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16,300 grants matching “fatty liver disease”
Alcohol and Metabolic Dysregulation in PLWH: Mechanisms Underlying Risk for Comorbidities
$95,222Patricia E Molina · Lsu Health Sciences Center · P60 · FY2023 · AA
Factors that modify insulin action
$95,184Maria G Buse · Medical University Of South Carolina · R01 · FY2010 · DK
Developing a Childhood Metabolic Syndrome Risk Score to Predict Adult Disease
$95,159Matthew James Gurka · West Virginia University · R21 · FY2011 · DK
Prevalence, Incidence, and Predictors of Subclinical and Clinical Vascular and Myocardial Disease: Pathophysiologic Pathways
$95,128Arshed A Quyyumi · Emory University · P01 · FY2025 · HL
Air pollution and health disparities in liver disease and cancer
$95,025Trang Vopham · Fred Hutchinson Cancer Research Center · K01 · FY2021 · DK
Regulation of Lipogenesis
$95,000Hei Sook Sul · University Of California Berkeley · R01 · FY2010 · DK
Adipose Tissue Macrophage Phenotype and Function
$94,961Anthony W Ferrante · Columbia University Health Sciences · R01 · FY2010 · DK
Clinical Research Network in Nonalcoholic Steatohepatitis
$94,808Kris Kowdley · Swedish Medical Center, First Hill · U01 · FY2016 · DK
Automated quantification of lipid droplets in fatty liver tissue sections
$94,761Patrick M McDonough · Vala Sciences, Inc. · R41 · FY2010 · DK
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** OBESITY AFFECTS 40% OF U.S. ADULTS (20-39 YEARS) AND 22% OF CHILDREN (12-19 YEARS) AND HAS A $173 BILLION/YEAR HEALTHCARE COST. OVERNUTRITION CONTRIBUTES TO OBESITY; HOWEVER, SPECIFIC NUTRITIONAL STRATEGIES FOR FEMALES ARE LACKING, DESPITE EXPERIENCING HIGHER RATES OF OBESITY. WOMEN AND GIRLS HAVE DIFFERENT HORMONES THAN THEIR MALE COUNTERPARTS, SUPPORTING THE NEED FOR SEX-SPECIFIC NUTRITIONAL RECOMMENDATIONS AND CONSIDERATIONS TO PREVENT OBESITY IN THIS POPULATION. THIS PROPOSAL INVESTIGATES THE RELATIONSHIPS BETWEEN THE DEVELOPMENT STAGE, HORMONES, AND NUTRITION'S CONTRIBUTION TO OBESITY DURING THE POSTPARTUM AND ADOLESCENT PERIODS OF FEMALES.BREAST MILK AND BREASTFEEDING ARE GOOD FOR BABIES AND MOMS. THE MAJORITY (83.2%) OF NEW MOTHERS GIVE NEWBORNS BREASTMILK. HOWEVER, THAT PERCENTAGE DECREASES IN THE FIRST FEW WEEKS OF THE POSTPARTUM PERIOD, DESPITE LACTATION'S BENEFITS. HOW BREASTFEEDING HELPS THE MOTHER NEEDS TO BE BETTER DEFINED. THIS PROPOSAL'S FIRST OBJECTIVE WILL USE STATE-OF-THE-ART TECHNIQUES TO UNDERSTAND HOW THE HORMONES INSULIN AND PROLACTIN CHANGE THE FAT IN BREAST MILK. THE FAT IN HUMAN MILK IS ESSENTIAL FOR THE BABY'S GROWTH AND BRAIN DEVELOPMENT. THEREFORE, IT IS VITAL TO UNDERSTAND HOW CHANGES IN THE MOTHER'S HEALTH MAY AFFECT THE MILK BEING FED TO HER INFANT.MANY REPRODUCTIVE-ASSOCIATED DISORDERS AFFECT WOMEN. THE MOST COMMON REPRODUCTIVE DISORDERIS POLYCYSTIC OVARY SYNDROME. THIS SYNDROMEAFFECTS UP TO 1 IN 5 FEMALES OF REPRODUCTIVE AGE AND IS CHARACTERIZED BY HIGH TESTOSTERONE CONCENTRATIONS. THIS SYNDROME OFTEN PRESENTS DURING PUBERTY AND INCREASES THE LIKELIHOOD OF DEVELOPING OBESITY, TYPE 2 DIABETES, AND FATTY LIVER DISEASE. THE SECOND