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24,576 grants matching “microbiome”
Adaptive Immune Response to Gut Microbiota in Juvenile & Adult Spondyloarthritis
$295,192Charles O Elson · University Of Alabama At Birmingham · P60 · FY2017 · AR
Synthesis and function of Queuosine in Bacteria
$295,048Valerie De Crecy-Lagard · University Of Florida · R01 · FY2020 · GM
Mucosal determinants of Cryptosporidium infection
$294,923Pablo C Okhuysen · Baylor College Of Medicine · U19 · FY2020 · AI
Project 4: Neurobehavioral and bioenergetic consequences of evolving resistance to polycyclic aromatic hydrocarbons in a multi-stressor environment
$294,912Nishad Jayasundara · Duke University · P42 · FY2025 · ES
NeuroGerm Core
$294,834David Mitchell Smith · University Of California, San Diego · P30 · FY2017 · MH
Adaptive Immune Response to Gut Microbiota in Juvenile & Adult Spondyloarthritis
$294,812Charles O Elson · University Of Alabama At Birmingham · P60 · FY2015 · AR
Adaptive Immune Response to Gut Microbiota in Juvenile & Adult Spondyloarthritis
$294,618Charles O Elson · University Of Alabama At Birmingham · P60 · FY2016 · AR
Project 3: Interactions between microbial metabolites, airway pathogens and airway epithelial cell function
$294,538James E. Gern · University Of Wisconsin-Madison · U19 · FY2024 · AI
NeuroGerm Core
$294,485David Mitchell Smith · University Of California, San Diego · P30 · FY2018 · MH
Glycan Utilization Profiling in Human Gut Microbiomes of Common Funds Data
$294,432Yanbin Yin · University Of Nebraska Lincoln · R03 · FY2025 · OD
Development of a Novel Biosensor to AccelerateInvestigations of the Gut Microbiome.
$294,404Dylan Nichols · Biomesense, Inc. · R43 · FY2021 · TR
Data Discovery: Computational Methods for Searching Short-Read Sequencing Experiments
$294,294Carleton Lee Kingsford · Carnegie-Mellon University · R01 · FY2020 · GM
Administrative Core
$294,291Claire M Fraser-Liggett · University Of Maryland Baltimore · U19 · FY2015 · AI
Bioanalytical Core
$294,276Xiaoming Yang · University Of South Carolina At Columbia · P30 · FY2025 · GM
Bioanalytical Core
$294,276Xiaoming Yang · University Of South Carolina At Columbia · P30 · FY2024 · GM
The Female Urinary Microbiome: Adjacent Microbiomes and Clinical Associations
$294,219Alan J Wolfe · Loyola University Chicago · P20 · FY2015 · DK
Recruitment, Data Collection & Sample Management Core
$294,169Anne L. Wright · University Of Arizona · P01 · FY2023 · AI
Project 2
$294,092Tomas Kirchhoff · New York University School Of Medicine · P50 · FY2023 · CA
Metabolic model-based integrative study of the relationship between the gut microbiome, metabolome, and diet
$294,071Elhanan Borenstein · University Of Washington · R01 · FY2017 · GM
Effects of Prenatal and Early Life Exposures on the Microbiome in American Indian Children.
$294,062Arielle R. Deutsch · Sanford Research/Usd · P20 · FY2020 · GM
Synthesis and function of Queuosine in Bacteria
$294,052Valerie De Crecy-Lagard · University Of Florida · R01 · FY2021 · GM
Radiation Effect on Immune Cells and the Microbiome
$294,014Laura Santambrogio · Weill Medical Coll Of Cornell Univ · U54 · FY2024 · CA
Dietary Supplements and Inflammation Phase-2: Isoxanthohumol as a treatment for estrogen-deficient-induced visceral hyperalgesia.
