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16,300 grants matching “fatty liver disease”
Hepatitis C Clinical Trial-Clinical Center
$86,066Jules L Dienstag · Massachusetts General Hospital · N01 · FY2009 · DK
Mitochondrial creatine metabolism and glucose utilization in humans.
$86,000Shana Erin McCormack · Children'S Hosp Of Philadelphia · R03 · FY2017 · DK
Elucidating dietary fructose and alcohol interactions during liver cancer development
$85,733Cholsoon Jang · University Of California-Irvine · R01 · FY2024 · AA
Elucidating dietary fructose and alcohol interactions during liver cancer development
$85,733Cholsoon Jang · University Of California-Irvine · R01 · FY2025 · AA
Novel Mechanisms Regulating the Adipocyte-Brain Hepatocyte Axis
$85,701Philipp E Scherer · Ut Southwestern Medical Center · P01 · FY2013 · DK
Metabolite profiling for Coronary Artery Disease in Nonalcoholic Fatty Liver Disease
$85,500Kathleen Elizabeth Corey · Massachusetts General Hospital · R03 · FY2018 · DK
Metabolite profiling for Coronary Artery Disease in Nonalcoholic Fatty Liver Disease
$85,500Kathleen Elizabeth Corey · Massachusetts General Hospital · R03 · FY2017 · DK
Role of RIPK1 and RIPK3 in liver injury.
$85,428Lily Dara · University Of Southern California · K08 · FY2021 · DK
Clinical Research Network in Nonalcoholic Steatohepatitis
$85,371Kris Kowdley · Swedish Medical Center, First Hill · U01 · FY2018 · DK
Community Outreach and Translation Core (Hricko)
$85,242Andrea M Hricko · University Of Southern California · P01 · FY2015 · ES
IN DAIRY CATTLE, THE DEVELOPMENT OF INSULIN RESISTANCE IN SKELETAL MUSCLE AND ADIPOSE TISSUE IS A KEY MATERNAL ADAPTATION TO SPARE GLUCOSE AND OTHER NUTRIENTS FOR THE MAMMARY SYNTHESIS OF MILK IN EARLY LACTATION. UNFORTUNATELY, UNCONTROLLED POSTPARTUM INSULIN RESISTANCE MAY CONTRIBUTE TO SEVERE BODY FAT MOBILIZATION AND PREDISPOSE DAIRY COWS TO METABOLIC DISEASES INCLUDING FATTY LIVER AND KETOSIS. IN MID-LACTATION COWS, INSULIN SENSITIVITY IS ENHANCED AND NUTRIENT UTILIZATION SHIFTS TOWARDS BODY FAT DEPOSITION AND AWAY FROM THE MAMMARY GLAND TO LIMIT MILK PRODUCTION. APPROACHES THAT MODULATE INSULIN SENSITIVITY AS A MEANS TO REDUCE ADIPOSE TISSUE BREAKDOWN OR ENHANCE GLUCOSE PARTITIONING TOWARDS THE MAMMARY GLAND FOR MILK SYNTHESIS HAVE POTENTIAL TO IMPROVE COW HEALTH AND MILK PRODUCTION EFFICIENCY (MILK PRODUCED PER UNIT OF FEED INTAKE) DEPENDING ON STAGE OF LACTATION. BY ADDRESSING THE ANIMAL NUTRITION, GROWTH AND LACTATION PROGRAM AREA PRIORITY, OUR GOAL IS TO DEFINE THE MECHANISMSTHAT MEDIATE INSULIN RESISTANCE IN DAIRY COWS. IN NON-RUMINANTS WITH TYPE 2 DIABETES, EXCESS FATTY ACIDS TRIGGER THE SYNTHESIS OF A SPHINGOLIPID CALLED CERAMIDE, WHICH IN TURN CAUSES INSULIN RESISTANCE. OUR BODY OF WORK SUGGESTS THAT THE DE NOVO SYNTHESIS AND ACCUMULATION OF CERAMIDE IN