OBJECTIVE WILL DETERMINE IF DECREASING DIETARY SUGARS AND IMPROVING THE DIET QUALITY OF ADOLESCENT GIRLS WILL RESULT IN WEIGHT LOSS AND IMPROVED HEALTH. GIVEN THE INCREASED RISK FOR OBESITY-ASSOCIATED CONDITIONS WITH POLYCYSTIC OVARY SYNDROME AND THE AGE OF ONSET, FINDING NONPHARMACEUTICAL INTERVENTIONS TO TREAT AND PREVENTCOMORBIDITIES IS IMPORTANT.THE COMBINATION OF THESE OBJECTIVES WILL LEAD TO A BETTER UNDERSTANDING OF THE EFFECTS OF OVERNUTRITION AND ITS ROLE IN OBESITY-ASSOCIATED RISKS. BY DOING THESE STUDIES, KNOWLEDGE WILL BE GAINED ABOUT HOW NUTRITION AND HORMONES AFFECT OBESITY IN GIRLS AND WOMEN IN THE U.S. THIS CAN HELP WITH THE DEVELOPMENT OF BETTER DIET RECOMMENDATIONS TO KEEP PEOPLE HEALTHY.
$94,696University Of Missouri System · · FY2023 · National Institute of Food and Agriculture
Alcohol and Metabolic Dysregulation in PLWH: Mechanisms Underlying Risk for Comorbidities
$94,637Patricia E Molina · Lsu Health Sciences Center · P60 · FY2022 · AA
The Role of Vitamin D Receptor in Liver Fibrosis
$94,527Ning Ding · Salk Institute For Biological Studies · K01 · FY2015 · DK
Metabolic effects of non-nutritive sweeteners
$94,396Kristina Rother · Eunice Kennedy Shriver National Institute Of Child Health & Human Development · ZIA · FY2020 · HD
Mechanisms of fat regulation by conserved anti-obesity genes
$94,264Tania Reis · University Of Colorado Denver · R01 · FY2022 · DK
Maternal High Fat Diet and Melanocortin System in Offspring
$94,120Kevin L Grove · Oregon Health & Science University · R01 · FY2010 · DK
Cardiometabolic effects of genetically decreased dipeptidyl peptidase-4 (DPP4) (Grant Transfer from UPENN)
$94,110Jessica Rose Wilson · Mayo Clinic Jacksonville · K23 · FY2021 · HL
Characterization of cinnabarinic acid mediated cytoprotection upon liver injury
$94,070Aditya D Joshi · University Of Texas Med Br Galveston · K01 · FY2015 · DK
Prenatal diet-stress interactions and the maternal metabolic response in human pregnancy
$94,059Karen Lindsay · University Of California-Irvine · K99 · FY2018 · HD
Prenatal diet-stress interactions and the maternal metabolic response in human pregnancy
$94,059Karen Lindsay · University Of California-Irvine · K99 · FY2019 · HD
Diabetes & Women's Health Study: long term health implications of GDM
$93,741Cuilin Zhang · Eunice Kennedy Shriver National Institute Of Child Health & Human Development · ZIA · FY2021 · HD
Signaling and Biotechology Program
$93,518Hui-Kuan Lin · Wake Forest University Health Sciences · P30 · FY2019 · CA
Epidemiology and Natural History of Wolman and Cholesteryl Ester Stor (Grabowski)
$93,276Gregory A. Grabowski · University Of Minnesota · U54 · FY2010 · NS
Metabolic rewiring regulates cancer growth and tumor-associated immune responses
$93,075Steven Zhao · Salk Institute For Biological Studies · K00 · FY2023 · CA
Pilot Project 1: A Partnership to Advance Liver Cancer Prevention with Pascua Yaqui Tribal Communities
$93,049David O. Garcia · University Of Arizona · U54 · FY2025 · CA
EXERCISE AND PIOGLITAZONE FOR HIV METABOLIC SYNDROMES
$93,014Kevin E Yarasheski · Washington University · M01 · FY2007 · RR