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24,576 grants matching “microbiome”
Environmental Health Outcomes Research Among Hurricane Harvey Survivors
$275,688Melissa L Bondy · Baylor College Of Medicine · R21 · FY2018 · ES
Collaborative Research: Building and testing predictions of context dependence of synergistic benefits to plants from multiple symbionts
$275,617Thomas G Platt · Kansas State University · · FY2024 · BIO
Kansas Center for Metabolism and Obesity REsearch (KC-MORE) - Human Energy Balance Core
$275,486Joseph E. Donnelly · University Of Kansas Medical Center · P20 · FY2025 · GM
Project 3: Application of the Microbiome and Microenvironment to Novel Non Endoscopic Screening and Surveillance in Barrett's Esophagus
$275,411Julian Abrams · Columbia University Health Sciences · U54 · FY2019 · CA
HONEY BEES ARE THE PRIMARY MANAGED INSECT POLLINATOR IN US AGRICULTURE, YET PROBLEMS PERSIST IN THE MANAGED POPULATION. TWO OF THE PRIMARY PROBLEMS WITH HONEY BEE COLONIES ARE DISEASE AGENTS (PATHOGENS AND PARASITES) AND DIMINISHED REPRODUCTIVE QUALITY OF QUEENS. FOR THE FORMER, BEEKEEPERS REGULARLY APPLY ANTIBIOTICS (TO CONTROL BACTERIAL PATHOGENS) AND ACARICIDES (TO CONTROL VARROA MITES) IN ORDER TO KEEP THEIR COLONIES HEALTHY. FOR THE LATTER, BEEKEEPERS OFTEN REPLACE THEIR QUEENS BECAUSE OF REDUCED LONGEVITY, PREMATURE FAILURE, OR EARLY REJECTION, BUT THE CAUSE(S) OF DIMINISHED REPRODUCTIVE QUALITY ARE STILL UNCLEAR. WE PROPOSE TO TEST A POTENTIAL LINK BETWEEN BEEKEEPER-APPLIED COMPOUNDS AND REDUCED QUALITY OF QUEENS (AND THE DRONES WITH WHICH THEY MATE). OUR OBJECTIVES ARE TO DETERMINE IF IN-HIVE TREATMENTS, I.E., ANTIBIOTICS AND ACARICIDES, (1) IMPACT THE REPRODUCTIVE HEALTH AND PHYSIOLOGY, (2) ACCUMULATE IN THE REPRODUCTIVE ORGANS, AND (3) ALTER THE GUT AND REPRODUCTIVE MICROBIOMES OF QUEENS AND DRONES. LASTLY, (4) WE WILL PROMOTE CLINICAL SERVICES FOR MEASURING QUEENS AND DRONES FOR BEEKEEPERS IN REAL TIME SO THAT THEY CAN MEASURE THESE EFFECTS IN THEIR OWN OPERATIONS. PRELIMINARY AND PUBLISHED WORK HAS DEMONSTRATED THAT BEEKEEPER-APPLIED MEDICATIONS MAY HAVE INDIRECT EFFECTS ON HONEY BEE FECUNDITY, THUS FINDING A BALANCE BETWEEN MAINTAINING COLONY HEALTH AND PRODUCTIVITY IS PARAMOUNT TO MAINTAIN A SUSTAINABLE MANAGED POLLINATOR POPULATION.WE PREDICT THAT THIS RESEARCH WILL LEAD TO IMPORTANT INFORMATION ABOUT THE IMPACTS OF IN-HIVE TREATMENTS ON THE REPRODUCTIVE FITNESS OF BOTH QUEENS AND DRONES. THIS INFORMATION WILL BE PARTICULARLY RELEVANT FOR BEEKEEPERS, BREEDERS, AND BEE VETERINARIANS. THROUGH THE NORTH CAROLINA STATE HONEY BEE QUEEN & DISEASE CLINIC AND THE UNIVERSITY OF NORTH CAROLINA AT GREENSBORO PLANT AND POLLINATOR CENTER, WE WILL PROMOTE CLINICAL SERVICES FOR MEASURING REPRODUCTIVE FITNESS OF QUEENS AND DRONES AS WELL AS HOST PUBLIC OUTREACH EVENTS TO COMMUNICATE OUR RESEARCH AND ADVISE BEST TREATMENTS PRACTICES TO BEEKEEPERS AND BEE VETERINARIANS BASED ON OUR FINDINGS. OVERALL, THIS WORK WILL IMPROVE THE QUALITY OF BEEKEEPER DECISION-MAKING AND CRITICAL ANALYSES, THROUGH PROMOTING DATA-DRIVEN MANAGEMENT PRACTICES. THE PROPOSED RESEARCH ADDRESSES THE AFRI PROGRAM AREA PRIORITY POLLINATOR HEALTH: RESEARCH AND APPLICATION BY INVESTIGATING THE IMPACT OF BEEKEEPER APPLIED ACARICIDES AND ANTIBIOTICS ON HONEY BEE REPRODUCTIVE HEALTH.
