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24,576 grants matching “microbiome”
Employing Humanized Microbiome Mice to Understand Immune Activation and Translational Therapeutic Potential in Glioblastoma
$329,317Braden Cox McFarland · University Of Alabama At Birmingham · R01 · FY2023 · CA
Employing Humanized Microbiome Mice to Understand Immune Activation and Translational Therapeutic Potential in Glioblastoma
$329,317Braden Cox McFarland · University Of Alabama At Birmingham · R01 · FY2025 · CA
Training in Mechanisms of Parasitism
$329,232Mary Edythe Wilson · University Of Iowa · T32 · FY2019 · AI
Project 1: Role of Microbiota and Myeloid cells in Mouse Models of Barretts Esophagus
$329,224Timothy Cragin Wang · Columbia University Health Sciences · U54 · FY2020 · CA
Baby Observational and Nutritional Study of Cystic Fibrosis
$329,214Bonnie W Ramsey · Seattle Children'S Hospital · R01 · FY2012 · DK
Molecular Mechanisms of Membrane Transport
$329,167David S Cafiso · University Of Virginia · R01 · FY2019 · GM
Identifying susceptibility factors for KSHV infection in human tonsil
$329,159Jennifer E Totonchy · Chapman University · R01 · FY2019 · CA
Consortium of Research Advancement Facilities and Training
$329,130Alika K Maunakea · University Of Hawaii At Manoa · P20 · FY2023 · GM
Project 1: Keiki Produce Prescription (KPRx) Program: Improving Diet Assessment and Quantifying Health Impacts
$329,126Monica Kazlausky Esquivel · University Of Hawaii At Manoa · P20 · FY2023 · GM
E3Gen: Multigenerational Effects of Toxicant Exposures on Life Course Health and Neurocognitive Outcomes in the ELEMENT Birth Cohorts
$329,021Karen Eileen Peterson · University Of Michigan At Ann Arbor · R24 · FY2020 · ES
Project 2: Arsenic- Obesity- Diabetes Interactions
$328,997Fernando Pardo-Manuel De Villena · Univ Of North Carolina Chapel Hill · P42 · FY2023 · ES
Center for Accelerating Precision Pain Self-Management
$328,997Angela Renee Starkweather · University Of Connecticut Storrs · P20 · FY2019 · NR
Lung Health Study in the Agricultural Health Study
$328,952Stephanie London · National Institute Of Environmental Health Sciences · ZIA · FY2018 · ES
Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS)
$328,947Kathryn M Anastos · Albert Einstein College Of Medicine · U01 · FY2019 · HL
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** SOUTH AFRICAN-STYLE AIR-DRIED BEEF (DROËWORS AND BILTONG) IS INCREASING IN POPULARITY IN THE USA. UNLIKE BEEF JERKY THAT IS HEATED TO 160OF AND HIGHER, THIS STYLE OF DRIED BEEF IS HELD AT AMBIENT TEMPERATURES OF ~75OFAND~55% RELATIVE HUMIDITY FOR 6-8 DAYS. DROËWORS IS A SAUSAGE-LIKE DRIED BEEF PRODUCT GENERATED FROM BEEF PIECES LEFT OVER FROM BILTONG PROCESSING.SINCE THESE PRODUCTS DO NOT RECEIVE A HEAT LETHALITY TREATMENT, USDA-FSIS REQUIRES THAT THEY PASS SIMILAR FOOD SAFETY PATHOGEN LETHALITY REQUIREMENTS AS HEAT-TREATED SHELF-STABLE BEEF JERKY. USDA-FSIS REGARDS AIR-DRIED BEEF PRODUCTS AS HAVING 'KNOWLEDGE GAPS' AND THEIR PROCESS SAFETY IS NOT ADEQUATELY COVERED IN THE SCIENTIFIC LITERATURE FOR THEM TO MAKE POLICY DECISIONS. PROCESSORS MUST USE ONE OF TWO USDA-FSIS PROCESS ALTERNATIVES TO MAKE THESE PRODUCTS DEMONSTRATING LETHALITY AGAINST A 'PATHOGEN OF CONCERN' AMONG RAW BEEF: 1) TEST ALL LOTS OF INGREDIENTS FOR SALMONELLA PRIOR TO USE (MUST TEST NEGATIVE) AND HAVE A PROCESS THAT DELIVERS A 2-LOG REDUCTION OF SALMONELLA, OR 2) HAVE A PROCESS THAT PROVIDES >5-LOG REDUCTION OF SALMONELLA WITHOUT TESTING. BECAUSE OF THE EXPENSE OF SALMONELLA TESTING, THE LATTER IS PREFERRED. IN RECENT YEARS, WE HAVE GENERATED PEER-REVIEWED RESEARCH ON THE BILTONG PROCESS THAT NOW SERVES AS USDA-FSIS VALIDATION FOR PROCESSORS. WE PROPOSE TO EXAMINE CONDITIONS TO ACHIEVE >5-LOG REDUCTIONS WITH DROËWORS DRIED BEEF WITH 4-STRAIN MIXTURES OF SALMONELLA SEROVARS, E. COLI O157:H7, L. MONOCYTOGENES, AND S. AUREUS DURING DROËWORS PROCESSING; EVALUATE A NON-PATHOGENIC BILTONG SURROGATE ORGANISM FOR IN-PLANT VALIDATION OF DROËWORS PROCESSING, AND PERFORM MICROBIOME ANALYSIS OF DROËWORS. AS WE PERFORMED WITHBILTONG, SUCCESSFUL COMPLETION OF THIS STUDY SHOULD PROVIDE AMPLE SCIENTIFIC DOCUMENTATIONFILLING SO-CALLED USDA-FSIS 'KNOWLEDGE GAPS' ONDROËWORS PROCESS LETHALITY,ALLOWING THEM TO MAKE SCIENCE-BASEDPOLICY DECISIONS ON THE DROËWORS PROCESS OF MANUFACTURE.
$328,947Oklahoma State University · · FY2023 · National Institute of Food and Agriculture
Microbiota-mediated fibrotic remodeling in the inflamed intestine
$328,933Janelle C Arthur · Univ Of North Carolina Chapel Hill · R01 · FY2024 · DK
Sequential, Multiple Assignment, Randomized Trial in Severe Asthma Protocol (SMART-SA)
$328,922John V Fahy · University Of California, San Francisco · UG1 · FY2022 · HL
Modeling Core
$328,845Luis A. Nunes Amaral · Northwestern University At Chicago · U19 · FY2021 · AI
CHEMICAL SCREENING AND OPTIMIZATION FACILITY - MANAGEMENT, ADMINISTRATION AND DATABASE CORE FUNCTION ACTIVITIES
$328,838Leyi Gong · Sri International · N01 · FY2024 · HD
Mechanisms of arsenic detoxification by the human microbiome
$328,787Seth T Walk · Montana State University - Bozeman · R01 · FY2017 · CA
Skin Barrier Adaptation
$328,783Cristina De Guzman Strong · Washington University · R56 · FY2020 · AR
Biospecimen Procurement & Utilization Core
$328,722Richard Bernard Hayes · New York University School Of Medicine · P20 · FY2021 · CA
Project 3: PREVENT: A first-in-human clinical trial of Griffithsin, an HIV entry
$328,566Ian Michael McGowan · University Of Louisville · U19 · FY2015 · AI
Shared Resource 08: Genomics (GSR)
$328,523Amanda Ewart Toland · Ohio State University · P30 · FY2022 · CA
Shared Resource 08: Genomics (GSR)
$328,523Amanda Ewart Toland · Ohio State University · P30 · FY2023 · CA