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24,576 grants matching “microbiome”
ADVANCING NEXT GENERATION GENOMIC TOOLS FOR DISCOVERY OF THE FOOD MICROBIOME: FROM THE FIELD TO THE STORE
$299,999Michigan State University · · FY2013 · National Institute of Food and Agriculture
PAPM EAGER: Tools for Investigating Micron-Scale Spatial Organization of Microbial Communities
$299,998Jessica L Mark Welch · Marine Biological Laboratory · · FY2016 · BIO
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** EDIBLE PLANTS HOST ABUNDANT MICROORGANISMS, MANY OF WHICH CAN SURVIVE TRANSIT THROUGH THE MAMMALIAN GUT AND MAY EVEN BE METABOLICALLY ACTIVE. PREVIOUS STUDIES HAVE QUANTIFIED MICROBIAL ABUNDANCE ON COMMERCIAL PRODUCE DURING HARVEST, STORAGE, TRANSPORTATION, AND AT POINT OF SALE, BUT LIMITED DATA EXISTS AT THE POINT OF CONSUMPTION, PARTICULARLY FOR GARDEN-FRESH PRODUCE. GARDEN-FRESH AND STORE-BOUGHT PRODUCE LIKELY HARBOR DISTINCT MICROBIAL COMMUNITIES, DUE TO DIFFERENCES IN HANDLING AND PROCESSING OVER THE SUPPLY CHAIN. SINCE GARDEN-FRESH PRODUCE TYPICALLY UNDERGO MINIMAL DISINFECTION PROCEDURES, THEY MAY YET HOST A BROAD DIVERSITY OF SOIL- AND PLANT-ASSOCIATED MICROBIOTA. EXPOSURE TO SOME OF THESE ENVIRONMENTAL MICROORGANISMS HAS BEEN LINKED WITH BENEFICIAL HEALTH EFFECTS, HOWEVER, OTHER MICROORGANISMS CONTAMINATING FRUITS AND VEGETABLES MAY BE PATHOGENIC.THIS PROJECT AIMS TO 1) CHARACTERIZE MICROBIAL COMMUNITIES OF GARDEN-FRESH AND STORE-BOUGHT PRODUCE AND 2) COMPARE EFFECTS OF CONSUMING GARDEN-FRESH VERSUS STORE-BOUGHT PRODUCE ON GUT MICROBIOME DIVERSITY AND COMPOSITION. IT WILL DO SO BY RECRUITING 20 HEALTHY ADULT GARDENERS TO PARTICIPATE IN A TWO-ARM CROSSOVER DIET TRIAL COMPARING CONSUMPTION OF USDA-RECOMMENDED DAILY AMOUNTS OF RAW FRUITS AND VEGETABLES SOURCED EITHER FROM THEIR OWN GARDEN (ARM 1) OR THE SAME FRUITS AND VEGETABLES FROM A SUPERMARKET (ARM 2). SUBJECTS WILL PROVIDE FRUIT/VEGETABLE AND FECAL SAMPLES DAILY DURING EACH ARM OF THE TRIAL. SHOTGUN METAGENOMIC SEQUENCING WILL BE USED TO CHARACTERIZE DIVERSITY AND COMPOSITION OF MICROBIAL COMMUNITIES INHABITING GARDEN-FRESH VS STORE-BOUGHT PRODUCE AND CHANGES IN THE HUMAN GUT MICROBIOME DURING EACH ARM OF THE TRIAL.
$299,998University Of Oregon · · FY2023 · National Institute of Food and Agriculture
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE MICROORGANISMS LIVING IN HONEY BEES (THE MICROBIOME) ARE KEY TO BEE HEALTH. DISRUPTIONS OF THE MICROBIOME OFTEN HAVE NEGATIVE CONSEQUENCES. YET WE KNOW VERY LITTLE ABOUT THE MOST ABUNDANT MICROBES IN HONEY BEES; THE VIRUSES THAT INFECT BACTERIA (BACTERIOPHAGES). OUR WORK SEEKS TO LEARN ABOUT THE ROLE THAT THESE VIRUSES PLAY IN THE HEALTH OF BEES; IF THEY AFFECT SUSCEPTIBILITY TO DISEASE AND HOW THEY CAN BE USED TO INFLUENCE THE BEE MICROBIOME. AN IMPROVED UNDERSTANDING OF HOW BACTERIOPHAGES INTERACT WITH BACTERIA AND ANIMAL HOSTS WILL RESULT IN INNOVATIVE WAYS TO INCREASE AGRICULTURAL PRODUCTION, ENSURE FOOD STABILITY, AND RELIEVE OUR DEPENDENCE ON ANTIBIOTICS IN AGRICULTURE.THE LONG-TERM GOAL OF THIS WORK IS TO MANIPULATE THE MICROBIAL COMMUNITY OF THE HIVE USING PHAGES TO REDUCE DISEASE. TOWARDS THIS GOAL, WE PROPOSE THREE OBJECTIVES: (1) TO UNDERSTAND THE DIFFERENCE BETWEEN DISEASED AND NON-DISEASED HONEY BEE MICROBIOMES, (2) TO IDENTIFY AND IMPROVE PHAGES THAT INFECT HONEY BEEPATHOGENS, AND (3) TO ADAPT PHAGES TO OVERCOME FOULBROOD RESISTANCE WHEN IT EVOLVES. DURING THIS PROJECT, WE WILL INNOVATE WAYS TO IMPROVE BEE HEALTH, TRAIN STUDENTS IN HIGH-DEMAND SKILLS, AND ENGAGE THE PUBLIC IN HONEY BEE AND SCIENTIFIC RESEARCH.
