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24,576 grants matching “microbiome”
PAPM EAGER: Microfluidic Root Exudate Sampler with High Spatio-Temporal Sampling Resolution
$300,000Liang Dong · Iowa State University · · FY2016 · BIO
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** SOILBORNE DISEASES POSE A SIGNIFICANT CHALLENGE TO AGRICULTURAL PRODUCTIVITY. THE RELIANCE ON SYNTHETIC PESTICIDES TO COMBAT THESE DISEASES HAS RAISED SUSTAINABILITY CONCERNS, NECESSITATING RESEARCH FOR EFFECTIVE AND ECONOMICALLY VIABLE ORGANIC ALTERNATIVES. THIS PROJECT FOCUSES ON HARNESSING LOBSTER SHELLS, AN ABUNDANT YET UNDERUTILIZED RESOURCE, TO DEVELOP COST-EFFECTIVE ORGANIC SOIL AMENDMENTS, AIMING AT IMPROVING CROP PRODUCTIVITY, PROMOTING HEALTHY SOIL MICROORGANISMS, AND SUPPRESSING SOILBORNE PATHOGENS. IN ADDITION, THE PROJECT AIMS TO UNDERSTAND THE INTRICATE INTERACTIONS AMONG STRUCTURAL AND COMPOSITIONAL PROPERTIES OF LOBSTER SHELLS, SOIL MICROBIOME, AND SOILBORNE DISEASES. AFTER COMPLETING THIS PROJECT, WE WILL DEVELOP A GREEN TECHNOLOGY TO PRODUCE HIGHLY EFFECTIVE AND AFFORDABLE ORGANIC SOIL AMENDMENT WHICH COULD SUPPRESS PATHOGEN AND IMPROVE SOIL HEALTH. THE OUTCOMES OF THE PROJECT WILL HAVE A POSITIVE IMPACT TO THE U.S. AGRICULTURAL SYSTEM. THIS PROJECT IS TRANSFORMATIVE. THE DEVELOPED TECHNOLOGY AND OBTAINED FINDINGS CAN BE APPLIED TO OTHER SHELL WASTES AND INSECT RESOURCES, AND CAN CONTRIBUTE TO CROP PRODUCTION ENHANCEMENT IN VARIOUS CONTEXTS.
$300,000University Of Maine System · · FY2024 · National Institute of Food and Agriculture
PER- AND POLYFLUORINATED ALKYL SUBSTANCES (PFAS) HAVE CONTAMINATED WATER SYSTEMS IN 50 STATES, WITH AN ESTIMATED 200 MILLION U.S. RESIDENTS RECEIVING PFAS-CONTAMINATED DRINKING WATER. PFAS ARE ALSO COMMONLY FOUND IN FOOD PACKAGING, SUCH AS FAST-FOOD PACKAGING AND DISPOSABLE PAPER PLATES.AMONG PFAS, 6:2 FLUOROTELOMER ALCOHOL (6:2 FTOH) IS THE MOST DOMINANT, ANDIT EASILY MIGRATES INTO FATTY FOODS. HOWEVER, KNOWLEDGE ABOUT HOW THE EXPOSUREOF 6:2 FTOH COULD INFLUENCE HUMAN GUT HEALTH IS VERY LIMITED. THEREFORE, THE GOAL OF THIS PROJECT IS TO DETERMINE THE INFLUENCE OF 6:2 FTOH ON THE GUT MICROBIOME-METABOLOME AND ITS ROLE IN COLONIC INFLAMMATION. ADDITIONALLY, APREVENTION STRATEGY BASED ON KALE CONSUMPTION WILL BE EVALUATED. TO OBTAIN THE GOAL OF THIS PROJECT,THE EFFECTS OF 6:2 FTOH ON THE GUT MICROBIOTA, GUT PERMEABILITY, COLON LENGTH, AND THE LEVELS OF INFLAMMATORY MARKERS,IN MALE AND FEMALE MICE, WILL BE DETERMINED. ALSO, THE EFFECT OFKALE CONSUMPTION ON MITIGATING THE NEGATIVE IMPACT OF 6:2 FTOHWILL BE EVALUATED. THE RESULT OF THIS PROJECT WILL PROVIDE NEW EVIDENCE ON THE DETRIMENTAL EFFECTS OF PFAS EXPOSURE.
