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38,696 grants matching “als”
Bridge2AI: Voice as a Biomarker of Health - Building an ethically sourced, bioaccoustic database to understand disease like never before
$4,660,942Yael Emilie Bensoussan · University Of South Florida · OT2 · FY2025 · OD
Clinical Psychoneuroendocrinology and Neuropsychopharmacology (CPN)
$4,639,701Lorenzo Leggio · National Institute On Alcohol Abuse And Alcoholism · ZIA · FY2018 · AA
Silence ALS: A Platform for the Discovery and Development of Antisense Therapeutics for Patients with Ultra-Rare Forms of ALS
$4,636,637Neil Alan Shneider · Columbia University Health Sciences · U01 · FY2025 · NS
JOINT CENTER FOR STRUCTURAL GENOMICS
$4,592,116Scripps Research Institute · P50 · FY2000 · GM
Molecular Targets Development Program
$4,524,126James McMahon · Basic Sciences · Z01 · FY2007 · CA
Synthetic DNA-launched and adjuvanted Env immunogens for HIV
$4,497,948David B. Weiner · Wistar Institute · U19 · FY2023 · AI
WE PROPOSE TO ACCOMPLISH SEVERAL OF THE RECOMMENDATIONS IDENTIFIED IN THE RECENT NAS REPORT FOR ASSESSMENT OF CUBESATS TO OBTAIN HIGH PRIORITY SCIENCE RETURN NAMELY ADDRESSING NEAR-TERM SCIENCE OPPORTUNITIES TO PROVIDE CONTINUITY OF KEY MEASUREMENTS TO MITIGATE POTENTIAL GAPS IN KEY OBSERVATIONAL RECORDS [NAS 2016]. BUILDING ON OUR RECENT ESTO (IIP AND ACT) DEVELOPMENT SUCCESSES INVOLVING THE DESIGN AND DEVELOPMENT OF A NEW INSTRUMENT AND DETECTOR CONCEPTS FOR MEASUREMENTS OF SSI THE PROPOSED EFFORT HERE WILL BRING NEW EMERGING TECHNOLOGY ADVANCEMENTS TO MATURATION BY DEMONSTRATING A COMPLETE SSI MISSION CONCEPT WITH INHERENT LOW MASS AND COMPACT DESIGN. ULTIMATELY IMPLEMENTING REDUNDANT AND OVERLAPPING SMALL SATELLITE CONCEPTS INVOLVING LOW-RISK COST EFFICIENT MEASUREMENT STRATEGIES CAN POTENTIALLY AMELIORATE THE LONG-TERM SOLAR DATA RECORD [SPARN AND PILEWSKIE 2016].THE CSIM CUBESAT FLIGHT MISSION WILL SPECIFICALLY ADDRESS THE DESIGN DEVELOPMENT AND DEMONSTRATION OF A NEW INTEGRATED PLATFORM CONCEPT FOR OBTAINING MEASUREMENTS OF SSI AND PROVIDING AN SI-TRACEABLE TIE TO EXISTING AND FUTURE SATELLITE RECORDS. BUILDING ON SUCCESSFUL PREVIOUS DEVELOPMENTS TO ADVANCE TRL OF AN INHERENT LOW MASS AND COMPACT SSI INSTRUMENT DESIGN (CSIM) THE PROPOSED EFFORT CSIM-FLIGHT DEMONSTRATION (CSIM-FD) WILL MATURE THE TECHNOLOGY BY INTEGRATING THE CSIM CONCEPT INTO A FULLY QUALIFIED SMALL SATELLITE (6U CUBESAT) SYSTEM AND VALIDATE ITS PERFORMANCE AGAINST EXISTING OBSERVATORY CAPABILITIES (NAMELY TSIS SIM EARLY MISSION MEASUREMENTS).BOTH TSIS SIM AND CSIM WILL BE TIED TO THE SPECTRAL IRRADIANCE TRACEABILITY SCALE OF THE LASPNISTSPECTRAL RADIOMETER FACILITY (SRF) AND THEREFORE ESTABLISH END-TO-END VERIFICATION OF THE ABSOLUTE SSI UNCERTAINTIES [RICHARD ET AL. 2011; HARBER ET AL. 2013]. MOREOVER IF UNEXPECTED TECHNICAL OR PROGRAMMATIC CHALLENGES RESULT IN THE FURTHER DELAY OF THE TSIS LAUNCH CSIM-FD WILL PROVIDE THE NECESSARY SSI DATA RECORD TIE BETWEEN SORCE AND TSIS BY OVERLAPPING WITH THE SORCE SIM OBSERVATIONS UNTIL TSIS IS OPERATIONAL. IF TSIS LAUNCHES ON-SCHEDULE IN LATE 2017 A TSIS-CSIM OPERATIONAL OVERLAP OFFERS ADVANTAGES THAT HAVE NOT BEEN EXPLOITED PREVIOUSLY. BECAUSE OF THE SI-TRACEABLE CALIBRATION TIE BETWEEN THE TWO INSTRUMENTS AN EARLY MISSION OVERLAP WILL ALLOW A CROSS-CALIBRATION OPPORTUNITY TO VERIFY ON-ORBIT THE ABSOLUTE ACCURACY AS WELL AS TEMPORAL AND SPECTRAL STABILITY VALIDATION. FURTHERMORE AS SHOWN IN FIGURE 2 OVERLAP WILL OCCUR DURING EXPECTED SOLAR MINIMUM CONDITIONS PROVIDING A UNIQUE OPPORTUNITY TO VALIDATE EARLY MISSION MULTI-CHANNEL DUTY-CYCLED STABILITY CORRECTIONS IN THE ABSENCE OF A HIGHLY VARIABLE SUN.