$294,004Prakash S. Nagarkatti · University Of South Carolina At Columbia · P20 · FY2023 · GM
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** A KEY COMPONENT OF MANAGING CROPS TO WITHSTAND ENVIRONMENTAL STRESS IS OPTIMIZING BENEFICIAL PLANT-MICROBE INTERACTIONS THAT IMPROVE WATER AND NUTRIENT AVAILABILITY TO PLANTS AND DETER PATHOGENS. STRATEGIES TO ACHIEVE THIS INCLUDE USE OF COVER CROPS TO STABILIZE SOIL AND SUSTAIN DIVERSE SOIL MICROBIAL COMMUNITIES, AND ADDITION OF COMPOST TO SUPPLEMENT CARBON AND NUTRIENTS AND IMPROVE SOIL PROPERTIES. BENEFITS FROM THESE STRATEGIES ARE SLOW TO EMERGE IN HOT, SEMI-ARID ENVIRONMENTS SUCH AS THE TEXAS SOUTHERN HIGH PLAINS (SHP), THE LEADING COTTON PRODUCTION AREA IN THE U.S. WHERE CROP AND BIOLOGICAL ACTIVITIES ARE LIMITED BY WATER AND NUTRIENT AVAILABILITY, DISCOURAGING GROWERS FROM INVESTING IN THESE PRACTICES. WE ALSO KNOW LITTLE ABOUT SOIL MICROBIOMES AND HOW THEY ARE INVOLVED IN CROP RESPONSE TO DROUGHT AND PATHOGENS IN THESE ALREADY STRESSFUL ENVIRONMENTS. TO ADDRESS THIS GAP, THIS PROJECT WILL 1) IDENTIFY CHANGES IN SOIL MICROBIOMES AND COTTON PRODUCTIVITY IN RESPONSE TO COVER CROPPING AND COMPOST APPLICATIONS ACROSS TWO SOIL TYPES, 2) QUANTIFY HOW THESE TREATMENTS AFFECT THE RESISTANCE AND RESILIENCE OF KEY MICROBIAL FUNCTIONS TO SEVERE DROUGHT, AND 3) QUANTIFY HOW THESE TREATMENTS AFFECT SOIL SUPPRESSIVENESS TO A COTTON PATHOGEN. THESE RESULTS WILL REVEAL THE COMBINED AND INDIVIDUAL EFFECTS OF COVER CROPPING AND COMPOST ADDITIONS ON SOIL MICROBIOMES AND COTTON PRODUCTIVITY ACROSS SOIL TYPES, AS WELL AS BETTER DEFINE THE ROLE OF SOIL MICROBES IN COTTON RESPONSE TO DROUGHT AND PATHOGENS.
$294,000Texas Tech University System · · FY2024 · National Institute of Food and Agriculture
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** CORONAVIRUS DISEASE 2019 (COVID-19), THE VIRAL MULTI-SYSTEM ILLNESS CAUSED BY THE NOVEL CORONAVIRUS SARS-COV-2, HAS RESULTED IN SIGNIFICANT MORBIDITY AND MORTALITY ACROSS THE WORLD. APPROXIMATELY 30% OF PATIENTS EXPERIENCE LONG-COVID SYNDROME PRESENTING WITH SYMPTOMS SUCH AS COGNITIVE DIFFICULTIES ('BRAIN FOG'), FATIGUE, DYSPNEA, AUTONOMIC DYSFUNCTION, DEPRESSION AND ANXIETY, LASTING BEYOND 12 WEEKS CAUSING SIGNIFICANT DISABILITY, AND THREATEN HEALTH AND WELLBEING OF MILLIONS AROUND THE WORLD. AT THE CURRENT TIME THERE IS NO EFFECTIVE TREATMENT FOR LONG-COVID.WALNUTS CONTAIN A MIXTURE OF NUTRIENTS AND PHYTOCHEMICALS INCLUDE MONOUNSATURATED FATTY ACIDS (MUFA), POLYUNSATURATED FATTY ACIDS (PUFA), AND ALPHA-LINOLENIC ACID (ALA) THAT ARE IMPORTANT TO HUMAN HEALTH. CROSS-SECTIONAL STUDIES FOUND THAT WALNUT CONSUMPTION WAS DIRECTLY ASSOCIATED WITH COGNITIVE FUNCTION. WALNUTS ARE RICH SOURCE OF ELLAGITANNINS AND ELLAGIC ACID THAT CAN BE FURTHER CONVERTED BY INTESTINAL MICROBIOTA TO UROLITHINS. ALL THOSE COMPOUNDS HAVE BEEN REPORTED TO EXHIBIT NUMEROUS BENEFICIAL EFFECTS ON HUMAN HEALTH OUR RECENT STUDY AT UCLA DEMONSTRATED THAT DAILY CONSUMPTION OF POMEGRANATE JUICE, ANOTHER RICH SOURCE OF ELLAGITANNINS STABILIZED THE ABILITY TO LEARN VISUAL INFORMATION OVER A 12-MO PERIOD IN IN MIDDLE-AGED AND OLDER ADULTS [8]. WE HAVE SHOWN POMEGRANATE AND MIXED NUTS INCLUDING WALNUTS COULD INCREASE BLOOD MICROBIOME METABOLITES OF TRYPTOPHAN METABOLITE INDOLE PROPIONATE (IPA) AND SEROTONIN LEVELS VIA CHANGE OF GUT MICROBIOTA. BOTH IPA AND SEROTONIN PLAY AN ESSENTIAL ROLE IN GUT-BRAIN AXIS INCLUDING COGNITIVE FUNCTION.OUR PROPOSED PILOT STUDY WILL INCLUDE 76 ADULTS (AGES 50-80 YEARS) WITH DOCUMENTED DIAGNOSIS OF SARS-COV2 INFECTION PRESENTING WITH LONG-COVID SYMPTOMS LASTING LONGER THAN 12 WEEKS. THEY WILL BE RANDOMIZED 1:1 TO USUAL CARE VS. AN INTERVENTION GROUP THAT WILL INCLUDE 2 OZ (57G) OF WALNUTS DAILY INTO THEIR HABITUAL DIET FOR 12 WEEKS. WE WILL COMPARE THE IMPROVEMENT IN SYMPTOMS OF COGNITIVE COMPLAINS OF BRAIN FOG, FATIGUE AND DEPRESSION OF THE ACTIVE INTERVENTION GROUP VS. USUAL CARE. IN THIS PILOT STUDY, WE WILL ASSESS ALL ASPECTS OF COGNITION, INCLUDING EPISODIC MEMORY, EXECUTIVE FUNCTION, PROCESSING SPEED, WORKING MEMORY, ATTENTION, AND LANGUAGE, IN ORDER TO DETERMINE THE MOST SENSITIVE OUTCOME MEASURES AS WELL AS TO ESTIMATE THE EFFECT SIZES FOR PLANNING A FUTURE RO1/UO1 OR OTHER FUNDING FOR AN EFFICACY TRIAL. ADDITIONALLY, WE WILL ALSO TEST THE METHODOLOGY PRIOR TO APPLICATION FOR A LARGER CLINICAL TRIAL TO ASSESS RECRUITMENT FEASIBILITY, ADHERENCE, SAFETY, AND ACCEPTABILITY OF THE INTERVENTIONS IN THIS POPULATION. WE WILL EXPLORE THE MECHANISM OF HOW WALNUT CONSUMPTION AFFECTS BRAIN FOG, FATIGUE AND MOOD SYMPTOMS BY MEASURE BACTERIAL TRYPTOPHAN METABOLITES. THE OUTCOME OF THE INVESTIGATION OF THE BENEFIT OF WALNUT CONSUMPTION WILL PROVIDE IMPORTANT NOVEL INFORMATION ON USING DIETARY SOURCES OF POLYUNSATURATED FATTY ACIDS AND PHYTOCHEMICALS TO,MITIGATE THE COMMON SYMPTOMS OF LONG-COVID.
$294,000University Of California, Los Angeles · · FY2023 · National Institute of Food and Agriculture