$300,000Florida State University · · FY2025 · National Institute of Food and Agriculture
FimH-Targeting Antibody-Recruiting Molecules as Novel Drugs for Preventing Complicated Urinary Tract Infections
$300,000Laurel McGrane · Fimbrion Therapeutics, Inc. · R43 · FY2023 · AI
The Female Urinary Microbiome and Urinary Incontinence
$300,000Linda Brubaker · Loyola University Chicago · R56 · FY2015 · DK
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** HERBICIDE-RESISTANT ITALIAN RYEGRASS POSES A SERIOUS THREAT TO GLOBAL AGRICULTURE, ESPECIALLY IN WINTER CROP PRODUCTION. IN ADDITION TO THE GENETIC FACTORS AND UNRESTRICTED HYBRIDIZATION, SEVERAL UNIQUE ECOLOGICAL TRAITS MAKE ITALIAN RYEGRASS A ROBUST INVADER AND A RESILIENT AND HERBICIDE-RESISTANCE-PRONE WEED AT A GLOBAL SCALE. IT HAS BEEN REPORTED THAT A SPECIFIC MICROBIOME, E.G., A SYMBIOTIC-ENDOPHYTE EPICHLOË SPP. PROVIDES ITALIAN RYEGRASS WITH INCREASED TOLERANCE TO MANY ABIOTIC STRESSES, INCLUDING DROUGHT, COMPETITION, AND SOMETIMES HERBICIDES. ADDITIONALLY, THERE IS EVIDENCE THAT CERTAIN ENVIRONMENTAL FACTORS CAN INFLUENCE THE STRESS RESPONSE IN WEED SPECIES AND, SUBSEQUENTLY, THE HERBICIDE EFFICACY, LEADING TO AGGRAVATED IMMUNITY OF THE WEEDS TO MULTIPLE HERBICIDE CHEMISTRIES. ALTHOUGH DISCUSSIONS WITH GROWERS IN EXTENSION MEETINGS AND FIELD VISITS TO WHEAT-PRODUCING COUNTIES IN ALABAMA INDICATE THAT SEVERAL ITALIAN RYEGRASS POPULATIONS ARE APPARENTLY SURVIVING SOME OF THE COMMONLY USED HERBICIDES APPLIED AT PREEMERGENCE AND POSTEMERGENCE STAGES IN THE REGION, NO WORK HAS BEEN DONE TO DOCUMENT THE CURRENT HERBICIDE RESISTANCE STATUS IN THIS WEED IN ALABAMA OR TO UNDERSTAND THE INFLUENCE OF KEY DRIVING FORCES TRIGGERING HERBICIDE RESISTANCE DEVELOPMENT AND SPREAD IN ALABAMA AND BEYOND. THIS PROJECT AIMS TO EVALUATE THE ABUNDANCE AND ASSOCIATION OF EPICHLOË SPP. TO HERBICIDE RESISTANCE DEVELOPMENT IN ITALIAN RYEGRASS POPULATIONS IN ALABAMA AND UNDERSTAND THE INTERACTIVE EFFECTS OF SOIL MOISTURE, TEXTURE, TEMPERATURE, AND CO2 LEVELS ON HERBICIDE RESISTANCE DEVELOPMENT. OUR OVERALL GOAL IS TO UNDERSTAND THE DRIVING FORCES OF HERBICIDE RESISTANCE ACQUISITION AND EXPRESSION IN ITALIAN RYEGRASS TO HELP DEVELOP INFORMED MANAGEMENT STRATEGIES FOR DEACCELERATING THE RESISTANCE EVOLUTION AND SPREAD.
