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24,576 grants matching “microbiome”
The UConn/JAX-GM Training Program in Genomic Science
$298,141Brenton R Graveley · University Of Connecticut Sch Of Med/Dnt · T32 · FY2022 · HG
Natural Product HCV Drugs from Rare Plant-Microbe Interactions
$298,115Mark T Hamann · Medical University Of South Carolina · R01 · FY2015 · AT
Impacts of Green Infrastructure on the Microbiome of Urban Stormwater: Reducing Threats to Public Health
$298,077Jay Martin · Ohio State University, The · · FY2018 · ENG
Glycosphingolipids from the Soil Microbiome, Understanding Structure and Biosynthesis
$298,068Paul Davis Boudreau · University Of Mississippi · P20 · FY2024 · GM
Integrated Biobanking Shared Resource
$298,016Michael M. Ittmann · Baylor College Of Medicine · P30 · FY2024 · CA
Integrated Biobanking Shared Resource
$298,016Michael M. Ittmann · Baylor College Of Medicine · P30 · FY2023 · CA
Integrated Biobanking Shared Resource
$298,016Michael M. Ittmann · Baylor College Of Medicine · P30 · FY2022 · CA
Integrated Biobanking Shared Resource
$298,016Michael M. Ittmann · Baylor College Of Medicine · P30 · FY2020 · CA
Project 4: The Role of Reactive Oxygen Species and the Microbiome in Toxicant Induced Liver Fibrosis
$298,015David A Brenner · University Of California, San Diego · P42 · FY2020 · ES
THIS INVESTIGATION ADDRESSES THE PROGRAM AREA PRIORITY TO SOLVE CRITICAL DISEASE ISSUES IMPACTING COMMERCIAL AQUACULTURE SPECIES. HATCHERY PRODUCTION OF SHELLFISH SEED IS REQUIRED TO SUPPLEMENT NATURAL RECRUITMENT AND MEET RISING INDUSTRY DEMAND FOR OYSTERS, SCALLOPS, AND HARD CLAMS. DESPITE CONSIDERABLE MEASURES AIMED AT THE ELIMINATION OF BACTERIAL PATHOGENS FROM AQUACULTURE SYSTEMS, DISEASE CONTINUES TO BE A MAJOR IMPEDIMENT TO RELIABLE LARVICULTURE PRODUCTION IN HATCHERIES, WITH PERIODIC BACTERIAL OUTBREAKS AFFECTING THE AVAILABILITY OF SEED AVAILABLE TO FARMERS. THERE IS A CRITICAL, UNMET NEED FOR NOVEL TOOLS TO PREVENT AND TREAT DISEASE OUTBREAKS AT AQUACULTURE FACILITIES. THE LONG-TERM GOAL OF OUR INVESTIGATION IS TO DEVELOP NEW TOOLS FOR BACTERIAL DISEASE MANAGEMENT IN AQUACULTURE (AND ALTERNATIVES TO ANTIBIOTIC TREATMENT) BY EXPLOITING KNOWLEDGE ON MICROBE-MICROBE-HOST-ENVIRONMENT INTERACTIONS. WE HAVE ISOLATED AND CHARACTERIZED THE MECHANISMS OF ACTION OF A PROBIOTIC BACTERIUM, PHAEOBACTER INHIBENS S4, ABLE TO SAFELY AND EFFECTIVELY PREVENT MORTALITY IN BIVALVE LARVAE CAUSED BY BACTERIAL PATHOGENS. HOWEVER, KNOWLEDGE GAPS REMAIN IN UNDERSTANDING THE MOLECULAR MECHANISMS THAT DICTATE FAVORABLE OUTCOMES FOR THESE INTERSPECIES INTERACTIONS, AND HOW THIS PROBIONT MAY AFFECT THE BACTERIAL COMMUNITY IN SHELLFISH HATCHERIES. WE HYPOTHESIZE THAT THE PROBIOTIC ACTIVITY OF S4 IS THE RESULT OF MULTIPLE CONTRIBUTING FACTORS, INCLUDING BENEFICIAL ALTERATION TO THE HOST AND CULTURE SYSTEM MICROBIOMES.THIS PROJECT WILL CHARACTERIZE CHANGES IN THE COMPOSITION (OBJECTIVE 1) AND FUNCTION (OBJECTIVE 2) OF THE MICROBIAL COMMUNITIES (THE MICROBIOMES) IN OYSTER HATCHERIES