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24,576 grants matching “microbiome”
Project 4: The Role of Reactive Oxygen Species and the Microbiome in Toxicant Induced Liver Fibrosis
$299,661David A Brenner · University Of California, San Diego · P42 · FY2017 · ES
Development of A Narrow Spectrum Anti-Tubercular Agent
$299,661Karen G. Anthony · L2 Diagnostics, Llc · R43 · FY2019 · AI
Development of a therapeutic bacterial consortium for constipation
$299,600Philip Peter Strandwitz · Holobiome, Inc. · R43 · FY2021 · DK
RoL: FELS: EAGER: Disease resistance as a product of synergy between host immunity and the microbiome
$299,530Britt L Koskella · University Of California-Berkeley · · FY2018 · BIO
Bioorganic Approaches Toward Novel Antimicrobial Agents Against Gram-Negative Bacteria
$299,528Steven D. Townsend · Vanderbilt University · R35 · FY2022 · GM
Bioorganic Approaches Toward Novel Antimicrobial Agents Against Gram-Negative Bacteria
$299,528Steven D. Townsend · Vanderbilt University · R35 · FY2021 · GM
Bioorganic Approaches Toward Novel Antimicrobial Agents Against Gram-Negative Bacteria
$299,528Steven D. Townsend · Vanderbilt University · R35 · FY2023 · GM
A therapeutic for Lyme disease based on Peptidoglycan Recognition Protein 1
$299,514Sukanya Narasimhan · L2 Diagnostics, Llc · R41 · FY2021 · AI
A therapeutic for Lyme disease based on Peptidoglycan Recognition Protein 1
$299,514Sukanya Narasimhan · L2 Diagnostics, Llc · R41 · FY2022 · AI
Colibactin-Producing Escherichia coli as an Environmental Stimulus Shaping Pre-Cancer Progression
$299,386Martha J. Shrubsole · Vanderbilt University Medical Center · U54 · FY2023 · CA
Metabolic model-based integrative study of the relationship between the gut microbiome, metabolome, and diet
$299,367Elhanan Borenstein · University Of Washington · R01 · FY2018 · GM
Collaborative Clinical Research on Non Alcoholic Stratohepatitis
$299,360Naga P. Chalasani · Indiana University Indianapolis · U01 · FY2015 · DK
Early Life Vaccination to Prevent HIV acquisition during Adolescence
$299,339Sallie R. Permar · Weill Medical Coll Of Cornell Univ · P01 · FY2021 · AI
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** ANTIMICROBIAL USE (AMU) IN FOOD ANIMALS IS A CONTRIBUTOR TO ANTIMICROBIAL RESISTANCE (AMR) GLOBALLY. THE EFFECTS OF AMU REDUCTION IN ANIMAL PRODUCTION AND WELFARE, FOOD SAFETY, AND ENVIRONMENTAL AMR MITIGATION ARE POORLY UNDERSTOOD. THE OBJECTIVE OF THIS PROPOSAL IS TO DETERMINE THE IMPACT OF AMU ON MICROBIAL DIVERSITY, PREVALENCE OF AMR GENES, AND GENES INVOLVED IN HORIZONTAL GENE TRANSFER IN ENVIRONMENTAL SAMPLES FROM ANTIMICROBIAL-FREE AND CONVENTIONAL (I.E., FARMS THAT USE ANTIMICROBIALS AS PROPHYLACTICS) FARMS. WE WILL ALSO COMPARE BIRD MORBIDITY AND MORTALITY BETWEEN THESE TWO CATEGORIES AND IDENTIFY FACTORS THAT CONTRIBUTE TO HEALTH AND DISEASE PREVENTION. THIS INFORMATION WILL BE USED TO INFORM PRODUCERS OF IMPORTANT FACTORS CONTRIBUTING TO AMR AND HOW TO CONTROL IT. IT WILL ALSO INFORM THE SOURCES OF AMR TRANSMISSION FROM OUTSIDE TO INSIDE POULTRY HOUSES AND HOW TO IMPROVE BIOSECURITY TO AVOID THESE EVENTS. OUR SPECIFIC OBJECTIVES ARE TO (1) IDENTIFY POPULATION DIVERSITY AND PREVALENCE OF AMR GENES IN ENVIRONMENTAL SAMPLES FROM BROILER, BREEDER, AND PULLET FARMS AND HATCHERIES USING METAGENOMIC APPROACHES; (2) IDENTIFY TRANSMISSION PATHWAYS OF AMR GENES BETWEEN SAMPLE TYPES AND LOCATION INSIDE AND OUTSIDE THE POULTRY HOUSE AND BETWEEN HOUSES; (3) IDENTIFY THE IMPACT OF AMU AND FARM PRACTICES ON MICROBIOME CONNECTIONS AND TRANSMISSION OF AMR GENES. THIS RESEARCH WILL INFORM BEST PRACTICES TO REDUCE AMU WITHOUT COMPROMISING ANIMAL HEALTH AND PRODUCTIVITY. MITIGATING AMR IN POULTRY FARMS WILL IMPROVE FOOD SAFETY IN THE USA BY AVOIDING FARM-TO-FORK TRANSMISSION OF AMR PATHOGENS AND IMPROVING FOOD PRODUCTION EFFICIENCY BY REDUCING RECALLS.