RESPONSE TO ADIPOSE TISSUE BREAKDOWN ALSO INHIBITS INSULIN SENSITIVITY TO SPARE GLUCOSE FOR MILK PRODUCTION IN DAIRY CATTLE. OUR DATA ALSO SUGGESTS THAT CERAMIDE MEDIATES THE ABILITY OF SOMATOTROPIN TO INHIBIT INSULIN ACTION AND PROMOTE LACTATION. THE CERAMIDE HYPOTHESIS WILL BE TESTED BY UTILIZING A VALIDATED PHARMACOLOGICAL APPROACH TO INHIBIT SERINE PALMITOYLTRANSFERASE WITHIN THE DE NOVO CERAMIDE SYNTHESIS PATHWAY TO DETERMINE WHETHER CERAMIDE CAUSES INSULIN RESISTANCE AND SPARES GLUCOSE FOR LACTATION IN DAIRY COWS. THIS ANIMAL SCIENCE RESEARCH IS IMPORTANT BECAUSE INCREASES IN MILK PRODUCTION EFFICIENCY AND IMPROVEMENTS IN ANIMAL HEALTH ARE NEEDED TO SUPPORT A SUSTAINABLE DAIRY INDUSTRY. BY CHARACTERIZING THE MECHANISMS OF INSULIN RESISTANCE IN CATTLE, WE CAN THEN WORK TOWARDS DEVELOPING NUTRITIONAL APPROACHES TO TARGET THESE MECHANISMS AND THUS ENHANCE MILK PRODUCTION AND HEALTH IN CATTLE.
$85,235Cornell University · · FY2021 · National Institute of Food and Agriculture
Community Engagement Core
$85,134Lauren Heberle · University Of Louisville · P42 · FY2021 · ES
Project 2
$84,935Scott Laurence Friedman · Icahn School Of Medicine At Mount Sinai · P20 · FY2011 · AA
Project 1
$84,934Scott Laurence Friedman · Icahn School Of Medicine At Mount Sinai · P20 · FY2011 · AA
The role of insulin signaling in the dyslipidemia of the metabolic syndrome
$84,893Sudha B Biddinger · Boston Children'S Hospital · R03 · FY2010 · DK
Mechanisms of Regulation of Retinoic Acid Homeostasis
$84,871Nina Isoherranen · University Of Washington · R01 · FY2020 · GM
Role of excess glycogenolysis in fasting hyperglycemia in obesity-associated T2DM
$84,786Eunsook Jin · Ut Southwestern Medical Center · K01 · FY2008 · DK
Regulation of mitochondrial metabolism by SIRT4
$84,750Marcia Haigis · Harvard Medical School · R01 · FY2014 · AG
Acot9 Promotes Lipotoxicity
$84,750Baran Ersoy · Weill Medical Coll Of Cornell Univ · R03 · FY2020 · DK
Effect of dendritic cell lipid content on hepatic inflammation and NASH pathogene
$84,750George Miller · New York University School Of Medicine · R03 · FY2014 · DK
Acot9 Promotes Lipotoxicity
$84,750Baran Ersoy · Weill Medical Coll Of Cornell Univ · R03 · FY2019 · DK
Machine learning-based multi-omics modeling and CRISPR/Cas9-mediated gene editing in elucidating molecular transducer of physical activity
$84,597Zhen Yan · University Of Virginia · U01 · FY2022 · AG
Metabolic rewiring regulates cancer growth and tumor-associated immune responses
$84,593Steven Zhao · Salk Institute For Biological Studies · K00 · FY2021 · CA
Non-Alcoholic Fatty Liver Disease in Young Adult Women
$84,414Children'S Hospital Med Ctr (Cincinnati) · M01 · FY2004 · RR
Development of an Intravenously Delivered Nanofiber to Target MMP-2 in Aortic Aneurysms
$84,364Benjamin Ledford · University Of Virginia · F32 · FY2024 · HL