$4,490,048The Regents Of The University Of Colorado · · FY2017 · National Aeronautics and Space Administration
Correction of Neurological Disease via Allele Specific Excision of Pathogenic Repeats
$4,490,047Jennifer A Doudna · University Of California Berkeley · U19 · FY2024 · NS
Synthetic DNA-launched and adjuvanted Env immunogens for HIV
$4,420,687David B. Weiner · Wistar Institute · U19 · FY2024 · AI
Section on Developmental Neurogenomics
$4,408,056Armin Raznahan · National Institute Of Mental Health · ZIA · FY2025 · MH
Procurement and Characterization of Postmortem Brain Tissue
$4,384,200Susan Amara · National Institute Of Mental Health · ZIC · FY2014 · MH
CLARITY: fully-assembled biology
$4,374,281Karl Alexander Deisseroth · Stanford University · R01 · FY2016 · MH
Correction of Neurological Disease via Allele Specific Excision of Pathogenic Repeats
$4,367,220Jennifer A Doudna · University Of California Berkeley · U19 · FY2025 · NS
Identification of Genes Causing Syndromic And Nonsyndromic Hearing Impairment
$4,356,041Thomas Baer Friedman · Deafness & Other Communication Disorders · Z01 · FY2007 · DC
Genetic, Cellular and Molecular Mechanisms in Autoimmunity to Retina
$4,334,483Rachel R. Caspi · National Eye Institute · ZIA · FY2025 · EY
Using Color as a Model System for studying Perception, Thoughts, and Action
$4,311,066Bevil Conway · National Eye Institute · ZIA · FY2023 · EY
UAB Alzheimer's Disease Research Center
$4,299,182Erik D Roberson · University Of Alabama At Birmingham · P30 · FY2024 · AG
UAB Alzheimer's Disease Research Center
$4,274,956Erik D Roberson · University Of Alabama At Birmingham · P30 · FY2025 · AG
CLARITY: fully-assembled biology
$4,271,527Karl Alexander Deisseroth · Stanford University · R01 · FY2015 · MH
FESD Type I: PLIOcene MAXimum sea level (PLIOMAX): Dynamic ice sheet-Earth response in a warmer world
$4,249,956Maureen E Raymo · Columbia University · · FY2011 · GEO
Neuropathogenesis of Retroviral Infections
$4,245,003Avindra Nath · National Institute Of Neurological Disorders And Stroke · ZIA · FY2015 · NS
The utilization of photonics technology to rapidly detect bioactive lipids associated with preeclampsia development
$4,228,935Scott W Walsh · Virginia Commonwealth University · U01 · FY2015 · HD
Genetic and epigenetic regulation of retinal development and aging
$4,226,755Anand Swaroop · National Eye Institute · ZIA · FY2017 · EY
Genetic, Cellular and Molecular Mechanisms in Autoimmunity to Retina
$4,226,384Rachel R. Caspi · National Eye Institute · ZIA · FY2023 · EY
Neuroblastoma Tumor Microenvironment: tumor growth and immune regulation
$4,216,302Carol Thiele-Galetto · Division Of Basic Sciences - Nci · ZIA · FY2022 · CA