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82,697 grants matching “vaccine development”
Molecular Genetics and Pathogenesis of Anthrax
$770,302Stephen Leppla · National Institute Of Allergy And Infectious Diseases · ZIA · FY2022 · AI
Vectors and Methods to Increase Immunogenicity during DNA Vaccination
$770,191Barney Graham · National Institute Of Allergy And Infectious Diseases · ZIA · FY2011 · AI
Duration of Hormonal Contraceptive Use: Immune Responses & Vaginal Microbiota
$770,085Khalil G Ghanem · Johns Hopkins University · R01 · FY2015 · AI
Administrative Core
$770,083Jenny P.y. Ting · Univ Of North Carolina Chapel Hill · U19 · FY2016 · AI
Promoting Adherence to TB Regimens in High-Risk Youth
$770,041Melbourne F Hovell · San Diego State University · R01 · FY2007 · HL
Protection and Immunity after Polyanhydride Nanoparticle Vaccination against Avian Influenza A Virus
$770,038Kevin L Legge · University Of Iowa · R01 · FY2023 · AI
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** AFRICAN SWINE FEVER VIRUS (ASFV) IS WIDESPREAD IN MANY SWINE PRODUCING COUNTRIES, CAUSING LARGE ECONOMIC LOSSES AND AFFECTING GLOBAL FOOD SECURITY. THERE ARE NO EFFECTIVE VACCINES OR TREATMENTS AVAILABLE FOR ASFV. ALTHOUGH THERE ARE STRONG EVIDENCE SUGGESTING THAT ANTIBODY IS AN IMPORTANT COMPONENT OF THE PROTECTIVE IMMUNITY, THE IDENTITY OF VIRAL PROTEINS CAPABLE OF ELICITING PROTECTIVE ANTIBODY RESPONSES IN PIGS REMAIN ELUSIVE. THIS KNOWLEDGE GAP SEVERELY HINDERS THE DEVELOPMENT OF EFFECTIVE ASFV VACCINES. IT IS OBSERVED THAT PIGS SURVIVING AN INFECTION WITH AN ASFV STRAIN OR THOSE IMMUNIZED WITH A LIVE-ATTENUATED VACCINE STRAIN DEVELOP SOLID HOMOLOGOUS PROTECTIVE IMMUNITY. ON THE OTHER HAND, PIGS VACCINATED WITH EXPERIMENTAL INACTIVATED ASF VACCINES DO NOT. WE HYPOTHESIZE THAT PIGS INFECTED WITH A LIVE ASFV STRAIN DEVELOP A DIFFERENT ANTIBODY PROFILE AS COMPARED TO THOSE VACCINATED WITH AN INACTIVATED VACCINE.THE PRIMARY GOAL OF THIS PROPOSED RESEARCH IS TO IDENTIFY VIRAL PROTEINS CAPABLE OF ELICITING A PROTECTIVE IMMUNE RESPONSE IN PIGS. IN THIS CURRENT APPLICATION, WE PROPOSE TO EMPLOY OUR RECENTLY DEVELOPED HIGH-THROUGHPUT ASSAY TO SYSTEMATICALLY SCREEN THE WHOLE ASFV PROTEOME USING ANTISERA COLLECTED FROM (1) PIGS RECOVERED FROM A NATURAL INFECTION WITH HIGHLY VIRULENT ASFV STRAIN IN THE FIELD, (2) PIGS VACCINATED WITH A LIVE-ATTENUATED ASF VACCINE AND (3) PIGS VACCINATED WITH AN INACTIVATED VACCINE. SUBSEQUENTLY, WE USED STATISTICAL TOOLS TO COMPARATIVELY ANALYZE ANTIBODY PROFILES AMONG THESE THREE POPULATIONS OF PIGS TO IDENTIFY VIRAL PROTEINS THAT HAVE THE POTENTIAL OF ELICITING PROTECTIVE ANTIBODY AGAINST ASFV.
$770,000Board Of Regents Of The University Of Nebraska · · FY2022 · National Institute of Food and Agriculture
Recurrent Tumor-Specific Alternately Processed Transcripts as a Source of Neoantigens for NF1-associated Malignant Peripheral Nerve Sheath Tumor Immunoprevention
$770,000David Andrew Largaespada · University Of Minnesota · UH3 · FY2023 · CA
Recurrent Tumor-Specific Alternately Processed Transcripts as a Source of Neoantigens for NF1-associated Malignant Peripheral Nerve Sheath Tumor Immunoprevention
$770,000David Andrew Largaespada · University Of Minnesota · UH3 · FY2021 · CA
Novel Concepts for the Eradication of HIV
$770,000Rafick-Pierre Sekaly · Oregon Health & Science University · DP1 · FY2009 · DA
Hunting the HIV-1 Unicorn
$770,000Sara Sawyer · University Of Colorado · DP1 · FY2019 · DA
Hunting the HIV-1 Unicorn
$770,000Sara Sawyer · University Of Colorado · DP1 · FY2018 · DA
Integrating genomics and the protein interactome for HPV+ head and neck cancer therapy
$769,993Jennifer R Grandis · University Of California, San Francisco · R35 · FY2020 · CA
Influence of maternal virome and HIV status on infant gut virome, growth and immunity
$769,959Heather Beryl Jaspan · Seattle Children'S Hospital · R01 · FY2022 · HD
A Multidisciplinary Approach to Understanding TB Latency and Reactivation
$769,928Petros C Karakousis · Johns Hopkins University · R01 · FY2012 · HL
Ontogeny and metabolism of lung alveolar macrophages in tuberculosis
$769,925Lu Huang · Univ Of Arkansas For Med Scis · R01 · FY2024 · AI
Sex specific immune response to SARS-CoV-2 leads to chronic neurologic symptoms
$769,918Louise Deborah McCullough · University Of Texas Hlth Sci Ctr Houston · R01 · FY2024 · MH
Reactions And Immunochemistry Of Carbohydrates
$769,891Pavol Kovac · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2015 · DK
Vascular macrophages and T cells in atherosclerosis
$769,886Klaus F. Ley · Augusta University · R35 · FY2025 · HL
Mucosal subunit vaccines against SARS CoV-2
$769,833Purnima Dubey · Ohio State University · R01 · FY2024 · AI
Mechanisms of Chronic Hepatitis B Infection and Therapeutic Vaccines
$769,814David R. Milich · Vaccine Research Institute Of San Diego · R01 · FY2009 · AI
Early HIV Effects on Gut Immunity and Inflammation for Seeding Viral Reservoirs
$769,753Satya Dandekar · University Of California At Davis · R01 · FY2017 · AI
A novel nanochannel system for sustained delivery of Tenofovir Alafenamide Fumarate and Emtricitabine for HIV pre-exposure prophylaxis
$769,740Alessandro Grattoni · Methodist Hospital Research Institute · R01 · FY2019 · AI
Global Network for Women's and Children's Health
$769,705Edward A Liechty · Indiana University Indianapolis · U01 · FY2012 · HD
Vascular macrophages and T cells in atherosclerosis
$769,654Klaus F. Ley · Augusta University · R35 · FY2023 · HL