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24,576 grants matching “microbiome”
CACHET - Environmental Biomarkers Core
$279,991Eric G Pamer · University Of Chicago · P30 · FY2023 · ES
Adaptive Reproducible High-Dimensional Nonlinear Inference for Big Biological Data
$279,949Yingying Fan · University Of Southern California · R01 · FY2019 · GM
Developing a reduced complexity model gut microbiome in the behavior model, Drosophila melanogaster
$279,923William Basil Ludington · Carnegie Institution Of Washington, D.C. · DP5 · FY2017 · OD
Biologic correlatives of chronic GVHD onset
$279,864Stephanie J Lee · Fred Hutchinson Cancer Research Center · U01 · FY2021 · CA
Collaborative Research: The stoichiometric trait distribution of the marine microbiome
$279,809Adam C Martiny · University Of California-Irvine · · FY2022 · GEO
Metalloenzyme structure, function and assembly
$279,792Catherine L Drennan · Massachusetts Institute Of Technology · R35 · FY2018 · GM
Understanding the Healthy Gut Virome and its Role in Human Health
$279,780Mark J Young · Montana State University - Bozeman · R01 · FY2016 · GM
Defining the dynamics of urobiome structure and function in postmenopausal women and its role in recurrent UTI susceptibility
$279,734Nicole Janell De Nisco · University Of Texas Dallas · R01 · FY2025 · DK
Training Program in Bioinformatics at the Intersection of Cancer Immunology and Microbiome
$279,732Kouros Owzar · Duke University · R25 · FY2022 · CA
FIBER CONSUMPTION IS STRONGLY LINKED TO IMPROVEMENTS IN HEALTH OUTCOMES. HOWEVER, CURRENT INTEREST IN PREBIOTIC FIBER SUPPLEMENTS FOCUSES PRIMARILY ON PREBIOTIC FIBERS MADE OFREPEATING UNITS OF VARYING LENGTHS WITH LOW STRUCTURAL DIVERSITY. IN CONTRAST, THEREARE COMPLEX, DIVERSE OLIGOSACCHARIDES COMPOSED OF A WIDER VARIETY OF SUBUNITSAND WITH VARYING DEGREES OF POLYMERIZATION ABUNDANTLY FOUND LINKED TO DIETARY PROTEINS. THE STRUCTURE OF THESE COMPLEX OLIGOSACCHARIDES (I.E. PREBIOTIC FIBERS)RESTRICT ACCESSIBILITY BY MANY GUT BACTERIA AND CAN SELECTIVELY ENRICH BENEFICIAL BACTERIA THAT BENEFIT HUMAN HEALTH. THE RELATIVE STRUCTURAL AND COMPOSITIONAL COMPLEXITY OF THESE COMPLEX OLIGOSACCHARIDES OFFERS AN IMPROVED PALETTE OF SELECTIVE, BIOACTIVE GLYCANS TO QUERY FOR SPECIFICITY IN ENRICHING BENEFICIAL BACTERIA IN THE GUT MICROBIOME.THIS PROJECT SEEKS TO CHARACTERIZE THEUTILIZATION OF THESE DIETARY PROTEIN-LINKED OLIGOSACCHARIDESBY HUMAN GUT MICROBES WITH A FOCUS ON A FAMILY OF ENZYMES KNOWN AS ENGASES, WHICH RELEASE THESE LINKED OLIGOSACCHARIDES FROMDIETARY PROTEINS INTACT. USINGIN VITROHUMAN GUT MICROBIOME MODELS, WE WILL EXAMINE THE DEGRADATION OF THESE OLIGOSACCHARIDES BY THE GUT MICROBIOME. WE WILL ALSO IDENTIFY ENZYMATIC STRATEGIES INVOLVED IN THE CONSUMPTION OF THESE OLIGOSACCHARIDESBY KEY MEMBERS OF THE GUT MICROBIOME TO RECONSTRUCT MICROBIAL TROPHIC NETWORKS. IDENTIFIED ENGASES WILL BE EXAMINED FOR SUITABILITY FOR USE IN FOOD PROCESSING APPLICATIONS TO RELEASE BIOACTIVE GLYCANS. FINALLY, WE WILL COMPARE THE PREBIOTIC ACTIVITY OFOLIGOSACCHARIDES RELEASED BY THESE ENGASES USING HUMAN GUT MICROBIOMES ININ VITRO.THE GOAL OF THIS WORK IS TO DEVELOP FOOD PROCESSING APPROACHES WHICH CAN ENRICH THE 'EFFECTIVE' FIBER CONTENT OF EXISTING FOODS OR FOOD INGREDIENTS (I.E. WHEY, PEA, SOY, EGG WHITE PROTEIN, OR OTHER FOOD PROTEINS) AND ULTIMATELY IMPROVE BOTH HUMAN HEALTH AND THE VALUE OF THESE INGREDIENTS.
$279,662Board Of Regents Of Nevada System Of Higher Education · · FY2022 · National Institute of Food and Agriculture
Research Core 1: Molecular Measures Core (RC1)
$279,649Virginia B. Kraus · Duke University · P30 · FY2019 · AG
Strep-CaDI: A fast, accurate, and sensitive point-of-care test for Group A Streptococcus
$279,557Zachary David Call · Burst Diagnostics Llc · R43 · FY2023 · AI
Control and Impacts of Disease of Zebrafish in Research Facilities
$279,464Michael Lawrence Kent · Oregon State University · R24 · FY2017 · OD
Metabolic correlates of disease activity and disability progression in pediatric MS
$279,374Emmanuelle Laurence Waubant · University Of California, San Francisco · R01 · FY2023 · NS
Core B: Biospecimens
$279,352Andrew Lewis Feldman · University Of Iowa · P50 · FY2018 · CA
A prospective multiethnic HFpEF cohort from California's Central Valley
$279,271Nipavan Chiamvimonvat · University Of California At Davis · U01 · FY2024 · HL
Role of taste signaling in airway epithelial function
$279,248Vijay Ramakrishnan · University Of Colorado Denver · K23 · FY2019 · DC
Delaware INBRE
$279,134Melinda K. Duncan · University Of Delaware · P20 · FY2024 · GM
Neonatal Microbiome, Exposures and Infection
$279,011Juliette Madan · Dartmouth College · P20 · FY2014 · GM
Advanced Training at the Interface of Engineering and Oral-Craniofacial Sciences
$278,862Hyun Koo · University Of Pennsylvania · T90 · FY2024 · DE
Multi-Omics Predictors of Oral HPV Outcomes among PLWH
$278,797Josue Perez-Santiago · University Of Puerto Rico Med Sciences · P20 · FY2024 · GM
Engineering bacterial behaviors to control microbiota invasion resistance
$278,599Raghuveer Parthasarathy · University Of Oregon · P01 · FY2018 · GM
GUT MICROBIOME AS A PREDICTOR OF RESPONSE TO CHEMOTHERAPY IN METASTATIC COLORECTAL CANCER
$278,587University Of Miami · · FY2020 · Defense Health Agency
Human Intestinal Microbial Ecologies of Indigenous Communities
$278,546Cecil M Lewis · University Of Oklahoma · R01 · FY2013 · GM
In Vivo Mechanism of Immune Response to Factor VIII: Project 2
$278,542Roland W. Herzog · Children'S Hosp Of Philadelphia · U54 · FY2021 · HL