FOLLOWING EXPOSURE TO THE PROBIONT S4 USING SEQUENCING ANALYSIS OF THOSE COMMUNITIES (16S RRNA GENE LIBRARY AND METATRANSCRIPTOME ANALYSIS). IT WILL ALSO EVALUATE THE IMPACT OF ENVIRONMENTAL FACTORS ON S4 ACTIVITY (OBJECTIVE 3). THIS RESEARCH WILL ILLUMINATE HOW THE LARVAL OYSTER MICROBIOME MAY BE ALTERED TOPROMOTE EITHER DISEASE RESISTANCE OR SENSITIVITY, AND MAY REVEAL ADDITIONAL COMMUNITY MEMBERS OR TRANSCRIPTS ASSOCIATED WITH HOST PROTECTION OR DISEASE. DETAILED KNOWLEDGE ON MECHANISMS OF ACTION OF PROBIONT S4 WILL FACILITATE OPTIMIZATION OF ITS USE AS A DISEASE MANAGEMENT TOOL IN SHELLFISH HATCHERIES.
$297,969University Of Rhode Island · · FY2019 · National Institute of Food and Agriculture
Project 2: Microbiome pathobionts and Lupus pathogenesis
$297,894Gregg Joshua Silverman · New York University School Of Medicine · P50 · FY2019 · AR
Improving the accessibility and relevance of Medical Nutritional Therapy among people with Type 2 diabetes in the Latino community through a customizable, AI-powered application.
$297,877Shireen Abdullah · Kamin Consulting, Inc. · R43 · FY2021 · NR
Vaginal immune effects of testosterone in transmasculine individuals
$297,761Florian Hladik · University Of Washington · R21 · FY2022 · AI
Glioblastoma tumor microenvironmental influence on acquired and inherent cancer therapy resistance.
$297,715Christopher D Willey · University Of Alabama At Birmingham · U01 · FY2020 · CA
Impact of prevalence of P. gingivalis and S. cristatus in oral health disparities
$297,679Hua Xie · Meharry Medical College · U54 · FY2020 · MD
Developmental Regulation of Drug Metabolism by Targeting the Gut Microbiome
$297,413Julia Yue Cui · University Of Washington · R01 · FY2018 · GM
Developmental Regulation of Drug Metabolism by Targeting the Gut Microbiome
$297,413Julia Yue Cui · University Of Washington · R01 · FY2014 · GM
Developmental Regulation of Drug Metabolism by Targeting the Gut Microbiome
$297,413Julia Yue Cui · University Of Washington · R01 · FY2016 · GM
Developmental Regulation of Drug Metabolism by Targeting the Gut Microbiome
$297,413Julia Yue Cui · University Of Washington · R01 · FY2015 · GM
Developmental Regulation of Drug Metabolism by Targeting the Gut Microbiome
$297,413Julia Yue Cui · University Of Washington · R01 · FY2017 · GM
Impact of prevalence of P. gingivalis and S. cristatus in oral health disparities
$297,263Hua Xie · Meharry Medical College · U54 · FY2021 · MD
Role of CYP2A and Hmox1 in the Diabetogenic Effects of Arsenic in Mine Tailings
$297,240Xinxin Ding · University Of Arizona · P42 · FY2024 · ES
Full Project II: Novel Risk Factors and Disease Associations of Liver Cancer in Guam
$297,229Tanisha F Aflague · University Of Guam · U54 · FY2020 · CA
Sample Repository for Human Genetic Research
$297,129Alissa Marie Resch · Coriell Institute For Medical Research · U41 · FY2020 · HG
Kansas Center for Metabolism and Obesity REsearch (KC-MORE) - Human Energy Balance Core
$297,052Joseph E. Donnelly · University Of Kansas Medical Center · P20 · FY2023 · GM