$299,997Regents Of The University Of Idaho · · FY2023 · National Institute of Food and Agriculture
PHYTOPHTHORA STEM AND ROOT ROT (PSR), CAUSED BY THE OOMYCETEPHYTOPHTHORA SOJAE, CAUSES SIGNIFICANT LOSSES IN SOYBEAN.P. SOJAESECRETES EFFECTOR PROTEINS CODED BY AVIRULENCE (AVR) GENES TO SUCCESSFULLY INFECT SOYBEAN. PSR IS PRIMARILY MANAGED BY PLANTING VARIETIES WITH RESISTANT GENES (RPS) THAT PREVENT INFECTION. HOWEVER, THE DURABILITY OF THESE GENES IS LIMITED TO 8-15 YEARS BECAUSE NEW VIRULENT PATHOTYPES EVOLVE TO BECOME VIRULENT AGAINST THERPSGENE. CONSEQUENTLY, NOVEL WAYS TO MANAGE THIS PSR ARE NEEDED.P. SOJAEIS ATTRACTED TO THE SOYBEAN RHIZOSPHERE BY ROOT EXUDATES. ROOT EXUDES ALSO TO ATTRACT BENEFICIAL MICROBES TO THE RHIZOSPHERE AND THESE MICROBES MAY SUPPRESS SOIL-BORNE PATHOGENS LIKEP. SOJAE. WE HYPOTHESIZE THATP. SOJAEUSES ITS EFFECTOR PROTEINS TOMANIPULATE THE HOST ROOT MICROBIOME FOR SUCCESSFUL INFECTION.STUDYING THE INTERACTION OF EFFECTOR PROTEINS WITH THE RHIZOSPHERE MICROBIOME MAY HELP US DISCOVER NOVEL BIO-BASED MATERIALS FOR BIOCONTROL OF PSR AND CONTRIBUTE TOTHE LONG-RANGE IMPROVEMENT IN AND SUSTAINABILITY OF US AGRICULTURE AND FOOD SYSTEMS. IN THE PROPOSED STUDY, WE WILL INVESTIGATE CHANGES IN ABUNDANCE, DIVERSITY, AND FUNCTION OF THE SOYBEAN ROOT MICROBIOME OVER TIME DURING COMPATIBLE AND INCOMPATIBLE SOYBEAN-P. SOJAEINTERACTIONS WITH TWO SOYBEAN GENOTYPES. THIS AIM ALIGNS WELL WITH THE PROGRAM AREA PRIORITY OF STUDYING FUNCTIONS OFAGRICULTURAL MICROBIOMES IN PLANT SYSTEMS AND NATURAL RESOURCES. THE OUTCOME OF THIS PROJECT WILL STRENGTHEN OUR RESEARCH PROGRAM BY CONTRIBUTING TO OUR UNDERSTANDING OF HOWP. SOJAEALTERS THE SOYBEAN ROOT MICROBIOME FOR INFECTION AND COLONIZATION. IN ADDITION, THIS STUDY WILL BUILD RESOURCES AND EXPERTISE FOR US TO BE MORE COMPETITIVE FOR EXTERNAL GRANT APPLICATIONS (NSF/USDA) TO STUDY BENEFICIAL AND PATHOGENIC MICROBE INTERACTIONS.
