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91,797 grants matching “obesity”
Human Translational Studies of Inflammation and Cardiometabolic Diseases: The Psoriasis, Atherosclerosis and Cardiometabolic disease (PACI) Initiative
$2,798,185Nehal Mehta · National Heart, Lung, And Blood Institute · ZIA · FY2020 · HL
For Hearing Component in the Hispanic Community Health Study (HCHS)
$2,797,773Lisa Lavange · Univ Of North Carolina Chapel Hill · N01 · FY2009 · HL
GENERAL CLINICAL RESEARCH CENTER
$2,796,869University Of Texas Sw Med Ctr/Dallas · M01 · FY2002 · RR
THIS PROJECT IS DESIGNED TO EXAMINE BEHAVIORAL AND ENVIRONMENTAL FACTORS THAT ARE POTENTIAL TARGETS FOR OBESITY PREVENTION. SPECIFICALLY, USING AN EXPERIMENTAL APPROACH, WE WILL TEST AN APPROACH TO PREVENT CHILDHOOD OBESITY BY ALTERING ASPECTS OF CHILDREN'S ENVIRONMENTS IN WAYS THAT INCREASE FOOD LITERACY, INCREASE EXPOSURE TO AND INTAKE OF VEGETABLES, AND INCREASE TIME SPENT IN ACTIVE PLAY. WE WILL ALSO DETERMINE WHETHER PROVIDING GUIDANCE TO CHILDCARE PROVIDERS AND CAREGIVERS ON PRACTICES THAT PROMOTE HEALTHY EATING AND ACTIVITY PATTERNS IN CHILDREN BOLSTERS THE EFFECTS OF THE CLASSROOM ENVIRONMENTAL MODIFICATIONS. LASTLY, WE WILL EXAMINE THE EFFICACY OF A COMPONENT DESIGNED TO INCREASE CHILDREN'S SELF-REGULATORY CAPACITY. PARTICIPANTS WILL INCLUDE APPROXIMATELY 1400 PREDOMINANTLY LOW-INCOME, PRESCHOOL CHILDREN AGES 3 TO 5 YEARS ATTENDING CENTER-BASED CHILDCARE PROGRAMS IN PENNSYLVANIA AND THEIR CAREGIVERS AND TEACHERS. THE RESULTS OF THE RESEARCH COMPONENT OF THE STUDY WILLBE USED TO INFORM THE DESIGN OF A RANDOMIZED CONTROL OBESITY PREVENTION TRIAL. FOR THE EXTENSION COMPONENT OF THE STUDY, WE WILL DESIGN A SERIES OF WHITEBOARD ANIMATIONS THAT WILL BE USED TO DELIVER NUTRITION EDUCATION TO LOW-LITERACY CAREGIVERS AND PRE-LITERACY CHILDREN. THE GOAL IS TO DEVELOP AND TEST MATERIALS THAT CAN BE WIDELY USED BY VARIOUS STAKEHOLDERS, INCLUDING CHILDCARE PROVIDERS, EXTENSION EDUCATORS, SUPPLEMENTAL NUTRITION ASSISTANCE PROGRAM (SNAP) EDUCATORS AND OTHER PROFESSIONALS. WE ARE PARTNERING WITH SEVERAL LOCAL AND NATIONAL STAKEHOLDERS, INCLUDING PENN STATE EXTENSION, PBS AND SESAME WORKSHOP TO ENGAGE OUR TARGET AUDIENCE AND FACILITATE WIDE DISSEMINATION OF OUTREACH MATERIALS.
$2,796,090The Pennsylvania State University · · FY2017 · National Institute of Food and Agriculture
Pre- and Postnatal Exposure Periods for Child Health: Common Risks and Shared Mechanisms
$2,790,263Thomas G O'Connor · University Of Rochester · UH3 · FY2019 · OD
Studies of Rare Cancers
$2,789,746Katherine McGlynn · Division Of Cancer Epidemiology And Genetics · ZIA · FY2022 · CA
PRIMARY PREVENTION PROGRAM -DATA COORDINATING CENTER
$2,787,269George Washington University · U01 · FY2001 · DK
Hyperpolarized 13C MRI of Placental Metabolic Abnormalities Resulting from the Western Diet
$2,787,105Charles A McKenzie · University Of Western Ontario · U01 · FY2015 · HD
MACS/WIHS Combined Cohort Study: Brooklyn Clinical Research Site (Bklyn CRS)
$2,786,708Deborah R. Gustafson · Suny Downstate Medical Center · U01 · FY2022 · HL
Framingham Project/Levy
$2,785,722Daniel Levy · National Heart, Lung, And Blood Institute · ZIA · FY2014 · HL
Atrial Fibrillation Post-GWAS: Mechanisms to Treatment
$2,784,815Mina Kay Chung · Cleveland Clinic Lerner Com-Cwru · P01 · FY2024 · HL
Role of G protein-coupled receptors in regulating glucose and energy homeostasis
$2,783,564Jurgen Wess · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2019 · DK
Regulators of Food Intake
$2,782,146Jonathan Krakoff · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2024 · DK
MACS/WIHS Combined Cohort Study: Brooklyn Clinical Research Site (Bklyn CRS)
$2,779,134Deborah R. Gustafson · Suny Downstate Medical Center · U01 · FY2021 · HL
Health Disparities in Alzheimer's Disease and Mild Cognitive Impairment among Mexican Americans
$2,776,237Sid E O'Bryant · University Of North Texas Hlth Sci Ctr · R01 · FY2020 · AG
