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24,576 grants matching “microbiome”
Role of the microbiome of the schistosome snail host
$297,000Frederic David Chevalier · Texas Biomedical Research Institute · R21 · FY2023 · AI
The Developing Brain: Influences and Outcomes
$296,960Sean Cl Deoni · University Of Colorado Denver · UG3 · FY2016 · OD
Early Life Rhinovirus Infection and Childhood Asthma
$296,946Marc B Hershenson · University Of Michigan At Ann Arbor · R01 · FY2016 · AI
Project 1: Profiling anti-Ro preclinical and clinical autoimmunity
$296,891Robert M Clancy · New York University School Of Medicine · P50 · FY2020 · AR
Effects of Prenatal and Early Life Exposures on the Microbiome in American Indian Children.
$296,846Arielle R. Deutsch · Sanford Research/Usd · P20 · FY2019 · GM
Regulation of Transcription by 6S RNA
$296,800Karen M Wassarman · University Of Wisconsin-Madison · R01 · FY2015 · GM
Novel Platforms for Human Intestinal Enteroids: Matrix, Mechanics, and Topography
$296,761Kathryn Jane Grande-Allen · Baylor College Of Medicine · U19 · FY2017 · AI
Downstream molecular mechanisms underlying cerebral cavernous malformation
$296,731Mark L Kahn · Duke University · P01 · FY2024 · NS
Research Training in Rheumatology at Massachusetts General Hospital
$296,659Andrew D Luster · Massachusetts General Hospital · T32 · FY2019 · AR
Animal and Phenotyping Core
$296,650Luanne L Peters · Jackson Laboratory · P30 · FY2019 · AG
Applying Association Mining and Group Based Trajectory Analyses to Characterize Spatial Temporal Trends of Community-Onset Antibiotic Resistant Staphylococcus aureus Infections in Children
$296,577Lilly Hsi-Chih Immergluck · Morehouse School Of Medicine · U54 · FY2024 · MD
A novel thermogel for topical treatment of ulcerative colitis with microbialmetabolite mimicry.
$296,475Jeffrey Linhardt · Intact Therapeutics, Inc. · R43 · FY2023 · DK
Determination of the importance of colonization history in the assembly of the ga
$296,460Jens Walter · University Of Nebraska Lincoln · R01 · FY2013 · GM
Longitudinal and functional dynamics of autoimmune gut microbiomes
$296,451Katherine Snowden Pollard · J. David Gladstone Institutes · R21 · FY2014 · AI
OBESITY IS A STATE OF METABOLIC DYSFUNCTIONS AND CHRONIC LOW-GRADE INFLAMMATION, WHICH ARE CAUSALLY LINKED TO OBESITY CO-MORBIDITIES, SUCH AS NONALCOHOLIC FATTY LIVER DISEASE (NAFLD) AND TYPE 2 DIABETES. WE HAVE SOUGHT THE IDENTIFICATION OF NEW AGRICULTURAL CROPS THAT MAY BE CONSUMED TO COMBAT OBESITY AND ITS ASSOCIATED DISEASES. EDIBLE BROWN SEAWEEDS EXERT ANTI-OBESITY, ANTI-HYPERLIPIDEMIC, AND ANTI-DIABETIC ACTIVITIES. THEREFORE, THERE HAS BEEN A GROWING INTEREST IN THE HEALTH BENEFITS OF SEAWEED PRODUCTS IN THE U.S., CONSEQUENTLY EXPANDING SEAWEED FARMING IN THE EASTERN COASTAL STATES. HOWEVER, STUDIES ON THE HEALTH BENEFITS OF U.S.-GROWN SEAWEED ARE VERY LIMITED. OUR RECENT STUDY PROVIDES EVIDENCE THAT CONSUMPTION OF SUGAR KELP (SACCHARINA LATISSIMA), A MAJOR EDIBLE BROWN ALGA GROWN IN THE U.S., PREVENTS THE DEVELOPMENT OF OBESITY AND ITS ASSOCIATED METABOLIC DISTURBANCES, INFLAMMATION, AND FIBROSIS IN THE LIVER AND WHITE ADIPOSE TISSUE OF DIET-INDUCED OBESITYMICE. INTERESTINGLY, MICE FED SUGAR KELP EXHIBITED DRASTIC ALTERATIONS IN THE GUT MICROBIOME, WHICH HAS AN ENORMOUS IMPACT ON THE HOST'S ENERGY METABOLISM. ALSO, POLYSACCHARIDES IN BROWN SEAWEEDS ACT AS PREBIOTICS. THEREFORE, OUR PRELIMINARY FINDINGS INDICATE A POTENTIAL CONTRIBUTION OF THE GUT MICROBIOTA TO THE HEALTH BENEFITS OF SUGAR KELP. WE WILL STUDY IN THE PROJECT WHETHER SUGAR KELP CONSUMPTION PREVENTS OBESITY AND ITS ASSOCIATED ABNORMALITIES BY ALTERING THE GUT MICROBIOTA WHOSE METABOLITES ENHANCE ENERGY EXPENDITURE BY FACILITATING BROWNING OF WHITE ADIPOSE TISSUE AND INCREASINGFECAL ENERGY EXCRETION DUE TO ITS HIGH FIBER CONTENT. ALSO, AS CONCERNS ON POTENTIAL ADVERSE EFFECTS OF IODINE AND HEAVY METALS EXIST WITH SUGAR KELP CONSUMPTION, WE WILL EVALUATE THEIR TOXICITY IN VIVO.
$296,436University Of Connecticut · · FY2022 · National Institute of Food and Agriculture
Environmental modulation of microbial conflict and cooperation
$296,391Jeff Gore · Massachusetts Institute Of Technology · R01 · FY2020 · GM
Training Program in Investigative Gastroenterology and Hepatology
$296,384Scott Laurence Friedman · Icahn School Of Medicine At Mount Sinai · T32 · FY2025 · DK
Project 4: The Role of Reactive Oxygen Species and the Microbiome in Toxicant Induced Liver Fibrosis
$296,361David A Brenner · University Of California, San Diego · P42 · FY2018 · ES
Environmental modulation of microbial conflict and cooperation
$296,357Jeff Gore · Massachusetts Institute Of Technology · R01 · FY2019 · GM
Development and Validation of a Non-Invasive Microbiome-Based Diagnostic Tool for Early Detection of Gestational Diabetes Mellitus
$296,351Nini Fan · Brooklyn Innoseq Inc. · R43 · FY2024 · HD
Environmental modulation of microbial conflict and cooperation
$296,325Jeff Gore · Massachusetts Institute Of Technology · R01 · FY2018 · GM
Environmental modulation of microbial conflict and cooperation
$296,294Jeff Gore · Massachusetts Institute Of Technology · R01 · FY2017 · GM
Mechanistic basis of exercise responses in liver disease
$296,183Srinivasan Dasarathy · Cleveland Clinic Lerner Com-Cwru · R01 · FY2025 · DK
Microbial Contributions to Arsenic Transformation in the Gut
$296,130Pawel R Kiela · University Of Arizona · P42 · FY2024 · ES
Chemical biology of type IV secretion systems
$296,116Carrie Shaffer · University Of Kentucky · P20 · FY2020 · GM