$299,989Arkansas State University · · FY2022 · National Institute of Food and Agriculture
EpiXact-FMT: A metagenomic, pharmacovigilance assay for microbiota therapeutics safety
$299,989Mohamad Sater · Day Zero Diagnostics, Inc. · R43 · FY2023 · AI
Development of Antibiotic-Free Clostridium difficile Therapeutics
$299,984Raquel Hontecillas · Biotherapeutics, Inc. · R43 · FY2019 · AI
Effects of ingestion of manufactured nanoparticles on endogenous microbiota and pathogen resistance in rainbow trout
$299,982Theodore B Henry · University Of Tennessee Institute Of Agriculture · · FY2014 · ENG
HEMP SEED, ONCE VIEWED AS A BY-PRODUCT OF THE HEMP FIBER INDUSTRY, HAS GAINED INCREASED ATTENTION AND POPULARITY DUE TO ITS NUTRITIONAL VALUE AND POTENTIAL BENEFITS IN IMPROVING GUT HEALTH.OUR RECENT PRELIMINARY STUDY REVEALED THAT HEMP SEED CONSUMPTION REDUCED COLONIC INFLAMMATION AND RELIEVED TISSUE DAMAGE IN A DEXTRAN SULFATE SODIUM-INDUCED INFLAMMATORY BOWEL DISEASE (IBD) MOUSE MODEL, INDICATING THE POTENTIAL ANTI-COLITIS PROPERTIES OF HEMP SEED. DESPITE THESE PROMISING FINDINGS, CRITICAL GAPS REMAIN. SPECIFICALLY, IT IS UNKNOWN WHETHER HEMP SEED CAN ALLEVIATE THE CHRONIC AND SPONTANEOUS PROGRESSION OF IBD, WHICH MORE CLOSELY REFLECTS THE HUMAN DISEASE COURSE. MOREOVER, THE EXTENT TO WHICH THE GUT MICROBIOTA CONTRIBUTES TO THE EFFECT OF HEMP SEED ON COLITIS REMAINS UNCLEAR.THIS APPLICATION AIMS TO DEFINE THE EFFECT AND MECHANISM BY WHICH HEMP SEED INFLUENCES COLITIS IN THE CHRONIC SPONTANEOUS IBD MOUSE MODEL. BASED ON OUR PRELIMINARY FINDINGS, WE HYPOTHESIZE THAT DIETARY CONSUMPTION OF HEMP SEED FAVORABLY ALTERS GUT MICROBIOTA AND ALLEVIATES COLITIS IN THE SPONTANEOUS IBD MOUSE MODEL. TO TEST OUR HYPOTHESIS, WE PROPOSE TWO SPECIFIC OBJECTIVES: 1) DETERMINE THE EFFECT OF HEMP SEED ON COLITIS-ASSOCIATED INFLAMMATORY RESPONSES AND BACTERIAL DYSBIOSIS, AND 2) CHARACTERIZE THE FUNCTIONAL ROLE OF GUT MICROBIOTA IN MEDIATING THE IMPACT OF HEMP SEED ON COLITIS. THE SUCCESSFUL COMPLETION OF THIS STUDY IS EXPECTED TO SIGNIFICANTLY ADVANCE OUR UNDERSTANDING OF THE HEMP SEED-MICROBIOME-INFLAMMATION AXIS AND COULD FACILITATE THE ESTABLISHMENT OF HEMP SEED AS A NOVEL FOOD OPTION FOR IBD PREVENTION AND GUT HEALTH IMPROVEMENT. THESE OUTCOMES ARE ALSO EXPECTED TO HAVE POSITIVE IMPACTS ON U.S. AGRICULTURE BY ADVANCING THE CULTIVATION AND PRODUCTION OF HEMP SEED AND ITS DERIVED FOOD PRODUCTS (HEMPSEED MILK, OIL, COOKIES, OR CEREAL) IN THE HEALTH MARKET, AND CREATING NOVEL ECONOMIC OPPORTUNITIES FOR THE HEMP INDUSTRY IN THE U.S.TOGETHER, THIS PROPOSAL ADDRESSES THE FOOD AND HUMAN HEALTH (A1343) PROGRAM AREA PRIORITY BY INVESTIGATING HOW HEMP SEED INFLUENCES GUT MICROBIOTA AND IBD, WITH THE LONG-TERM GOAL OF IDENTIFYING SUSTAINABLE FOOD SOURCES TO PREVENT IBD AND IMPROVE GUT HEALTH.