$299,322Auburn University · · FY2024 · National Institute of Food and Agriculture
MACHINE LEARNING APPROACHES FOR INTEGRATING MULTI-OMICS DATA TO EXPAND MICROBIOME ANNOTATION
$299,299University Of Arizona · · FY2023 · Department of Energy
A Novel Anti-inflammatory and Anti-oxidant Therapy for Treating Non-healing Diabetic Foot Ulcers
$299,249David Jackson · Ceria Therapeutics, Inc. · R43 · FY2022 · DK
Training Program in Investigative Gastroenterology
$299,226Fred S. Gorelick · Yale University · T32 · FY2013 · DK
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** SOIL MICROBIOMES PLAY VITAL ROLES IN AGROECOSYSTEMS, MEDIATING PROCESSES LIKE DECOMPOSITION AND CARBON SEQUESTRATION. GIVEN THEIR INTRINSIC CONNECTIONS TO SOIL HEALTH, INTEGRATING NEW MICROBIAL PERSPECTIVES OFFERS TRANSFORMATIVE APPROACHES FOR SUSTAINABLE SOIL MANAGEMENT. HOWEVER, WE CURRENTLY LACK A ROBUST FRAMEWORK FOR UNDERSTANDING HOW DIFFERENT AGRONOMIC PRACTICES CAN EFFECTIVELY RECRUIT AND OPTIMIZE SOIL MICROBIOMES THAT ENHANCE ECOSYSTEM FUNCTIONS AND CLIMATE CHANGE RESILIENCE. ORGANIC FARMING PRACTICES SUCH AS THE USE OF COVER CROPS OR CARBON-RICH SOIL AMENDMENTS CAN INCREASE SOIL CARBON. FOR FARMERS IN THE COASTAL PLAINS, THESE BENEFITS CAN BE HIGHLY VARIABLE ACROSS SYSTEMS. THE GOAL OF THIS PROJECT IS TO MEASURE HOW SOIL MICROBIOMES RESPOND TO ORGANIC TRANSITION AND TO QUANTIFY MICROBIAL FUNCTIONS RELATED TO CARBON DYNAMICS AND COMMUNITY RESILIENCE. WE WILL STUDY SOILS FROM A THREE-YEAR ORGANIC TRANSITION FIELD EXPERIMENT AT TWO LOCATIONS IN NORTH CAROLINA TESTING HOW DIFFERENT AMENDMENTS (COMPOST, 50/50 COMPOST AND BIOCHAR, BIOCHAR) AND APPLICATION RATES CAN ACCELERATE SOIL HEALTH BENEFITS. TO ACCOMPLISH THIS, WE WILL PERFORM AMPLICON AND METAGENOME SEQUENCING TO DETERMINE HOW DIFFERENT ORGANIC TREATMENTS SHAPE MICROBIOME COMPOSITION AND GENETIC FUNCTIONAL POTENTIAL (OBJECTIVE 1). MOLECULAR DATA WILL LEVERAGE MEASUREMENTS OF MICROBIAL BIOMASS, RESPIRATION, CARBON UTILIZATION, AND ENZYME FUNCTIONAL POTENTIAL (OBJECTIVE 2). FINALLY, WE WILL ASSESS HOW ORGANIC AMENDMENTS IMPACT COMMUNITY RESILIENCE BY MEASURING CO2 AND N2O FLUX USING SOIL INCUBATIONS WITH SIMULATED EXTREME PRECIPITATION EVENTS (OBJECTIVE 3). WE AIM TO BUILD A PREDICTIVE FRAMEWORK FOR USING AGRONOMIC PRACTICES AND ORGANIC AMENDMENTS TO OPTIMIZE SOIL MICROBIOMES AND BENEFICIAL ECOSYSTEM FUNCTIONS THAT SUPPORT CLIMATE CHANGE RESILIENCE.
$299,213North Carolina State University · · FY2024 · National Institute of Food and Agriculture
Texas Medical Center Training Program in Antimicrobial Resistance
$299,169Anthony Richard Flores · University Of Texas Hlth Sci Ctr Houston · T32 · FY2021 · AI
Collaborative Research:(PRISM) - Predicting Resilience in Soil Microbiomes through multi-scale analysis of monsoon-driven adaptations
$299,147Malak M Tfaily · University Of Arizona · · FY2025 · BIO
Biological validation of phage host-range identified by proximity guided metagenomics
$299,132Ivan Liachko · Phase Genomics, Inc. · R43 · FY2023 · AI
EAGER: Novel genome-based method to measure taxon-specific phytoplankton growth rates in natural communities
$299,097Bettie B Ward · Princeton University · · FY2017 · GEO
Data Science Core
$299,078Dean Billheimer · University Of Arizona · P01 · FY2024 · AI
A novel, non-antibiotic, microbiome-directed agent to prevent post-surgical infection
$299,066John C. Alverdy · Covira Surgical · R42 · FY2023 · AI
Chemical biology of type IV secretion systems
$299,064Carrie Shaffer · University Of Kentucky · P20 · FY2022 · GM