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16,300 grants matching “fatty liver disease”
Immunologic and Fat-Associated Predictors of Insulin Resistance in Treated HIV
$116,302Suneil Krishna Koliwad · University Of California, San Francisco · R01 · FY2019 · DK
Ethanol Effects on the Transcriptional Regulatory Network in Liver Regeneration -
$116,250Joannes B Hoek · Thomas Jefferson University · R01 · FY2012 · AA
Peripheral CB1 Receptor Antagonist for Therapeutic Use in Metabolic Syndrome
$116,170Donald Lo · National Center For Advancing Translational Sciences · ZIA · FY2018 · TR
The effects of orange juice compared with sugar-sweetened beverage on risk factors and metabolic processes associated with the development of cardiovascular disease and type 2 diabetes
$116,015Kimber Lee Stanhope · University Of California At Davis · R01 · FY2022 · HL
Adipocyte lipolysis, adipose tissue function, and lipodystrophy
$115,500Erin E Kershaw · University Of Pittsburgh At Pittsburgh · R56 · FY2016 · DK
Calorie restriction and aging
$115,433Rafael De Cabo · National Institute On Aging · ZIA · FY2022 · AG
DNA Repair Deficiency Associated with Obesity and the Meatbolic Syndrome
$115,406R Stephen Lloyd · Oregon Health & Science University · R56 · FY2007 · DK
Genetics of Diabetes in the Amish
$115,388Alan R. Shuldiner · University Of Maryland Baltimore · R01 · FY2009 · DK
The effects of ketogenic diet on alcohol intoxication
$115,307Xinyi Li · University Of Pennsylvania · K99 · FY2025 · AA
Investigating the impact of abnormal lipid metabolism on mouse intervertebral disc
$115,301Joe Kodama · University Of Maryland Baltimore · K99 · FY2025 · AR
Adipocyte Biology and Molecular Nutrition Core
$115,134Nada A. Abumrad · Washington University · P30 · FY2011 · DK
Adipocyte Biology and Molecular Nutrition Core
$115,134Nada A. Abumrad · Washington University · P30 · FY2012 · DK
Adipocyte Biology and Molecular Nutrition Core
$115,130Nada A. Abumrad · Washington University · P30 · FY2015 · DK
Longitudinal Study of Early NAFLD Progression and the Gut Microbiome in Asian Americans, Native Hawaiians and Whites
$115,080Unhee Lim · University Of Hawaii At Manoa · R01 · FY2025 · MD
NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) IS CONNECTED WITH ALTERATIONS IN GUT MICROBES (THE MICROBIOTA) AND BILE ACIDS. RESEARCH SUGGESTS THERE ARE CONNECTIONS BETWEEN THE GUT, THE MICROBIOTA, AND THE LIVER, OR THE GUT-MICROBIOTA-LIVER AXIS. INDEED, GUT MICROBES MAY DIRECTLY INFLUENCE LIVER HEALTH THROUGH THE BY-PRODUCTS THEY PRODUCE. DIETARY PATTERNS THAT EMPHASIZE DIETARY FIBER AND MONOUNSATURATED FATTY ACIDS (MUFAS), SUCH AS THE MEDITERRANEAN DIET, ARE LINKED TO BENEFICIAL CHANGES IN MICROBIAL COMMUNITY COMPOSITION AND REDUCTIONS IN LIVER FAT. AVOCADOS ARE UNIQUELY REPRESENTATIVE OF THE MEDITERRANEAN DIET. THEY ARE RICH SOURCES OF DIETARY FIBER, MUFAS, AND PHYTOSTEROLS. HOWEVER, THE IMPACT OF AVOCADO INTAKE ON THE GUT-MICROBIOTA LIVER AXIS AMONG INDIVIDUALS WITH AND WITHOUT NAFLD IS UNDER-STUDIED. ACCORDINGLY, THIS STUDY WILL ANALYZE SAMPLES OBTAINED FROM A RANDOMIZED CONTROLLED TRIAL OF AVOCADO CONSUMPTION AMONG ADULTS WITH OVERWEIGHT OR OBESITY TO ADDRESS AN EXISTING RESEARCH GAP. OUR OBJECTIVES ARE TO: 1) ASSESS RELATIONSHIPS BETWEEN DIET, GUT MICROBES, AND LIVER FAT; 2) ASSESS DIFFERENCES IN MICROBES, MICROBIAL BYPRODUCTS, AND BILE ACIDS BY COMPARING GROUPS OF INDIVIDUALS WITH HIGH AND LOW AMOUNTS OF LIVER FAT; AND 3) DETERMINE THE IMPACT OF AVOCADO CONSUMPTION ON THE GUT-MICROBIOTA-LIVER AXIS. THIS PROJECT IS IMPORTANT BECAUSE IT WILL EVALUATE HOW EATING A NUTRIENT-DENSE WHOLE FOOD (AVOCADO) MAY HELP IMPROVE GUT AND LIVER HEALTH.
$115,054University Of Illinois · · FY2019 · National Institute of Food and Agriculture
Rac1 Promotes Hepatic Stellate Accumulation/Activation in Liver Injury
$114,762Steve S Choi · Duke University · K08 · FY2011 · DK
Rac1 Promotes Hepatic Stellate Accumulation/Activation in Liver Injury
$114,762Steve S Choi · Duke University · K08 · FY2012 · DK
Zinc Finger Protein 949 as a Potential Transcriptional Suppressor of Adipocyte Hypertrophy - Resubmission - 1
$114,750Henry H Ruiz · New York Inst Of Technology · R03 · FY2025 · DK
Effects of miR-30c deficiency on plasma cholesterol and atherosclerosis
$114,452M Mahmood Hussain · Nyu Winthrop Hospital · R01 · FY2020 · HL
STUDIES OF MECHANISMS AND TREATMENT OF LIVER DISEASE
$114,420Virginia Commonwealth University · K24 · FY2000 · DK
Fish oil for depression in multiple sclerosis
$114,301Lynne H Shinto · Oregon Health & Science University · K23 · FY2007 · AT
The effects of adiponectin on liver insulin resistance
$114,233Terry Peter Combs · Univ Of North Carolina Chapel Hill · K01 · FY2007 · DK
Role of Ncb5or in Insulin Production
$114,133H. Franklin Bunn · Brigham And Women'S Hospital · R01 · FY2008 · DK
Aging and CR effects on the Plasma Membrane Redox System
$114,054Rafael De Cabo · National Institute On Aging · ZIA · FY2025 · AG
Adipocyte Biology and Molecular Nutrition Core
$114,009Nada A. Abumrad · Washington University · P30 · FY2014 · DK