MIND Diet Intervention to Prevent Alzheimer's Disease
$2,773,089Martha C. Morris · Rush University Medical Center · R01 · FY2016 · AG
Molecular pathological epidemiology of colorectal cancer
$2,769,837Ulrike Peters · Fred Hutchinson Cancer Research Center · U01 · FY2015 · CA
Emory Prevention Research Center
$2,768,138Michelle C Kegler · Emory University · U48 · FY2021 · DP
Genotyping the Understanding America Study to generate novel opportunities for research on cognitive functioning and dementia
$2,763,177Titus Johannes Galama · University Of Southern California · R01 · FY2023 · AG
University of Pennsylvania HIV Clinical Trials Unit
$2,761,412Ian Frank · University Of Pennsylvania · UM1 · FY2025 · AI
Genetic analysis of type II diabetes in Finnish population
$2,760,336Francis Sellers Collins · National Human Genome Research Institute · ZIA · FY2019 · HG
New Biospecimens to Enhance Research in the California Teachers Study Cohort
$2,757,186James V Lacey · Beckman Research Institute/City Of Hope · UM1 · FY2015 · CA
Continuation of the NuMoM2b Heart Health Study
$2,756,035Rebecca Boehm McNeil · Research Triangle Institute · U01 · FY2025 · HL
THERE IS GROWING EVIDENCE THAT WHOLE GRAIN (WG) INTAKE PLAYS AN IMPORTANT ROLE IN CHRONIC DISEASE PREVENTION. HOWEVER, NUMEROUS HUMAN STUDIES HAVE FAILED TO SUPPORT CLEAR-CUT CONCLUSIONS ON THE TOPIC, DUE TO INDIVIDUAL METABOLIC VARIATION AND A LACK OF ACCURATE TOOLS TO ASSESS DIETARY INTAKE AND INTERNAL DOSAGE. TO BETTER UNDERSTAND THE EFFECTS OF DIET ON HEALTH MAINTENANCE AND ON THE RISK OF CHRONIC DISEASE, BIOMARKERS FOR THEIR EXPOSURE AND EFFECTS ARE NEEDED. THE MOLECULAR SIGNATURES OF WG INTAKE REMAIN UNDEFINED. THE MAJOR DIETARY CEREALS - WHEAT, RYE, AND OAT - CONTAIN DIFFERENT UNIQUE PHYTOCHEMICALS. 5-N-ALKYLRESORCINOLS (ARS) ARE PRESENT IN HIGH AMOUNTS IN WG WHEAT AND RYE, BUT ARE ABSENT FROM WG OATS. ARS AND THEIR METABOLITES HAVE BEEN REPORTED AS EXPOSURE BIOMARKERS FOR THE INTAKE OF WG WHEAT AND RYE. IN CONTRAST, AVENANTHRAMIDES (AVAS) AND OAT SAPONINS (AVENACOSIDES A AND B) ARE PHYTOCHEMICALS UNIQUE TO WG OATS. OUR HYPOTHESIS IS BIOACTIVE WG PHYTOCHEMICALS, AND THEIR METABOLITES, CAN SERVE AS THE BIOMARKERS OF WG INTAKE, REFLECT INTER-INDIVIDUAL DIFFERENCES, AND AFFECT ENDOGENOUS METABOLOME. WE RECENTLY FOUND THAT THE COMBINATION OF TARGETED AND NON-TARGETED METABOLOMICS APPROACHES CAN EFFECTIVELY IDENTIFY BIOMARKERS OF WG WHEAT INTAKE. TO TEST OUR HYPOTHESIS, WE WILL USE A TARGETED METABOLOMICS APPROACH TO IDENTIFY THE EXPOSURE BIOMARKERS OF WG WHEAT AND OAT AFTER AN ACUTE INTAKE IN A PHARMACOKINETIC STUDY IN AIM 1. IN AIM 2, WE WILL CONDUCT A CHRONIC DOSE-RESPONSE HUMAN FEEDING STUDY TO VALIDATE THE EXPOSURE BIOMARKERS IDENTIFIED IN AIM 1, IDENTIFY THE CHANGES OF THE ENDOGENOUS METABOLITES USING NON-TARGETED METABOLOMICS APPROACHES, DETERMINE WHETHER OBESITY, AGE, AND GENDER ARE MODERATORS THAT AFFECT THE METABOLIC RESPONSE TO WG, AND INVESTIGATE THE IMPACT OF GUT MICROBIOTA ON THE METABOLISM OF WG PHYTOCHEMICALS. AT THE COMPLETION OF THESE STUDIES, OUR EXPECTATION IS THAT WE WILL HAVE IDENTIFIED WG PHYTOCHEMICALS AND THEIR METABOLITES AS THE EXPOSURE MARKERS TO REFLECT WG WHEAT OR OAT INTAKE, AND THE ENDOGENOUS METABOLITES AS THE BIOMARKERS OF WG WHEAT OR OAT INTAKE FOR THEIR BENEFICIAL HEALTH EFFECTS. OUR FINDINGS WILL ESTABLISH THE BASIS FOR FUTURE MECHANISTIC STUDIES OF THE ROLE OF WGS IN HEALTH, AND PROVIDE NOVEL INSIGHT INTO RELIABLE SPECIFIC BIOLOGICAL INDICATORS FOR WG INTAKE AND EVENTUALLY LEAD TO FUTURE INDIVIDUALIZED NUTRITION. THIS KNOWLEDGE COULD BE UTILIZED TO IMPROVE HOW TO ASSESS THE IMPACT OF WG ON HEALTH.
$2,755,449North Carolina Agricultural And Technical State University · · FY2018 · National Institute of Food and Agriculture
Northern New England Clinical and Translational Research Network
$2,752,644Clifford J Rosen · Mainehealth · U54 · FY2023 · GM