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24,576 grants matching “microbiome”
High-Throughput High-Content Nanoscale Extracellular Vesicle Analysis
$298,999Gregory W Faris · Numentus Technologies Inc. · R43 · FY2024 · GM
Antifungal Compound Discovery from Metagenomes
$298,997David Alan Mead · Lucigen Corporation · R43 · FY2014 · AI
DIETARY INTERVENTION OF VITAMIN A-ENRICHED FOODS COULD POTENTIALLY CONTRIBUTE TO AN ANTI-INFLAMMATORY GUT MICROBIOME PROFILE AND REDUCE COLONIC AND SYSTEMIC INFLAMMATION IN HUMANS THROUGH UNCLEAR MECHANISMS. ATLANTIC MACKEREL FISH IS A LOW-COST, COMMONLY AVAILABLE SEAFOOD CONTAINING HIGH VITAMIN A LEVELS, PREDOMINANTLY RETINOL, IN THE FISH FILLETS. THERE REMAINS A SUBSTANTIAL KNOWLEDGE GAP REGARDING HOW ATLANTIC MACKEREL AND ITS BIOACTIVE COMPONENT RETINOL ALTER GUT MICROBIOME AND INFLAMMATION. THUS, WE PROPOSE A PRE-CLINICAL APPROACH USING YOUNG-ADULT SPRAGUE DAWLEY RATS AS MODELS TO PURSUE THE FOLLOWING TWO SPECIFIC OBJECTIVES: 1) EVALUATE THE ANTI-INFLAMMATORY PROPERTIES OF ATLANTIC MACKEREL FISH FILLETS VIA REBALANCING OF GUT MICROBIOME IN DSS-INDUCED INTESTINAL INFLAMMATION AND TEST THE ROLE OF DIET-INDUCED GUT MICROBIOME ALTERATION ON INFLAMMATION IN GERM-FREE MICE, AND 2) DETERMINE THE UNDERLYING METABOLIC MECHANISM BY WHICH RETINOL, AS ONE OF THE ATLANTIC MACKEREL BIOACTIVE COMPOUNDS, EXERTS THE ANTI-INFLAMMATORY ROLE THROUGH REGULATING CERTAIN ASPECTS OF GUT MICROBIOME GROWTH, METABOLISM, AND FUNCTION IN VITAMIN A DEFICIENT DSS RAT MODELS. THE RESULTS FROM THIS RESEARCH ARE EXPECTED TO HAVE A SIGNIFICANT IMPACT ON PUBLIC HEALTH BY PROVIDING NEW INSIGHTS INTO ATLANTIC MACKEREL AS A HEALTHY DIETARY OPTION THAT COULD REDUCE LOCAL AND SYSTEMATIC INFLAMMATION THROUGH DIFFERENTIAL EXPRESSION OF THE GUT MICROBIOME.
$298,923Oklahoma State University · · FY2022 · National Institute of Food and Agriculture
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** IN A SERIES OF STUDIES WE HAVE DEMONSTRATED THAT MICE FED A DIET FORMULATED TO MIMIC AVERAGE AMERICAN MACRO AND MICRONUTRIENT INTAKES (TOTAL WESTERN DIET, TWD) HAVE INCREASED INFLAMMATORY GENE EXPRESSION, GUT INFLAMMATION, COLITIS SEVERITY, AND CHANGES TO THE GUT MICROBIOME COMPARED TO MICE FED HEALTHY CONTROL DIETS. RECENTLY, OTHERS HAVE SHOWN THAT PSYCHOLOGICAL STRESS (PS) HAS SIMILAR DETRIMENTAL GUT HEALTH EFFECTS INCLUDING INCREASED INFLAMMATORY GENE EXPRESSION, DECREASED MUCIN THICKNESS, AND CHANGES TO THE GUT MICROBIOME AND METABOLOME. CONSIDERING THAT POOR DIET AND PS ARE COMMON IN CONTEMPORARY SOCIETY AND CAN OCCUR SIMULTANEOUSLY, WE HAVE A KEEN INTEREST IN DETERMINING INTERACTIONS BETWEEN DIET, PS, AND GUT HEALTH. THE WORK PROPOSED IN THIS SEED GRANT WOULD EXTEND OUR WELL-ESTABLISHED DIET/COLITIS MODEL TO INCLUDE ANOTHER ENVIRONMENTAL STRESSOR, PS. MOREOVER, WE PROPOSE TO USE RAMAN SPECTROSCOPY (RS) COUPLED WITH MACHINE LEARNING TO DEVELOP A NOVEL GUT INFLAMMATION MEASURE THAT WILL BE FASTER AND LESS EXPENSIVE THAN TRADITIONAL HISTOPATHOLOGY MEASURES. BASED ON OUR PREVIOUS STUDIES, WE HYPOTHESIZE THAT TWD-FED MICE SUBJECTED TO PS WILL HAVE INCREASED INFLAMMATORY GENE EXPRESSION, GUT INFLAMMATION, AND COLITIS DISEASE ACTIVITY RELATIVE TO MICE FED CONTROL DIETS. THIS NOVEL DATA WILL INCREASE OUR UNDERSTANDING OF HOW DIET AND PS INTERACT TO MODIFY GUT HEALTH. THE PROPOSAL ADDRESSES THE PROGRAM AREA, FOOD AND HUMAN HEALTH PRIORITY AREA (A1343) AND SPECIFICALLY ADDRESSES THE STATED PRIORITY: INVESTIGATE THE ROLE OF THE FOOD COMPONENTS OR CONTAMINANTS ON THE HUMAN GUT MICROBIOME AND ITS METABOLITES, AND THE SUBSEQUENT IMPACT ON HUMAN HEALTH.