$300,000Auburn University · · FY2024 · National Institute of Food and Agriculture
Vitamin D Fluctuations and the Mucosal Immune Response
$300,000Margherita T Cantorna · Pennsylvania State University, The · R01 · FY2019 · AT
Developing generalized engineering tools to create enhanced phage therapy for the clinic and commercialization
$300,000Robert McBride · Felix Biotechnology, Inc. · R41 · FY2022 · AI
Alterations and Renovations
$300,000William W King · University Of Louisville · P20 · FY2018 · GM
Kidney Precision Medicine Program (KPMP): Columbia AKI Recruitment Site
$300,000Krzysztof Kiryluk · Columbia University Health Sciences · UH3 · FY2021 · DK
Vitamin D Fluctuations and the Mucosal Immune Response
$300,000Margherita T Cantorna · Pennsylvania State University, The · R01 · FY2017 · AT
Vitamin D Fluctuations and the Mucosal Immune Response
$300,000Margherita T Cantorna · Pennsylvania State University, The · R01 · FY2016 · AT
ABI Innovation: Collaborative Research: Computational framework for inference of metabolic pathway activity from RNA-seq data
$300,000Aleksandr Z Zelikovskiy · Georgia State University Research Foundation, Inc. · · FY2016 · BIO
Interactions between the microbiome, metabolome, and immune system as underlying mechanisms of ALS pathogenesis
$300,000Benjamin Joseph Murdock · University Of Michigan At Ann Arbor · R01 · FY2022 · TS
Kidney Precision Medicine Program (KPMP): Columbia AKI Recruitment Site
$300,000Krzysztof Kiryluk · Columbia University Health Sciences · UH3 · FY2019 · DK
NSF2026: EAGER: Groundwater Microbial Communities as Sentinels of Environmental Change
$300,000Matthew Schrenk · Michigan State University · · FY2020 · GEO
SBIR PA22-176 - Culture-free microbial enrichment for diagnosis and characterization of anti-microbial resistance
$300,000Sandeep Kasoji · Triangle Biotechnology, Inc. · R43 · FY2023 · IP
Deciphering Molecular Networks Driving Community-Level Functions: A Generalizable Systems Biology Framework for Microbiome Research and Engineering.
$300,000Ophelia S Venturelli · Duke University · · FY2024 · BIO
PAPM EAGER: NANOPARTICLE MICROARRAY FOR HIGH-THROUGHPUT CHEMICAL PHENOTYPING OF MICROBIOME
$300,000Iowa State University Of Science And Technology · · FY2017 · National Institute of Food and Agriculture
PAPM EAGER: Identifying Small Molecule Inhibitors that Manipulate
$300,000Emily Balskus · Harvard University · · FY2016 · BIO
FimH-Targeting Antibody-Recruiting Molecules as Novel Drugs for Preventing Complicated Urinary Tract Infections
$300,000Laurel McGrane · Fimbrion Therapeutics, Inc. · R43 · FY2024 · AI
An immunotherapeutic IgY formulation against norovirus diarrhea
$300,000Julius G Goepp · Scaled Microbiomics, Llc · R41 · FY2023 · AI
Using novel pre-harvest, resistance-conferring treatments to prevent foodborne pathogenic outbreaks in produce
$299,999Murli Manohar · Ascribe Bioscience Inc. · R41 · FY2022 · AI
THIS IS A SEED PROPOSAL FOCUSED ON AN UNDEREXPLORED GENUS OF GUT BACTERIA THAT WE HAVE PREVIOUSLY FOUND DISPROPORTIONATELY ASSOCIATED WITH DIETARY OBESITY. IN A SERIES OF OUR PREVIOUS STUDIES, WE OBSERVED THAT A RARELY STUDIED BACTERIUM, "TURICIBACTER", IS ALMOST COMPLETELY DEPLETED BY DIETARY OBESITY BUT NOT GENETIC OBESITY. THE WESTERN-STYLE DIET (WSD) REPRESENTS ONE OF THE MAJOR CONTRIBUTORS TO THE CURRENT RAPID INCREASE OF DIETARY OBESITY. MUSHROOMS POSSESS A UNIQUE DIETARY COMPOSITION RICH WITH MULTIPLE NUTRIENTS THAT ARE COMPLEMENTARY TO WSD. THE OBJECTIVES OF THIS SEED GRANT IS TO DETERMINE THE ROLE OF THIS UNDEREXPLORED GENUS IN INTESTINAL DYSFUNCTION ASSOCIATED WITH DIETARY OBESITY, AND TO EXAMINE THE EFFECT OF MUSHROOM ON RESHAPING GUT MICROBIOME TOWARDS IMPROVING WSD-IMPAIRED GUT HEALTH. THE COMPLETION OF THIS STRENGTHENING SEED PROJECT WILL NOT ONLY PROVIDE THE MECHANISTIC UNDERSTANDING OF THE ROLE OF THE UNDERSTUDIED GENUS IN DIETARY OBESITY AND GUT HEALTH, BUT ALSO PROVIDE IMPORTANT INSIGHT INTO MUSHROOMS AS A WHOLE-FOOD APPROACH TO IMPROVE THE QUALITY OF WSD AND GUT HEALTH.