$275,407University Of North Carolina At Greensboro · · FY2022 · National Institute of Food and Agriculture
Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)
$275,349Norah A. Terrault · University Of Southern California · U01 · FY2020 · DK
Training in Molecular and Cell Biology of Allergy
$275,334David H Broide · University Of California, San Diego · T32 · FY2021 · AI
Multiscale Stochastic Modeling To Meet the Needs Of Modern Microbial Biology
$275,303Andrew Mugler · University Of Pittsburgh At Pittsburgh · R35 · FY2025 · GM
Neuropathology Core
$275,302Vahram Haroutunian · Icahn School Of Medicine At Mount Sinai · P30 · FY2023 · AG
Project 1 - Epidemiologic studies of gastric carcinogenesis
$275,300Douglas Morgan · Vanderbilt University Medical Center · P01 · FY2017 · CA
Local and systemic specific immunity, microbiome and H. pylori infection in child
$275,283Steven J Czinn · University Of Maryland Baltimore · U19 · FY2010 · AI
Metagenomic discovery and optimization of novel endolysins targeting Cutibacterium acnes to treat acne vulgaris
$275,250Oliver Wei Liu · Topaz Biosciences, Inc. · R43 · FY2023 · AR
Mechanistic basis of exercise responses in liver disease
$275,231Srinivasan Dasarathy · Cleveland Clinic Lerner Com-Cwru · R01 · FY2024 · DK
Administrative Core
$275,196William Charles Nierman · J. Craig Venter Institute, Inc. · U19 · FY2017 · AI
Novel Strategies for Prevention of Necrotizing Enterocolitis
$275,137Hala Chaaban · University Of Oklahoma Hlth Sciences Ctr · P20 · FY2022 · GM
Pilot Projects Program
$275,070Michael Anthony Gallo · Rbhs-Robert Wood Johnson Medical School · P30 · FY2016 · ES
Pilot Projects Program
$275,070Michael Anthony Gallo · Rbhs-School Of Public Health · P30 · FY2018 · ES
Pilot Projects Program
$275,070Michael Anthony Gallo · Rbhs-Robert Wood Johnson Medical School · P30 · FY2014 · ES
Pilot Projects Program
$275,070Michael Anthony Gallo · Rbhs-School Of Public Health · P30 · FY2017 · ES
Pilot Projects Program
$275,070Michael Anthony Gallo · Rbhs-Robert Wood Johnson Medical School · P30 · FY2015 · ES
SBIR Phase I: Engineering the Plant Microbiome to Reduce Disease in Crops
$274,999Andrea K Wallace · Robigo, Inc. · · FY2023 · TIP
In Vivo Mechanism of Immune Response to Factor VIII: Project 2
$274,989Roland W. Herzog · Children'S Hosp Of Philadelphia · U54 · FY2022 · HL
THE CATFISH INDUSTRY LOSSES MILLIONS OF DOLLARS EVERY YEAR DUE TO BACTERIAL DISEASE IN POOR WATER QUALITY SYSTEMS. WE PROPOSE THAT INFECTION IN FISH IS LINKED TO THE DAMAGE OF BENEFICIAL MICROBIOME IN THE NOSE AND GUT, BY AQUACULTURE WATER WITH HIGH AMOUNTS OF FISH WASTE. THUS, RECOVERING THE MICROBIOME OF MAIN EXTERNAL ORGANS WITH PROBIOTIC TREATMENTS, CAN IMPROVE THE FISH IMMUNE SYSTEM, AND THEREFORE REDUCE SICKNESS.IN THIS PROJECT, WE WILL IDENTIFY CATFISH NOSE AND GUT MICROBIOME THAT ARE TOLERANT TO POOR QUALITY WATERS. THEN, WE WILL DESIGN AND PRODUCE PROBIOTIC TREATMENTS FOR NOSE AND GUT OF FISH AND WILL ASSESS THEIR ABILITY TO PROTECT AGAINST INFECTIONS. SPECIFICALLY, WE WILL TARGET FOR PROBIOTIC TREATMENTS THAT PROTECT FROM THE HOLE IN THE HEAD DISEASE IN CATFISH, WITH OUR LONG-TERM GOAL BEING TO DEVELOP FOOD PROBIOTICS THAT CAN PREVENT BACTERIAL ILLNESS IN INTENSIVE CULTURE SYSTEMS.
$274,958Texas State University · · FY2021 · National Institute of Food and Agriculture
Glycosphingolipids from the Soil Microbiome, Understanding Structure and Biosynthesis
$274,920Paul Davis Boudreau · University Of Mississippi · P20 · FY2023 · GM
Cefalu: Project 3; Moringa Isothiocyanates for Metabolic Resilience Moringa (Raskins)
$274,870Ilya Raskin · Lsu Pennington Biomedical Research Ctr · P50 · FY2015 · AT