$299,965Purdue University · · FY2025 · National Institute of Food and Agriculture
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** AGRICULTURAL SOILS OFTEN SUFFER FROM DEGRADATION DUE TO OVERUSE, LEADING TO DECREASED YIELDS, INCREASED SOIL PATHOGENS, AND ADVERSE ENVIRONMENTAL IMPACTS. TO COMBAT THIS, PRACTICES THAT PROMOTE SOIL HEALTH ARE INCREASINGLY RECOMMENDED, AS THEY CAN ENHANCE THE LONG-TERM PRODUCTIVITY OF AGRICULTURAL SOILS. PERENNIAL HERBACEOUS PLANTS, WITH THEIR DENSE AND DEEP ROOT SYSTEMS, SHOW GREAT POTENTIAL FOR IMPROVING SOIL HEALTH. HOWEVER, THERE ARE SIGNIFICANT GAPS IN OUR UNDERSTANDING OF HOW ROOT-MICROBE-SOIL INTERACTIONS CONTRIBUTE TO SOIL HEALTH, ESPECIALLY AT DEPTHS BEYOND 20 CM. IDENTIFYING THE CONNECTIONS BETWEEN ROOT TRAITS AND SOIL PROCESSES IS CRUCIAL FOR SELECTING PLANTS THAT ENHANCE SOIL HEALTH THROUGHOUT THE SOIL PROFILE.THIS NEW INVESTIGATOR SEED GRANT FOCUSES ON UNDERSTANDING HOW FOUR FORAGE SPECIES IMPROVE SOIL HEALTH UP TO A DEPTH OF 1 METER. BY CONDUCTING FOUNDATIONAL RESEARCH ALIGNED WITH THE NIFA SOIL HEALTH PROGRAM PRIORITY AREA (A1401), WE AIM TO ADVANCE SCIENTIFIC KNOWLEDGE OF SOIL PHYSICAL AND BIOGEOCHEMICAL PROCESSES. THROUGH DETAILED GREENHOUSE AND FIELD EXPERIMENTS, WE WILL EXPLORE THE RELATIONSHIPS BETWEEN ROOT TRAITS, RHIZOSPHERE AND SOIL MICROBIOMES, AND OVERALL SOIL HEALTH. THESE INSIGHTS WILL BENEFIT FORAGE CROP PRODUCERS, AGRONOMISTS, SOIL HEALTH PRACTITIONERS, AND SCIENTISTS. BY ESTABLISHING A FOUNDATION FOR FUTURE COLLABORATIONS AND RESEARCH, THIS PROJECT SUPPORTS THE SEED GRANT GOAL OF PREPARING FOR FUTURE AFRI GRANT APPLICATIONS. OUR FINDINGS WILL BE SHARED WITH BOTH SCIENTIFIC AND AGRICULTURAL COMMUNITIES, ULTIMATELY AIDING IN THE SELECTION OF PLANTS THAT PROMOTE SOIL HEALTH OUTCOMES.
$299,959The Pennsylvania State University · · FY2025 · National Institute of Food and Agriculture
BioFe Mechanism of Action for the treatment of iron deficiency anemia
$299,955Darren Wolfe · Sidero Bioscience, Llc · R43 · FY2020 · HL
A novel Probiotic for Preventing and Treating Clostridium Difficile Pathogenesis
$299,953Gary Fanger · Rise Therapeutics, Llc · R43 · FY2018 · AI
A Novel Probiotic Engineered for Enhanced Immunological Function for Treating Inflammatory Bowel Disease
$299,931Gary Fanger · Rise Therapeutics, Llc · R43 · FY2019 · AI
Applying Association Mining and Group Based Trajectory Analyses to Characterize Spatial Temporal Trends of Community-Onset Antibiotic Resistant Staphylococcus aureus Infections in Children
$299,914Lilly Hsi-Chih Immergluck · Morehouse School Of Medicine · U54 · FY2025 · MD
Project 2: Microbiome pathobionts and Lupus pathogenesis
$299,907Gregg Joshua Silverman · New York University School Of Medicine · P50 · FY2020 · AR
Discovery of bacterial consortia to treat recurrent vulvovaginal candidiasis: a generalizable platform for phenotypic microbial community screening
$299,907Jared Scott Kehe · Concerto Biosciences · R43 · FY2022 · AI
Non-Invasive Single-Cell Morphometry and Tracking in Living Bacterial Biofilms
$299,893Andreas Gahlmann · University Of Virginia · R01 · FY2024 · GM
RFA-TS-24-010: Ambient Air Pollution as a Potential Risk Factor for ALS - Using a Multiomics Approach in a High-Quality Epidemiologic Study
$299,877Fang Fang · Karolinska Institute · R01 · FY2025 · TS
ABI Innovation: Collaborative Research: Computational framework for inference of metabolic pathway activity from RNA-seq data
$299,828Frank J Stewart · Georgia Tech Research Corporation · · FY2016 · BIO
Integrative Molecular Epidemiology Workshop
$299,784Shelley S Tworoger · American Association For Cancer Research · R25 · FY2025 · CA
Continuous glucose monitoring: determinants and prediction of diabetes mellitus development in the Framingham Heart Study
$299,750Nicole L Spartano · Boston University Medical Campus · R01 · FY2025 · DK
IRES: Human-Wildlife Feedbacks in the Mountains of Southwest China
$299,746Vanessa K Hull · University Of Florida · · FY2021 · O/D
Rapid and broad pathogen profiling system for infection in newborn
$299,734Mridu Sinha · Meliolabs Inc. · R43 · FY2019 · AI
Development of therapeutic GABA-producing bacteria
$299,717Philip Peter Strandwitz · Holobiome, Inc. · R44 · FY2019 · DK
Comprehensive Genomics Shared Facility
$299,694Michael R Crowley · University Of Alabama At Birmingham · P30 · FY2020 · CA