$299,999University Of Massachusetts · · FY2022 · National Institute of Food and Agriculture
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** BERRIES POSSESS VARIOUS HEALTH-ENHANCING PROPERTIES, PRIMARILY ATTRIBUTED TO THE POTENT ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF POLYPHENOLS THEREIN. ANTHOCYANINS (ANCS), MAJOR POLYPHENOLS IN BERRIES, ARE MAINLY RESPONSIBLE FOR THE PROTECTIVE EFFECTS OF BERRIES AGAINST OBESITY-INDUCED INFLAMMATION. AS BERRY ANCS ARE EXTENSIVELY BIOTRANSFORMED BY THE GUT MICROBIOTA, INDIVIDUALS WITH A DIFFERENT GUT MICROBIOME COMPOSITION, SUCH AS LEAN VS. OBESE, MAY PRODUCE DISTINCT ANC METABOLITES. IMPORTANTLY, A SIGNIFICANT GAP IN OUR KNOWLEDGE EXISTS AS TO HOW BERRIES PREVENT CHRONIC INFLAMMATION IN OBESITY AND WHETHER THE MODULATION OF THE GUT MICROBIOME PLAYS A ROLE. MOST STUDIES IN THE LITERATURE MERELY MEASURE KNOWN BIOMARKERS OF INFLAMMATION AND INFLAMMATORY PATHWAYS TO EXPLAIN THE ANTI-INFLAMMATORY EFFECTS OF BERRIES. HOWEVER, EMERGING EVIDENCE, INCLUDING OURS, EMPHASIZES THAT MONOCYTES IN THE CIRCULATION AND THE SPLEEN ARE LIKELY CRITICAL MODULATORS OF THE INFLAMMATORY RESPONSE.WE PUT FORTH THE HYPOTHESIS THAT LEAN AND OBESE MICE PRODUCE DISTINCT BLACKCURRANT ANC METABOLITES DUE TO THEIR DIFFERENCES IN GUT MICROBIOTA. THE GUT-DERIVED BLACKCURRANT ANC METABOLITES EXERT ANTI-INFLAMMATORY EFFECTS BY MODULATING THE NUMBER AND THE PHENOTYPES OF SPLENIC AND CIRCULATING MONOCYTES. TO TEST THIS HYPOTHESIS, WE WILL DETERMINE THE CONTRIBUTION OF THE GUT MICROBIOTA TO THE PREVENTIVE ROLES OF BLACKCURRANT AGAINST OBESITY-ASSOCIATED METABOLIC DYSFUNCTIONS AND INFLAMMATION; AND EVALUATE THE EFFECTS OF BLACKCURRANT ANC METABOLITES ON THE MODULATION OF CIRCULATING AND SPLENIC MONOCYTE NUMBER AND PHENOTYPES AS RELATED TO INFLAMMATION.
$299,999University Of Connecticut · · FY2022 · National Institute of Food and Agriculture