 · AR
Multi-allelic copy number variation of the human genome
$500,000Steven Andrew McCarroll · Harvard Medical School · R01 · FY2012 · HG
Multiphoton upgrade of confocal microscope for live organ and tissue imaging
$500,000Madesh Muniswamy · University Of Pennsylvania · S10 · FY2007 · RR
Reconstitution of Regulatory T Cells After Stem Cell Transplantation
$500,000Jerome Ritz · Dana-Farber Cancer Inst · R01 · FY2017 · CA
Comparative Effectiveness of Biologics for Psoriasis
$500,000Joel M Gelfand · University Of Pennsylvania · RC1 · FY2010 · AR
THERE IS NOW A STRONG CONSENSUS THAT THE GUT MICROBIOME IS A CRUCIAL DETERMINANT OF HOST PHYSIOLOGY AND HEALTH. IT IS ALSO CLEAR THAT PERTURBING THIS COMMUNITY WITH ANTIBIOTICS CAN HAVE VASTLY NEGATIVE HEALTH CONSEQUENCES RANGING FROM CLOSTRIDIODES DIFFICILE COLITIS TO CHRONIC CONDITIONS SUCH AS OBESITY AND AUTOIMMUNE DISEASES. THUS, AS WE WORK TO IMPROVE ANTIMICROBIAL THERAPY, WE MUST DEVELOP TREATMENT METHODOLOGIES THAT TARGET PATHOGENS WHILE PRESERVING THE OVERALL STRUCTURE AND FUNCTION OF THE MICROBIOME FROM ANTIBIOTIC-INDUCED DYSBIOSIS. DIETARY FIBER IS A KEY POSITIVE DETERMINANT OF MICROBIOME METABOLISM AND COMPOSITION. RECENT DATA FROM OUR GROUP INDICATE THAT THE METABOLIC ACTIVITY OF THE MICROBIOME IS A CRUCIAL DETERMINANT OF ANTIBIOTIC-INDUCED MICROBIOME DISRUPTION AND THAT PURIFIED FIBER PROVIDES PREBIOTIC PROTECTION TO THIS COMMUNITY DURING TREATMENT. SINCE FIBER IS NOT TYPICALLY CONSUMED IN THE PURIFIED FORM, IN THIS GRANT WE WILL PROFILE THE IMPACT OF THREE KEY COMMODITYGRAINS WITH HIGH FIBER CONTENT, FIELD CORN, WHOLE GRAIN WHEAT AND WHOLE GRAIN OATS, ON THE COMPOSITION OF THE MURINE MICROBIOME AND ITS RESPONSE TO ANTIBIOTICS. WE HYPOTHESIZE THAT SUPPLEMENTATION WITH THESE GRAINS WILL REDUCE THE DETRIMENTAL IMPACT OF ANTIBIOTICS ON THE MICROBIOME AND PROMOTE RECOVERY AFTER TREATMENT. WE WILL ALSO TEST IF THIS PROTECTION IS ASSOCIATED WITH IMPROVED HOST HEALTH INDICATORS SUCH AS: GUT BARRIER FUNCTION, REDUCED INFLAMMATORY RESPONSE, AND ELEVATED PROTECTION FROM ENTERIC PATHOGENS. IN THE LONG-TERM, IDENTIFYING PREBIOTIC WHOLE GRAINS WHICH ARE CAPABLE OF REDUCING ANTIBIOTIC-ASSOCIATED COMPLICATIONS WILL, IN TURN, PROMOTE THE CONSUMPTION OF THESE AGRICULTURALLY IMPORTANT GRAINS AND IMPROVE HUMAN HEALTH.
$500,000Brown University · · FY2020 · National Institute of Food and Agriculture
DMS/NIGMS 1: Developing a mathematical framework to understand viral-cellular transduction for cellular reprogramming
$500,000Andrey V Kuznetsov · North Carolina State University · · FY2025 · MPS
Comprehensive functional characterization and dissection of noncoding regulatory elements and human genetic variation
$500,000Pardis Christine Sabeti · Broad Institute, Inc. · UM1 · FY2018 · HG
Phase 2/3 Study of Toca 511-Toca FC vs SOC in Recurrent GBM-AA IND 14173 9Jul2015
$500,000Sophie Visonneau · Tocagen, Inc. · R01 · FY2018 · FD