$298,832Utah State University · · FY2024 · National Institute of Food and Agriculture
Bacteria and pathogen characterizations using outer membrane vesicles
$298,794Gregory W Faris · Numentus Technologies Inc. · R43 · FY2023 · AI
Project 1: HDAC inhibition and GVHD
$298,786Pavan Reddy · Icahn School Of Medicine At Mount Sinai · P01 · FY2017 · CA
Biomedical Resource Core
$298,728Paul A Welling · Johns Hopkins University · U54 · FY2024 · DK
Training in Mechanisms of Parasitism
$298,681Mary Edythe Wilson · University Of Iowa · T32 · FY2018 · AI
Bioorganic Approaches Toward Novel Antimicrobial Agents Against Gram-Negative Bacteria
$298,678Steven D. Townsend · Vanderbilt University · R35 · FY2019 · GM
JUST AS NASA USED THE REMOTELY OPERATED VEHICLES (ROV) SPIRIT AND OPPORTUNITY TO GATHER AND RELAY INFORMATION THAT CONTINUES TO BROADEN UNDERSTANDING OF MARS, WE WILL DEVELOP ROVS THAT WILL TRANSFORM OUR KNOWLEDGE OF RUMEN BIOLOGY AND FERMENTATION CHEMISTRY, WITH BACKING FROM NSF. THE RUMEN IS ONE OF THE PRIMARY DIGESTIVE CHAMBERS IN THE STOMACH OF A RUMINANT ANIMAL, SUCH AS A COW. ALTHOUGH THE COW RUMEN IS A VERY SPECIFIC ENVIRONMENT, IMPROVING OUR ABILITY TO STUDY THIS ECOSYSTEM PROVIDES NOTABLE OPPORTUNITY TO ENHANCE UNDERSTANDING OF FERMENTATION, FOOD PRODUCTION, AND ENERGY GENERATION, NOT JUST WITHIN CATTLE BUT WITHIN ANAEROBIC FERMENTATION ENVIRONMENTS IN GENERAL. RUMEN MICROORGANISMS ARE SOME OF THE WORLD'S MOST EFFICIENT FERMENTERS OF FIBROUS MATERIALS HIGH IN CELLULOSE; HOWEVER, ONLY A FRACTION OF THE SPECIES IN THE RUMEN MICROBIOME HAVE BEEN SEQUENCED OR CULTURED. THE RUMEN ECOSYSTEM IS A COMPLEX HETEROGENEOUS ENVIRONMENT STRATIFIED VERTICALLY AND HORIZONTALLY THAT CONTAINS MYRIAD SPECIALIZED MICROCLIMATES CAUSED BY DIFFERING DENSITY OF FEED PARTICLES AND O2 CONCENTRATIONS, AMONG OTHER FACTORS. THESE MICROCLIMATES ARE BELIEVED TO CREATE OPTIMAL ENVIRONMENTS FOR UNIQUE MICROBIAL SPECIES THAT MAY HAVE DIFFERING FERMENTATION CAPACITY AND THE STRATIFICATION WITHIN THE RUMEN MAY BE ONE CAUSE FOR DIFFICULTY IN CULTURING MANY OF THESE MICROORGANISMS OUTSIDE THE ANIMAL.A CURRENT ROADBLOCK HAMPERING ADVANCEMENT IN RUMEN PHYSIOLOGY AND MICROBIOLOGY IS THAT CONTEMPORARY RESEARCH TOOLS AND METHODS LACK THE ABILITY TO ACHIEVE THE NECESSARY DETAIL IN MEASUREMENT AND SAMPLE COLLECTION. KEY LIMITATIONS OF CURRENT TECHNOLOGIES INCLUDE: 1) LACK OF MOTILITY; 2) FAILURE TO SELF-IDENTIFY LOCATION WITHIN THE ANIMAL; 3) INABILITY TO RETRIEVE SAMPLES FOR LATER ANALYSIS; AND 4) POOR PRECISION AND ACCURACY. FOR EXAMPLE, BOLUS-DELIVERED TEMPERATURE AND PH PROBES CAN GENERATE PRECISE REAL-TIME MEASUREMENTS BUT SINK TO ONE LOCATION (TYPICALLY IN THE RETICULUM, BUT ULTIMATELY UNKNOWN TO THE RESEARCHER) AND OUTPUT VALUES CAN DRIFT OVER TIME. A DYNAMIC, PRECISE AND ACCURATE "MAP" OF THE RUMEN ENVIRONMENT THROUGH RUMEN ROV WOULD PROVIDE AN UNPRECEDENTED UNDERSTANDING OF THIS COMPLEX ECOSYSTEM. TO ADDRESS THIS GAP, WE WILL CONSTRUCT A ROBOTIC RUMEN ROV CAPABLE OF NAGIVATING, SAMPLING, AND CHARACTERIZING THE RUMEN AND ITS CONTENTS.
