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17,054 grants matching “genome editing”
Administrative Core
$162,285Alexander Marson · University Of California, San Francisco · P01 · FY2023 · AI
Administrative Core
$162,253Eric N Olson · Ut Southwestern Medical Center · P50 · FY2020 · HD
Investigating the role of mitochondria in thoracic aortic aneurysm pathogenesis
$162,000Benjamin John Landis · Indiana University Indianapolis · K23 · FY2020 · HL
APOBEC3G and RNA granules: restricting HIV infection and Alu retrotransposition
$162,000Ya-Lin Chiu · J. David Gladstone Institutes · K22 · FY2008 · AI
Investigating the role of mitochondria in thoracic aortic aneurysm pathogenesis
$162,000Benjamin John Landis · Indiana University Indianapolis · K23 · FY2022 · HL
Role of alveolar epithelial cell-derived cellular communication network factor 2 (CCN2) in alveologenesis and bronchopulmonary dysplasia
$162,000Deepthi Alapati · Nemours Children'S Hospital, Delaware · K08 · FY2020 · HL
The Role of the Adaptor Protein SH2B3 in Type 1 Diabetes
$162,000Eric J Allenspach · Seattle Children'S Hospital · K08 · FY2021 · DK
Investigating the role of mitochondria in thoracic aortic aneurysm pathogenesis
$162,000Benjamin John Landis · Indiana University Indianapolis · K23 · FY2021 · HL
Investigating the role of mitochondria in thoracic aortic aneurysm pathogenesis
$162,000Benjamin John Landis · Indiana University Indianapolis · K23 · FY2019 · HL
Prioritizing and Characterizing T Cell-Relevant Genetic Variants Associated with Autoimmune Diseases
$162,000John Philip Ray · Benaroya Research Inst At Virginia Mason · K22 · FY2021 · AI
The Role of the Adaptor Protein SH2B3 in Type 1 Diabetes
$162,000Eric J Allenspach · Seattle Children'S Hospital · K08 · FY2020 · DK
Role of alveolar epithelial cell-derived cellular communication network factor 2 (CCN2) in alveologenesis and bronchopulmonary dysplasia
$162,000Deepthi Alapati · Nemours Children'S Hospital, Delaware · K08 · FY2024 · HL
Role of alveolar epithelial cell-derived cellular communication network factor 2 (CCN2) in alveologenesis and bronchopulmonary dysplasia
$162,000Deepthi Alapati · Nemours Children'S Hospital, Delaware · K08 · FY2022 · HL
Non-Invasive Monitoring of CRISPR/Cas-Edited Chimeric Antigen Receptor T (CAR-T) Cells with Reporter Gene-Based Magnetic Resonance Imaging and Positron Emission Tomography
$162,000John Andrew Ronald · University Of Western Ontario · UH2 · FY2020 · EB
Role of alveolar epithelial cell-derived cellular communication network factor 2 (CCN2) in alveologenesis and bronchopulmonary dysplasia
$162,000Deepthi Alapati · Nemours Children'S Hospital, Delaware · K08 · FY2023 · HL
Community organizing: Harnessing the interactions of the microbiome as a basis for novel therapeutic strategies
$162,000Julia Oh · Jackson Laboratory · K22 · FY2016 · AI
Investigating the role of mitochondria in thoracic aortic aneurysm pathogenesis
$162,000Benjamin John Landis · Indiana University Indianapolis · K23 · FY2023 · HL
The Role of the Adaptor Protein SH2B3 in Type 1 Diabetes
$162,000Eric J Allenspach · Seattle Children'S Hospital · K08 · FY2022 · DK
Role of alveolar epithelial cell-derived cellular communication network factor 2 (CCN2) in alveologenesis and bronchopulmonary dysplasia
$162,000Deepthi Alapati · Nemours Children'S Hospital, Delaware · K08 · FY2021 · HL
AMERICANS LEAD THE WORLD IN FOOD WASTE. THOUGH IT MAY NOT BE A STATISTIC TO BE PROUD OF THERE IS A WAY TO TURN THINGS AROUND! EACH YEAR WE THROW AWAY 60 MILLION TONS OF FOOD, ALMOST HALF OF ALL PRODUCE SOLD. WHILE A SMALL PORTION OF THE FOOD WASTE IS USED AS ANIMAL FEED MOST OF IT ENDS UP IN LANDFILLS, CONTRIBUTING TO GLOBAL WARMING ANDGASSES THAT ARE 25 TIMES MORE POWERFUL THEN FUMES FROM MOTORIZED VEHICLES (CARBON DIOXIDE). ONE POSSIBLE SOLUTION IS TO TURN THIS FOOD WASTE INTO SOMETHING WE CAN ALL BENEFIT FROM. THROUGH THE USE OF A SPECIAL WASTE EATING BACTERIUM, BACILLUS LICHENIFORMIS YNP5-TSU, WE CAN CONVERT WASTE INTO A USEFUL BIOFUEL CALLED BUTANEDIOL (BDL).OUR GOAL FOR THIS PROJECT IS TO DETERMINE THE BEST FERMENTATION SETTINGS AND GENETIC MODIFICATIONS FOR B. LICHENIFORMIS YNP5-TSU SO THE MAXIMUM AMOUNT OF BIOFUEL CAN BE PRODUCED. MANY FERMENTATION PARAMETERS SUCH AS; PH, TEMPERATURE, DISSOLVED OXYGEN CONTENT, AND FEEDSTOCK COMPOSITION HAVE SIGNIFICANT EFFECTS ON BDL OUTPUT AND WILL BE CALCULATED THROUGH USE OF 2-LITER NEW BRUNSWICK® FERMENTERS AND HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC). IN ORDER TO REMOVE OTHER UNWANTED FERMENTATION END-PRODUCTS, GENETIC MODIFICATIONS TO B. LICHENIFORMIS YNP5-TSU THROUGH THE NEWLY DISCOVERED CRISPR-CAS9 GENOME EDITING TOOL WILL ALSO BE PERFORMED.THROUGH THESE TECHNIQUES MENTIONED WE WILL BE ABLE TO PROVIDE VALUABLE DATA ON HOW THIS UNIQUE MICROORGANISM DEGRADES FOOD WASTE AND CONVERTS IT INTO BIOFUEL. COMPLETION OF THIS PROJECT WILL ALSO GIVE INSIGHT TOWARDS THE NEXT STEP; IMPLEMENTATION OF B. LICHENIFORMIS YNP5-TSU INTO LARGE SCALE PRODUCTION AND ULTIMATELY LEAD TO A NEW SUSTAINABLE ENERGY RESOURCE FROM FOOD WASTE.
$161,917Virginia Polytechnic Institute & State University · · FY2019 · National Institute of Food and Agriculture
Genome Engineering & iPSC Center Core
$161,750Jeffrey D Milbrandt · Washington University · P01 · FY2019 · DK
NICHD-California Birth Defects Study
$161,622James Mills · Eunice Kennedy Shriver National Institute Of Child Health & Human Development · ZIA · FY2021 · HD
Modeling Endothelial Dysfunction in LMNA-related Dilated Cardiomyopathy
$161,558Nazish Sayed · Stanford University · K01 · FY2020 · HL
Project 1
$161,500Charles G. Mullighan · St. Jude Children'S Research Hospital · U54 · FY2023 · CA
Specificity of RPSA-dependent translational control in mouse and human fetal spleen cells
$161,500Licia Selleri · University Of California, San Francisco · R03 · FY2023 · HD