$298,678Virginia Polytechnic Institute & State University · · FY2019 · National Institute of Food and Agriculture
Bioorganic Approaches Toward Novel Antimicrobial Agents Against Gram-Negative Bacteria
$298,678Steven D. Townsend · Vanderbilt University · R35 · FY2020 · GM
Training in Molecular and Cell Biology of Allergy
$298,645David H Broide · University Of California, San Diego · T32 · FY2023 · AI
Biostatistics and Bioinformatics Shared Facility
$298,604Karan P. Singh · University Of Alabama At Birmingham · P30 · FY2018 · CA
Kansas Center for Metabolism and Obesity REsearch (KC-MORE) - Human Energy Balance Core
$298,556Joseph E. Donnelly · University Of Kansas Medical Center · P20 · FY2024 · GM
Microbiome and Ocular Inflammatory Disease
$298,524Robert Nussenblatt · National Eye Institute · ZIA · FY2015 · EY
Infections of specific periodontal microbiota are associated with risk for age-related macular degeneration
$298,500Chung-Jung Chiu · Ada Forsyth Institute, Inc. · R21 · FY2019 · EY
Bayesian multivariate image analysis for studying oral microbiome biogeography
$298,500Jacqueline R Starr · Ada Forsyth Institute, Inc. · R21 · FY2018 · DE
Role of Innate Immunity and Microbiome in the Inflammation of Aging and Long-Term Antiretroviral Therapy
$298,493Namita Rout · Tulane University Of Louisiana · P20 · FY2017 · GM
MRI: Track 3 Acquisition of Helium Recovery Equipment: Supporting Long-Term Sustainability for Baylor University's NMR Core Facility
$298,422Xianzhong Xu · Baylor University · · FY2024 · MPS
Role of CYP2A and Hmox1 in the Diabetogenic Effects of Arsenic in Mine Tailings
$298,368Xinxin Ding · University Of Arizona · P42 · FY2022 · ES
Role of CYP2A and Hmox1 in the Diabetogenic Effects of Arsenic in Mine Tailings
$298,368Xinxin Ding · University Of Arizona · P42 · FY2021 · ES
Role of CYP2A and Hmox1 in the Diabetogenic Effects of Arsenic in Mine Tailings
$298,368Xinxin Ding · University Of Arizona · P42 · FY2023 · ES
Microbiome, Environment, and Neurodevelopmental Delay (MEND)
$298,366Doris Jean Rodriguez · Emory University · P50 · FY2016 · ES
Primordially conserved principles governing mucosal immune responses to pathogens and microbiota
$298,307J. Oriol Sunyer · University Of Pennsylvania · R01 · FY2017 · GM
Training Program in Investigative Gastroenterology
$298,290Fred S. Gorelick · Yale University · T32 · FY2019 · DK